To Connect is to Be Influenced: What Determines a Third-party’s Forgiveness Attitudes to Conflicting Groups’ Violent Partisan Members

The present research sought to answer the question of what determines an uninvolved third party’s forgiveness attitudes to conflicting groups’ violent partisan members. Specifically, Bangladeshi participants read a fictitious interview with a radicalized Palestinian who declared his intention to avenge himself against Israelis for his personal and collective plight by carrying out a suicide bombing attack. Findings revealed that an empathy manipulation (high empathy = other focused or low empathy = objective focused) influenced participants’ forgiveness attitudes towards the radicalized Palestinian such that in the high empathy condition participants were more forgiving of the target than participants in the low empathy condition. Moreover, while the strength of their religious identification (Islam) played no significant role, participants’ tendency to attribute the target’s decision to situational factors fully mediated the effects of empathy on forgiveness

Solitary Langerhans cell histiocytosis of liver with sclerosing cholangitis in an adult female

Liver is affected as a late complication of high risk cases of Langerhans cell histiocytosis. Sclerosing cholangitis is a rare pattern associated with Langerhans cell histiocytosis of liver, which is even rarer in the adult population and has high mortality. The treatment is difficult and may require liver transplantation. We report a unique case of a 40-year-old female who developed sclerosing cholangitis associated with Langerhans cell histiocytosis without any evidence of involvement of other systems. Our patient required only surgery, and had been followed up for two years without recurrence. We could not find any other case of solitary liver involvement of Langerhans cell histiocytosis in literature published so far

Studies on protein content of cestode Cotugnia and its host Gallus gallus domesticus

The present study deals with the protein content in cestode parasite Cotugnia digonopora and its host tissue i.e. normal and infected intestinal tissue of Gallus gallus domesticus. The result obtained an amount of protein content in the present study indicates that the amount of proteins present in cestode parasites is lower as compared to protein present in infected intestine as well as in normal intestine.&nbsp

Antibiotic resistance pattern of Pseudomonas aeruginosa isolated from pus samples at tertiary care cancer hospital

Background: Pseudomonas aeruginosa is one of the most frequent opportunistic microorganisms causing infections in cancer patients. The aim of the study was to determine the antibiotic susceptibility of Pseudomonas aeruginosa and multidrug-resistant (MDR) isolates in cancer patients. Methods: A retrospective study was conducted from January 2022 to December 2022 at Government Cancer Hospital, Aurangabad. A total of 143 pus samples were collected from both IPD and OPD patients. Pus samples were collected as per standard procedure and were inoculated on blood and MacConkey agar. The isolates were identified by standard protocols using biochemical tests. The antibiotic susceptibility pattern of each isolate was checked as per Clinical and Laboratory Standards Institute (CLSI) guidelines 2022 using Kirby-Bauer's disc diffusion method and VITEK 2 Automation. Data analysis was done by statical method with statistical software SPSS version 22. Results: Out of 143 clinical samples 33 samples (23%) were positive for Pseudomonas aeruginosa growth. mean age of patients was 50 years old out of 33 isolates 12 (36%) isolates were multidrug-resistant, 11 (33%) isolates were extensively drug-resistant and 1 (3%) were pan-drug-resistant. The majority of isolates were responsive to polymyxin B 32 (96%) and colistin 32 (96%); However, the resistance to gentamycin, ceftazidime, and amikacin was higher, at 66%, 60%, and 57%, respectively.   Conclusions: This hospital-based retrospective study will help to implement better infection control strategies and improve the knowledge of antibiotic resistance patterns among clinicians. Thus, there is a need for an antibiotic stewardship program to monitor the resistant pattern in a tertiary care   cancer hospital

An Assessment to Human Perception to the Origin of Coronavirus by the Impact of Climate Change and Preventative Management of Pandemic Coronavirus COVID-19

On 12 January 2020, the WHO confirmed that a novel coronavirus was the cause of a respiratory illness in a cluster of people in Wuhan City, China. The aims of the study to assess the human perception to the origin of Coronavirus with relation to nature and find out preventative management about coronavirus. Primary data was collected for analyzing some factors regarding the Coronavirus microorganism formed by the impact of climate change. Primary data was collected through an online questionnaire survey. An online questionnaire survey is used for human perception for taking public opinion about the origin of Coronavirus and preventative management which are conducted in Bangladesh. SPSS software is used for Linear Regression analysis and correlation with some variables. A total of three variables were considered in the model estimation of which are dependent variables Coronavirus microorganism formed by the impact of climate change and independent variables such as Coronavirus microorganism formed by the impact of environmental pollution, Coronavirus microorganism formed by the impact of global heat and Coronavirus microorganism originated by the sources of the impact of ice melting polar region. From the analysis, it is found that the Coronavirus microorganism formed by the impact of climate change that makes a unique and statistically significant contribution to the prediction. Among 200 respondents, about 70% of peoples said “Maybe” Coronavirus microorganism formed by the impact of climate change, and it’s some factor. It is also found from the correlation analysis that the epidemic effects of COVID-19 will high on Bangladesh, if immigrant persons come, if Curfew doesn’t issue, if peoples are not conscious, if peoples are not properly using mask and hand gloves, if they are not maintaining social distance and lock down rules. In the finding that, in the polar region, there are many ice stacks where thousands of years ago, the animals are dead but the virus and bacteria are in a state of sleep. As the heat increases, all glaciers and permafrost start to melt in the Polar region. As a result, many types of viruses, bacteria are starting to live. These viruses including Coronavirus will be mixed with different environmental elements such as water, biodiversity. This will easily affect biodiversity and other animals including humans. Above all Climate change may play a significant role in the transmission of many infectious diseases including Coronavirus. Community responses are important for outbreak management during the early phase of major preventive options

