Determinan Pemberantasan Sarang Nyamuk Dengue pada Rumah Tangga di Bogor Tahun 2016

Determinants of dengue mosquito eradication (PSN) in the households in Bogor in 2016PurposeThis study aimed to determine the factors that affect of PSN on housewives in Cibinong and the factors found that influence were: job, knowledge, attitude, behavior of housewife, counselling, active jumantik, giving abatement and the number of container.MethodsA cross-sectional study was conducted using 125 housewifes in Cibinong sub-district. The statistical analysis used chi-square and multiple logistic regression tests.ResultsThis study showed that counseling and the existence of jumantik cadre were the determinants of the application of mosquito nest eradication. Counseling was the most influential factor on the application of mosquito nest eradication.Conclusion Dengue control and prevention counseling should be given to all age groups in the community regularly and it is recommended to reactivate jumantik cadres

Epithelial Wnt Ligand Secretion Is Required for Adult Hair Follicle Growth and Regeneration

β-Catenin, a key transducer molecule of Wnt signaling, is required for adult hair follicle growth and regeneration. However, the cellular source of Wnt ligands required for Wnt/β-catenin activation during anagen induction is unknown. In this study, we genetically deleted Wntless (Wls), a gene required for Wnt ligand secretion by Wnt-producing cells, specifically in the hair follicle epithelium during telogen phase. We show that epithelial Wnt ligands are required for anagen, as loss of Wls in the follicular epithelium resulted in a profound hair cycle arrest. Both the follicular epithelium and dermal papilla showed markedly decreased Wnt/β-catenin signaling during anagen induction compared with control hair follicles. Surprisingly, hair follicle stem cells that are responsible for hair regeneration maintained expression of stem cell markers but exhibited significantly reduced proliferation. Finally, we demonstrate that epidermal Wnt ligands are critical for adult wound-induced de novo hair formation. Collectively, these data show that Wnt ligands secreted by the hair follicle epithelium are required for adult hair follicle regeneration and provide new insight into potential cellular targets for the treatment of hair disorders such as alopecia

ARTE E UTOPIA - O TEATRO DO BREAD & PUPPET

ABSTRACT: The Bread and Puppet Theatre was founded in New York in the 1960s and is certainly among the most important and long-lasting contributors to modern American theatre history. The troupe's Domestic Resurrection Circus emerged in the context of the countercultural goals of the 1960s and 70s and by the end of the "postmodern" 1990s, attracting audiences of over 30,000 spectators. This study is about Bread and Puppet Theatre's epic circuses and plays and asserts the need and urgency of critical relationship between theatre and utopian thought

Supersymmetric Extension of the Standard Model with Naturally Stable Proton

A new supersymmetric standard model based on N=1 supergravity is constructed, aiming at natural explanation for the proton stability without invoking an ad hoc discrete symmetry through R parity. The proton is protected from decay by an extra U(1) gauge symmetry. Particle contents are necessarily increased to be free from anomalies, making it possible to incorporate the superfields for right-handed neutrinos and an SU(2)-singlet Higgs boson. The vacuum expectation value of this Higgs boson, which induces spontaneous breakdown of the U(1) symmetry, yields large Majorana masses for the right-handed neutrinos, leading to small masses for the ordinary neutrinos. The linear coupling of SU(2)-doublet Higgs superfields, which is indispensable to the superpotential of the minimal supersymmetric standard model, is replaced by a trilinear coupling of the Higgs superfields, so that there is no mass parameter in the superpotential. The energy dependencies of the model parameters are studied, showing that gauge symmetry breaking is induced by radiative corrections. Certain ranges of the parameter values compatible with phenomena at the electroweak energy scale can be derived from universal values of masses-squared and trilinear coupling constants for scalar fields at a very high energy scale.Comment: 32 pages, Revtex, 7 figure

A Supersymmetric Model with an Extra U(1) Gauge Symmetry

In the standard model the proton is protected from decay naturally by gauge symmetries, whereas in the ordinary minimal supersymmetric standard model an ad hoc discrete symmetry is imposed for the proton stability. We present a new supersymmetric model in which the proton decay is forbidden by an extra U(1) gauge symmetry. Particle contents are necessarily increased to be free from anomalies, incorporating right-handed neutrinos. Both Dirac and Majorana masses are generated for neutrinos, yielding non-vanishing but small masses. The superpotential consists only of trilinear couplings and the mass parameter $\mu$ of the minimal model is induced by spontaneous breaking of the U(1) symmetry.Comment: 10 pages, Revte

Models of Yukawa interaction in the two Higgs doublet model, and their collider phenomenology

Possible models of Yukawa interaction are discussed in the two Higgs doublet model (THDM) under the discrete symmetry imposed to avoid the flavor changing neutral current at the leading order. It is known that there are four types of such models corresponding to the possible different assignment of charges for the discrete symmetry on quarks and leptons. We first examine decay properties of Higgs bosons in each type of the models, and summarize constraints on the models from current experimental data. We then shed light on the differences among these models in collider phenomenology. In particular, we mainly discuss so-called the Type-II THDM and the Type-X THDM. The Type-II THDM corresponds to the model with the same Yukawa interaction as the minimal supersymmetric standard model (MSSM). On the other hand, in the Type-X THDM, additional Higgs bosons can predominantly decay into leptons. This scenario may be interesting because of the motivation for a light charged Higgs boson scenario such as in the TeV scale model of neutrino, dark matter and baryogenesis. We study how we can distinguish the Type-X THDM from the MSSM at the Large Hadron Collider and the International Linear Collider.Comment: 33 pages, 41 eps files, version accepted for publication in Physical Review

Implementation of earlier antibiotic administration in patients with severe sepsis and septic shock in Japan: a descriptive analysis of a prospective observational study.

