Identity, community and care in online accounts of hereditary colorectal cancer syndrome

Sociological literature has explored how shifts in the point at which individuals may be designated as diseased impact upon experiences of ill health. Research has shown that experiences of being genetically “at risk” are shaped by and shape familial relations, coping strategies, and new forms of biosociality. Less is known about how living with genetic risk is negotiated in the everyday and over time, and the wider forms of identity, communities and care this involves. This article explores these arrangements drawing on online bloggers’ accounts of Familial Adenomatous Polyposis (FAP). We show how accounts of genetic risk co-exist with more palpable experiences of FAP in everyday life, notably the consequences of prophylactic surgeries. We consider how the act of blogging represents but also constitutes everyday experiences of hereditary cancer syndrome as simultaneously ordinary and exceptional, and reflect on the implications of our analysis for understanding experiences of genetic cancer risk

CCAFS site atlas – Kaffrine

CCAFS site atlas for Kaffrine, Senegal

CCAFS site atlas – Kollo / Fakara

CCAFS site atlas for Kollo / Fakara, Niger

CCAFS site atlas – Lawra – Jirapa / Lawra

CCAFS site atlas for Lawra – Jirapa / Lawra, Ghana

CCAFS site atlas – Yatenga / Tougou

CCAFS site atlas for Yatenga / Tougou, Burkina Faso

CCAFS site atlas – Segou / Cinzana

CCAFS site atlas for Segou / Cinzana, Mali

CCAFS Site Portfolio: Core Sites in the CCAFS Regions: East Africa, West Africa and South Asia

The CGIAR Research Program Climate Change, Agriculture, Food Security (CCAFS) is a 10-year research initiative launched by CGIAR and the Earth System Science Partnership (ESSP). CCAFS seeks to overcome the threats to agriculture and food security in a changing climate, exploring new ways of helping vulnerable rural communities adjust to global changes in climate. CCAFS brings together the world’s best researchers in agricultural science, development research, climate science, and Earth System science to identify and address the most important interactions, synergies and trade- offs between climate change, agriculture and food security. CCAFS also involves farmers, policy makers, donors, non-governmental organizations and other stakeholders to integrate their knowledge and needs into the tools and approaches that are being developed. The overall goal of CCAFS is to overcome the additional threats posed by a changing climate to achieving food security, enhancing livelihoods and improving environmental management. In 2010/2011, CCAFS initially focused on three regions: East Africa (EA), West Africa (WA) and South Asia (SA). Two additional target regions (Southeast Asia and Latin America) were added in late 2012. This report outlines the site selection process of current and future sites and provides a brief overview of the initially selected CCAFS sites

B Cells as Prognostic Biomarker After Surgery for Colorectal Liver Metastases

Background: The aim of this study was to identify more accurate variables to improve prognostication of individual patients with colorectal liver metastases (CRLM). Clinicopathological characteristics only partly explain the large range in survival rates. Methods: MessengerRNA expression profiles of resected CRLM of two patient groups were analysed by mRNA sequencing: poor survivors (death from recurrent disease 60 months after surgery). Tumour and adjacent liver parenchyma samples were analysed. Results: MessengerRNA expression profiling of the tumour samples identified 77 genes that were differentially expressed between the two survival groups at a False Discovery Rate (FDR) <0.1. In the adjacent liver parenchyma samples only one gene, MTRNR2L1, showed significantly higher expression in the good survivors. Pathway analysis showed higher expression of immune-related and stroma-related genes in tumour samples from good survivors. Expression data was then validated by immunohistochemistry in two cohorts comprising a total of 125 patients. Immunohistochemical markers that showed to be associated with good survival in the total cohort were: high K/L+ infiltration in tumour stroma [p = 0.029; OR 2.500 (95% CI 1.100–5.682)] and high CD79A+ infiltration in tumour stroma [p = 0.036; OR 2.428 (95%CI 1.062–5.552)]. Conclusions: A high stromal infiltration of CD79A+ B cells and K/L+ plasma cells might be favourable prognostic biomarkers after surgery for CRLM