Nonparametric Bayesian Multiple Comparisons for Dependence Parameter in Bivariate Exponential Populations

A nonparametric Bayesian multiple comparisons problem (MCP) for dependence parameters in I bivariate exponential populations is studied. A simple method for pairwise comparisons of these parameters is also suggested. The methodology by Gopalan and Berry (1998) is extended using Dirichlet process priors, applied in the form of baseline prior and likelihood combination to provide the comparisons. Computation of the posterior probabilities of all possible hypotheses are carried out through a Markov Chain Monte Carlo, Gibbs sampling, due to the intractability of analytic evaluation. The process of MCP for the dependent parameters of bivariate exponential populations is illustrated with a numerical example

Response of dust on thermal emission spectra observed by Planetary Fourier Spectrometer (PFS) on-board Mars Express (MEX)

38-44The thermal emission spectra have provided many useful insights about the Martian atmosphere and surface. The interpretation of the thermal emission spectra can give us information about atmospheric temperature, pressure, mineralogy and presence of atmospheric constituents including their isotopes. In the present work, we have analysed the thermal emission data for dust storm season on Mars. The signature of dust in the thermal emission spectra for Martian Year (MY) 28 confirm the presence (Ls=280o and 300o) and the absence (Ls=240o and 320o) of the dust storm at latitude range 0o-10oS, 10o-20oS and 20o-30oS. We have compared our results with earlier mission data with thermal emission measurements made by Planetary Fourier Spectrometer (PFS) on-board Mars Express (MEX) between wave numbers 250-1400 cm-1. We have observed features at wave numbers 600-750 cm-1 and 900-1200 cm-1 due to absorptions by CO2 and dust respectively. We have obtained brightness temperatures from thermal emission spectra by inverting the Planck function. The maximum brightness temperature ~280o K was measured at Ls=240o when Mars received a large amount of solar radiation at perihelion. The minimum brightness temperature ~ 220o K was observed at Ls=320o in the absence of dust storm. In presence of dust storm, thermal emission spectra and brightness temperatures were reduced by factors of ~ 3.0 and ~1.3, respectively, between wave numbers 900-1200 cm-1 in comparison to that observed in absence of dust storm

Response of dust on thermal emission spectra observed by Planetary Fourier3 Spectrometer (PFS) on-board Mars Express (MEX)

The thermal emission spectra have provided many useful insights about the Martian atmosphere and surface. The interpretation of the thermal emission spectra can give us information about atmospheric temperature, pressure, mineralogy and presence of atmospheric constituents including their isotopes. In the present work, we have analysed the thermal emission data for dust storm season on Mars. The signature of dust in the thermal emission spectra for Martian Year (MY) 28 confirms presence (Ls=280o and 300o) and absence (Ls=240o and 320o) of the dust storm at latitude range 0o-10oS, 10o-20oS and 20o-30oS. We have compared our results with earlier mission data with thermal emission measurements made by Planetary Fourier Spectrometer (PFS) on-board Mars Express (MEX) between wave numbers 250-1400 cm-1. We have observed features at wave numbers 600-750 cm-1 and 900-1200 cm-1 due to absorptions by CO2 and dust respectively. We have obtained brightness temperatures from thermal emission spectra by inverting the Planck function. The maximum brightness temperature ~280 K is measured at Ls=240o when Mars received a large amount of solar radiation at perihelion. The minimum brightness temperature ~ 220o K is observed at Ls=320o in the absence of dust storm. In presence of dust storm thermal emission spectra and brightness  temperatures are reduced by factors of ~ 3.0 and ~1.3 respectively between wave numbers 900-1200 cm-1 in comparison to that observed in absence of dust storm

Effects of Relationship Marketing on Customer Retention and Competitive Advantage: A Case Study on Grameen Phone Ltd.

