Some Immunological and Hematological Parameters among Refugees in Kawergosk Camp – Erbil Governorate

The study included 258 Syrian refugees of different ages and sex and another 60 volunteers as control group (C.G). These refugees were in Kawergosk camp in Erbil Governorate. Blood was collected from each individual for the estimation of white blood cell (WBC), eosinophil, iron, hemoglobin (Hb), and immunoglobulin E (IgE) levels. Mean serum levels of IgE among male and female refugees showed highly significant increasing when compared to C.G. Most of the refugees had normal iron levels, where iron concentrations were more than 65 mg/dl among 67 males and more than 50 mg/dl among 104 females and 48 children, while some had iron deficiency in which the majority were female (9 males, 24 females, and 6 children had iron deficiency). In addition, Hb concentrations were normal among 65 males (more than 13.0 g/dl), 89 females (more than 11.0 g/dl), and 48 children (more than 12.0 g/dl). However, anemia was found among 8 men, 42 women, and 6 children. It was revealed that there was a highly significant rising in eosinophils in male and female refugees in comparison to C.G. WBC count is non-significantly slightly increased in both male’s and female’s refugees when compared to C.G

Investigation the Coating of Hydroxyapatite on Titanium Substrate by Pulse Laser Deposition

بحثت هذه الدراسة وأعدت طلاء مركب للمزروعات الجراحية باستخدام المواد السيراميكيه النشطه بايولوجيا (bioactive) مثل الهيدروكسيابتايت كطلاءات للمزروعات المعدنيه التي تشجع النمو الطبيعي للعظام عند نقاط التماس بينها وبين العظم الحي. ان الهيدروكسيابتايت (Ca10(PO4)6(OH)2)) او فوسفات الكالسيوم يستخدم كطلاء للمعادن بسبب توافقيته الحياتيه الممتازه كما انه ذو هيكل مشابه للانسجه الصلبه في جسم الانسان. إن تطبيق الطلاء HA على ركائز التيتانيوم أنتجت باستخدام تقنية الترسيب بالليزر النبضي (Pulsed Laser Deposition). في هذا البحث استخدم (HA) كهدف ((Target تم كبسه عند ضغط (150MPa) مع حجم حبيبي مقداره 2.745 µm)) واستخدامه في عملية الطلاء بواسطة تقنية(PLD). أجريت عدة اختبارات لتوصيف طبقة الطلاء مثل XRD وSEM وAFM وEDX لتحديد كمية كلا من الكالسيوم (Ca) والفسفور (P) في طبقة الطلاء. وبعدها تم اختبار الصلاده وخشونة السطح لطبقه الطلاء HA)). تم اجراء اختبار التآكل باستخدام طريقة استكمال منحني تافل في محلول Hank's solution لكل النماذج المطليه وغير المطليه، حيث حصلنا في هذا الاختبار على تحسن كبير في مقاومة التآكل للعينات المطليه عند عدد نبضات 4000 نبضة بمقدار 99.88%.This study investigated and prepared a coating for surgical implants by using hydroxyapatite (HA) empowers characteristic bone that developed at a medium for prosthetic the parts of human body. HA is the generally manufactured from both Calcium (Ca) and Phosphate (P) to produce (Ca10(PO4)6(OH)2) that used as a base material for covering mineral embeds because of its incredible biocompatibility and comparable the synthesis and structure to sclerous tissues of the human body. HA, coatings on titanium substrates have been produced by Pulses laser deposition (PLD) techniques. HA used in this search pressed at pressure (150MPa) with particle size (2.745 µm) and used as a target in coating by (PLD) techniques. Surface characterization studies of the coatings such as XRD, SEM, AFM and EDX to detect the amount of (Ca) and (P) in coating layer were carried out. Then test the micro-hardness, surface roughness for HA coating .Corrosion behavior for uncoated and coated samples with various number of pulses in Hank’s solution by using OCP and the potentially static polarization test were achieved also, , in this test we obtained a greatly improved in corrosion resistance of the samples B1 after coating by 99.88%

