Reusable modelling and simulation of flexible manufacturing for next generation semiconductor manufacturing facilities

Automated material handling systems (AMHS) in 300 mm semiconductor manufacturing facilities may need to evolve faster than expected considering the high performance demands on these facilities. Reusable simulation models are needed to cope with the demands of this dynamic environment and to deliver answers to the industry much faster. One vision for intrabay AMHS is to link a small group of intrabay AMHS systems, within a full manufacturing facility, together using what is called a Merge/Diverge link. This promises better operational performance of the AMHS when compared to operating two dedicated AMHS systems, one for interbay transport and the other for intrabay handling. A generic tool for modelling and simulation of an intrabay AMHS (GTIA-M&S) is built, which utilises a library of different blocks representing the different components of any intrabay material handling system. GTIA-M&S provides a means for rapid building and analysis of an intrabay AMHS under different operating conditions. The ease of use of the tool means that inexpert users have the ability to generate good models. Models developed by the tool can be executed with the merge/diverge capability enabled or disabled to provide comparable solutions to production demands and to compare these two different configurations of intrabay AMHS using a single simulation model. Finally, results from simulation experiments on a model developed using the tool were very informative in that they include useful decision making data, which can now be used to further enhance and update the design and operational characteristics of the intrabay AMHS

Effectiveness of esterified whey proteins fractions against Egyptian Lethal Avian Influenza A (H5N1)

<p>Abstract</p> <p>Background</p> <p>Avian influenza A (H5N1) virus is one of the most important public health concerns worldwide. The antiviral activity of native and esterified whey proteins fractions (α- lactalbumin, β- lactoglobulin, and lactoferrin) was evaluated against A/chicken/Egypt/086Q-NLQP/2008 HPAI (H5N1) strain of clade 2.2.1 (for multiplicity of infection (1 MOI) after 72 h of incubation at 37°C in the presence of 5% CO₂) using MDCK cell lines.</p> <p>Result</p> <p>Both the native and esterified lactoferrin seem to be the most active antiviral protein among the tested samples, followed by β- lactoglobulin. α-Lactalbumin had less antiviral activity even after esterification.</p> <p>Conclusion</p> <p>Esterification of whey proteins fractions especially lactoferrin and β-lactoglobulin enhanced their antiviral activity against H5N1 in a concentration dependent manner.</p

An Updated Meta-Analysis of Endothelial Nitric Oxide Synthase Gene: Three Well-Characterized Polymorphisms with Hypertension

BACKGROUND: Numerous individually underpowered association studies have been conducted on endothelial nitric oxide synthase (eNOS) genetic variants across different ethnic populations, however, the results are often irreproducible. We therefore aimed to meta-analyze three eNOS widely-evaluated polymorphisms, G894T (rs1799983) in exon 7, 4b/a in intron 4, and T-786C (rs2070744) in promoter region, in association with hypertension from both English and Chinese publications, while addressing between-study heterogeneity and publication bias. METHODS: Data were analyzed using Stata software (version 11.0), and random-effects model was applied irrespective of between-study heterogeneity, which was evaluated by subgroup and meta-regression analyses. Publication bias was weighed using the Egger's test and funnel plot. RESULTS: There were total 19284/26003 cases/controls for G894T, and 6890/6858 for 4b/a, and 5346/6392 for T-786C polymorphism. Overall comparison of allele 894T with 894G in all study populations yielded a 16% increased risk for hypertension (odds ratio [OR] = 1.16; 95% confidence interval [95% CI]: 1.07-1.27; P = 0.001), and particularly a 32% increased risk (95% CI: 1.16-1.52; P<0.0005) in Asians and a 40% increased risk (95% CI: 1.19-1.65; P<0.0005) in Chinese. Further subgroup analyses suggested that published languages accounted for the heterogeneity for G894T polymorphism. The overall OR of allele 4a versus 4b was 1.29 (95% CI: 1.13-1.46; P<0.0005) in all study populations, and this estimate was potentiated in Asians (OR = 1.42; 95% CI: 1.16-1.72; P<0.0005). For T-786C, ethnicity-stratified analyses suggested a significantly increased risk for -786C allele (OR = 1.25; 95% CI: 1.06-1.47; P = 0.007) and -786CC genotype (OR = 1.69; 95% CI: 1.20-2.38; P = 0.003) in Whites. As an aside, the aforementioned risk estimates reached significance after Bonferroni correction. Finally, meta-regression analysis on other study-level covariates failed to provide any significance for all polymorphisms. CONCLUSION: We, via a comprehensive meta-analysis, ascertained the role of eNOS G894T and 4b/a polymorphisms on hypertension in Asians, and T-786C polymorphism in Whites

