Exploiting Emotions via Composite Pretrained Embedding and Ensemble Language Model

Decisions in the modern era are based on more than just the available data; they also incorporate feedback from online sources. Processing reviews known as Sentiment analysis (SA) or Emotion analysis. Understanding the user's perspective and routines is crucial now-a-days for multiple reasons. It is used by both businesses and governments to make strategic decisions. Various architectural and vector embedding strategies have been developed for SA processing. Accurate representation of text is crucial for automatic SA. Due to the large number of languages spoken and written,  polysemy and syntactic or semantic issues were common. To get around these problems, we developed effective composite embedding (ECE), a method that combines the advantages of vector embedding techniques that are either context-independent (like glove & fasttext) or context-aware (like  XLNet) to effectively represent the features needed for processing.  To improve the performace towards emotion or  sentiment we proposed stacked ensemble model of deep lanugae models.ECE with Ensembled model is evaluated on balanced  dataset to prove that it is a reliable embedding technique and a generalised model for SA.In order to evaluate ECE, cutting-edge ML and Deep net language models are deployed and comapared. The model is evaluated using benchmark datset such as  MR, Kindle along with realtime tweet dataset of user complaints . LIME is used to verify the model's predictions and to provide statistical results for sentence.The model with ECE embedding provides state-of-art results with real time dataset as well

Gambaran Peresepan Digoksin Pada Pasien Gagal Jantung Yang Dirawat Jalan Di RSUP Dr. Kariadi Semarang

ABSTRACKBackground Heart failure is a clinical syndrome caused by abnormalitiesof cardiac structure or function. The prevalence of heart failure is increasing andcaused loss of quality of life. Heart failure treatment guidelines has beenprepared to guide medical treatment and doctors in providing treatmentrecommendations. There are various classes of drugs used in the treatment ofheart failure, one of which is digoxin. Nowadays it has been discovered that notall heart failure patients should be given digoxin.Aim To know wether the prescripction of digoxin in heart failure outpatientof dr. Kariadi Semarang Central Hospital is in conformity with the guidelines forthe treatment of heart failure that used Internationally.Methods This was a descriptive study. Research data were the medicalrecords of outpatient heart failure patients who received digoxin therapy in dr.Kariadi Semarang Central Hospital in January 2011 to December 2011 andcomplemented by the data of ECG and echocardiography. Data were collectedwith a total sampling method. In this study, the administration of digoxin followedheart failure guidelines issued by the European Society of Cardiology (ESC) andAmerican Heart Association (AHA), the heart failure patients with atrialfibrillation (AF) or patients with sinus rhythm but with left ventricle ejectionfraction (LVEF) ≤ 40%. Digoxin was indicated for heart failure patients with AFor patients with sinus rhythm but with the left ventricular ejection fraction (LVEF)≤ 40%Results There were 121 patients who received digoxin therapy, 74 patients(61,2%) received digoxin therapy with proper indications. The reason forprescribing digoxin were atrial fibrillation (n = 18, 14.9%), LVEF ≤40% (n = 21,17.4%), or both (n = 35, 28.9%). Forty six patients (38.0%) received digoxintherapy,without proper indications.Conclusion There were 61,2% patients who received digoxin therapy withapropriate indication and 38,8% patients with inappropriate indications

Differential Resistance Reaction of Maize Genotypes to Maize Stem Borer (Chilo Partellus Swinhoe) at Chitwan, Nepal

Maize stem borer (MSB), Chilo partellus Swinhoe, Lepidoptera: Pyralidae is one of the most important insect pest of maize in Nepal. Host plant resistance is the cost-effective, ecologically sound and stable approach to reduce damage by stem borers. Forty four maize genotypes were screened for resistance to maize stem borer at the research field of National Maize Research Program, Rampur during spring seasons (March to June) of two consecutive years 2013 and 2014. The maize genotypes were evaluated in randomized complete block design with three replications and data were collected on foliar damage rating, tunnel length and number of exit holes made by the borer. The foliar damage and tunnel length damage were significant for genotypes for both the years. The exit holes were not significant in 2013 but significant in 2014 ranging from 2-6 scale. The foliar rating ranged from 2 to 5.5 in 2013 and 1.1 to 4.5 in 2014 on a 1-9 rating scale. The highly resistant genotypes (<2.0 score) were R-POP-2 and RML-5/RML-8. The tunnel length ranged from 3.2 to 22.5 cm in 2013 and 4.2 to 20.4 cm in 2014 on 0- >10 cm scale. The least susceptible genotypes (<5 cm) were RampurSO3F8, RampurSO3FQ02 and RampurS10F18. The genotypes having least exit holes (2.0) in 2014 were RampurSO3F8, RampurSO3FQ02, RampurS10F18. Thus less damage parameters were observed in R-POP-2, RML-5/RML-8, RampurSO3F8, RampurSO3FQ02 and RampurS10F18 and therefore they can be used as parents or as sources of resistance in breeding program