Impedance responses and size-dependent resonances in topolectrical circuits via the method of images

Resonances in an electric circuit occur when capacitive and inductive components are present together. Such resonances appear in admittance measurements depending on the circuit's parameters and the driving AC frequency. In this study, we analyze the impedance characteristics of nontrivial topolectrical circuits such as one- and two-dimensional Su-Schrieffer-Heeger circuits and reveal that size-dependent anomalous impedance resonances inevitably arise in finite $LC$ circuits. Through the \textit{method of images}, we study how resonance modes in a multi-dimensional circuit array can be nontrivially modified by the reflection and interference of current from the structure and boundaries of the lattice. We derive analytic expressions for the impedance across two corner nodes of various lattice networks with homogeneous and heterogeneous circuit elements. We also derive the irregular dependency of the impedance resonance on the lattice size, and provide integral and dimensionally-reduced expressions for the impedance in three dimensions and above.Comment: 24 pages, 10 figure

The effect of pramipexole extended release on the levodopa equivalent daily dose in Lebanese Parkinson diseased patients

Objective: The objective of this study is to compute the potential benefit of Pramipexole ER on total levodopa equivalent dose (LED) and Unified Parkinson Disease Rating Score (UPDRS-III) compared to mono- or combined therapy of pramipexole IR and/or carbidopa/levodopa. Methods: This is a retrospective observational study conducted in a specialized PD (Parkinson Disease) and movement disease center in Lebanon between January and December 2017. Results: A total of 176 patient’s record was reviewed. Pramipexole ER showed a significant difference on the mean changes in LED and UPDRS-III score. After 13 weeks of initiating Pramipexole ER, the mean decrease in LED was -49.42 mg for all patients (p < 0.001, CI 95% [35.28-63.55]) and the mean decrease in UPDRS-III score for all patients was -6 points (P< 0.001). According to the subgroup analysis, patients aged 65 years and below, the change in mean total LED from baseline ( 350.80 mg) was a decrease of 63.19 mg with a p<0.001, CI 95% [42.07-84.31]. In patients aged more than 65 years and shifted to mono or combined pramipexole ER therapy, the change in mean total LED from baseline (559.25 mg) was a decrease of 34.67 mg with a p<0.001 CI 95% [16.16-53.18]. In addition the results showed that in patients having an UPDRS-III score of less than or equal to 33, the change in mean total LED from baseline (436.73 mg) was a decrease of 56.76 mg (p<0.001; CI 95% [41.32-72.20]). However, in patients having an UPDRS-III score of more than 33 the change in mean total LED from baseline (545.06 mg) was a decrease of 2.96 mg with a p value < 0.844 CI 95% [27.32-33.15]. Conclusions: This study demonstrated the efficacy of Pramipexole ER on decreasing the total levodopa equivalent dose (LED).The role of health care professionals is to maintain the patient on the lowest effective levodopa equivalent daily dose and optimize the treatment therapy, thus decreasing the side effects that might arise from overdosing of antiparkinsonian drugs

Performance Based Time History Analysis of Five Story Shear Frame Building Using MATLAB and ETABS

This paper compares the time history analysis results for state space representation (SSR) method using MATLAB with the result conducted using ETABS. The equation of motion of the structure subjected to seismic excitation represented by second-order linear non-homogeneous differential equation. This equation reduced to two coupled first order differential equations and state space representation was formulated to represent the system in matrix form and MATLAB Simulink was used to determine response of the structure. The objectives of this study are i) to conduct a comparative study between the state space representation which is a powerful tool with results of ETABS. ii) to investigate the accuracy of SSR method. iii) to conduct a performance based dynamic analysis for shear frame structures and study outcome responses of the structure. This analysis was based on the assumptions, i) the total story mass is lumped at the center of story diaphragm. ii) No deflection occurs in beams; story beams are infinitely rigid in comparison to story columns. iii) no changes in the nature of the boundary conditions during and after the analysis iv) the system is elastic linear time-invariant (ELTI) and material nonlinearity is not considered. So that that structural degree of freedom decreased to be equivalent to the number of storys. The results showed a significant similarity in comparison with ETABS software. The maximum absolute difference of displacement and story drift ratio was 3.35mm and 0.0016 was obtained at the roof of third and fifth story respectively

