Maternal employment, breastfeeding, and health: Evidence from maternity leave mandates

Public health agencies around the world have renewed efforts to increase the incidence and duration of breastfeeding. Maternity leave mandates present an economic policy that could help achieve these goals. We study their efficacy focusing on a significant increase in maternity leave mandates in Canada. We find very large increases in mothers' time away from work post-birth and in the attainment of critical breastfeeding duration thresholds. However, we find little impact on the self-reported indicators of maternal and child health captured in our data.

Social Security and Retirement around the World: Historical Trends in Mortality and Health, Employment, and Disability Insurance Participation and Reforms - Introduction and Summary

This is the introduction and summary to the fifth phase of an ongoing project on Social Security Programs and Retirement Around the World. The first phase described the retirement incentives inherent in plan provisions and documented the strong relationship across countries between social security incentives to retire and the proportion of older persons out of the labor force. The second phase documented the large effects that changing plan provisions would have on the labor force participation of older workers. The third phase demonstrated the consequent fiscal implications that extending labor force participation would have on net program costs—reducing government social security benefit payments and increasing government tax revenues. The fourth phase presented analyses of the relationship between the labor force participation of older persons and the labor force participation of younger persons in twelve countries. We found no evidence that increasing the employment of older persons will reduce the employment opportunities of youth and no evidence that increasing the employment of older persons will increase the unemployment of youth. This phase is intended to set the stage for and inform future more formal analysis of disability insurance programs, with this key question: Given health status, to what extent are the differences in LFP across countries determined by the provisions of disability insurance programs? Here we first consider changes in mortality over time and in particular the relationship between mortality and labor force participation, thinking of mortality as one indicator of health that is comparable across countries and over time in the same country. We then consider how mortality is related to other indicators of health status, in particular self-assessed health and then how trends in DI participation are related to changes in health. Finally we consider the effect on disability insurance participation of “natural experiments” in which the disability insurance reforms were not prompted by changes in health status or by changes in the employment circumstances of older workers. We find that these “exogenous” reforms can have a very large effect on the labor force participation of older workers.

Orexin-1 receptor-cannabinoid CB1 receptor heterodimerization results in both ligand-dependent and -independent coordinated alterations of receptor localization and function

Following inducible expression in HEK293 cells, the human orexin-1 receptor was targeted to the cell surface but became internalized following exposure to the peptide agonist orexin A. By contrast, constitutive expression of the human cannabinoid CB1 receptor resulted in a predominantly punctate, intracellular distribution pattern consistent with spontaneous, agonistindependent internalization. Expression of the orexin-1 receptor in the presence of the CB1 receptor resulted in both receptors displaying the spontaneous internalization phenotype. Single cell fluorescence resonance energy transfer imaging indicated the two receptors were present as heterodimers/oligomers in intracellular vesicles. Addition of the CB1 receptor antagonist SR-141716A to cells expressing only the CB1 receptor resulted in re-localization of the receptor to the cell surface. Although SR-141716A has no significant affinity for the orexin-1 receptor, in cells co-expressing the CB1 receptor, the orexin-1 receptor was also re-localized to the cell surface by treatment with SR-141716A. Treatment of cells co-expressing the orexin-1 and CB1 receptors with the orexin-1 receptor antagonist SB-674042 also resulted in re-localization of both receptors to the cell surface. Treatment with SR-141716A resulted in decreased potency of orexin A to activate the mitogen-activated protein kinases ERK1/2 only in cells co-expressing the two receptors. Treatment with SB-674042 also reduced the potency of a CB1 receptor agonist to phosphorylate ERK1/2 only when the two receptors were co-expressed. These studies introduce an entirely novel pharmacological paradigm, whereby ligands modulate the function of receptors for which they have no significant inherent affinity by acting as regulators of receptor heterodimers

In Rem Jurisdiction; Due Process; Minimum Contacts; State Statutes; Shaffer v. Heitner