Anti-Osteoclastic Effect of Zinc Studied in MCF-7 Induced Osteoclastogenesis

Bone which a key structural support of the body, undergoes dynamic micro structural remodelling all over life to control automatic stress and calcium requirement in the body. A number of risk factors including oxidative stress, apoptosis and abnormal intracellular Ca2+ metabolism have been postulated to play a function in the inception and progress of bone osteolysis. Cancer cells establish a tight relationship with the host tissue, secreting factors that stimulate or inhibit bone cells, receiving signals generated from the bone remodelling activity, and displaying some features of bone cells. This interplay between tumour and bone cells alters the physiological bone remodelling, leading to the generation of a vicious cycle that promotes bone metastasis growth. Zinc is one of the most relevant minerals to human health, because of its antioxidant properties. The present study was aimed to investigate protective role of zinc against bone metastasis. In the present study, TRAP positive multinucleated cell count was low compared to CM treated cells. Zinc treatment suppressed MCF-7 induced mRNA levels of cytoplasmic 1 (Nfatc1), TRAP and Cathepsin-K. Hence, it can be concluded that zinc decreases osteoclastogenesis induced by MCF-7 cells. Keywords: Oxidative stress; Metastasis; Bone remodelling; Zinc

TARGETING NUCLEAR FACTOR KAPPA B WITH CHELATED ZINC COMPOUNDS TOWARDS ANTICANCER DRUG DESIGN

Objective: The objective of the study was to analyse the target-ligand interactions between nuclear factor-κB (NF-κB) and chelated Zinc compounds and to explore the anticancer drug potential of these ligands by a bio computational approach. Methods: Bioinformatics databases and tools were applied for the study. Three dimensional structure of the target NF-κB was retrieved from Protein Data Bank (PDB). The optimized structures of two chelated Zinc compounds, Zinc acetate and Zinc orotate were taken for docking studies with the target using docking tool AutoDock 4.2. Drug properties of the ligands were further assessed by Molinspiration server. Results: Docking results as predicted by AutoDock and as visualized by PyMol viewer were effective for both the ligands. Comparatively, Zinc orotate showed minimum energy and more interactions with the target. Both the ligands satisfied the Lipinski’s rule of five with zero violations. Conclusion: The findings emphasized the promising role of chelated Zinc compounds as potent drug candidates in anti-cancer drug design against NF-κB

CD9 Expression by Human Granulosa Cells and Platelets as a Predictor of Fertilization Success during IVF

Objective. To determine whether CD9 expression on human granulosa cells (GCs) and platelets could predict the success of conventional fertilization of human oocytes during in vitro fertilization (IVF). Methods. Thirty women undergoing IVF for nonmale factor infertility participated. Platelets from venous blood and GCs separated from retrieved oocytes were prepared for immunofluorescence. Flow cytometry quantified the percent of GCs expressing CD9, and CD9 surface density on GCs and platelets. Fertilization rate was determined for the total number of oocytes, and the number of mature oocytes per patient. Correlations tested for significant relationships (P < .05) between fertilization rates and CD9 expression. Results. CD9 surface density on human GCs is inversely correlated with fertilization rate of oocytes (P = .04), but the relationship was weak. Conclusion. More studies are needed to determine if CD9 expression on GCs would be useful for predicting conventional fertilization success during IVF

Quantifying the relationship between human Lyme disease and Borrelia burgdorferi exposure in domestic dogs

Lyme disease (LD) is the most common vector-borne disease in the United States. Early confirmatory diagnosis remains a challenge, while the disease can be debilitating if left untreated. Further, the decision to test is complicated by under-reporting, low positive predictive values of testing in non-endemic areas and travel, which together exacerbate the difficulty in identification of newly endemic areas or areas of emerging concern. Spatio-temporal analyses at the national scale are critical to establishing a baseline human LD risk assessment tool that would allow for the detection of changes in these areas. A well-established surrogate for human LD incidence is canine LD seroprevalence, making it a strong candidate covariate for use in such analyses. In this paper, Bayesian statistical methods were used to fit a spatio-temporal spline regression model to estimate the relationship between human LD incidence and canine seroprevalence, treating the latter as an explanatory covariate. A strong non-linear monotonically increasing association was found. That is, this analysis suggests that mean incidence in humans increases with canine seroprevalence until the seroprevalence in dogs reaches approximately 30%. This finding reinforces the use of canines as sentinels for human LD risk, especially with respect to identifying geographic areas of concern for potential human exposure

