Design and Assessment of an Interactive Digital Tutorial for Undergraduate-Level Sandstone Petrology

This study describes the goals, features and effectiveness of a digital interactive tutorial which was created to provide undergraduates a 'virtual microscope' resource for learning sandstone petrology. The goal of the tutorial is to provide students exposure to the highly visual subject matter of petrography outside the confines of organized laboratory exercises. The hope is that widespread use of such digital interactive formats will allow students to gain high levels of expertise with description and interpretation of earth materials despite the reduced amounts of hands-on laboratory practice that are allowed by modern curricula. Educational levels: Graduate or professional

Tetrahydrobiopterin analogues with NO-dependent pulmonary vasodilator properties

Reduced NO levels due to the deficiency of tetrahydrobiopterin (BH4) contribute to impaired vasodilation in pulmonary hypertension Due to the chemically unstable nature of BH4 it was hypothesised that oxidatively stable analogues of BR, would be able to support NO synthesis to improve Endothelial dysfunction in pulmonary hypertension Two analogues of BH4 namely 6-hydroxymethyl pterin (HMP) and 6-acetyl 7 7-dimethyl 7 8-dihydropterin (ADDP) were evaluated for vasodilator activity on precontracted rat pulmonary artery rings ADDP was administered to pulmonary hypertensive rats followed by measurement of pulmonary vascular resistance in perfused lungs and eNOS expression by immunohistochemistry ADDP and HMP caused significant relaxation in vitro in rat pulmonary arteries depleted of BH4 with a maximum relaxation at 0 3 mu M (both P<005) Vasodilator activity of ADDP and HMP was completely abolished following preincubation with the NO synthase inhibitor L-NAME ADDP and HMP did not alter relaxation induced by carbachol or spermine NONOate BH4 Itself did not produce relaxation In rats receiving ADDP 141 mg/kg/day pulmonary vasodilation induced by calcium ionophore A23187 was augmented and eNOS immunoreactivity was increased In conclusion ADDP and HMP are two analogues of BH4 which can act as oxidatively stable alternatives to BH4 in causing NO-mediated vasorelaxation Chronic treatment with ADDP resulted in Improvement of NO-mediated pulmonary artery dilation and enhanced expression of eNOS in the pulmonary vascular endothelium Chemically stable analogue, of BH4 may be able to limit endothelial dysfunction in the pulmonary vasculatur

An Introduction to the Special Section on Professional Standards in Human Services

An introduction is presented in which the editor discusses various reports within the issue on topics related to human services including accreditation, code of ethics, and assessment tool

USING RESPONSE SURFACE METHODOLOGY WITH A MULTIVARIATE RESPONSE TO IMPROVE THE QUAlITY OF A FOOD PRODUCT

Nutrition in health is a major area of focus in our national health priorities as we move into the 21st century. The government, food industry, food scientists, health professionals, and all disciplines that can assist need to work together in the development of healthful food products and encourage Americans to make healthful food choices (Drishell, 1990). Experimentation science provides strategies for helping food scientists improve existing food products and develop new ones. This paper describes a process where design of experiments and response surface methodology were utilized in the formulation development to guide product development of a healthful muffin that would meet predetermined nutritional parameters and reasonable sensory quality characteristics

The channels of technology acquisition in commercial firms, and the NASA dissemination program

Technology acquisition in commercial firms, and NASA dissemination progra

1863-11-07 S. Milliken requests that Captain Davis be promoted upon his return from Libby Prison

https://digitalmaine.com/cw_me_4th_regiment_corr/1427/thumbnail.jp

United Kingdom: Citizenship education in the United Kingdom: comparing England, Northern Ireland, Scotland and Wales

Purpose: In this country case study the authors undertake a comparative analysis of citizenship education across the four nations of the UK. The curriculum and contexts in England, Scotland, Wales and Northern Ireland are first described. Then the article considers how each national example engages with fundamental expectations of citizenship education, specifically in relation to questions of citizenship status and the relationship between citizens and the state; political identity; and active citizenship processes. Approach: Drawing on the authors’ collective experience and insights into policy and practice in each nation, we started with a ‘generative conversation’ to identify key issues for inclusion in this case study. Findings: The article unearths a variety of constraints and problems, and situates these in a broader policyscape in which policy accretion and policy approximation generate a permissive culture, which has undermined the promise of citizenship education as an entitlement for all young people

1862-05-15 S.L. Milliken recommends Sheridan F. Miller for appointment as lieutenant

https://digitalmaine.com/cw_me_4th_regiment_corr/1181/thumbnail.jp

1863-03-12 S.L. Milliken recommends Orderly Sergeant Henry W. Ladd for promotion

https://digitalmaine.com/cw_me_4th_regiment_corr/1359/thumbnail.jp

1863-08-15 S.L. Milliken encloses letter from William Rust and others in favor of promotion of James Doak

https://digitalmaine.com/cw_me_4th_regiment_corr/1392/thumbnail.jp