The purpose of this paper is to evaluate whether Relationship Marketing (RM) creates competitive advantage and retains customers for businesses. In order to evaluate RM practices in Grameen Phone (GP), two hundred and sixty five respondents were surveyed. Findings show that GP has been applying RM successfully, consequently retaining customers and achieving competitive advantage. However, GP should emphasize on internal marketing practices and on enhancing employee satisfaction and customer care

686 La Revue de Santé de la Méditerranée orientale

ABSTRACT A placebo-controlled trial compared 6% hexadecyl-phosphorylcholine (HePC) and 12% benzethonium chloride ointment with placebo ointment for treatment of cutaneous leishmaniasis. Cuta--neous lesions were experimentally induced by inoculation with leishmania promastigotes in 60 golden hamsters. Forty (40) animals were treated with drug and 20 with placebo ointment applied twice daily for 15 days. After treatment, all lesions were significantly reduced in size in the treatment group compared with the placebo ointment. No parasites were detected in smears from 35/40 of the drug-treated lesions and no relapses occurred over 120 days of observation. 5 Efficacy of hexadecyl-phosphorylcholine ointment for treatment of cutaneous La pommade d'héxadécylphosphocholine pour le traitement de la leishmaniose cutanée : essai sur l'animal RÉSUMÉ Un essai contrôlé contre placebo a comparé une pommade contenant 6 % d'héxadécyl--phosphocholine et 12 % de chlorure de benzéthonium avec une pommade placebo pour le traitement de la leishmaniose cutanée. Les lésions cutanées ont été induites expérimentalement par inoculation de promastigotes de leishmania sur 60 hamsters dorés. Quarante (40) animaux ont été traités avec le médicament et 20 avec la pommade placebo appliquée deux fois par jour pendant 15 jours. Après le traitement, toutes les lésions ont significativement diminué en taille dans le groupe du traitement par rapport à la pommade placebo. Aucun parasite n'a été détecté dans les frottis de 35 des 40 lésions traitées par le médicament et aucune rechute ne s'est produite pendant 120 jours d'observation

Latent activity of curcumin against leishmaniasis in vitro

In this study the anti-proliferative effect of curcumin (curcuma longa) that is the active ingredient of ground dried rhizome has been studied against three local and three reference leishmanial strains, Leishmania major, Leishmania tropica and Leishmania infantum (Pakistani isolate). Curcumin has shown an average IC50 of 5.3mM against promastigotes of various leishmanial strains which is much lower as compared with pentamidine that is one of the basic treatments against leishmaniasis. The main draw back attributed to these assays performed on promastigotes is the heterogeneity of results compared with those obtained with intracellular amastigotes or with in vivo effect. We also tested activity of curcumin against axenic amastigote like cells (AALC) of L. major strain (MHOM/PK/88/DESTO). Curcumin proves to be far more potent then pentamidine against AALC which further strengthens the fact about its leishmaniacidal activity

Primary antibody deficiency in a tertiary referral hospital: A 30-year experiment

Background: Primary antibody deficiency (PAD) is the most common group of primary immunodeficiency disorders (PID), with a broad spectrum of clinical features ranging from severe and recurrent infections to asymptomatic disease. Objectives: The current study was performed to evaluate and compare demographic and clinical data in the most common types of PAD. Materials and Methods: We performed a retrospective review of the medical records of all PAD patients with a confirmed diagnosis of common variable immunodeficiency (CVID), hyper IgM syndrome (HIgM), selective IgA deficiency (SIgAD), and X-linked agammaglobulinemia (XLA) who were diagnosed during the last 30 years at the Children�s Medical Center, Tehran, Iran. Results: A total number of 280 cases of PAD (125 CVID, 32 HIgM, 63 SIgAD, and 60 XLA) were enrolled in the study. The median (range) age at the onset of disease in CVID, HIgM, SIgAD, and XLA was 2 (0-46), 0.91 (0-9), 1 (0-26), and 1 (0-10) years, respectively. Gastrointestinal infections were more prevalent in CVID patients, as were central nervous system infections in XLA patients. Autoimmune complications were more prevalent in HIgM patients, malignancies in CVID patients, and allergies in SIgAD patients. The mortality rate for CVID, HIgM, and XLA was 27.2, 28.1, and 25, respectively. No deaths were reported in SIgAD patients. Conclusions: SIgAD patients had the best prognosis. While all PAD patients should be monitored for infectious complications, special attention should be paid to the finding of malignancy and autoimmune disorders in CVID and HIgM patients, respectively. © 2015 Esmon Publicidad

Antispasmodic and vasodilator activities of Morinda citrifolia root extract are mediated through blockade of voltage dependent calcium channels