Genetic variation of macronutrient tolerance in Drosophila melanogaster

Carbohydrates, proteins and lipids are essential nutrients to all animals; however, closely related species, populations, and individuals can display dramatic variation in diet. Here we explore the variation in macronutrient tolerance in Drosophila melanogaster using the Drosophila genetic reference panel, a collection of similar to 200 strains derived from a single natural population. Our study demonstrates that D. melanogaster, often considered a "dietary generalist", displays marked genetic variation in survival on different diets, notably on high-sugar diet. Our genetic analysis and functional validation identify several regulators of macronutrient tolerance, including CG10960/GLUT8, Pkn and Eip75B. We also demonstrate a role for the JNK pathway in sugar tolerance and de novo lipogenesis. Finally, we report a role for tailless, a conserved orphan nuclear hormone receptor, in regulating sugar metabolism via insulin-like peptide secretion and sugar-responsive CCHamide-2 expression. Our study provides support for the use of nutrigenomics in the development of personalized nutrition.Peer reviewe

Влияние многоосной ходовой системы машинно-тракторных агрегатов на плотность почвы

Use of the powerful tractors as a part of the machine-and-tractor units (MTU) is limited to high impact of their propellers (deformers) on the soil. The increase in tractor weigh and the multiple MTU passes result in overconsolidation of the soil. As a result, physical and mechanical soil properties are modified. The modified quality of soil structure is difficult to be restored entirely. As a result the intensive tilled soil degrades with time and all that creates the ecosystem disbalance of cultivated land. The power method based on regularities of absorption of energy by various soil layers was applied to calculate indicators of soil consolidation. The energy method based on the regularities of the energy absorption by different soil layers was applied to calculate the soil consolidation rate. The conducted researches show that at a pressure of 150 kPa and humidity of 19.2 percent the soddy podzolic loam sand soil density increased from 970 to 1260 kg per cubic metre. The increase in number of the drive system axles can reduce the consolidation of the topsoil as well as lower layer.The intensity of decrease of soil panning considerably decreases when quantity of axes is over four. If the pressure upon the high workhardening soil is constant (the sizes of wheels increase at reduction of axes quantity) then the reducing of the dip of the wheel track can be obtained by increasing the number of the drive system axles. On the low work-hardening soil the effect of reduction of depth is not so much. Increasing the number of axles and the size of wheels for low work-hardening moisty soils is equally effective for reducing the dip of the wheel track. For the overmoist soils it will be better to increase the sizes of a basic surface of running system. If the number of axes is more than four then the decrease of high work-hardening soils consolidation will be less intensive.Применение энергонасыщенных тракторов, входящих в состав машинно-тракторных агрегатов (МТА), ограничивается высоким воздействием их движителей (деформаторов) на почву. Увеличение массы тракторов, многочисленные проходы МТА по полю приводят к чрезмерному уплотнению почвы, что сопровождается изменением ее физико-механических свойств. Разрушенная структура почвы не восстанавливается полностью, в результате чего интенсивно обрабатываемая почва с течением времени деградирует, и в конечном итоге все это нарушает эко- логию агроландшафтов. Для расчета показателей уплотнения почвы применен энергетический метод, основанный на закономерностях поглощения энергии различными слоями почвы. Получены закономерности уплотнения почв с плотным основанием при различных режимах нагружения. Проведенные исследования показывают, что при давлении 150 кПа на дерново-подзолистую легкосуглинистую почву влажностью 19,2% плотность увеличилась с 970 до 1260 кг/м3 . Показали, что увеличение количества осей ходовой системы при сохранении общей нагрузки снижает уплотнение верхнего слоя почвы и высоту уплотняемого слоя. При увеличении количества осей свыше четырех интенсивность убывания уплотнения заметно снижается. Установили, что при сохранении давления на почву постоянным (размеры колес увеличиваются при уменьшении количества осей) для сильно упрочняющихся почв глубина следа снижается с увеличением количества осей ходовой системы. На слабоупрочняющихся почвах эффект уменьшения глубины следа и уплотнения почвы при увеличении количества осей ниже по сравнению со следообразованием на сильноупрочняющихся почвах. Показали, что на увлажненных слабоупрочняющихся почвах для снижения глубины следа эффективно увеличение количества осей и размеров колес. На переувлажненных почвах лучше увеличить размеры опорной поверхности ходовой системы. При повышении количества осей свыше четырех интенсивность убывания плотности сильноупрочняющихся почв снижается.