The decision of Shaffer v. Heitner marks a significant departure from established principles concerning in rem jurisdiction. No longer may a court take jurisdiction of a lawsuit merely by sequestering any property of the defendant that happens to be located in that state

Experiences of generating COTS components when automating medicinal product evaluations

This paper reports on experiences of generating COTS components when designing and deploying component based software architecture for automation and interoperation of medicinal product evaluations across different countries in the world. Our generic architectural model renders two sets of software components that are candidates for COTS components. We identify which role such COTS components may play and outline our approach of generating them. We advocate that such COTS components are developed with a specific component platform in mind and must adhere to constraints of our software architecture

Design patterns for automation of marketing authorisations in pharmaceutical industry

This paper reports on the experiences of using existing and creating new design patterns when deploying layered and component based software architecture that automates procedures for marketing authorization. We use the strategy pattern within the generic architecture and deploy the architectural components with the Model-View-Controller (MVC) and front controller patterns. Three domain specific patterns have been created and named as: look-up, submission and evaluation. We advocate that our combination of general and domain specific patterns (i) facilitate the design of distributed software applications, (ii) can be reused in any problem domain where workflows similar to submission and evaluations of application licenses occur, and (iii) comprise commercial-off-the-shelf (COTS) components that fit within our software architecture

We Could, but Should We? Ethical Considerations for Providing Access to GeoCities and Other Historical Digital Collections

We live in an era in which the ways that we can make sense of our past are evolving as more artifacts from that past become digital. At the same time, the responsibilities of traditional gatekeepers who have negotiated the ethics of historical data collection and use, such as librarians and archivists, are increasingly being sidelined by the system builders who decide whether and how to provide access to historical digital collections, often without sufficient reflection on the ethical issues at hand. It is our aim to better prepare system builders to grapple with these issues. This paper focuses discussions around one such digital collection from the dawn of the web, asking what sorts of analyses can and should be conducted on archival copies of the GeoCities web hosting platform that dates to 1994.This research was supported by the Natural Sciences and Engineering Research Council of Canada, the Social Sciences and Humanities Research Council of Canada, the US National Science Foundation (grants 1618695 and 1704369), the Andrew W. Mellon Foundation, Start Smart Labs, and Compute Canada

The spectral content of SDO/AIA 1600 and 1700 \AA\ filters from flare and plage observations

The strong enhancement of the ultraviolet emission during solar flares is usually taken as an indication of plasma heating in the lower solar atmosphere caused by the deposition of the energy released during these events. Images taken with broadband ultraviolet filters by the {\em Transition Region and Coronal Explorer} (TRACE) and {\em Atmospheric Imaging Assembly} (AIA 1600 and 1700~\AA) have revealed the morphology and evolution of flare ribbons in great detail. However, the spectral content of these images is still largely unknown. Without the knowledge of the spectral contribution to these UV filters, the use of these rich imaging datasets is severely limited. Aiming to solve this issue, we estimate the spectral contributions of the AIA UV flare and plage images using high-resolution spectra in the range 1300 to 1900~\AA\ from the Skylab NRL SO82B spectrograph. We find that the flare excess emission in AIA 1600~\AA\ is { dominated by} the \ion{C}{4} 1550~\AA\ doublet (26\%), \ion{Si}{1} continua (20\%), with smaller contributions from many other chromospheric lines such as \ion{C}{1} 1561 and 1656~\AA\ multiplets, \ion{He}{2} 1640~\AA, \ion{Si}{2} 1526 and 1533~\AA. For the AIA 1700~\AA\ band, \ion{C}{1} 1656~\AA\ multiplet is the main contributor (38\%), followed by \ion{He}{2} 1640 (17\%), and accompanied by a multitude of other, { weaker} chromospheric lines, with minimal contribution from the continuum. Our results can be generalized to state that the AIA UV flare excess emission is of chromospheric origin, while plage emission is dominated by photospheric continuum emission in both channels.Comment: Accepted for publication in ApJ Skylab NRL SO82B data used in this work available at http://dx.doi.org/10.5525/gla.researchdata.68