17 research outputs found
Personality traits modulate skin conductance response to emotional pictures: An investigation with Cloninger's model of personality
Several studies found strong relationships between main personality dimensions and emotions, and more particularly between neuroticism and negative emotions, as well as between extraversion and positive ones. In these studies, personality was mainly assessed with respect to the big five model, and emotions were evaluated with subjective rating scales. To extend the exploration of the associations between personality and emotion, the aim of the present study was to investigate the relationships between Cloninger's dimensions of personality and emotional reactivity assessed by skin conductance response (SCR). In 55 normal subjects, SCR was recorded while they were presented pictures selected as positive, negative and neutral from the International Affective Picture System. The results showed no influence of personality on response magnitude, but subjects with higher harm avoidance scores showed longer half-recovery times for negative relative to neutral pictures. This result is consistent with the dispositional bias of harm avoidance to respond intensely to signals of aversive stimuli. (c) 2006 Elsevier Ltd. All rights reserved
The combined immunodetection of AP-2α and YY1 transcription factors is associated with ERBB2 gene overexpression in primary breast tumors
INTRODUCTION: Overexpression of the ERBB2 oncogene is observed in about 20% of human breast tumors and is the consequence of increased transcription rates frequently associated with gene amplification. Several studies have shown a link between activator protein 2 (AP-2) transcription factors and ERBB2 gene expression in breast cancer cell lines. Moreover, the Yin Yang 1 (YY1) transcription factor has been shown to stimulate AP-2 transcriptional activity on the ERBB2 promoter in vitro. In this report, we examined the relationships between ERBB2, AP-2alpha, and YY1 both in breast cancer tissue specimens and in a mammary cancer cell line. METHODS: ERBB2, AP-2alpha, and YY1 protein levels were analyzed by immunohistochemistry in a panel of 55 primary breast tumors. ERBB2 gene amplification status was determined by fluorescent in situ hybridization. Correlations were evaluated by a chi2 test at a p value of less than 0.05. The functional role of AP-2alpha and YY1 on ERBB2 gene expression was analyzed by small interfering RNA (siRNA) transfection in the BT-474 mammary cancer cell line followed by real-time reverse transcription-polymerase chain reaction and Western blotting. RESULTS: We observed a statistically significant correlation between ERBB2 and AP-2alpha levels in the tumors (p < 0.01). Moreover, associations were found between ERBB2 protein level and the combined high expression of AP-2alpha and YY1 (p < 0.02) as well as between the expression of AP-2alpha and YY1 (p < 0.001). Furthermore, the levels of both AP-2alpha and YY1 proteins were inversely correlated to ERBB2 gene amplification status in the tumors (p < 0.01). Transfection of siRNAs targeting AP-2alpha and AP-2gamma mRNAs in the BT-474 breast cancer cell line repressed the expression of the endogenous ERBB2 gene at both the mRNA and protein levels. Moreover, the additional transfection of an siRNA directed against the YY1 transcript further reduced the ERBB2 protein level, suggesting that AP-2 and YY1 transcription factors cooperate to stimulate the transcription of the ERBB2 gene. CONCLUSION: This study highlights the role of both AP-2alpha and YY1 transcription factors in ERBB2 oncogene overexpression in breast tumors. Our results also suggest that high ERBB2 expression may result either from gene amplification or from increased transcription factor levels
Individual differences in the Behavioral Inhibition System are associated with orbitofrontal cortex and precuneus gray matter volume
Does Personality Modulate Skin Conductance Responses to Emotional Stimuli?
peer reviewedSeveral studies showed that personality modulates emotional responsiveness, though most of them used subjective ratings as the measure of emotion. The present study extends personality-emotion relationship findings to psychophysiological methods, more precisely to skin conductance responses (SCRs). SCRs were recorded in 54 normal subjects following the presentation of neutral and emotional pictures. Results showed that half-recovery time was modulated by harm avoidance (HA) as a function of emotional valence: Low-HA subjects showed longer half-recovery time following the presentation of pleasant pictures relative to neutral ones, whereas high-HA subjects showed no extended half-recovery time. These results support the hypothesis that personality modulates some aspects of somatic emotional reactivity, and together with previous results, they suggest that this phenomenon is highly dependent upon the characteristics of the emotional material
Can ICTS enhance neurocognitive processes of emotional perception in autism spectrum: Insights of event-related potentials?
Autonomic aspect of emotional response in depressed patients: relationships with personality.
STUDY AIM: Affective symptoms are major descriptors of depression; therefore, a lot of studies investigated emotional-responsiveness modulation in depression, and reported either a potentiation of negative affects, a reduction of positive affects, or a reduction of both positive and negative affects. On the other hand, personality was classically found to be modulated in depression, with behavioral inhibition system (BIS)-related dimensions (namely harm avoidance (HA), neuroticism) showing higher scores in depressed subjects. The aim of this study was to investigate the relationships between emotional responsiveness (as measured by skin conductance response [SCR]) and personality in depression. METHODS: SCR was recorded following the presentation of neutral, pleasant, and unpleasant pictures in 20 depressed subjects and 20 controls. RESULTS: Pleasant pictures elicited more and larger responses than unpleasant ones in control but not in depressed subjects. This effect was not modulated by personality. Moreover, depressed subjects were found to show generally faster half-recovery times and to rate emotional pictures as less arousing than control subjects and these effects disappeared when BIS-related dimensions were controlled. CONCLUSIONS: These results suggest that BIS-related dimensions are independent from the specifically reduced responses to pleasant pictures, but are involved in the observed general affect reducing
Personality modulation of P300 wave recorded within an emotional oddball protocol.
OBJECTIVES: Several studies reported that personality modulates responses to emotional stimuli, including cognitive and attentional aspects of the emotional response. The aim of this study was to refine these results while using visual event-related potentials (ERPs) and referring to Cloninger's personality model. METHODS: ERPs were recorded in 46 normal subjects within a visual oddball protocol with checkerboards as the standard stimuli and pictures selected as neutral, pleasant or unpleasant from the International Affective Picture System as the target stimuli. RESULTS: N200 amplitude was smaller and P300 amplitude was larger following the presentation of pleasant pictures in low-harm avoidance but not high-harm avoidance subjects. CONCLUSIONS: These results support the idea that both automatic and selective cognitive processing of emotional pictures is modulated by personality