271 research outputs found
The pivotal role of cholesterol absorption inhibitors in the management of dyslipidemia
Elevated low-density lipoprotein (LDL)-cholesterol is associated with a significantly increased risk of coronary heart disease. Ezetimibe is the first member of a new class of selective cholesterol absorption inhibitors. It impairs the intestinal reabsorption of both dietary and hepatically excreted biliary cholesterol. Ezetimibe is an effective and safe agent for lowering LDL-C and non HDL-C. Short term clinical trials have established the role of ezetimibe monotherapy and its use in combination with statins. Furthermore, ezetimibe and statin combination therapy increased the percentage of patients who achieved their LDL-C treatment goal. Studies using surrogate markers of atherosclerosis have suggested a possible role of ezetimibe in combating atherosclerosis. Ezetimibe provides an effective therapeutic strategy for the management of homozygous familial hypercholesterolemia (HoFH) and sitosterolemia. The lack of outcomes and long term safety data is attributed to the relatively recent introduction of this medication
Are the effects of nicotinic acid on insulin resistance precipitated by abnormal phosphorous metabolism?
Nicotinic acid is a unique cholesterol modifying agent that exerts favorable effects on all cholesterol parameters. It holds promise as one of the main pharmacological agents to treat mixed dyslipidemia in metabolic syndrome and diabetic patients. The use of nicotinic acid has always been haunted with concerns that it might worsen insulin resistance and complicate diabetes management. We will discuss the interaction between phosphorous metabolism and carbohydrate metabolism and the possibility that worsening of insulin resistance could be related to adrug induced alteration in phosphorous metabolism, and the implications of that in medical management of diabetes and metabolic syndrome patients with mixed dyslipidemia
A Comprehensive Exploration of Chemical Inventory: Multifaceted Challenges and Profound Insights
This paper provides a comprehensive exploration of the multifaceted challenges and profound insights associated with chemical inventory. It highlights the critical findings and contributions in the areas of safety, efficiency, and compliance within chemical inventory facilities. By emphasizing the importance of robust risk assessments, implementation of safety measures, adherence to regulatory frameworks, and development of comprehensive emergency response plans, this paper aims to foster safer, more efficient, and compliant chemical inventory environments. Drawing attention to the tragic Beirut port explosion in 2020, this paper underscores the urgent need to address the challenges inherent in chemical inventory and presents valuable insights to mitigate potential hazards
Universal vortex formation in rotating traps with bosons and fermions
When a system consisting of many interacting particles is set rotating, it
may form vortices. This is familiar to us from every-day life: you can observe
vortices while stirring your coffee or watching a hurricane. In the world of
quantum mechanics, famous examples of vortices are superconducting films and
rotating bosonic He or fermionic He liquids. Vortices are also observed
in rotating Bose-Einstein condensates in atomic traps and are predicted to
exist for paired fermionic atoms. Here we show that the rotation of trapped
particles with a repulsive interaction leads to a similar vortex formation,
regardless of whether the particles are bosons or (unpaired) fermions. The
exact, quantum mechanical many-particle wave function provides evidence that in
fact, the mechanism of this vortex formation is the same for boson and fermion
systems.Comment: 4 pages, 4 figure
Investigation of optical and electrical properties of Cobalt-doped Ge-Sb-S thin film
Amorphous Germanium Antimony Sulphide (Ge-Sb-S) doped with Cobalt (Co) have been deposited on glass substrates by thermal evaporation technique on a glass substrate. The films deposited onto glass substrates are characterized by Energy Dispersive X-ray Fluorescence Spectrometer, UV–VIS spectrophotometer, Raman spectroscopy, and Capacitance-Voltage Keithley meter. The optical band gap was calculated from the UV–Visible spectrum and found to be 2.05 eV. Raman spectroscopy measurements reveal that a wide band spectrum from 300 to 410 cm−1 centered at 355 cm−1. The Raman shift peaks at 325 cm−1 and 350 cm−1 are as-signed to the bond stretching mode Sb-S and Ge-S, respectively. In addition, from the obtained Raman spectra it is concluded that the presence of Co doped with Ge-Sb-S. The capacitance and conductance versus voltage measurements were performed at different temperatures. The results show a slight increase in the capacitance with temperature and it reaches a maximum value around 150 °C, and eventually it becomes negative. This behavior is interpreted in terms of the nucleation growth process and the thermally activated conduction process with measured activation energy of 0.79 eV.This work is funded by the University Program for Advanced Research - United Arab Emirates University , (project no. 31S313 ).Scopu
The accountancy profession and emerging economies : reflections on the case of Syria at the margins of the global order
Syria, prior to the outbreak of extreme violence in 2011, was seeking increased economic liberalisation and aspiring to gain a larger stake in the global economy after a long period of isolation and animosity with the West. The authors elaborate, with critical insight, on how, before the violent events of more recent times, Syrian accountants were mobilising debates and shaping their professional identity vis-Ã -vis the new role they envisaged for the accountancy profession in this era of globalisation. Future research possibilities are considered, including reflecting in this context on the terrible and tragic events impacting Syria in recent times
Kelvin Modes of a fast rotating Bose-Einstein Condensate
Using the concept of diffused vorticity and the formalism of rotational
hydrodynamics we calculate the eigenmodes of a harmonically trapped
Bose-Einstein condensate containing an array of quantized vortices. We predict
the occurrence of a new branch of anomalous excitations, analogous to the
Kelvin modes of the single vortex dynamics. Special attention is devoted to the
excitation of the anomalous scissors mode.Comment: 7 pages, 3 figures, submitted to Phys. Rev.
Reflecting on Hybrid Events: Learning from a Year of Hybrid Experiences
The COVID-19 pandemic led to a sudden shift to virtual work and events, with the last two years enabling an appropriated and rather simulated togetherness - the hybrid mode. As we return to in-person events, it is important to reflect on not only what we learned about technologies and social justice, but about the types of events we desire, and how to re-design them accordingly. This SIG aims to reflect on hybrid events and their execution: scaling them across sectors, communities, and industries; considering trade-offs when choosing technologies; studying best practices and defining measures of "success"for hybrid events; and finally, identifying and charting the wider social, ethical, and legal implications of hybrid formats. This SIG will consolidate these topics by inviting participants to collaboratively reflect on previous hybrid experiences and what can be learned from them
- …