Peningkatan Kemampuan Motorik Halus melalui Kegiatan Menggunting dan Menempel pada Anak Usia 4-5 Tahun di Paud Aisyiyah 3 Pontianak

The purpose of this study is to know: 1) Learning planning with cutting and sticking activities to improve fine motor skills in children aged 4-5 years in PAUD Aisyiyah 3 with, 2) Implementation of learning through cutting and sticking activities to improve fine motor skills in children aged 4-5 years in early childhood Aisyiyah 3 Pontianak and 3) Improvement of fine motor skills of children after following the activity of cutting and sticking to children aged 4-5 years in early childhood Aisyiyah 3 Pontianak. Researchers use descriptive method. The form of this research is classroom action research. Data analysis used in this research is observation, and interview. The steps used in this study are as follows: 1). Planning, 2). Implementation, 3). Observation or Observation and 4). Reflection. Data analysis techniques used are observation / observation and interview / conversation and gathering tool is the format of observation and interview guide. The result of the research shows that 1) Learning planning using cutting and sticking technique to improve fine motor in accordance with the steps that have been determined in improving the fine motor of the child with the category is not arranged in cycle 1 and in cycle II with the categories well arranged. 2) Implementation of learning using cutting and sticking techniques to improve fine motor has been implemented by the teacher well as according to the planning prepared by the teacher, both in cycle I and cycle II and 3) Improvement of fine motor development of children after following learning by cutting techniques and attached, progressed very well in cycle I mean motor fine of child equal to 59,29 and increase in cycle II become 89,41. This means the fine motor of the child has improved very well

The Pentahelix Partnership Responses during Covid-19 Pandemic in Makassar

Background: A Partnership is one of the strategies for accelerating responses of Covid-19, especially in understanding the decisions made by the government and the various reactions of the community regarding the Covid-19 pandemic. Objective: This study aims to explore partnership efforts pentahelix involving the government, academia, community, business sectors, and the media in handling Covid-19. Methods: The qualitative study was carried out through in-depth interviews with 18 participants consisting of government, media, academics, and community elements. The participants were members of the Covid-19 Handling Task Force (Covid-19 Task Force) and people who were directly involved in handling Covid-19 in Makassar. The content analysis was performed using the collected data. The themes that emerge from the data are the pentahelix partnership with the government, community groups, academics, business sectors, and mass media. The data were collected from December 2022 to March 2023. Results: The pentahelix partnership involves 5 parties: government, community, academics, business sectors, and the media. The partnership is accomplished through coordination, collaboration, participation, and mutual assistance. This partnership is established in the implementation of government policies in handling Covid-19 with the formation of Task Forces where the community participates in its implementation. Coordination between the government and academics regarding ways to resolve the Covid-19 case; collaboration with business sectors in providing facilities and infrastructure for handling Covid-19 activities as well as with the media that assist in disseminating information, public education, and news related to the incident of Covid-19 was adopted to implement the health policies during this pandemic. Conclusion: handling covid-19 with pentahelix partnerships was carried out through coordination, collaboration, participation, and mutual assistance of all parties. The partnership process is a strategy for implementing health programs related to the handling of Covid-19 which are regulated by the government

Pengaruh Penggunaan Multi Nutrients Sauce (Mns) Ero II Dalam Ransum Terhadap Pertambahan Bobot Tubuh Sapi Potong

This study aims to determine the effect of the use of Multi Nutrients Sauce (MNS) ERO II in the ration on feed consumption and average daily gain of beef cattle. The research was conducted October 30th, 2015 - December 6th, 2015 at Ngudi Makmur farmer group, Mulyo Asri village, Tulang Bawang Tengah district, Tulang Bawang Barat regency. Samples ration was analysed at the Laboratory of Nutrition and Feed Science. Department of Animal Husbandry, Faculty of Agriculture, University of Lampung. The experimental design used was a randomized block design (CRD) with three treatments and four blocks. The treatments were: 1. Basal diet; 2. Basal diet + 10% MNS; and 3. Unila diets + 10% MNS. Result of experiment showed that the addition of MNS ERO II significantly affected (P<0.05) on consumption, and average daily gain of beef cattle

Advanced gynecologic malignancies treated with a combination of the VEGF inhibitor bevacizumab and the mTOR inhibitor temsirolimus.

