Baryons in Holographic QCD

We study the baryon in holographic QCD with $D4/D8/\bar{D8}$ multi-$D$ brane system. In holographic QCD, the baryon appears as a topologically non-trivial chiral soliton in a four-dimensional effective theory of mesons. We call this topological soliton as Brane-induced Skyrmion. Some review of $D4/D8/\bar{D8}$ holographic QCD is presented from the viewpoints of recent hadron physics and phenomenologies. Four-dimensional effective theory with pions and $\rho$ mesons is uniquely derived from the non-abelian Dirac-Born-Infeld (DBI) action of $D8$ brane with $D4$ supergravity background, without small amplitude expansion of meson fields to discuss chiral solitons. For the hedgehog configuration of pion and $\rho$-meson fields, we derive the energy functional and the Euler-Lagrange equation of Brane-induced Skyrmion from the meson effective action induced by holographic QCD. Performing the numerical calculation, we obtain the pion profile $F(r)$ and the $\rho$-meson profile $G(r)$ of the Brane-induced Skyrmion, and estimate its total energy, energy density distribution, and root-mean-square radius. These results are compared with the experimental quantities of baryons and also with the profiles of standard Skyrmion without $\rho$ mesons. We analyze interaction terms of pions and $\rho$ mesons in Brane-induced Skyrmion, and consider the role of $\rho$-meson component appearing in baryons.Comment: 28 pages, 11 figure

Impact of irreversibility and uncertainty on the timing of infrastructure projects

This paper argues that because of the irreversibility and uncertainty associated with Build - Operate - Transfer (BOT) infrastructure projects, their financial evaluation should also routinely include the determination of the value of the option to defer the construction start-up. This ensures that project viability is comprehensively assessed before any revenue or loan guarantees are considered by project sponsors to support the project. This paper shows that the framework can be used even in the context of the intuitive binomial lattice model. This requires estimating volatility directly from the evolution of the net operating income while accounting for the correlation between the revenue and costs functions. This approach ensures that the uncertainties usually associated with toll revenues, in particular, are thoroughly investigated and their impact on project viability is thoroughly assessed. This paper illustrates the usefulness of the framework with data from an actual (BOT) toll road project. The results show that by postponing the project for a couple of years the project turns out to be viable, whereas it was not without the deferral. The evaluation approach proposed therefore provides a better framework for determining when and the extent of government financial support, if any, that may be needed to support a BOT project on the basis of project economics. The analysis may also be applicable to private sector investment projects, which are characterized by irreversibility and a high rate of uncertainty

Brane-induced Skyrmion on S^3: baryonic matter in holographic QCD

We study baryonic matter in holographic QCD with D4/D8/\bar{D8} multi-D brane system in type IIA superstring theory. The baryon is described as the "brane-induced Skyrmion", which is a topologically non-trivial chiral soliton in the four-dimensional meson effective action induced by holographic QCD. We employ the "truncated-resonance model" approach for the baryon analysis, including pion and \rho meson fields below the ultraviolet cutoff scale M_KK \sim 1GeV, to keep the holographic duality with QCD. We describe the baryonic matter in large N_c as single brane-induced Skyrmion on the three-dimensional closed manifold S^3 with finite radius R. The interactions between baryons are simulated by the curvature of the closed manifold S^3, and the decrease of the size of S^3 represents the increase of the total baryon-number density in the medium in this modeling. We investigate the energy density, the field configuration, the mass and the root-mean-square radius of single baryon on S^3 as the function of its radius R. We find a new picture of "pion dominance" near the critical density in the baryonic matter, where all the (axial) vector meson fields disappear and only the pion field survive. We also find the "swelling" phenomena of the baryons as the precursor of the deconfinement, and propose the mechanism of the swelling in general context of QCD. The properties of the deconfinement and the chiral symmetry restoration in the baryonic matter are examined by taking the proper order parameters. We also compare our truncated-resonance model with another "instanton" description of the baryon in holographic QCD, considering the role of cutoff scale M_KK.Comment: 25 pages, 12 figure

Community perceptions of a malaria vaccine in the Kintampo districts of Ghana.

BACKGROUND: Malaria remains the leading cause of morbidity and mortality in sub-Saharan Africa despite tools currently available for its control. Making malaria vaccine available for routine use will be a major hallmark, but its acceptance by community members and health professionals within the health system could pose considerable challenge as has been found with the introduction of polio vaccinations in parts of West Africa. Some of these challenges may not be expected since decisions people make are many a time driven by a complex myriad of perceptions. This paper reports knowledge and perceptions of community members in the Kintampo area of Ghana where malaria vaccine trials have been ongoing as part of the drive for the first-ever licensed malaria vaccine in the near future. METHODS: Both qualitative and quantitative methods were used in the data collection processes. Women and men whose children were or were not involved in the malaria vaccine trial were invited to participate in focus group discussions (FGDs). Respondents, made up of heads of religious groupings in the study area, health care providers, traditional healers and traditional birth attendants, were also invited to participate in in-depth interviews (IDIs). A cross-sectional survey was conducted in communities where the malaria vaccine trial (Mal 047RTS,S) was carried out. In total, 12 FGDs, 15 IDIs and 466 household head interviews were conducted. RESULTS: Knowledge about vaccines was widespread among participants. Respondents would like their children to be vaccinated against all childhood illnesses including malaria. Knowledge of the long existing routine vaccines was relatively high among respondents compared to hepatitis B and Haemophilus influenza type B vaccines that were introduced more recently in 2002. There was no clear religious belief or sociocultural practice that will serve as a possible barrier to the acceptance of a malaria vaccine. CONCLUSION: With the assumption that a malaria vaccine will be as efficacious as other EPI vaccines, community members in Central Ghana will accept and prefer malaria vaccine to malaria drugs as a malaria control tool. Beliefs and cultural practices as barriers to the acceptance of malaria vaccine were virtually unknown in the communities surveyed

