Going beyond customers - a business segmentation approach using network pictures to identify network segments

Existing approaches to segmentation, in particular business segmentation, are often conceptualized and applied in a limiting way, providing a narrow interpretation of the surrounding business network. This could be attributed to a rather myopic view of the multiple complexities and indirect links inherent in networks of business exchange relationships. The task for companies developing innovative segmentation approaches is to simultaneously enhance the company’s understanding of downstream as well as upstream preferences and resources, while going beyond immediate interaction partners to include relevant indirect business partners. The challenge is therefore not to identify attractive customer segments, but attractive network segments. As such, the managerial challenge becomes one of creating a business network segmentation from the perspective of a focal company within this network, taking a far wider interpretation of the concept of segmentation. Using the concept of network pictures, we outline the different dimensions that are important within a business network segmentation, and exemplify their use through a case study of an entrepreneurial company. Our study contributes to the literature by providing a detailed example of a practical application of abstract concepts, in this case the translation of the network picture concept into a way to apply a business network segmentation to an entrepreneurial context

Value dimensions and relationship postures in dyadic 'key relationship programmes'

Business-to-business marketing is often concerned with the way in which companies manage strategically important relationships with their counterparts: their Key Relationship Programmes (KRPs). These relationships can be managed through the implementation of specific managerial and organisational structures, commonly implemented via Key Account Programmes (on the supplier side) or Key Supplier Programmes (on the customer side). Underlying this managerial process is an implicit assumption that these important relationships bring some form of additional value to one or both parties involved. However, a dyadic view of how this value is created and shared between the parties remains an under-researched area. In this conceptual paper, we use the multi-faceted value construct introduced in Pardo et al. (2006) and posit that the buyer's or seller's value strategies can be best understood as being internally, exchange, or relationship based. This in turn allows us to analyse the value gained as being the outcome of one of nine generic key relationship postures within any dyadic KRP. We focus on an analysis of so-called "managed" relationship postures and identify a number of dyadic activities and competencies that we hypothesise are important in managing such KRPs, and which can form the basis for further empirical research

Properties of a new quasi-axisymmetric configuration

A novel, compact, quasi-axisymmetric configuration is presented which exhibits low fast-particle losses and is stable to ideal MHD instabilities. The design has fast-particle loss rates below 8\% for flux surfaces within the half-radius, and is shown to have an MHD-stability limit of a normalised pressure of $\langle\beta\rangle=3\%$ where $\langle\beta\rangle$ is volume averaged. The flux surfaces at various plasma betas and currents as calculated using the SPEC equilibrium code are presented. Neoclassical transport coefficients are shown to be similar to an equivalent tokamak, with a distinct banana regime at half-radius. An initial coil design study is presented to assess the feasibility of this configuration as a fusion-relevant experiment

Five-year Results of Elastin and Collagen Markers as Predictive Tools in the Management of Small Abdominal Aortic Aneurysms

AbstractObjective small abdominal aortic aneurysms (AAAs) do rupture and only half of AAAs above 5 cm would have ruptured unoperated. Furthermore, conservative treatment of AAAs may cause psychological side effects and impaired quality of life. To optimise the indication and time for operation for AAAs, we analysed whether serum elastin peptides (EP), procollagen-IIIN-terminal propeptide (PIIINP), and the initial AAA size could predict operation for AAAs in initially conservatively treated AAA. Material and methods in 1994, 4404 65–73 year old males were invited to hospital-based screening for AAAs by ultrasonography. Seventy-six percent attended. One hundred and forty-one (4.2%) had AAAs (def: +30 mm). Nineteen were offered operation (AAA +50 mm), and 112 were followed with annual control scans for 1–5 years (mean 2.5 years). Of these, 99 had their EP (ng/ml) and PIIINP (ng/ml) determined using ELISA and RIA techniques. Two observers and one scanner were used. Results the mean expansion rate was 2.7 mm/year. The initial AAA size (r=0.46; 0.26–0.61), EP ( r =0.31; 0.11–0.49), and NPIIIP ( r =0.24; 0.02–0.44) was independently significant associated to expansion rate in a multiple linear regression analysis including the three mentioned variables. The multivariate formula could by ROC curve analysis predict cases reaching 5 cm in diameter within 5 years with a sensitivity and specificity of 91% and 87%, respectively, increasing to 91% and 94%, respectively, by accepting a 2 mm variation in those measurements. Twenty-three were lost to follow up, 21 of these due to death or severe illness. Of these, seven would have been predicted to reach an AAA size recommendable for surgery. If all 23 were included in the analysis, the sensitivity and specificity would have been 87% and 85%, respectively. Conclusion a predictive model using EP, PIIINP, and initial AAA size seems capable of predicting nine out of 10 AAAs that will be operated on within 5 years. However, a larger sample size is needed for clinical recommendations

Completeness and positive predictive value of registration of upper limb embolectomy in the Danish National Vascular Registry

