235 research outputs found
Doclea alla fine dell'Antichità. Studi e ricerche per la storia di una città abbandonata della Prevalitania. DUKLJA NA KRAJU ANTIČKOG DOBA. STUDIJE I ISTRAZIVANJA ISTORIJE JEDNOG NAPUŠTENOG GRADA PREVALITANIJE
Global Antifungal Profile Optimization of Chlorophenyl Derivatives against Botrytis cinerea and Colletotrichum gloeosporioides
Twenty-two aromatic derivatives bearing a chlorine atom and a different chain in the para or meta
position were prepared and evaluated for their in vitro antifungal activity against the phytopathogenic
fungi Botrytis cinerea and Colletotrichum gloeosporioides. The results showed that maximum inhibition
of the growth of these fungi was exhibited for enantiomers S and R of 1-(40-chlorophenyl)-
2-phenylethanol (3 and 4). Furthermore, their antifungal activity showed a clear structure-activity
relationship (SAR) trend confirming the importance of the benzyl hydroxyl group in the inhibitory
mechanism of the compounds studied. Additionally, a multiobjective optimization study of the
global antifungal profile of chlorophenyl derivatives was conducted in order to establish a rational
strategy for the filtering of new fungicide candidates from combinatorial libraries. The MOOPDESIRE
methodology was used for this purpose providing reliable ranking models that can be
used later
Applications of Genetic Algorithms on the Structure−Activity Relationship Analysis of Some Cinnamamides
The efficacy of preopoerative instruction in reducing anxiety following gyneoncological surgery: a case control study
<p>Abstract</p> <p>Background</p> <p>This is a quasi-experimental case control research focusing on the impact of systematic preoperative instruction on the level of postoperative anxiety in gyneoncologic patients. The population studied consists of the gyneoncologic surgery patients admitted to the Gynecologic Oncology Service at Zekai Tahir Burak Gynecology Training and Research Hospital from May to September 2010.</p> <p>Patients and methods</p> <p>Through a random sampling, 60 patients were recruited in each group. The study group was given a systematic preoperative instruction while the control group was given routine nursing care. Patients were interviewed in the postoperative period and anxiety was measured. The data-collecting tool consisted of the Individual Information Form and the State-Trait Anxiety Inventory. The collected data were analyzed by using the SPSS Program to find the frequency, the percentage, the mean and the standard variables, and the hypothesis was tested with Chi-square, variance, and t-independent test.</p> <p>Results</p> <p>It was found that the incidence rates from the post-operative anxiety score of the study group were lower than those of the control group (p < .05). The results of this research demonstrated that gyneoncologic surgery patients who were given systematic preoperative instruction felt less anxious than the ones who were given merely a routine nursing care.</p> <p>Conclusions</p> <p>Results of this study suggest that preoperative instruction programs aiming at informing gyneoncologic surgery patients at the preoperative stage should be organized in hospitals and have an essential role.</p
Optimisation of the synthesis of vancomycin-selective molecularly imprinted polymer nanoparticles using automatic photoreactor
Quantitative prediction of integrase inhibitor resistance from genotype through consensus linear regression modeling
Green method by diffuse reflectance infrared spectroscopy and spectral region selection for the quantification of sulphamethoxazole and trimethoprim in pharmaceutical formulations
Optimization of the Ion Source-Mass Spectrometry Parameters in Non-Steroidal Anti-Inflammatory and Analgesic Pharmaceuticals Analysis by a Design of Experiments Approach
Chamomile decoction extract inhibits human neutrophils ROS production and attenuates alcohol-induced haematological parameters changes and erythrocytes oxidative stress in rat
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