A phase II study of a 5T4 oncofoetal antigen tumour-targeted superantigen (ABR-214936) therapy in patients with advanced renal cell carcinoma

In a phase II study, 43 renal cell carcinoma patients were treated with individualised doses of ABR-214936; a fusion of a Fab recognising the antigen 5T4, and Staphylococcal enterotoxin A. Drug was given intravenously on 4 consecutive days, treatment was repeated 1 month later. Treatment was associated with moderate fever and nausea, but well tolerated. Of 40 evaluable patients, 28 had disease control at 2 months, and at 4 months, one patient showed partial response (PR) and 16 patients stable disease. Median survival, with minimum follow-up of 26 months was 19.7 months with 13 patients alive to date. Stratification by the Motzer's prognostic criteria highlights prolonged survival compared to published expectation. Patients receiving higher drug exposure had greater disease control and lived almost twice as long as expected, whereas the low-exposure patients survived as expected. Sustained interleukin-2 (IL-2) production after a repeated injection appears to be a biomarker for clinical effect, as the induced-IL-2 level on the day 2 of treatment correlated with survival. The high degree of disease control and the prolonged survival suggest that this treatment can be effective. These findings will be used in the trial design for the next generation of drug, with reduced antigenicity and toxicity

Reusable Tool For 300Mm Intrabay Amhs Modeling And Simulation

The transition to 300mm wafer size introduced a lot of new technologies to wafer fabrication facilities that mandated the presence of intrabay automated material handling systems (AMHS) for moving wafer carriers between the stockers and production tools within a bay. The design of intrabay AMHS depends on the configuration and the mode of delivery. A generic reusable tool is developed for modeling and simulation of the 300mm intrabay AMHS different designs. The tool relies on a built-in database and a library containing the different components of intrabay AMHS and the different processing tools. The design of the generic tool guarantees its reusability for building different models of bays with virtually any design. The tool output includes a number of AMHS performance metrics that can be used effectively in comparing different designs of an intrabay AMHS. © 2007 IEEE

Modeling Course Design and Delivery Processes: A Case Study in an Egyptian Higher Education Institution

AbstractIn a competitive environment where academic institutions are under pressure to develop employable graduates, the quality of education has become a crucial differentiator. Hence, a major pragmatic motivation for this article was to be able to improve the quality of education: in particular, to improve the course design and delivery processes of one of the postgraduate programs within an Egyptian higher education institution. This improvement was achieved using process modeling approaches; a mixture of hard and soft modeling techniques were applied, and a case study approach was used to analyze findings both with respect to the utility of tools and the process improvement itself. Lessons learned led to suggestions for the best ways of combing approaches which included a ‘novel’ hybrid RAD-SSM model being suggested. This combined approach promises to be useful for analyzing different processes and identifying possible areas for improving educational processes

Adherence of Renal Transplant Recipients to Once-daily, Prolonged-Release and Twice-daily, Immediate-release Tacrolimus-based Regimens in a Real-life Setting in Sweden