BackgroundBevacizumab and temsirolimus are active agents in gynecologic tumors. Temsirolimus attenuates upregulation of HIF-1α levels, a resistance mechanism for antiangiogenics, and targets the PI3-kinase/AKT/mTOR axis, commonly aberrant in these tumors.Patients and methodsWe analyzed safety and responses in 41 patients with gynecologic cancers treated as part of a Phase I study of bevacizumab and temsirolimus.ResultsMedian age of the 41 women was 60 years (range, 33-80 years); median number of prior systemic therapies was 4 (1-11). Grade 3 or 4 treatment-related toxicities included: thrombocytopenia (10%), mucositis (2%), hypertension (2%), hypercholesterolemia (2%), fatigue (7%), elevated aspartate aminotransferase (2%), and neutropenia (2%). Twenty-nine patients (71%) experienced no treatment-related toxicity greater than grade 2. Full FDA-approved doses of both drugs (bevacizumab 15mg/kg IV Q3weeks and temsirolimus 25mg IV weekly) were administered without dose-limiting toxicity. Eight patients (20%) achieved stable disease (SD) &gt; 6 months and 7 patients (17%), a partial response (PR) [total = 15/41 patients (37%)]. Eight of 13 patients (62%) with high-grade serous histology (ovarian or primary peritoneal) achieved SD &gt; 6 months/PR.ConclusionBevacizumab and temsirolimus was well tolerated. Thirty-seven percent of heavily-pretreated patients achieved SD &gt; 6 months/PR, suggesting that this combination warrants further study

Training Students on the Effective Use of Translator Services: How Can You Treat Someone You Don’t Understand?

In 2005, the Virginia Commonwealth University School of Medicine partnered with the Inova Health System to create the first regional branch medical campus in Northern Virginia. As a part of this partnership, the VCU School of Medicine Inova Campus accepts a minimum of twenty-four medical students from the third and fourth year classes annually. In an effort to better prepare the incoming students for their clinical years and an extremely diverse patient population, a video was created to demonstrate effective use of translator services

The Medical Futures Program: How One Regional Medical Campus Educates Its Community

Poster created for the 2012 GRMC Session of the AAMC Annual Meeting. The Virginia Commonwealth University School of Medicine Inova Campus has extensive ties to the northern Virginia community. The Medical Futures Program was created to provide valuable information regarding medical school admissions and current physician workforce issues to high school and university students, their parents, and guests

Selection of Apps for Teaching Difficult Mathematics Topics: An Instrument to Evaluate Touch-Screen Tablet and Smartphone Mathematics Apps

Manipulatives—including the more recent touch-screen mobile device apps—belong to a broader network of learning tools. As teachers continue to search for learning materials that aid children to think mathematically, they are faced with a challenge of how to select materials that meet the needs of students. The profusion of virtual learning tools available via the Internet magnifies this challenge. What criteria could teachers use when choosing useful manipulatives? In this chapter, we share an evaluation instrument for teachers to use to evaluate apps. The dimensions of the instrument include: (a) the nature of the curriculum addressed in the app— emergent, adaptable or prescriptive, and relevance to current, high quality curricula—high, medium, low; (b) degree of actions and interactions afforded by the app as a learning tool— constructive, manipulable, or instructive interface; (c) the level of interactivity and range of options offered to the user —multiple or mono, or high, moderate or low; and, (d) the quality of the design features and graphics in the app—rich, high quality or impoverished, poor quality. Using these dimensions, researchers rated the apps on a three-level scale: Levels I, II, and III. Few apps were classified as Level III apps on selected dimensions. This evaluation instrument guides teachers when selecting apps. As well, the evaluation instrument guides developers in going beyond apps that are overly prescriptive, that focus on quizzes, that are text based, and include only surface aspects of using multi-modality in learning, to apps that are more aligned with emergent curricula, that focus also on conceptual understanding, and that utilize multiple, interactive representations of mathematics concepts

Dual EGFR inhibition in combination with anti-VEGF treatment in colorectal cancer.

Preclinical studies demonstrate that epidermal growth factor receptor (EGFR) signals through both kinase-dependent and independent pathways and that combining a small-molecule EGFR inhibitor, EGFR antibody, and/or anti-angiogenic agent is synergistic. We conducted a dose-escalation, phase I study combining erlotinib, cetuximab, and bevacizumab. The subset of patients with metastatic colorectal cancer was analyzed for safety and antitumor activity. Forty-one patients with heavily pretreated metastatic colorectal cancer received treatment on a range of dose levels. The most common treatment-related grade ≥2 adverse events were rash (68%), hypomagnesemia (37%), and fatigue (15%). Thirty of 34 patients (88%) treated at the full FDA-approved doses of all three drugs tolerated treatment without drug-related dose-limiting effects. Eleven patients (27%) achieved stable disease (SD) ≥6 months and three (7%) achieved a partial response (PR) (total SD&gt;6 months/PR= 14 (34%)). Of the 14 patients with SD≥6 months/PR, eight (57%) had received prior sequential bevacizumab and cetuximab, two (5%) had received bevacizumab and cetuximab concurrently, and four (29%) had received prior bevacizumab but not cetuximab or erlotinib (though three had received prior panitumumab). The combination of bevacizumab, cetuximab, and erlotinib was well tolerated and demonstrated antitumor activity in heavily pretreated patients with metastatic colorectal cancer