513 research outputs found
Equilibrium spherically curved 2D Lennard-Jones systems
To learn about basic aspects of nano-scale spherical molecular shells during
their formation, spherically curved two-dimensional N-particle Lennard-Jones
systems are simulated, studying curvature evolution paths at zero-temperature.
For many N-values (N<800) equilibrium configurations are traced as a function
of the curvature radius R. Sharp jumps for tiny changes in R between
trajectories with major differences in topological structure correspond to
avalanche-like transitions. For a typical case, N=25, equilibrium
configurations fall on smooth trajectories in state space which can be traced
in the E-R plane. The trajectories show-up with local energy minima, from which
growth in N at steady curvature can develop.Comment: 10 pages, 2 figures, to be published in Journal of Chemical Physic
REGIONALY IMPORTANT SINCRO.GRID SMART GRID PROJECT
Regional transmission and distribution challenges has evolved and changed a lot in recent years.
Four contradictory influences increasingly affected the operations of Slovenian and Croatian
electricity systems. Regional electricity systems experienced increasing support of RES integration
to meet the EU targets, a lower electricity consumption due to the economic crisis, a growing lack
of centralized electricity production for electric system support and the high interconnectivity
between the neighboring control zones. TSOs and DSOs observed growing network overvoltage
issues as well as a decrease in secondary reserve capacities. Such situation starts to impact national
and regional renewable integration targets affecting the security of supply at European level.
SINCRO.GRID joint investment project addressed the above-mentioned issues in a sustainable
manner. Such cross-border systemic approach will bring synergetic benefits. It will enable an
acceptable level of security of operation for at least the next ten years hosting levels of RES in line
with the trends foreseen to reach the 2030 targets safely. The project is going to integrate new
active elements in the transmission and distribution grids. It leans on the following main pillars:
deployment of six compensation devices, deployment of advanced dynamic thermal rating (DTR)
systems, deployment of electricity storage systems, integration of distributed renewable generation
(DG) and deployment of a virtual cross-border control center (VCBCC). A key aspect of the
SINCRO.GRID project lies in the synergy brought by the simultaneous innovative deployment of a
portfolio of mature technology-based solutions bring high benefits and positive externalities for the
region and European Union
Advances in the management of gout: Critical appraisal of febuxostat in the control of hyperuricemia
Gout recently passed rheumatoid arthritis to become the most common inflammatory arthritis in the United States (US). However, epidemiologic studies indicate that the quality of gout management is suboptimal owing to both patient and physician issues. Only three options for urate-lowering therapy are currently available in the US: allopurinol, probenecid, and recently, febuxostat. Probenecid is generally safe except for the occurrence of urolithiasis, but is only effective for the subset of patients with better kidney function. Allopurinol use is limited due to its side effects, potential toxicity of uncertain magnitude in patients with renal disease, and failure to achieve targeted serum urate levels. In part this failure may be due to the necessity for it to be titrated for optimal therapeutic effect. Febuxostat is a new medication that may offer several advantages and can be given as an alternative to allopurinol. We review the basic biology and clinical performance of febuxostat, and consider the potential utility of this agent in comparison to the older, better-established gout therapeutics
Dynamics of Air-Fluidized Granular System Measured by the Modulated Gradient Spin-echo
The power spectrum of displacement fluctuation of beads in the air-fluidized
granular system is measured by a novel NMR technique of modulated gradient
spin-echo. The results of measurement together with the related spectrum of the
velocity fluctuation autocorrelation function fit well to an empiric formula
based on to the model of bead caging between nearest neighbours; the cage
breaks up after a few collisions \cite{Menon1}. The fit yields the
characteristic collision time, the size of bead caging and the diffusion-like
constant for different degrees of system fluidization. The resulting mean
squared displacement increases proportionally to the second power of time in
the short-time ballistic regime and increases linearly with time in the
long-time diffusion regime as already confirmed by other experiments and
simulations.Comment: 4 figures. Submited to Physical Review Letters, April 200
Complexation of DNA with Cationic Surfactant
Transfection of an anionic polynucleotide through a negatively charged
membrane is an important problem in genetic engineering. The direct association
of cationic surfactant to DNA decreases the effective negative charge of the
nucleic acid, allowing the DNA-surfactant complex to approach a negatively
charged membrane. The paper develops a theory for solutions composed of
polyelectrolyte, salt, and ionic surfactant. The theoretical predictions are
compared with the experimental measurements.Comment: 9 pages, 3 figure
Critical swelling of particle-encapsulating vesicles
We consider a ubiquitous scenario where a fluctuating, semipermeable vesicle
is embedded in solution while enclosing a fixed number of solute particles. The
swelling with increasing number of particles or decreasing concentration of the
outer solution exhibits a continuous phase transition from a fluctuating state
to the maximum-volume configuration, whereupon appreciable pressure difference
and surface tension build up. This criticality is unique to
particle-encapsulating vesicles, whose volume and inner pressure both
fluctuate. It implies a universal swelling behavior of such vesicles as they
approach their limiting volume and osmotic lysis.Comment: 4 pages, 1 figur
Theoretical model for the formation of caveolae and similar membrane invaginations
We study a physical model for the formation of bud-like invaginations on fluid lipid membranes under tension, and apply this model to caveolae formation. We demonstrate that budding can be driven by membrane-bound proteins, provided that they exert asymmetric forces on the membrane that give rise to bending moments. In particular, caveolae formation does not necessarily require forces to be applied by the cytoskeleton. Our theoretical model is able to explain several features observed experimentally in caveolae, where proteins in the caveolin family are known to play a crucial role in the formation of caveolae buds. These include 1), the formation of caveolae buds with sizes in the 100-nm range and 2), that certain N- and C-termini deletion mutants result in vesicles that are an order-of-magnitude larger. Finally, we discuss the possible origin of the morphological striations that are observed on the surfaces of the caveolae
Fluctuation spectrum of fluid membranes coupled to an elastic meshwork: jump of the effective surface tension at the mesh size
We identify a class of composite membranes: fluid bilayers coupled to an
elastic meshwork, that are such that the meshwork's energy is a function
\textit{not} of the real microscopic membrane area ,
but of a \textit{smoothed} membrane's area , which corresponds to the
area of the membrane coarse-grained at the mesh size . We show that the
meshwork modifies the membrane tension both below and above the scale
, inducing a tension-jump . The
predictions of our model account for the fluctuation spectrum of red blood
cells membranes coupled to their cytoskeleton. Our results indicate that the
cytoskeleton might be under extensional stress, which would provide a means to
regulate available membrane area. We also predict an observable tension jump
for membranes decorated with polymer "brushes"
A Sucrose Solution Application to the Study of Model Biological Membranes
The small-angle X-ray and neutron scattering, time resolved X-ray small-angle
and wide-angle diffraction coupled with differential scanning calorimetry have
been applied to the investigation of unilamellar and multilamellar
dimyristoylphosphatidylcholine (DMPC) vesicles in sucrose buffers with sucrose
concentrations from 0 to 60%. Sucrose buffer decreased vesicle size and
polydispersity and increased an X-ray contrast between phospholipid membrane
and bulk solvent sufficiently. No influence of sucrose on the membrane
thickness or mutual packing of hydrocarbon chains has been detected. The region
of sucrose concentrations 30%-40% created the best experimental conditions for
X-ray small-angle experiments with phospholipid vesicles.Comment: PDF: 10 pages, 6 figures. MS Word sours
- …