Two-flavor QCD at finite temperature and chemical potential in a functional approach

We summarize recent results obtained in the Dyson-Schwinger formalism to study the chiral and deconfinement phase transitions of quenched and unquenched QCD at finite temperature and chemical potential. In the quenched case we compare SU(2) and SU(3) gauge theories by taking lattice data for the gluon as an input for the quark Dyson-Schwinger equation. As compared to previous investigations we find a clearer distinction between the second order transition of the two-color theory and the (weak) first order transition of the three-color gauge theory. We then extend this study to unquenched QCD at finite chemical potential by taking matter effects to the gluon into account and investigate the order of the chiral phase transition and the behavior of the deconfinement transition. What we find are coinciding phase transitions up to a critical endpoint which is located at large chemical potential.Comment: 7 pages, 5 figures, contribution to the proceedings of the International School of Nuclear Physics, Erice 201

How large is "large NcN_c" for Nuclear matter?

We argue that a so far neglected dimensionless scale, the number of neighbors in a closely packed system, is relevant for the convergence of the large $N_c$ expansion at high chemical potential. It is only when the number of colors is large w.r.t. this new scale (\sim \order{10}) that a convergent large $N_c$ limit is reached. This provides an explanation as to why the large $N_c$ expansion, qualitatively successful in in vacuum QCD, fails to describe high baryo-chemical potential systems, such as nuclear matter. It also means that phenomenological claims about high density matter based on large $N_c$ extrapolations should be treated with caution.Comment: Proceedings of CPOD2010 conference, in Dubna. Results based on Phys.Rev.C82, 055202 (2010), http://arxiv.org/abs/1006.247

Conversion of the LIMA1 tumour suppressor into an oncogenic LMO-like protein by API2-MALT1 in MALT lymphoma.

MALT1 is the only known paracaspase and is a critical mediator of B- and T-cell receptor signalling. The function of the MALT1 gene is subverted by oncogenic chimeric fusions arising from the recurrent t(11;18)(q21;q21) aberration, which is the most frequent translocation in mucosa-associated lymphoid tissue (MALT) lymphoma. API2-MALT1-positive MALT lymphomas manifest antibiotic resistance and aggressive clinical behaviour with poor clinical outcome. However, the mechanisms underlying API2-MALT1-induced MALT lymphomagenesis are not fully understood. Here we show that API2-MALT1 induces paracaspase-mediated cleavage of the tumour suppressor protein LIMA1. LIMA1 binding by API2-MALT1 is API2 dependent and proteolytic cleavage is dependent on MALT1 paracaspase activity. Intriguingly, API2-MALT1-mediated proteolysis generates a LIM domain-only (LMO)-containing fragment with oncogenic properties in vitro and in vivo. Importantly, primary MALT lymphomas harbouring the API2-MALT1 fusion uniquely demonstrate LIMA1 cleavage fragments. Our studies reveal a novel paracaspase-mediated oncogenic gain-of-function mechanism in the pathogenesis of MALT lymphoma.This work was supported in part by NIH grants R01 DE119249 and R01 CA136905 (K.S.J.E-J.), R01 CA140806 (M.S.L.) and the Department of Pathology at the University of Michigan.This is the accepted manuscript. The final version is available from Nature at http://www.nature.com/ncomms/2015/150108/ncomms6908/full/ncomms6908.html

Gross-Neveu Models, Nonlinear Dirac Equations, Surfaces and Strings

Recent studies of the thermodynamic phase diagrams of the Gross-Neveu model (GN2), and its chiral cousin, the NJL2 model, have shown that there are phases with inhomogeneous crystalline condensates. These (static) condensates can be found analytically because the relevant Hartree-Fock and gap equations can be reduced to the nonlinear Schr\"odinger equation, whose deformations are governed by the mKdV and AKNS integrable hierarchies, respectively. Recently, Thies et al have shown that time-dependent Hartree-Fock solutions describing baryon scattering in the massless GN2 model satisfy the Sinh-Gordon equation, and can be mapped directly to classical string solutions in AdS3. Here we propose a geometric perspective for this result, based on the generalized Weierstrass spinor representation for the embedding of 2d surfaces into 3d spaces, which explains why these well-known integrable systems underlie these various Gross-Neveu gap equations, and why there should be a connection to classical string theory solutions. This geometric viewpoint may be useful for higher dimensional models, where the relevant integrable hierarchies include the Davey-Stewartson and Novikov-Veselov systems.Comment: 27 pages, 1 figur

Holographic chiral magnetic spiral

We study the ground state of baryonic/axial matter at zero temperature chiral-symmetry broken phase under a large magnetic field, in the framework of holographic QCD by Sakai-Sugimoto. Our study is motivated by a recent proposal of chiral magnetic spiral phase that has been argued to be favored against previously studied phase of homogeneous distribution of axial/baryonic currents in terms of meson super-currents dictated by triangle anomalies in QCD. Our results provide an existence proof of chiral magnetic spiral in strong coupling regime via holography, at least for large axial chemical potentials, whereas we don't find the phenomenon in the case of purely baryonic chemical potential.Comment: 24 pages, 15 figure