BACKGROUND: Time to antibiotic administration is a key element in sepsis care; however, it is difficult to implement sepsis care bundles. Additionally, sepsis is different from other emergent conditions including acute coronary syndrome, stroke, or trauma. We aimed to describe the association between time to antibiotic administration and outcomes in patients with severe sepsis and septic shock in Japan. METHODS: This prospective observational study enrolled 1184 adult patients diagnosed with severe sepsis based on the Sepsis-2 criteria and admitted to 59 intensive care units (ICUs) in Japan between January 1, 2016, and March 31, 2017, as the sepsis cohort of the Focused Outcomes Research in Emergency Care in Acute Respiratory Distress Syndrome, Sepsis and Trauma (FORECAST) study. We compared the characteristics and in-hospital mortality of patients administered with antibiotics at varying durations after sepsis recognition, i.e., 0-60, 61-120, 121-180, 181-240, 241-360, and 361-1440 min, and estimated the impact of antibiotic timing on risk-adjusted in-hospital mortality using the generalized estimating equation model (GEE) with an exchangeable, within-group correlation matrix, with "hospital" as the grouping variable. RESULTS: Data from 1124 patients in 54 hospitals were used for analyses. Of these, 30.5% and 73.9% received antibiotics within 1 h and 3 h, respectively. Overall, the median time to antibiotic administration was 102 min [interquartile range (IQR), 55-189]. Compared with patients diagnosed in the emergency department [90 min (IQR, 48-164 min)], time to antibiotic administration was shortest in patients diagnosed in ICUs [60 min (39-180 min)] and longest in patients transferred from wards [120 min (62-226)]. Overall crude mortality was 23.4%, where patients in the 0-60 min group had the highest mortality (28.0%) and a risk-adjusted mortality rate [28.7% (95% CI 23.3-34.1%)], whereas those in the 61-120 min group had the lowest mortality (20.2%) and risk-adjusted mortality rates [21.6% (95% CI 16.5-26.6%)]. Differences in mortality were noted only between the 0-60 min and 61-120 min groups. CONCLUSIONS: We could not find any association between earlier antibiotic administration and reduction in in-hospital mortality in patients with severe sepsis

Frontiers in Pigment Cell and Melanoma Research

We identify emerging frontiers in clinical and basic research of melanocyte biology and its associated biomedical disciplines. We describe challenges and opportunities in clinical and basic research of normal and diseased melanocytes that impact current approaches to research in melanoma and the dermatological sciences. We focus on four themes: (1) clinical melanoma research, (2) basic melanoma research, (3) clinical dermatology, and (4) basic pigment cell research, with the goal of outlining current highlights, challenges, and frontiers associated with pigmentation and melanocyte biology. Significantly, this document encapsulates important advances in melanocyte and melanoma research including emerging frontiers in melanoma immunotherapy, medical and surgical oncology, dermatology, vitiligo, albinism, genomics and systems biology, epidemiology, pigment biophysics and chemistry, and evolution

Administration route-dependent vaccine efficiency of murine dendritic cells pulsed with antigens

 Dendritic cells (DCs) loaded with tumour antigens have been successfully used to induce protective tumour immunity in murine models and human trials. However, it is still unclear which DC administration route elicits a superior therapeutic effect. Herein, we investigated the vaccine efficiency of DC2.4 cells, a murine dendritic cell line, pulsed with ovalbumin (OVA) in the murine E.G7-OVA tumour model after immunization via various routes. After a single vaccination using 1 × 106OVA-pulsed DC2.4 cells, tumour was completely rejected in the intradermally (i.d.; three of four mice), subcutaneously (s.c.; three of four mice), and intraperitoneally (i.p.; one of four mice) immunized groups. Double vaccinations enhanced the anti-tumour effect in all groups except the intravenous (i.v.) group, which failed to achieve complete rejection. The anti-tumour efficacy of each immunization route was correlated with the OVA-specific cytotoxic T lymphocyte (CTL) activity evaluated on day 7 post-vaccination. Furthermore, the accumulation of DC2.4 cells in the regional lymph nodes was detected only in the i.d.-and s.c.-injected groups. These results demonstrate that the administration route of antigen-loaded DCs affects the migration of DCs to lymphoid tissues and the magnitude of antigen-specific CTL response. Furthermore, the immunization route affects vaccine efficiency. © 2001 Cancer Research Campaign http://www.bjcancer.co