Bacterial reduction of N-oxides of tobacco- specific nitrosamines (TSNA)

1 Contrary to established metabolic pattern, a recent investigation of NNK metabolism produced in rat urine higher levels of 4-(methylnitrosamino)-1-(3-pyridyl)-1- butanone (NNK) and 4-(methylnitrosamino)-1-(3-pyri dyl)-1-butanol (NNAL) than their N-oxides, suggesting that reconversion of N-oxides could occur after urine formation. 2 To verify the possible role of bacteria in the reduction of NNK-N-oxide and NNAL-N-oxide to their respective parent compounds, NNK and NNAL, in smokers with urinary tract infection (UTI), the N-oxides were isolated from the urine of rats treated with 5-3HNNK and individually incubated at 37°C with ten bacterial species in sterile human urine under different pH regimens. After incubation with the bacteria, aliquots of culture media were analyzed by high pressure liquid chromatography (HPLC) with radiochemical detection. 3 Escherichia coli, Enterobacter cloacae, Klebsiella pneumoniae and Proteus mirabilis possessed varying capacity to regenerate NNK and NNAL from their N- oxides while others showed no detectable reductive capability within 24 h. 4 This result constitutes the first experimental evidence that in tobacco users with concomitant UTI, bacterial regeneration of the procarcinogenic NNK and NNAL from their N-oxides could occur in the bladder leading to increased carcinogen burden in these individuals

Riparian vegetation classification from airborne laser scanning data with an emphasis on cottonwood trees

The high point density of airborne laser mapping systems enables achieving a detailed description of geographic objects and the terrain. Growing experience indicates, however, that extracting useful information directly from the data can be difficult. In this study, small-footprint lidar data were used to differentiate between young, mature, and old cottonwood trees in the San Pedro River Basin near Benson, Arizona, USA. The lidar data were acquired in June 2003, using the Optech Incorporated ALTM 1233 (Optech Incorporated, Toronto, Ont.), during flyovers conducted at an altitude of 750 m. The lidar data were preprocessed to create a two-band image of the study site: a high-accuracy canopy altitude model band, and a near-infrared intensity band. These lidar-derived images provided the basis for supervised classification of cottonwood age categories, using a maximum likelihood algorithm. The results of classification illustrate the potential of airborne lidar data to differentiate age classes of cottonwood trees for riparian areas quickly and accurately. © 2006, Taylor & Francis Group, LLC. All rights reserved

Loophole-free Bell test for continuous variables via wave and particle correlations

We derive two classes of multi-mode Bell inequalities under local realistic assumptions, which are violated only by the entangled states negative under partial transposition in accordance with the Peres conjecture. Remarkably, the failure of local realism can be manifested by exploiting wave and particle correlations of readily accessible continuous-variable states, with very large violation of inequalities insensitive to detector-efficiency, which makes a strong case for a loophole-free test.Comment: 4 pages, published versio

Penggunaan Media Teknologi, Student Engagement, Dan Kinerja Dalam Pembelajaran Akuntansi: Studi Kasus Pada Accounting Software “Accurate”

The purpose of this study is to research the relation about accounting software (Accurate)and student engagement and student performance. A number of 186 students in accounting class of Maranatha Christian University participated in this research and valid data is 128. Regression Linear and descriptive analysis are used in this research. The results show that the value of R-square is 0.993, it indicates that there is linear correlation between engagement and students’ score in practical accounting software (Accurate)

Reply to the comment on "Loophole-free Bell test for continuous variables via wave and particle correlations"

In a recent note, Cavalcanti and Scarani (CS) constructed a counter local-hidden-variable model to explain the violation of our inequalities in Phys. Rev. Lett. 105, 170404 (2010). Here, we briefly discuss some issues in response to the comments raised by CS.Comment: published versio

Investigating ultra-low velocity zones in the southern hemisphere using an Antarctic dataset

Given limited seismic coverage of the lowermost mantle, less than one-fifth of the core-mantle boundary (CMB) has been surveyed for the presence of ultra-low velocity zones (ULVZs). Investigations that sample the CMB with new geometries are therefore important to further our understanding of ULVZ origins and their potential connection to other deep Earth processes. Using core-reflected ScP waves recorded by the recently deployed Transantarctic Mountains Northern Network in Antarctica, the current study aims to expand ULVZ investigations in the southern hemisphere. Our dataset samples the CMB in the vicinity of New Zealand, providing coverage between an area to the northeast, where ULVZ structure has been previously identified, and another region to the south, where prior evidence for a ULVZ was inconclusive. This area is of particular interest because the data sample across the boundary of the Pacific Large Low Shear Velocity Province (LLSVP). The Weddell Sea region near Antarctica is also well sampled, providing new information on a region that has not been previously studied. A correlative scheme between a large database of 1-D synthetic seismograms and the observed ScP data demonstrates that ULVZs are required in both study regions. Modeling uncertainties limit our ability to definitively define ULVZ characteristics but also likely indicate more complex 3-D structure. Given that ULVZs are detected within, along the edge of, and far from the Pacific LLSVP, our results support the hypothesis that ULVZs are compositionally distinct from the surrounding mantle and are not solely related to partial melt. ULVZs may be ubiquitous along the CMB; however, they may be thinner in many regions than can be resolved by current methods. Mantle convection currents may sweep the ULVZs into thicker piles in some areas, pushing these anomalies toward the boundaries of LLSVPs

2D Bayesian automated tilted-ring fitting of disk galaxies in large HI galaxy surveys: 2DBAT

We present a novel algorithm based on a Bayesian method for 2D tilted-ring analysis of disk galaxy velocity fields. Compared to the conventional algorithms based on a chi-squared minimisation procedure, this new Bayesian-based algorithm suffers less from local minima of the model parameters even with highly multi-modal posterior distributions. Moreover, the Bayesian analysis, implemented via Markov Chain Monte Carlo (MCMC) sampling, only requires broad ranges of posterior distributions of the parameters, which makes the fitting procedure fully automated. This feature will be essential when performing kinematic analysis on the large number of resolved galaxies expected to be detected in neutral hydrogen (HI) surveys with the Square Kilometre Array (SKA) and its pathfinders. The so-called '2D Bayesian Automated Tilted-ring fitter' (2DBAT) implements Bayesian fits of 2D tilted-ring models in order to derive rotation curves of galaxies. We explore 2DBAT performance on (a) artificial HI data cubes built based on representative rotation curves of intermediate-mass and massive spiral galaxies, and (b) Australia Telescope Compact Array (ATCA) HI data from the Local Volume HI Survey (LVHIS). We find that 2DBAT works best for well-resolved galaxies with intermediate inclinations (20 deg < i < 70 deg), complementing three-dimensional techniques better suited to modelling inclined galaxies.Comment: Accepted for publication in MNRAS; 46 pages, 33 figure