Lipid profile during pregnancy in HIV-infected women

Purpose: We investigated the evolution of serum lipid levels in HIV-infected pregnant women and the potential effect of antiretroviral treatment during pregnancy using data from a national surveillance study. Method: Fasting lipid measurements collected during routine care in pregnancy were used, analyzing longitudinal changes and differences in lipid values at each trimester by protease inhibitors (Pls) and stavudine use. Multivariate analyses were used to control for simultaneous factors potentially leading to hyperlipidemia. Study population included 248 women. Results: Lipid values increased progressively and significantly during pregnancy: mean increases between the first and third trimesters were 141.6 mg/dL for triglycerides (p <.001), 60.8 mg/dL for total cholesterol (p <.001), 13.7 mg/dL for HDL cholesterol (p <.001), and 17.8 mg/dL for LDL cholesterol (p =.001). At all trimesters, women on PIs had significantly higher triglyceride values compared to women not on Pis. The effect of Pls on cholesterol levels was less consistent. Stavudine showed a dyslipidemic effect at first trimester only. Multivariate analyses confirmed these observations and suggested a potential role of other cofactors in the development of hyperlipidemia during pregnancy. Conclusion: The changes observed point to the need to further explore the causes and the clinical correlates of hyperlipidemia during pregnancy in women with HIV

Potature in arboricoltura da legno

To give some application utilities to product high quality wood with walnut, cherry and ash some technique of pruning are tested and adapted to be applied to product wood with these three species

La selvicoltura delle specie sporadiche in Toscana.

Le venticinque specie sporadiche trattate in questo volume si incontrano raramente in Toscana, sia perche\u301 le condizioni ecologiche adatte al loro sviluppo si realizzano solo saltuariamente, sia perche\u301 la gestione selvicolturale dei soprassuoli forestali che le ospitano ha favorito altre specie. La loro presenza nei boschi della regione e\u300 stimata in circa 90 milioni di piante e i benefici che esse producono sono di tipo ambientale, naturalistico, paesaggistico e, non ultimo, economico-produttivo. La presente pubblicazione, la terza della collana \u201dSupporti tecnici alla Legge Regionale Forestale della Toscana\u201d, intende promuovere una migliore conoscenza di queste specie e valorizzarne la multifunzionalita\u300 e le potenzialita\u300 produttive per assortimenti legnosi di pregio. Percio\u300 descrive tecniche selvicolturali e strategie gestionali specifiche, talvolta poco conosciute dagli operatori forestali della regione, ma di facile applicabilita\u300, nel rispetto della normativa vigente e in particolare della Legge Regionale Forestale (LR 39/200) e del relativo Regolamento Forestale. Fornisce inoltre un\u2019esauriente descrizione delle caratteristiche delle specie trattate e, ove esistano i presupposti ecologici e ambientali necessari, illustra le tecniche selvicolturali ritenute idonee a valorizzarne le produzioni legnose

Impact of antiretroviral treatment on lipid profile during pregnancy in HIV-infected women

To define serum lipid changes in HIV-infected pregnant women undergoing antiretroviral treatment, clarifyning the independent effects of pregnancy, HIV infection and antiretroviral tratment on cholesterol and triglycerides values

Lipid profile during pregnancy in HIV-infected women

Purpose: We investigated the evolution of serum lipid levels in HIV-infected pregnant women and the potential effect of antiretroviral treatment during pregnancy using data from a national surveillance study. Method: Fasting lipid measurements collected during routine care in pregnancy were used, analyzing longitudinal changes and differences in lipid values at each trimester by protease inhibitors (Pls) and stavudine use. Multivariate analyses were used to control for simultaneous factors potentially leading to hyperlipidemia. Study population included 248 women. Results: Lipid values increased progressively and significantly during pregnancy: mean increases between the first and third trimesters were 141.6 mg/dL for triglycerides (p <.001), 60.8 mg/dL for total cholesterol (p <.001), 13.7 mg/dL for HDL cholesterol (p <.001), and 17.8 mg/dL for LDL cholesterol (p =.001). At all trimesters, women on PIs had significantly higher triglyceride values compared to women not on Pis. The effect of Pls on cholesterol levels was less consistent. Stavudine showed a dyslipidemic effect at first trimester only. Multivariate analyses confirmed these observations and suggested a potential role of other cofactors in the development of hyperlipidemia during pregnancy. Conclusion: The changes observed point to the need to further explore the causes and the clinical correlates of hyperlipidemia during pregnancy in women with HIV

Massive genome inversion drives coexistence of divergent morphs in common quails

Non filtered SNP data generated with genotyping-by-sequencing (GBS) for the article "Massive genome inversion drives coexistence of divergent morphs in common quails", Current Biology.Peer reviewe

The mother-to-child HIV transmission epidemic in Europe: evolving in the East and established in the West

OBJECTIVES: To carry out an epidemiological analysis of the emerging epidemic in an Eastern European country and to compare the approach to prevention of mother-to-child transmission (MTCT) with that in Western Europe. DESIGN: Prospective cohort study established in 1985 in Western Europe and extended to Ukraine in 2000. METHODS: Data on 5967 HIV-infected pregnant women and their infants (1251 from Ukraine and 4716 from Western/Central Europe) was analysed. Factors associated with transmission were identified with logistic regression. RESULTS: HIV-infection among pregnant women enrolled in Western European centres has shifted from being largely injecting drug use (IDU)-related to heterosexually-acquired; in Ukraine IDU also gradually declined with women increasingly identified without specific risk factors. In Ukraine in 2000-2004 most (80%) women received single dose nevirapine (sdNVP) and/or short-course zidovudine prophylaxis [MTCT rate 4.2%; 95% confidence interval (CI), 1.8-8.0 for sdNVP with short-course zidovudine]; 2% (n = 27) received antenatal HAART and 33% (n = 418) delivered by elective caesarean section (CS); in Western European centres 72% of women received HAART (MTCT rate 1.0%; 95% CI, 0.4-1.9) and 66% delivered by elective CS during the same period. CONCLUSIONS: Our findings indicate distinct differences in the epidemics in pregnant women across Europe. The evolution of the MTCT epidemic in Ukraine does not appear to be following the same pattern as that in Western Europe in the 1980s and 1990s. Although uptake of preventive MTCT prophylaxis has been rapid in both Western Europe and Ukraine, substantial challenges remain in the more resource-constrained setting in Eastern Europe