Herramienta de evaluación de gestión para la toma de decisiones en la Fundación V&C basada en la NTC ISO 9001:2015

The objective of this research is to design assessment tool for decision-making management in the Fundación Valor y Compromiso (V&C), with the support of process leaders who provided information through the application of a survey, this technique allowed to obtain a diagnosis of the company regarding the use of the current tool. Subsequently, the selection of the most significant management indicators in each process and the design of their respective technical sheet were carried out. Then, the results obtained for the year 2019 were consolidated into a comprehensive evaluation instrument. In the next stage, a pilot test was implemented for the process leaders, which are responsible for monitoring and controlling the management indicators, measuring the performance of each indicator through the qualification obtained concerning a projected goal. In this way, the assessment tool contributes to the continuous improvement of the organization, and connotes itself as an instrument for planning and reviewing activities. Likewise, this tool facilitates decision-making on preventive and corrective actions in processes that have low or high performance, improving the most critical processes such as commercial management and social management, and maintaining the best-performing processes such as legal, contracting and purchases, according to the results obtained in the pilot test carried out.El objetivo de la presente investigación es el diseño de una herramienta de evaluación de gestión para la toma de decisiones en la Fundación Valor y Compromiso (V&C), con el apoyo de los líderes de proceso que aportaron información mediante la aplicacion de una encuesta, esta técnica permitió obtener un diagnóstico de la empresa en cuanto al uso de la herramienta actual. Seguidamente, se llevo a cabo la selección de los indicadores de gestión más significativos en cada proceso y el diseño de su respectiva ficha técnica. Luego, se consolidaron los resultados obtenidos del año 2019 en un instrumento de evaluación integral. En la siguiente etapa, se implementó una prueba piloto a los líderes de proceso, responsables del seguimiento y control de los indicadores de gestión, midiendo el desempeño de cada indicador a través de la calificación obtenida con relación a una meta proyectada. De esta forma, la herramienta de evaluación de gestión aporta al mejoramiento continuo de la organización, y se connota como un instrumento para la planeación y revisión de actividades. Asimismo, esta herramienta facilita la toma de decisión sobre las acciones preventivas y correctivas en los procesos que presentan un bajo o alto desempeño, mejorando los procesos más críticos como gestión comercial y gestión social, y manteniendo los procesos con mejor desempeño como jurídica y contratación y compras, según los resultados obtenidos en la prueba piloto realizada

Extended gamma-ray sources around pulsars constrain the origin of the positron flux at Earth

The unexpectedly high flux of cosmic ray positrons detected at Earth may originate from nearby astrophysical sources, dark matter, or unknown processes of cosmic-ray secondary production. We report the detection, using the HighAltitude Water Cherenkov Observatory (HAWC), of extended tera-electron volt gamma-ray emission coincident with the locations of two nearby middle-aged pulsars (Geminga and PSR B0656+14). The HAWC observations demonstrate that these pulsars are indeed local sources of accelerated leptons, but the measured tera-electron volt emission profile constrains the diffusion of particles away from these sources to be much slower than previously assumed. We demonstrate that the leptons emitted by these objects are therefore unlikely to be the origin of the excess positrons, which may have a more exotic origin.Comment: 16 pages (including supplementary material), 5 figure

Magnetic Resonance Imaging Tissue Signatures Associated With White Matter Changes Due to Sporadic Cerebral Small Vessel Disease Indicate That White Matter Hyperintensities Can Regress

Background White matter hyperintensities (WMHs) might regress and progress contemporaneously, but we know little about underlying mechanisms. We examined WMH change and underlying quantitative magnetic resonance imaging tissue measures over 1 year in patients with minor ischemic stroke with sporadic cerebral small vessel disease. Methods and Results We defined areas of stable normal‐appearing white matter, stable WMHs, progressing and regressing WMHs based on baseline and 1‐year brain magnetic resonance imaging. In these areas we assessed tissue characteristics with quantitative T1, fractional anisotropy (FA), mean diffusivity (MD), and neurite orientation dispersion and density imaging (baseline only). We compared tissue signatures cross‐sectionally between areas, and longitudinally within each area. WMH change masks were available for N=197. Participants' mean age was 65.61 years (SD, 11.10), 59% had a lacunar infarct, and 68% were men. FA and MD were available for N=195, quantitative T1 for N=182, and neurite orientation dispersion and density imaging for N=174. Cross‐sectionally, all 4 tissue classes differed for FA, MD, T1, and Neurite Density Index. Longitudinally, in regressing WMHs, FA increased with little change in MD and T1 (difference estimate, 0.011 [95% CI, 0.006–0.017]; −0.002 [95% CI, −0.008 to 0.003] and −0.003 [95% CI, −0.009 to 0.004]); in progressing and stable WMHs, FA decreased (−0.022 [95% CI, −0.027 to −0.017] and −0.009 [95% CI, −0.011 to −0.006]), whereas MD and T1 increased (progressing WMHs, 0.057 [95% CI, 0.050–0.063], 0.058 [95% CI, 0.050 –0.066]; stable WMHs, 0.054 [95% CI, 0.045–0.063], 0.049 [95% CI, 0.039–0.058]); and in stable normal‐appearing white matter, MD increased (0.004 [95% CI, 0.003–0.005]), whereas FA and T1 slightly decreased and increased (−0.002 [95% CI, −0.004 to −0.000] and 0.005 [95% CI, 0.001–0.009]). Conclusions Quantitative magnetic resonance imaging shows that WMHs that regress have less abnormal microstructure at baseline than stable WMHs and follow trajectories indicating tissue improvement compared with stable and progressing WMHs

