Asymmetric hypersonic flow

A general method for the analysis of the inviscid asymmetric hypersonic flow fields enveloping smooth bodies of general shape is given. The method is based on the assumption of a thin shock layer which yields an expression for pressure in generalized Mises coordinates. Numerical results for elliptic cones at angle of attack are shown to compare well with experiments and other theories. The computing logic for a blunt body is described, and a limiting solution at the stagnation point is presented

Inviscid flow about blunted cones of large opening angle at angle of attack

Application of a general method for calculation of inviscid hypersonic flow fields is discussed. General considerations are analyzed along with the sonic corner and the stagnation region. It is concluded that the complications caused by the requirement for sonic flow at the rear corner and particularly by the uncertain position of the stagnation streamline lead to sufficient difficulties with convergence of iterations that a practical procedure is not likely to be found

Development of a method of analysis and computer program for calculating the inviscid flow about the windward surfaces of space shuttle configurations at large angles of attack

A general method developed for the analysis of inviscid hypersonic shock layers is discussed for application to the case of the shuttle vehicle at high (65 deg) angle of attack. The associated extensive subsonic flow region caused convergence difficulties whose resolution is discussed. It is required that the solution be smoother than anticipated

Exactly solvable quantum spin tubes and ladders

We find families of integrable n-leg spin-1/2 ladders and tubes with general isotropic exchange interactions between spins. These models are equivalent to su(N) spin chains with N=2^n. Arbitrary rung interactions in the spin tubes and ladders induce chemical potentials in the equivalent spin chains. The potentials are n-dependent and differ for the tube and ladder models. The models are solvable by means of nested Bethe Ansatz.Comment: 6 pages, Latex, 1 eps fig, to appear in J. Phys.

Quantum Algorithms: Entanglement Enhanced Information Processing

We discuss the fundamental role of entanglement as the essential nonclassical feature providing the computational speed-up in the known quantum algorithms. We review the construction of the Fourier transform on an Abelian group and the principles underlying the fast Fourier transform algorithm. We describe the implementation of the FFT algorithm for the group of integers modulo 2^n in the quantum context, showing how the group-theoretic formalism leads to the standard quantum network and identifying the property of entanglement that gives rise to the exponential speedup (compared to the classical FFT). Finally we outline the use of the Fourier transform in extracting periodicities, which underlies its utility in the known quantum algorithms.Comment: 17 pages latex, no figures. To appear in Phil. Trans. Roy. Soc. (Lond.) 1998, Proceedings of Royal Society Discussion Meeting ``Quantum Computation: Theory and Experiment'', held in November 199

Five Sided

Sada Kernodle: There are seven billion people existing on this earth. That’s seven billion unique and complex minds viewing our natural world. My work includes images of organic life with the physical world. Through this, I hope to inspire those billions of minds to create, explore, and gradually heal through the process of making art. The combination of the human mind, body, and spirit with nature in its rawest form, has the ability to create powerful art pieces. This is the new global footprint for the world. Elliecia Hall: My art is about balance and imbalance. It’s both light and dark. I take dark themes and present them through a feminine and colorful lens. Feminine things are often perceived as innocent and naive, but I’ve never felt that to be true to my experience. I use art to articulate myself more fully; to bring life to the anger in my heart as much as the joy in my soul. Dreams and nightmares have had such an effect on my life. Most of my earliest memories have been of my sleeping world. And while my world is affected so strongly by the darkness of sleep, I see the world in vibrant color, and look to paint my illustrations in the same way I see everything around me. Josh Kukowski: I am an artist with his mind in the future. I find myself obsessed with the unknown that the future holds. My work should evoke the sense of wonder and motivation that is felt when we sent the first man to space and the first man to the moon. I create scenes with visual and textual reality, so others join me, invited into the world and experience the wonder yet unknown. My work focuses on scale and the scale of humans to their creations that already is and could be in the future. I want people to view my work and find themselves swept from the pres¬ent, where many seem to be stuck, and into my future. Kaitlynn Moslen: Watercolor has been my medium of choice for years because of its ability to slowly build the scene with con¬trolled washes of color. The gossamer layers of watercolor have an enchanting effect translating the narratives I explore. Dreams often reflect my emotional state in subtle, surreal ways. I consider the symbols and incon¬gruities in my dreams and I often arrive at revelations or find solutions to problems. My dreams operate with insight at a level beyond what I have in the waking world. These are translated into my artwork through the expression of a human figure along with symbolic aspects of the natural world. This usually includes serene bodies of water, trees and foliage found in unexpected places, and docile forest animals. Sarah Walden: Ever since I was a little girl my mother inspired me in the gardens with her flowers. It is in the gardens that I found my inspiration for art. Working in the garden is inspiring to me. I want to be a part of the process that points to the path of art. Illustrative images affects the influence of my viewers. I intend to express deep sublim¬inal images to spark creativity within my viewers lives, that will encourage them to work for a better future as well. The subliminal in my work deals with human emotions and experiences. Art can be used to heal and bring people together to make a change. A few people can be a big change. The mission for my art is to inspire others, so that I may inspire the rest of the world to save itself though creativity. Though the elements of art, expression is created, transferring knowledge from the artist to the viewer. Art is more than just materiality; it is the silent language of color and form that speaks to the consciousness of the audience

Molecular basis of APC/C regulation by the spindle assembly checkpoint.

