Crystallization Kinetics of Cocoa Fat Systems: Experiments and Modeling

Isothermal crystallization kinetics of unseeded and seeded cocoa butter and milk chocolate is experimentally investigated under quiescent conditions at different temperatures in terms of the temporal increase in the solid fat content. The theoretical equations of Avrami based on one-, two- and three-dimensional crystal growth are tested with the experimental data. The equation for one-dimensional crystal growth represents well the kinetics of unseeded cocoa butter crystallization of form α and β′. This is also true for cocoa butter crystal seeded milk chocolate. The sterical hindrance due to high solids content in chocolate restricts crystallization to lineal growth. In contrast, the equation for two-dimensional crystal growth fits best the seeded cocoa butter crystallization kinetics. However, a transition from three- to one-dimensional growth kinetics seems to occur. Published data on crystallization of a single component involving spherulite crystals are represented well by Avrami's three-dimensional theoretical equation. The theoretical equations enable the determination of the fundamental crystallization parameters such as the probability of nucleation and the number density of nuclei based on the measured crystal growth rate. This is not possible with Avrami's approximate equation although it fits the experimental data well. The crystallization can be reasonably well defined for single component systems. However, there is no model which fits the multicomponent crystallization processes as observed in fat system

Does true Gleason pattern 3 merit its cancer descriptor?

Nearly five decades following its conception, the Gleason grading system remains a cornerstone in the prognostication and management of patients with prostate cancer. In the past few years, a debate has been growing whether Gleason score 3 + 3 = 6 prostate cancer is a clinically significant disease. Clinical, molecular and genetic research is addressing the question whether well characterized Gleason score 3 + 3 = 6 disease has the ability to affect the morbidity and quality of life of an individual in whom it is diagnosed. The consequences of treatment of Gleason score 3 + 3 = 6 disease are considerable; few men get through their treatments without sustaining some harm. Further modification of the classification of prostate cancer and dropping the label cancer for Gleason score 3 + 3 = 6 disease might be warranted

Environmental Geophysics at Kings Creek Disposal Site and 30th Street Landfill, Aberdeen Proving Ground, Maryland

Geophysical studies on the Bush River Peninsula in the Edgewood Area of Aberdeen Proving Ground, Maryland, delineate landfill areas and provide diagnostic signatures of the hydrogeologic framework and possible contaminant pathways. These studies indicate that, during the Pleistocene Epoch, alternating stands of high and low seal levels resulted in a complex pattern of shallow channel-fill deposits in the Kings Creek area. Ground-penetrating radar studies reveal a paleochannel greater than 50 ft deep, with a thalweg trending offshore in a southwest direction into Kings Creek. Onshore, the ground-penetrating radar data indicate a 35-ft-deep branch to the main channel, trending to the north-northwest directly beneath the 30th Street Landfill. Other branches are suspected to meet the offshore paleochannel in the wetlands south and east of the 30th Street Landfill. This paleochannel depositional system is environmentally significant because it may control the shallow groundwater flow regime beneath the site. Electromagnetic surveys have delineated the pre-fill lowland area currently occupied by the 30th Street Landfill. Magnetic and conductive anomalies outline surficial and buried debris throughout the study area. On the basis of geophysical data, large-scale dumping has not occurred north of the Kings Creek Disposal Site or east of the 30th Street Landfill

Establishment of a new human osteosarcoma cell line, UTOS-1: cytogenetic characterization by array comparative genomic hybridization

The cytogenetic characteristics of osteosarcoma (OS) remain controversial. The establishment of a new human OS cell line may improve the characterization. We report the establishment of a new human osteosarcoma cell line, UTOS-1, from a typical osteoblastic OS of an 18-year-old man. Cultured UTOS-1 cells are spindle-shaped, and have been maintained in vitro for over 50 passages in more than 2 years. Xenografted UTOS-1 cells exhibit features typical of OS, such as production of osteoid or immature bone matrix, and proliferation potency in vivo. UTOS-1 also exhibit morphological and immunohistochemical characteristics typical of osteoblastic OS. Chromosomal analysis by G-band show 73~85 chromosomes with complicated translocations. Array CGH show frequent gains at locus DAB2 at chromosome 5q13, CCND2 at 12p13, MDM2 at 12q14.3-q15, FLI and TOP3A at 17p11.2-p12 and OCRL1 at Xq25, and show frequent losses at HTR1B at 6q13, D6S268 at 6q16.3-q21, SHGC17327 at 18ptel, and STK6 at 20q13.2-q13.3. The UTOS-1 cell line may prove useful for biologic and molecular pathogenetic investigations of human OS

Nurses' perceptions of aids and obstacles to the provision of optimal end of life care in ICU

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Crystallization Kinetics of Cocoa Fat Systems: Experiments and Modeling

ISSN:1558-9331ISSN:0003-021

Gorlin-Goltz syndrome: A rare case report

Gorlin-Goltz syndrome (GGS) is an autosomal dominant disorder with a high degree of penetrance and variable expressivity. It is a rare phakomatosis characterized by multiple odontogenic keratocysts (OKCs), bifid ribs, and other abnormalities. The incidence of the GGS is estimated at 1 in 57,000–1 in 256,000 in the general population. The OKC is frequently the presenting manifestation of this syndrome. We report a case of a 25-year-old male patient, presenting with a swelling in the right side of the face which was diagnosed as GGS by correlating the clinical findings, histological findings, and evaluating the various tools of imaging. In the case of GGS, it is of great importance to make an early diagnosis since the severity of complications such as maxillofacial deformities related to the jaw cysts can be avoided