BMP signals: Mediated by stroma or thymocytes?

This is an invited comment on the paper by Hager-Theodorides AL, et al. Cell Cycle 2014; 13:324–33; PMID:24240189; http://dx.doi.org/10.4161/cc.27118 which is published in the same journa

Probing 3-D matter distribution at z~2 with QSO multiple lines of sight

We investigate the 3-D matter distribution at z~2 with high resolution (R ~ 40000) spectra of QSO pairs and groups obtained with the UVES spectrograph at ESO VLT. Our sample is unique for the number density of objects and the variety of separations, between 0.5 and 7 proper Mpc. We compute the real space cross-correlation function of the Lyman-alpha forest transmitted fluxes. There is a significant clustering signal up to ~2 proper Mpc, which is still present when absorption lines with high column density (log N > 13.8) are excluded.Comment: Poster paper presented at the IAU Colloquium #199 on "Probing Galaxies through Quasar Absorption Lines" held in Shanghai, China from March 14th to 18th, 200

Tomography of the intergalactic medium with Ly-alpha forests in close QSO pairs

We study the three-dimensional distribution of non virialised matter at z~2 using high resolution spectra of QSO pairs and simulated spectra drawn from cosmological hydrodynamical simulations. We have collected the largest sample of QSO pairs ever observed with UVES at the ESO-VLT, with angular separations between ~1 and 14 arcmin. The observed correlation functions of the transmitted flux in the HI Lyman alpha forest along and transverse to the lines of sight are in good agreement implying that the distortions in redshift space due to peculiar velocities are small. The clustering signal is significant up to velocity separations of ~200 km/s, or about 3 h^{-1} comoving Mpc. The regions at lower overdensity (rho/ < 6.5) are still clustered but on smaller scales (Delta v < 100 km/s). The observed and simulated correlation functions are compatible at the 3 sigma level. A better concordance is obtained when only the low overdensity regions are selected for the analysis or when the effective optical depth of the simulated spectra is increased artificially, suggesting a deficiency of strong lines in the simulated spectra. We found that also a lower value of the power-law index of the temperature-density relation for the Lyman alpha forest gas improves the agreement between observed and simulated results. If confirmed, this would be consistent with other observations favouring a late HeII reionization epoch (at z~3). We remark the detection of a significant clustering signal in the cross correlation coefficient at a transverse velocity separation Delta v_{\perp} ~500 km/s whose origin needs further investigation.Comment: Accepted for publication in MNRAS, revised version matching the accepted on

Recommendations from recent graduates in medicine, nursing and pharmacy on improving interprofessional education in university programs: A qualitative study

Background: Interprofessional education (IPE) has been recognized as an innovative approach for the development of a collaborative, practice-ready health workforce, but is not used consistently in undergraduate health professional programs. We sought to explore the reflections of graduates on the IPE experiences they had during their undergraduate education and training. It was anticipated that having completed their pre-vocational education and spent up to two years working in a clinical environment, recent graduates would be well-placed to provide insights into the value of the IPE opportunities they had, and to suggest approaches for improving these opportunities in undergraduate programs. Methods. This study was part of a larger research project (Interprofessional Education for the Quality use of Medicines; IPE for QuM) which used focus groups as part of an interpretive research design to inform other aspects of the research. Here, we report on focus groups with recent graduates recruited from area health services across Australia. Results: Sixty-eight recent graduates working in New South Wales, Western Australia, and Tasmania participated in 12 focus group sessions. In this paper, we report on new graduates' reflections on their experiences of IPE as part of their university degree, as well as their recommendations to improve interprofessional education before graduation. The new graduates were unanimous in valuing IPE from their current perspective of being in the health workforce. Most IPE experiences recalled were regarded as positive, but those valued most highly were experiences that involved genuine engagement and opportunities to interact with students in other professions working on a relevant problem. Clinical placement was a missed opportunity with few structured meaningful interprofessional learning experiences. Surprisingly there was little social contact between professions in universities even when programs were co-located, thus reinforcing professional silos. Conclusions: The graduates provided many insightful reflections about the value of university-based IPE and their preparedness for clinical practice. Although universally acclaimed as a good idea there is much room for improvement. We put forward a set of suggestions to improve IPE and guide the design of future IPE efforts. © 2014 Gilligan et al.; licensee BioMed Central Ltd