VAMOS: a Pathfinder for the HAWC Gamma-Ray Observatory

VAMOS was a prototype detector built in 2011 at an altitude of 4100m a.s.l. in the state of Puebla, Mexico. The aim of VAMOS was to finalize the design, construction techniques and data acquisition system of the HAWC observatory. HAWC is an air-shower array currently under construction at the same site of VAMOS with the purpose to study the TeV sky. The VAMOS setup included six water Cherenkov detectors and two different data acquisition systems. It was in operation between October 2011 and May 2012 with an average live time of 30%. Besides the scientific verification purposes, the eight months of data were used to obtain the results presented in this paper: the detector response to the Forbush decrease of March 2012, and the analysis of possible emission, at energies above 30 GeV, for long gamma-ray bursts GRB111016B and GRB120328B.Comment: Accepted for pubblication in Astroparticle Physics Journal (20 pages, 10 figures). Corresponding authors: A.Marinelli and D.Zaboro

Rationale and design of a longitudinal study of cerebral small vessel diseases, clinical and imaging outcomes in patients presenting with mild ischaemic stroke: Mild Stroke Study 3

Background: Cerebral small vessel disease is a major cause of dementia and stroke, visible on brain magnetic resonance imaging. Recent data suggest that small vessel disease lesions may be dynamic, damage extends into normal-appearing brain and microvascular dysfunctions include abnormal blood–brain barrier leakage, vasoreactivity and pulsatility, but much remains unknown regarding underlying pathophysiology, symptoms, clinical features and risk factors of small vessel disease. Patients and Methods: The Mild Stroke Study 3 is a prospective observational cohort study to identify risk factors for and clinical implications of small vessel disease progression and regression among up to 300 adults with non-disabling stroke. We perform detailed serial clinical, cognitive, lifestyle, physiological, retinal and brain magnetic resonance imaging assessments over one year; we assess cerebrovascular reactivity, blood flow, pulsatility and blood–brain barrier leakage on magnetic resonance imaging at baseline; we follow up to four years by post and phone. The study is registered ISRCTN 12113543. Summary: Factors which influence direction and rate of change of small vessel disease lesions are poorly understood. We investigate the role of small vessel dysfunction using advanced serial neuroimaging in a deeply phenotyped cohort to increase understanding of the natural history of small vessel disease, identify those at highest risk of early disease progression or regression and uncover novel targets for small vessel disease prevention and therapy

Search for Decaying Dark Matter in the Virgo Cluster of Galaxies with HAWC

The decay or annihilation of dark matter particles may produce a steady flux of very-high-energy gamma rays detectable above the diffuse background. Nearby clusters of galaxies provide excellent targets to search for the signatures of particle dark matter interactions. In particular, the Virgo cluster spans several degrees across the sky and can be efficiently probed with a wide field-of-view instrument. The High Altitude Water Cherenkov (HAWC) observatory, due to its wide field of view and sensitivity to gamma rays at an energy scale of 300 GeV--100 TeV is well-suited for this search. Using 2141 days of data, we search for gamma-ray emission from the Virgo cluster, assuming well-motivated dark matter sub-structure models. Our results provide some of the strongest constraints on the decay lifetime of dark matter for masses above 10 TeV.Comment: 7 pages, 3 figures. Submitted to PR

Evaluación de la comprensión sobre Tablas Estadísticas en estudiantes de Educación Primaria

Este trabajo da cuenta de la organización y estructura del resultado de la respuesta observada sobre tablas estadísticas en estudiantes de Educación Primaria de escuelas municipalizadas en la provincia de Osorno-Chile. Se aplicó una prueba con cuatro preguntas abiertas a una muestra de 233 estudiantes de tercero y sexto nivel. Las respuestas fueron clasificadas según un continuo que va desde la incompetencia a la maestría: la capacidad, operaciones implicadas, consistencia y conclusiones. Los resultados muestran que las respuestas de los estudiantes se agrupan, mayoritariamente, en el enfoque de aprendizaje superficial, esto significa que, aunque entrega datos relevantes lo hace en forma aislada, los ordenan pero, falla en la conexión entre ellos. Se observó que no hay diferencias significativas entre la estructura y organización de las respuestas que elaboran los estudiantes de tercero y sexto año