Ljubica V Andersen1, Leif S Mortensen2, Jes S Lindholt3, Ole Faergeman4, Eskild W Henneberg3, Lars Frost51Department of Pharmacology, Odense University Hospital, Denmark; 2UNI-C, The Danish IT Centre for Education and Research, Aarhus, Denmark; 3Vascular Research Unit, Department of Vascular Surgery, Viborg Hospital, Denmark; 4Department of Cardiology and Internal Medicine, Aarhus University Hospital, Denmark; 5Department of Medicine, Silkeborg Hospital, DenmarkObjective: To evaluate completeness and positive predictive value of the Danish National Vascular Registry regarding registration of the surgical procedures: embolectomy of brachial, ulnar, or radial artery. Study design and settings: The study was based on first-time embolectomies in the brachial, ulnar, or radial artery performed in Denmark from January 1, 1990 to December 31, 2002. The data were primarily retrieved from the Danish National Vascular Registry and secondarily from the Danish National Registry of Patients. Medical records were retrieved using a standardized form.Results: In total, 1433 incident cases of first-time embolectomy were found in both registries. The positive predictive value of the registration was 97.5% (95% confidence interval [CI]; 96.4–98.4). The degree of completeness was 86.5% (95% CI; 84.3–88.5). For the registration period from 1990 till 1996 the degree of completeness was 78.2% (95% CI; 74.4–81.7), and from 1997 till 2002 it was 93.8% (95% CI; 91.6–95.7). Conclusion: The completeness and positive predictive value of registration of embolectomy in the upper limb in the Danish National Vascular Registry was 86.5% and 97.5%, respectively. This registry can be a valuable tool for epidemiological research and quality-monitoring. Keywords: positive predictive value, completeness, capture-recapture method, validity, embolectomy, registration

Late childhood and adolescence growth sensitivity to political transition: the case of South African Cape Coloured schoolchildren during and post-apartheid

South Africa underwent major social and economic change between 1987 and 1995. The release of Nelson Mandela in February 1990 proclaimed an end to the political system of apartheid, and the first freely elected non-White government in 1994 instigated social and economic reforms aimed at alleviating the consequences of apartheid. This paper aims to examine the impact of these socio-economic and political changes on height, weight and body mass index (BMI) in childhood and late adolescence. An analysis was carried out of longitudinal data of 258 urban and rural South African Cape Coloured schoolchildren (6-18 years old) across the transitional periods from apartheid between 1987 and 1990, to this transition between 1991 and 1993, and finally to post-apartheid between 1994 and 1995. The anthropometric measures were standardized into age independent Z-scores. Analyses of variance with repeated measures were conducted to examine the growth in height, weight and BMI across these periods. The results show a significant main effect of measurement periods on height, weight and BMI Z-scores. Across time, the subjects increased in overall size, height, weight and BMI. For all the anthropometric measures there was a significant interaction effect between measurement period and sex, but none between measurement period and SES. The average increase in height, weight and BMI across time differed significantly for girls and boys, the average z-scores being greater in girls than in boys. For boys, there was little difference in height, weight and BMI Z-scores according to SES, and little increase across periods. Girls were generally taller, heavier with greater BMI than boys, and their scores increased across the time periods. High SES girls were taller, heavier and had higher BMI than low SES girls. Across the measurement periods, BMI and weight somewhat converged between the high and low SES girls. In the discussion these differences reflecting social sex distinctions are addressed.Madelief G.B.C. Bertens, Stanley Ulijaszek, Slawomir Koziel and Maciej Henneber

New perspectives on evolutionary medicine: the relevance of microevolution for human health and disease

Evolutionary medicine (EM) is a growing field focusing on the evolutionary basis of human diseases and their changes through time. To date, the majority of EM studies have used pure theories of hominin macroevolution to explain the present-day state of human health. Here, we propose a different approach by addressing more empirical and health-oriented research concerning past, current and future microevolutionary changes of human structure, functions and pathologies. Studying generation-to-generation changes of human morphology that occurred in historical times, and still occur in present-day populations under the forces of evolution, helps to explain medical conditions and warns clinicians that their current practices may influence future humans. Also, analyzing historic tissue specimens such as mummies is crucial in order to address the molecular evolution of pathogens, of the human genome, and their coadaptations.Frank Jakobus Rühli and Maciej Henneber

Critical gradient turbulence optimization toward a compact stellarator reactor concept

Integrating turbulence into stellarator optimization is shown by targeting the onset for the ion-temperature-gradient mode, highlighting effects of parallel connection length, local magnetic shear, and flux surface expansion. The result is a compact quasihelically symmetric stellarator configuration, admitting a set of uncomplicated coils, with significantly reduced turbulent heat fluxes compared to a known stellarator. The new configuration combines low values of neoclassical transport, good alpha particle confinement, and Mercier stability at a plasma beta of almost 2$\%$.Comment: 5 pages, 5 figures. Phys. Rev. Research 5, L032030 (2023