In the dividing eukaryotic cell, the spindle assembly checkpoint (SAC) ensures that each daughter cell inherits an identical set of chromosomes. The SAC coordinates the correct attachment of sister chromatid kinetochores to the mitotic spindle with activation of the anaphase-promoting complex (APC/C), the E3 ubiquitin ligase responsible for initiating chromosome separation. In response to unattached kinetochores, the SAC generates the mitotic checkpoint complex (MCC), which inhibits the APC/C and delays chromosome segregation. By cryo-electron microscopy, here we determine the near-atomic resolution structure of a human APC/C–MCC complex (APC/C(MCC)). Degron-like sequences of the MCC subunit BubR1 block degron recognition sites on Cdc20, the APC/C coactivator subunit responsible for substrate interactions. BubR1 also obstructs binding of the initiating E2 enzyme UbcH10 to repress APC/C ubiquitination activity. Conformational variability of the complex enables UbcH10 association, and structural analysis shows how the Cdc20 subunit intrinsic to the MCC (Cdc20(MCC)) is ubiquitinated, a process that results in APC/C reactivation when the SAC is silenced

Molecular mechanism of APC/C activation by mitotic phosphorylation.

In eukaryotes, the anaphase-promoting complex (APC/C, also known as the cyclosome) regulates the ubiquitin-dependent proteolysis of specific cell-cycle proteins to coordinate chromosome segregation in mitosis and entry into the G1 phase. The catalytic activity of the APC/C and its ability to specify the destruction of particular proteins at different phases of the cell cycle are controlled by its interaction with two structurally related coactivator subunits, Cdc20 and Cdh1. Coactivators recognize substrate degrons, and enhance the affinity of the APC/C for its cognate E2 (refs 4-6). During mitosis, cyclin-dependent kinase (Cdk) and polo-like kinase (Plk) control Cdc20- and Cdh1-mediated activation of the APC/C. Hyperphosphorylation of APC/C subunits, notably Apc1 and Apc3, is required for Cdc20 to activate the APC/C, whereas phosphorylation of Cdh1 prevents its association with the APC/C. Since both coactivators associate with the APC/C through their common C-box and Ile-Arg tail motifs, the mechanism underlying this differential regulation is unclear, as is the role of specific APC/C phosphorylation sites. Here, using cryo-electron microscopy and biochemical analysis, we define the molecular basis of how phosphorylation of human APC/C allows for its control by Cdc20. An auto-inhibitory segment of Apc1 acts as a molecular switch that in apo unphosphorylated APC/C interacts with the C-box binding site and obstructs engagement of Cdc20. Phosphorylation of the auto-inhibitory segment displaces it from the C-box-binding site. Efficient phosphorylation of the auto-inhibitory segment, and thus relief of auto-inhibition, requires the recruitment of Cdk-cyclin in complex with a Cdk regulatory subunit (Cks) to a hyperphosphorylated loop of Apc3. We also find that the small-molecule inhibitor, tosyl-l-arginine methyl ester, preferentially suppresses APC/C(Cdc20) rather than APC/C(Cdh1), and interacts with the binding sites of both the C-box and Ile-Arg tail motifs. Our results reveal the mechanism for the regulation of mitotic APC/C by phosphorylation and provide a rationale for the development of selective inhibitors of this state

Exactly solvable quantum spin ladders associated with the orthogonal and symplectic Lie algebras

We extend the results of spin ladder models associated with the Lie algebras $su(2^n)$ to the case of the orthogonal and symplectic algebras $o(2^n),\ sp(2^n)$ where n is the number of legs for the system. Two classes of models are found whose symmetry, either orthogonal or symplectic, has an explicit n dependence. Integrability of these models is shown for an arbitrary coupling of XX type rung interactions and applied magnetic field term.Comment: 7 pages, Late

Phase diagram of the su(8) quantum spin tube

We calculate the phase diagram of an integrable anisotropic 3-leg quantum spin tube connected to the su(8) algebra. We find several quantum phase transitions for antiferromagnetic rung couplings. Their locations are calculated exactly from the Bethe Ansatz solution and we discuss the nature of each of the different phases.Comment: 10 pages, RevTeX, 1 postscript figur