<p>Abstract</p> <p>Background</p> <p><it>Morinda citrifolia </it>(Noni) is an edible plant with wide range of medicinal uses. It occurs exclusively in tropical climate zone from India through Southeast Asia and Australia to Eastern Polynesia and Hawaii. The objective of this study was to explore the possible mode(s) of action for its antispasmodic, vasodilator and cardio-suppressant effects to rationalize its medicinal use in gut and cardiovascular disorders.</p> <p>Methods</p> <p>Isolated tissue preparations such as, rabbit jejunum, rat and rabbit aorta and guinea pig atria were used to test the antispasmodic and cardiovascular relaxant effects and the possible mode of action(s) of the 70% aqueous-ethanolic extract of <it>Morinda citrifolia </it>roots (Mc.Cr).</p> <p>Results</p> <p>The Mc.Cr produced a concentration-dependent relaxation of spontaneous and high K⁺induced contractions in isolated rabbit jejunum preparations. It also caused right ward shift in the concentration response curves of Ca⁺⁺, similar to that of verapamil. In guinea-pig right atria, Mc.Cr caused inhibition of both atrial force and rate of spontaneous contractions. In rabbit thoracic aortic preparations, Mc.Cr also suppressed contractions induced by phenylephrine (1.0 μM) in normal- Ca⁺⁺and Ca⁺⁺-free Kerb's solutions and by high K⁺, similar to that of verapamil. In rat thoracic aortic preparations, Mc.Cr also relaxed the phenylephrine (1.0 μM)-induced contractions. The vasodilatory responses were not altered in the presence of L-NAME (0.1 mM) or atropine (1.0 μM) and removal of endothelium.</p> <p>Conclusions</p> <p>These results suggest that the spasmolytic and vasodilator effects of Mc.Cr root extract are mediated possibly through blockade of voltage-dependent calcium channels and release of intracellular calcium, which may explain the medicinal use of <it>Morinda citrifolia </it>in diarrhea and hypertension. However, more detailed studies are required to assess the safety and efficacy of this plant.</p

Comparison of MRI- and TRUS-Informed Prostate Biopsy for Prostate Cancer Diagnosis in Biopsy-Naive Men: A Systematic Review and Meta-Analysis.

PURPOSE: Multiparametric magnetic resonance imaging (mpMRI) with informed targeted biopsies (TGBX) has changed the paradigm of prostate cancer (PCa) diagnosis. Randomized studies have demonstrated a diagnostic benefit of Clinically significant (CS) for TGBX compared to standard systematic biopsies (SBX). We aimed to evaluate whether mpMRI-informed TGBX has superior diagnosis rates of any-, CS-, high-grade (HG)-, and clinically insignificant (CI)-PCa compared to SBX in biopsy-naive men. METHODS: Data was searched in Medline, Embase, Web of Science, and Evidence-based medicine reviews-Cochrane Database of systematic reviews from database inception until 2019. Studies were selected by two authors independently, with disagreements resolved by consensus with a third author. Overall 1951 unique references were identified, and 100 manuscripts underwent full-text review. Data were pooled using random-effects models. The meta-analysis is reported according to the PRISMA statement. The study protocol is registered with PROSPERO (CRD42019128468). RESULTS: Overall 29 studies (13,845 patients) were analyzed. Compared to SBX, use of mpMRI-informed TGBX was associated with a 15% higher rate of any PCa diagnosis (95% CI 10-20%, p\u3c0.00001). This relationship was not affected by the study methodology (p=0.11). Diagnosis of CS and HG PCa were more common in the mpMRI-informed TGBX group (risk difference of 11%, 95% CI 0-20%, p=0.05, and 2%, 95% CI 1-4%; p=0.005, respectively) while there was no difference in diagnosis of CI PCa (risk difference of 0, 95% CI -3-3%, p=0.96). Notably, the exclusion of SBX in the mpMRI-informed TGBX arm significantly modified the association between a mpMRI strategy and lower rates of CI PCa diagnosis (p=0.01) without affecting the diagnosis rates of CS- or HG-PCa. CONCLUSIONS: In comparison to SBX, a mpMRI-informed TGBX strategy results in a significantly higher diagnosis rate of any-, CS-, and HG-PCa. Excluding SBX from mpMRI-informed TGBX was associated with decreased rates of CI-PCa diagnosis without affecting diagnosis of CS- or HG-PCa