21 research outputs found
In vitro effect of nanosilver toxicity on fibroblast and mesenchymal stem cell lines
Get PDFNanotechnology presents countless opportunities to develop new and improved consumer products for the benefit of the society . A most prominent nanoproduct is nanosilver. Nanosilver particles are generally smaller than 100 nm and contain 20–15,000 silver atoms. Despite the wide application of nanomaterials, there is a serious lack of information concerning their impact on human health. In the previous study we reported the cytotoxic of nanosilver on osteoblast G292 cancer cell line and the amount of IC50 determined as 3.42 µg/ml (Moaddab et al., Iran. Nano Lett., Vol. 1, No. 1, January 2011, pp. 11-16). The purpose of the present study is to assess the biological assay of nanosilver on two normal cell lines of fibroblast (HF2), and mesenchymal stem cells . The effect of nanosilver on these cells is evaluated by light microscopy, and by cell proliferation and standard cytotoxicity assays. The results demonstrate a concentration-dependent toxicity for the cells tested, and IC50 was determined as 6.33, and 6.68 µg/ml in mesenchymal stem cell, and fibroblast HF2, respectively. There is no significant difference between the 24 h and 48 h of cells exposure to nanosilver. The results show that Nano-Ag possesses low toxicity to normal cells and can display potential application in cancer chemoprevention and chemotherapy
OPTIMUM MIXED (MARITIME- AERIAL) ROUTE-PLANNING USING MINIMUM SPANNING TREE AND INTEGER PROGRAMMING
No full textBased on World Tourism Organization (WTO) statistics in recent 70 years, the
number of tourists has increased from 25 million in 1950 to 1 billion and 235
million in 2016. Extending and developing the transport network is one of the
main reasons for this growth. A more developed transport network can improve
the tourism rate in country which in return can help the economic growth rate.
Iran is considered a very rich country in terms of natural and historical
tourism resources; moreover, it has a great potential to become one of the main
tourism hubs in the region. Meanwhile, in some cities and places, tourism
standards have improved; however, in the southern islands of Iran, despite
eye-catching attractions, there has not been enough concerns about them and
this issue can be improved by developing the current transport network and
designing a new one. In this study, based on the system-system approach, the
focus is to design and offer different maritime and air transport solutions
between some of Iran's islands in Persian Gulf. In this regard, the research
aims to minimize the total cost of a combinational trip consisting of both
aerial as well as maritime routes. The devised methodology was applied to
finding optimal connecting routes among Persian Gulf islands. The method
exploits both Direct Operating Cost (DOC) as well as the value of ``time
factor''. In this study, the final network optimization was performed using two
methods of minimum spanning tree and integer programming with exact solution,
taking into account time factor of \$ 6 and \$ 8 per hour. The results of the simultaneous allocation of aircraft and passenger ships indicate the use of
ships at distances less than 300 km at a time factor of \$ 6 per hour and distances less than 200 km at a time factor of \$ 8 per hour; also, a comparison of the two optimization methods used for network design shows that the design of the tourism network by integer programming and the hub-and-spoke network
design by the minimum spanning tree will be efficient
High prevalence of goiter in an iodine replete area: do thyroid auto-antibodies play a role?
No full textHigh prevalence of goiter in an iodine replete area: do thyroid auto-antibodies play a role?
No full textEvaluation of Antifungal Effect of Silver Nanoparticles Against Microsporum canis, Trichophyton mentagrophytes and Microsporum gypseum
No full textTurmeric extract loaded nanoliposome as a potential antioxidant and antimicrobial nanocarrier for food applications
No full textFrequency of Mutations Associated with Rifampicin Resistance in Mycobacterium tuberculosis
No full textPain relief produces negative reinforcement through activation of mesolimbic reward-valuation circuitry
No full textRelief of pain is rewarding. Using a model of experimental postsurgical pain we show that blockade of afferent input from the injury with local anesthetic elicits conditioned place preference, activates ventral tegmental dopaminergic cells, and increases dopamine release in the nucleus accumbens. Importantly, place preference is associated with increased activity in midbrain dopaminergic neurons and blocked by dopamine antagonists injected into the nucleus accumbens. The data directly support the hypothesis that relief of pain produces negative reinforcement through activation of the mesolimbic reward–valuation circuitry