Clustering in the 2dF QSO Redshift Survey

We present clustering results from the 2dF QSO Redshift Survey (2QZ) which currently contains over 20,000 QSOs at z<3. The two-point correlation function of QSOs averaged over the entire survey (~1.5) is found to be similar to that of local galaxies. When sub-dividing the sample as a function of redshift, we find that for an Einstein-de Sitter universe QSO clustering is constant (in comoving coordinates) over the entire redshift range probed by the 2QZ, while in a universe with Omega_0=0.3 and Lambda_0=0.7 there is a marginal increase in clustering with redshift. Sub-dividing the 2QZ on the basis of apparent magnitude we find only a slight difference between the clustering of QSOs of different apparent brightness, with the brightest QSOs having marginally stronger clustering. We have made a first measurement of the redshift space distortion of QSO clustering, with the goal of determining the value of cosmological parameters (in partcular Lambda_0) from geometric distortions. The current data do not allow us to discriminate between models, however, in combination with constraints from the evolution of mass clustering we find Omega_0=1-Lambda_0=0.23 +0.44-0.13 and beta(z~1.4)=0.39 +0.18-0.17. The full 2QZ data set will provide further cosmological constraints.Comment: 5 pages, 7 figures. Contributed to the 'Where's the Matter' conference in Marseille 25-29 June 200

First Results from the 2dF QSO redshift survey

We present some initial results from the 2dF QSO redshift survey. The aim of the survey is to produce an optically-selected catalogue of 25000 QSOs over the redshift range 0<z<3 using the 2-degree field at the Anglo-Australian Telescope.Comment: 7 pages, 6 figures, submitted to proceedings of ESO Deep Fields conferenc

The 2dF QSO Redshift Survey - 10K@2K!

With ~10000 QSO redshifts, the 2dF QSO Redshift Survey (2QZ) is already the biggest individual QSO survey. The aim for the survey is to have ~25000 QSO redshifts, providing an order of magnitude increase in QSO clustering statistics. We first describe the observational parameters of the 2dF QSO survey. We then describe several highlights of the survey so far; we present new estimates of the QSO luminosity function and the QSO correlation function. We also present the first estimate of the QSO power spectrum from the 2QZ catalogue, probing the form of the fluctuation power-spectrum out to the \~1000h-1Mpc scales only previously probed by COBE. We find a power spectrum which is steeper than the prediction of standard CDM and more consistent with the prediction of Lambda-CDM. The best-fit value for the power spectrum shape parameter for a range of cosmologies is Gamma=0.1+-0.1. Finally, we discuss how the complete QSO survey will be able to constrain the value of Omega_Lambda by combining results from the evolution of QSO clustering and from a geometric test of clustering isotropy.Comment: 11 pages, 6 figures, latex, eso and springer sty files included. To appear in the proceedings of the MPA/ESO/MPA conference "Mining the Sky", Garching, July 31 - August 4 2000, eds. A.J. Banday et a

Sonic Hedgehog is a determinant of γδ T-Cell differentiation in the Thymus

Here we investigate the function of Hedgehog (Hh) signaling in thymic γδ T-cell maturation and subset differentiation. Analysis of Hh mutants showed that Hh signaling promotes γδ T-cell development in the thymus and influences γδ T-cell effector subset distribution. Hh-mediated transcription in thymic γδ cells increased γδ T-cell number, and promoted their maturation and increased the γδNKT subset, whereas inhibition of Hh-mediated transcription reduced the thymic γδ T-cell population and increased expression of many genes that are normally down-regulated during γδ T-cell maturation. These changes were also evident in spleen, where increased Hh signaling increased γδNKT cells, but reduced CD27-CD44+ and Vγ2+ populations. Systemic in vivo pharmacological Smoothened-inhibition reduced γδ T-cell and γδNKT cells in the thymus, and also reduced splenic γδ T-cell and γδNKT populations, indicating that Hh signaling also influences homeostasis of peripheral γδ T-cell populations. Taken together our data indicate that Sonic Hedgehog is an important determinant of γδ T-cell effector subset differentiation