A comparison of three class separability measures

Measures of class separability can provide valuable insights into data, and suggest promising classification algorithms and approaches in data mining. We compare three simple class separability measures used in supervised machine learning. Their relative effectiveness is evaluated through their functional relationships and their random projections of data onto R 2 for visualization. We conclude that the simple direct class separability measure of a dataset is an easier and more informative measure for separability than the class scatter matrices approach and it correlates well with Thornton’s Separability’s index

Research supervision: Perceptions of postgraduate nursing students at a higher education institution in KwaZulu-Natal, South Africa

Background. Scientific advancement, particularly in the area of information communication technology (ICT), challenges the mode of knowledgeadvancement at universities. Such challenges are especially evident in the area of postgraduate (PG) research supervision, particularly in the light ofthe changing students’ demography, whereby there is a radical shift from full-time campus-based students to part-time students. This challenge iscompounded by many countries not considering research competency as a requirement for PG supervision – the result of static and outdated curricula.Objective. To explore the perceptions of PG nursing students with regard to the research supervision process.Methods. A quantitative research study was conducted at the University of KwaZulu-Natal (UKZN), Durban, South Africa using non-convenience sampling.The PG Research Experience Survey questionnaire was adapted for the current study. Ethical clearance was obtained from UKZN’s Ethics Committee.The population consisted of the PG coursework Master’s nursing students who were registered for the research project module during 2012. A total of 56students participated, with a response rate of 70%. Data were analysed using the Statistical Package for the Social Sciences 19 (SPSS 19) (IBM Corp., USA).Results. The findings revealed that more than half of the respondents (66.2%; n=37) rated the level of support from research supervisors as moderateon a scale of low to high. The period of research supervision, mode of attendance and status within the university were identified as factors influencingthe perceptions of support from research supervisors.Conclusion. This study recommends that, to improve the quality of research supervision, there is a need to include a research supervision module inthe curriculum of nurse educators and to adopt online research supervision, underpinned by the extensive use of ICT to accommodate both part-timeand full-time PG students

Party political chaplaincy? – Methodist ministry to political parties

The debate on church and party politics is far from being exhausted in South Africa. Although the Methodist Church of Southern Africa discourages the participation of clergy persons in political parties, it is becoming critical that the church offers a prophetic voice in the political sphere. Issues of morality and spirituality within the political parties necessitate a careful involvement of the Church in politics. This article therefore sets out to offer a theological reflection on the (possible) ministry of Methodist clergy persons to political parties in South Africa

Finite Element Model updating using Hamiltonian Monte Carlo techniques

Abstract: Bayesian techniques have been widely used in finite element model (FEM) updating. The attraction of these techniques is their ability to quantify and characterise the uncertainties associated with dynamic systems. In order to update an FEM, the Bayesian formulation requires the evaluation of the posterior distribution function. For large systems this function is difficult to solve analytically. In such cases the use of sampling techniques often provides a good approximation of this posterior distribution function. The hybrid Monte Carlo (HMC) method is a classic sampling method used to approximate high-dimensional complex problems. However, the acceptance rate (AR) of HMC is sensitive to the system size, as well as to the time step used to evaluate the molecular dynamics (MD) trajectory. The shadow HMC technique (SHMC), which is a modified version of the HMC method, was developed to improve sampling for large-system sizes by drawing from a modified shadow Hamiltonian function. However, the SHMC algorithm performance is limited by the use of a non-separable modified Hamiltonian function. Moreover, two additional parameters are required for the sampling procedure, which could be computationally expensive. To overcome these weaknesses the separable shadow HMC (S2HMC) method has been introduced. This method uses a transformation to a different parameter space to generate samples. In this paper we analyse the application and performance of these algorithms, including the parameters used in each algorithm, their limitations and the effects on model updating. The accuracy and the efficiency of the algorithms are demonstrated by updating the finite element models of two real mechanical structures. It is observed that the S2HMC algorithm has a number of advantages over the other algorithms; for example, the S2HMC algorithm is able to efficiently sample at larger time steps while using fewer parameters than the other algorithms

Malaria control – two years' use of insecticide treated bednets compared with insecticide house spraying in Kwazulu-Natal

Objectives_ The objective of this study was to produce data indicating whether insecticide-treated bednets should replac insecticide house spraying as a malaria control method in South Africa_ We report 2 years of preliminary data on malaria incidence comparing areas receiving insecticidetreated bednets and those subjected to house spraying in northern KwaZulu-Natal.Design, setting and subjects. In order to measure significant reductions in malaria incidence between the two interventions, a geographical information system (GIS) was used to identify and create seven pairs of geographical blood ; (areas) in the malaria high-risk areas of Ndumu and Makani in Ingwavuma magisterial district, KwaZulu-Natal, Individual blocks were then randomly allocated to either insecticide-treated bednets or house spraying with deltamethrin. Malaria cases were either routinely recorded by surveillance agents at home or were reported to the nearest health facility_Results and conclusions. The results show that 2 years' use of insecticide-treated bednets by communities in Ndumu and Makanis, KwaZulu-Natal, significantly reduced the malaria incidence both in 1997 (rate ratio (RR) =0_879, 95% confidence interval (Cn 0.80 - 0.95, P =0.04) and in 1998 (RR = 0.667, Cl 0_61 - 0.72, P = 0.0001). Using a t-test, these significant reductions were further confirmed by an assessment of the rate of change between 1996 and 1998, showing a 16% reduction in malaria incidence in blocks using bednets and an increase of 45% in sprayed areas (t = 2.534, P = 0.026 (12 df». In order to decide whether bednets : should replace house spraying in South Africa, we need more : data on the efficacy of treated bednets, their long-term acceptability and the cost of the two interventions