Heat Shock Protein 47: A Novel Biomarker of Phenotypically Altered Collagen-Producing Cells

Heat shock protein 47 (HSP47) is a collagen-specific molecular chaperone that helps the molecular maturation of various types of collagens. A close association between increased expression of HSP47 and the excessive accumulation of collagens is found in various human and experimental fibrotic diseases. Increased levels of HSP47 in fibrotic diseases are thought to assist in the increased assembly of procollagen, and thereby contribute to the excessive deposition of collagens in fibrotic areas. Currently, there is not a good universal histological marker to identify collagen-producing cells. Identifying phenotypically altered collagen-producing cells is essential for the development of cell-based therapies to reduce the progression of fibrotic diseases. Since HSP47 has a single substrate, which is collagen, the HSP47 cellular expression provides a novel universal biomarker to identify phenotypically altered collagen-producing cells during wound healing and fibrosis. In this brief article, we explained why HSP47 could be used as a universal marker for identifying phenotypically altered collagen-producing cells

Analysis of customer satisfaction in services industry: A case study of private universities in Karachi, Pakistan

The purpose of this study is to analyze which factors have influence on the satisfaction of customers in service sector which can ultimately affects organization’s profitability. This study attempts to examine the relationship between students’ satisfaction and others variables such as service quality, empathy and customer relationship management. The investigation is conducted both from a theoretical and empirical point of view after conducting a pilot study, the instrument was administered to 100 under graduate and postgraduates who were selected based on random sampling from the four private universities of Karachi, Pakistan. The analysis started with descriptive analysis followed by regression, correlation and reliability analyses. The empirical results of the relationships in this study provide support for the Hishamuddin study (2008), which identified the factors contributing to the satisfaction of students. The results verify that service quality and empathy has significant impact on the students’ satisfaction level, while female were found to be more satisfied. The outcomes of the study also showed positive relationship among all the three explanatory variables and dependent variable

Reframing Gender Justice in an Unequal, Volatile World: IDS’ Directions for Future Research on Gender and Sexuality in Development

At a time of major changes in global politics and trends, and major shifts in international development following the establishment of the global Sustainable Development Goals in Agenda 2030, the Gender and Sexuality cluster at the Institute of Development Studies engaged in collaborative discussions and consultations over nine months with partner organisations, networks, external experts and policymakers. Following this process through most of 2016, this brief outlines our priority directions for future research on gender and sexuality in development in an increasingly unequal, polarised and volatile world.UK Department for International Developmen

Genomic variant sharing: a position statement.

Sharing de-identified genetic variant data is essential for the practice of genomic medicine and is demonstrably beneficial to patients. Robust genetic diagnoses that inform medical management cannot be made accurately without reference to genetic test results from other patients, as well as population controls. Errors in this process can result in delayed, missed or erroneous diagnoses, leading to inappropriate or missed medical interventions for the patient and their family. The benefits of sharing individual genetic variants, and the harms of not sharing them, are numerous and well-established. Databases and mechanisms already exist to facilitate deposition and sharing of pseudonomised genetic variants, but clarity and transparency around best practice is needed to encourage widespread use, prevent inconsistencies between different communities, maximise individual privacy and ensure public trust. We therefore recommend that widespread sharing of a small number of individual genetic variants associated with limited clinical information should become standard practice in genomic medicine. Information robustly linking genetic variants with specific conditions is fundamental biological knowledge, not personal information, and therefore should not require consent to share. For additional case-level detail about individual patients or more extensive genomic information, which is often essential for clinical interpretation, it may be more appropriate to use a controlled-access model for data sharing, with the ultimate aim of making as much information as open and de-identified as possible with appropriate consent

Radiographic severity of knee osteoarthritis is conditional on interleukin 1 receptor antagonist gene variations

BACKGROUND: A lack of biomarkers that identify patients at risk for severe osteoarthritis (OA) complicates development of disease-modifying OA drugs. OBJECTIVE: To determine whether inflammatory genetic markers could stratify patients with knee OA into high and low risk for destructive disease. METHODS: Genotype associations with knee OA severity were assessed in two Caucasian populations. Fifteen single nucleotide polymorphisms (SNPs) in six inflammatory genes were evaluated for association with radiographic severity and with synovial fluid mediators in a subset of the patients. RESULTS: Interleukin 1 receptor antagonist (IL1RN) SNPs (rs419598, rs315952 and rs9005) predicted Kellgren-Lawrence scores independently in each population. One IL1RN haplotype was associated with lower odds of radiographic severity (OR=0.15; 95% CI 0.065 to 0.349; p<0.0001), greater joint space width and lower synovial fluid cytokine levels. Carriage of the IL1RN haplotype influenced the age relationship with severity. CONCLUSION: IL1RN polymorphisms reproducibly contribute to disease severity in knee OA and may be useful biomarkers for patient selection in disease-modifying OA drug trials