Design of leather footwear for diabetics containing chlorhexidine digluconate microparticles

2-s2.0-85093852990ChlorHexidine Digluconate [CHD] was encapsulated inside an ethylcellulose shell material [Aquacoat ECD], and then spray dried to produce mixed microparticles (MPs). The validity and functional quality of the resultant [CHD-MPs] were analyzed on vamp and lining leather which are used to manufacture shoes for diabetics. The morphology, efficiency of encapsulation and in vitro release characteristics of the [CHD-MPs] were optimized in order to impregnate [CHD-MPs] onto leather footwear for diabetics. Scanning electron microscopy (SEM) was used to characterize the [CHD-MPs] and the leathers treated with it. SEM images illustrated that the [CHD-MPs] were spherical, smooth in shape and adhered well to leather. In vitro CHD-release studies from its MPs, and for leather treated with it were performed in phosphate buffer saline at pH =7.2. There was an inherently controlled release behaviour of CHD for all the formulations on leather. Finally, microbiologic studies on leather treated with [CHD-MPs] were done. This study suggested that footwear containing [CHD-MPs] is/will improve the quality of daily life for diabetics. © 2020 American Leather Chemists Association. All rights reserved

Encapsulated chlorhexidine digluconate usage on the diabetic footwear upper leathers

34th International Union of Leather Technologists and Chemist Societies Congress, IULTCS 2017 -- 5 February 2017 through 8 February 2017 -- 133186It is important for a therapeutic shoe to have a wearable quality and its comfortable use is also prominent in terms of providing an increase in user's quality of life. In long-term treatment of diseases, medical products which are to be manufactured with medical leather materials might be a prominent alternative via local effect application as an adjuvant to the treatment. It is aimed in this study to produce micro-particles which contain the active agent chlorhexidine digluconate and application of these micro-particles on upper leather for manufacturing diabetic shoes while providing them a functional quality. Within the scope of the project, micro-particles loaded with drugs were obtained via spraying chlorhexidine digluconate active agent and through spraying with ethyl cellulose polymer and ustulation. In vitro characterisation studies were performed on the acquired microparticles. Additionally, active agent quantitation and in vitro drug delivery studies were also performed. Following the studies, the determined optimum microparticle formulations were applied on the leather, then existence and efficiency of microparticles within the leather was shown in the subsequent studies

Polymeric Nanoparticles that Combine Dexamethasone and Naproxen for the Synergistic Inhibition of Il12b

Recent studies have demonstrated in vivo synergistic immunosuppressive and anti-inflammatory capacity of dexamethasone (Dx) and naproxen (NAP) in collagen-induced arthritis (CIA) rats. However, the molecular basis of this synergistic effect is barely understood. The low solubility of these drugs and their adverse effects hamper their efficacy on the treatment of inflammatory processes making nanoparticulated systems promising candidates to overcome these drawbacks. The aim of this work is the preparation of polymeric nanoparticles (NPs) that combine NAP and Dx in different concentrations, and the evaluation of the expression of key genes related to autoimmune diseases like CIA. To do so, self-assembled polymeric NPs that incorporate covalently-linked NAP and physically entrapped Dx are designed to have hydrodynamic properties that, according to bibliography, may improve retention and colocalization of both drugs at inflammation sites. The rapid uptake of NPs by macrophages is demonstrated using coumarine-6-loaded NPs. Dx is efficiently encapsulated and in vitro biological studies demonstrate that the Dx-loaded NAP-bearing NPs are noncytotoxic and reduce lipopolysaccharide- induced NO released levels at any of the tested concentrations. Moreover, at the molecular level, a significant synergistic reduction of Il12b transcript gene expression when combining Dx and NAP is demonstrated.Authors would like to thank the Spanish Ministry of Science, Innovation and Universities (MAT2017-84277-R and SAF2017-82223-R) and CIBER-BBN for the financial support of this project. E.E.-C. and Y.P. would like to thank the training program for Academic Staff (FPU15/06109 and FPU15/06170, respectively) of the Spanish Ministry of Education Culture and Sport. The kind support by Alvaro González- Gómez, Rosana Ramírez, and David Gómez, in the synthesis, cell culture and SEM experiments is greatly appreciatedPeer reviewe

Preparation and characterization of textile-based carrier systems for anal fissure treatment

WOS: 000418886900002PubMed ID: 29105520Anal fissure is common and painful disease of anorectum. In this study, microparticles containing nifedipine and lidocaine HCl were prepared by spray drying and applied to bio-degradable and bio-stable tampons. Characterization of microparticles was determined by visual analyses, mass yield, particle size measurement, encapsulation efficiency, drug loading and in vitro drug release. Mass yield was between 5.5 and 45.9%. The particle size was between 15.1 and 26.8 mu m. Encapsulation efficiency were 96.142 +/- 5.931 and 85.571 +/- 3.301; drug loading were 65.261 +/- 3.914% and 37.844 +/- 4.339% of L2 and N1, respectively. Well-separated, mainly spherical microparticles with suitable properties were obtained. Optimum microparticles were applied to tampons. Physical properties and visual characteristics of tampons were investigated before and after binder application. In vitro drug release from tampons were also examined. According to the results, textile-based carrier systems loaded microparticles containing nifedipine and lidocaine HCl will be an effective and promising alternative for current anal fissure treatment.Dokuz Eylul UniversityDokuz Eylul University [2014.KB.FEN.045]This study was supported by a research grant from Dokuz Eylul University (2014.KB.FEN.045). The authors would like to thank Res. Assist. Akar DOGAN, Mechanical Engineering, Dokuz Eylul University for enabling to use compressibility tester. The authors would also like to acknowledge Ege University Pharmaceutical Sciences Research Center (FABAL) for enabling to use its laboratory instruments (UPLC)