Mechanism of enhanced freshness formulation in optimizing antioxidant retention of gold kiwifruit (Actinidia chinensis) harvested at two maturity stages

Kiwifruit exhibits a climacteric ripening pattern and has as an extremely perishable nature. Considering that high perishability leads to a loss in antioxidants and overall nutritional quality. This study aimed to examine the efficacy of enhanced freshness formulation (EFF), a hexanal-based formulation containing antioxidants such as geraniol, α-tocopherol and ascorbic acid, on maintaining the bioactive compounds of gold kiwifruit (cv. ‘Y368’) harvested at two maturity stages. Kiwifruits were treated with three treatments, namely, control (untreated fruit), 0.01 and 0.02% (v/v) EFF. Fruits were treated with 8 weeks of cold storage at 0°C and 90% relative humidity, then transferred to 20°C for 8 days. Three bioactive compounds (ascorbic acid, total phenolics and flavonoids), antioxidant capacities using DPPH and FRAP assays, polyphenol oxidase, ascorbate oxidase, phenylalanine and tyrosine ammonia lyase enzyme activities were evaluated. The results showed that EFF significantly (p < 0.05) influenced bioactive compounds, antioxidant capacities and the activity of enzymes involved in the synthesis and oxidation of bioactive compounds. The maturity stage significantly influenced the content of bioactive compounds. Later harvested kiwifruit had greater content of bioactive compounds, compared to earlier harvested kiwifruit. The total phenolic content was 0.77, 1.09 and 1.22 mg GAE g−1 FW for control, 0.01 and 0.02% EFF, respectively. The FRAP antioxidant concentration was 0.76, 0.91 and 0.96 μmol Fe (II) g−1 FW for control, 0.01 and 0.02% EFF. The findings illustrate the capacity of EFF to optimize bioactive compounds and storability of kiwifruit during postharvest storage

Discrepancy between Mtb-specific IFN-γ and IgG responses in HIV-positive people with low CD4 counts

Background: Tuberculosis (TB) is a leading infectious cause of death worldwide and treating latent TB infection (LTBI) with TB preventative therapy is a global priority. This study aimed to measure interferon gamma (IFN-γ) release assay (IGRA) positivity (the current reference standard for LTBI diagnosis) and Mtb-specific IgG antibodies in otherwise healthy adults without HIV and those living with HIV (PLWH). Methods: One-hundred and eighteen adults (65 without HIV and 53 antiretroviral-naïve PLWH), from a peri-urban setting in KwaZulu-Natal, South Africa were enrolled. IFN-γ released following stimulation with ESAT-6/CFP-10 peptides and plasma IgG antibodies specific for multiple Mtb antigens were measured using the QuantiFERON-TB Gold Plus (QFT) and customized Luminex assays, respectively. The relationships between QFT status, relative concentrations of anti-Mtb IgG, HIV-status, sex, age and CD4 count were analysed. Findings: Older age, male sex and higher CD4 count were independently associated with QFT positivity (p = 0.045, 0.05 and 0.002 respectively). There was no difference in QFT status between people with and without HIV infection (58% and 65% respectively, p = 0.06), but within CD4 count quartiles, people with HIV had higher QFT positivity than people without HIV (p = 0.008 (2nd quartile), <0.0001 (3rd quartile)). Concentrations of Mtb-specific IFN-γ were lowest, and relative concentrations of Mtb-specific IgGs were highest in PLWH in the lowest CD4 quartile. Interpretation: These results suggest that the QFT assay underestimates LTBI among immunosuppressed people with HIV and Mtb-specific IgG may be a useful alternative biomarker for Mtb infection. Further evaluation of how Mtb-specific antibodies can be leveraged to improve LTBI diagnosis is warranted, particularly in HIV-endemic areas. Fundings: NIH, AHRI, SHIP: SA-MRC and SANTHE

The emergence of insecticide resistance in central Mozambique and potential threat to the successful indoor residual spraying malaria control programme.

BACKGROUND: Malaria vector control by indoor residual spraying was reinitiated in 2006 with DDT in Zambézia province, Mozambique. In 2007, these efforts were strengthened by the President's Malaria Initiative. This manuscript reports on the monitoring and evaluation of this programme as carried out by the Malaria Decision Support Project. METHODS: Mosquitoes were captured daily through a series of 114 window exit traps located at 19 sentinel sites, identified to species and analysed for sporozoites. Anopheles mosquitoes were collected resting indoors and tested for insecticide resistance following the standard WHO protocol. Annual cross sectional household parasite surveys were carried out to monitor the impact of the control programme on prevalence of Plasmodium falciparum in children aged 1 to 15 years. RESULTS: A total of 3,769 and 2,853 Anopheles gambiae s.l. and Anopheles funestus, respectively, were captured from window exit traps throughout the period. In 2010 resistance to the pyrethroids lambda-cyhalothrin and permethrin and the carbamate, bendiocarb was detected in An. funestus. In 2006, the sporozoite rate in An. gambiae s.s. was 4% and this reduced to 1% over 4 rounds of spraying. The sporozoite rate for An. funestus was also reduced from 2% to 0 by 2008. Of the 437 Anopheles arabiensis identified, none were infectious. Overall prevalence of P. falciparum in the sentinel sites fell from 60% to 32% between October 2006 and October 2008. CONCLUSION: Both An. gambiae s.s. and An. funestus were controlled effectively with the DDT-based IRS programme in Zambézia, reducing disease transmission and burden. However, the discovery of pyrethroid resistance in the province and Mozambique's policy change away from DDT to pyrethroids for IRS threatens the gains made here