Distinguishing sequences for partially specified FSMs

Distinguishing Sequences (DSs) are used inmany Finite State Machine (FSM) based test techniques. Although Partially Specified FSMs (PSFSMs) generalise FSMs, the computational complexity of constructing Adaptive and Preset DSs (ADSs/PDSs) for PSFSMs has not been addressed. This paper shows that it is possible to check the existence of an ADS in polynomial time but the corresponding problem for PDSs is PSPACE-complete. We also report on the results of experiments with benchmarks and over 8 * 106 PSFSMs. © 2014 Springer International Publishing

Generating a checking sequence with a minimum number of reset transitions

Given a finite state machine M, a checking sequence is an input sequence that is guaranteed to lead to a failure if the implementation under test is faulty and has no more states than M. There has been much interest in the automated generation of a short checking sequence from a finite state machine. However, such sequences can contain reset transitions whose use can adversely affect both the cost of applying the checking sequence and the effectiveness of the checking sequence. Thus, we sometimes want a checking sequence with a minimum number of reset transitions rather than a shortest checking sequence. This paper describes a new algorithm for generating a checking sequence, based on a distinguishing sequence, that minimises the number of reset transitions used.This work was supported in part by Leverhulme Trust grant number F/00275/D, Testing State Based Systems, Natural Sciences and Engineering Research Council (NSERC) of Canada grant number RGPIN 976, and Engineering and Physical Sciences Research Council grant number GR/R43150, Formal Methods and Testing (FORTEST)

Insights into GABA receptor signalling in TM3 Leydig cells

gamma-Aminobutyric acid (GABA) is an emerging signalling molecule in endocrine organs, since it is produced by endocrine cells and acts via GABA(A) receptors in a paracrine/autocrine fashion. Testicular Leydig cells are producers and targets for GABA. These cells express GABA(A) receptor subunits and in the murine Leydig cell line TM3 pharmacological activation leads to increased proliferation. The signalling pathway of GABA in these cells is not known in this study. We therefore attempted to elucidate details of GABA(A) signalling in TM3 and adult mouse Leydig cells using several experimental approaches. TM3 cells not only express GABA(A) receptor subunits, but also bind the GABA agonist {[}H-3] muscimol with a binding affinity in the range reported for other endocrine cells (K-d = 2.740 +/- 0.721 nM). However, they exhibit a low B-max value of 28.08 fmol/mg protein. Typical GABA(A) receptor-associated events, including Cl- currents, changes in resting membrane potential, intracellular Ca2+ or cAMP, were not measurable with the methods employed in TM3 cells, or, as studied in part, in primary mouse Leydig cells. GABA or GABA(A) agonist isoguvacine treatment resulted in increased or decreased levels of several mRNAs, including transcription factors (c-fos, hsf-1, egr-1) and cell cycle-associated genes (Cdk2, cyclin D1). In an attempt to verify the cDNA array results and because egr-1 was recently implied in Leydig cell development, we further studied this factor. RT-PCR and Western blotting confirmed a time-dependent regulation of egr-1 in TM3. In the postnatal testis egr-1 was seen in cytoplasmic and nuclear locations of developing Leydig cells, which bear GABA(A) receptors and correspond well to TM3 cells. Thus, GABA acts via an untypical novel signalling pathway in TM3 cells. Further details of this pathway remain to be elucidated. Copyright (c) 2005 S. Karger AG, Base