Background. In this study we investigated medication adherence of kidney transplant patients (KTPs) to an immediate-release tacrolimus (IR-T) regimen and, after conversion, to a prolonged-release tacrolimus (PR-T) regimen in routine clinical practice. Methods. This was a non-interventional, observational, multicenter Swedish study. We included adult KTPs with stable graft function, remaining on IR-T or converting from IR-T to PR-T. Data were collected at baseline, and months 3, 6, and 12 post-baseline. The primary endpoint was adherence using the Basel Assessment of Adherence to Immunosuppressive Medication Scale (BAASIS). Secondary assessments included tacrolimus dose and trough levels, clinical laboratory parameters (eg, estimated glomerular filtration rate), and adverse drug reactions (ADRs). Results. Overall, data from 233 KTPs were analyzed (PR-T, n = 175; IR-T, n = 58). Mean change in PR-T dose from baseline (4.8 mg/d) to month 12 was -0.2 mg/d, and for IR-T (4.2 mg/d) was-0.4 mg/d; tacrolimus trough levels remained similar. Overall adherence was similar between baseline and month 12 in both groups (PR-T: 54.4% vs 57.0%, respectively; IR-T: 65.5% vs 69.4%); timing adherence followed a similar pattern. The probability of taking adherence improved between baseline and month 12 (odds ratio, 1.97; P =.0092) in the PR-T group only. Mean BAASIS visual analog scale score at baseline was 94.3 11.1% (PR-T) and 95.3 7.6% (IR-T), and &gt;95% at subsequent visits. Laboratory parameters remained stable. Eight (4.6%) patients receiving PR-T (none receiving IR-T) had ADRs considered probably/possibly treatment-related. Conclusion. Disparity existed between high, patient-perceived and low, actual adherence. Overall adherence to the immunosuppressive regimen (measured by BAASIS) did not improve significantly over 12 months in stable KTPs converting to PR-T or remaining on IR-T; renal function remained stable.Correction in: TRANSPLANTATION PROCEEDINGS,Volume:52, Issue:10, Pages:3238-3245DOI:10.1016/j.transproceed.2020.06.001</p

Product-service systems in Egypt: a multi case evaluation of field repair

Purpose – The purpose of this paper aims to evaluate field repair within product-service system (PSS) models operated by multinational manufacturers in the Egyptian emerging market to better understand the unique characteristics of this evolving market and to identify differences compared to established markets. Design/methodology/approach – Case research was conducted on multinational manufacturers providing field repair services in Egypt. The sample is made up of 12 companies across different industries using convenience and purposive sampling. Data were collected using structured interviews. Findings – There is no common model for field repair PSSs provision in the Egyptian emerging market even within the same industry, which is influenced by several factors. One of these factors is the market type being emerging or established. However, some commonalities have been found between some industries such as computer, telecommunications and document processing. Yet, there is no structural difference in the supply networks used to provide field repair service offerings in the Egyptian emerging market compared to established markets with the trend of outsourcing evident as a main attribute of a PSS in emerging markets. The main differences between established and emerging markets are related to country, culture and customer factors, which are market-based. Among the main challenges and risks that internationalized manufacturers face in Egypt, is the low level of customer awareness. Research limitations/implications – Findings are limited to the studied cases and industries; yet, internationalized firms must deal with some unique challenges and difficulties in emerging markets. Practical implications – This paper assesses PSS requirements and provides deeper insights for companies looking to provide or expand manufacturing-based offerings into the Egyptian emerging market

Initial Stress and Gravity on P-Wave Reflection from Electromagneto-Thermo-Microstretch Medium in the Context of Three-Phase Lag Model

The present paper studied the reflection of thermo-microstretch waves under the generalized thermoelasticity theory which is employed to study the reflection of plane harmonic waves from a semi-infinite elastic solid under the effect of the electromagnetic field, initial stress, and gravity. The formulation is applied under the thermoelasticity theory with three-phase lag, and the reflection coefficient ratio variations with the angle of incidence under different conditions are obtained. Numerical results obtained from the present study are presented graphically and discussed. It is observed that the initial stress, gravitation, and electromagnetic field exert some influence in the thermo-microstretch medium due to reflection of P-waves