Excited state intramolecular proton transfer in hydroxyanthraquinones: Toward predicting fading of organic red colorants in art.

Compositionally similar organic red colorants in the anthraquinone family, whose photodegradation can cause irreversible color and stability changes, have long been used in works of art. Different organic reds, and their multiple chromophores, suffer degradation disparately. Understanding the details of these molecules' degradation therefore provides a window into their behavior in works of art and may assist the development of improved conservation methods. According to one proposed model of photodegradation dynamics, intramolecular proton transfer provides a kinetically favored decay pathway in some photoexcited chromophores, preventing degradation-promoting electron transfer (ET). To further test this model, we measured excited state lifetimes of substituted gas-phase anthraquinones using high-level theory to explain the experimental results. The data show a general structural trend: Anthraquinones with 1,4-OH substitution are long-lived and prone to damaging ET, while excited state intramolecular proton transfers promote efficient quenching for hydroxyanthraquinones that lack this motif

Affinity Proteomic Profiling of Plasma, Cerebrospinal Fluid, and Brain Tissue within Multiple Sclerosis

Cet article est basé sur une correspondance inédite (1844-1846) entre une femme suisse de la haute société et son médecin, Antoine Despine. La patiente fut soignée à Aix-les-Bains, en Savoie, par les eaux, l’électrothérapie et le magnétisme animal. Cette correspondance est située dans le contexte historique des controverses de l’époque sur le magnétisme animal et, plus précisément, des théories, des pratiques et du style thérapeutique de Despine. L’article s’attache au personnage féminin et il montre comment la relation patient-thérapeute est en interrelation avec un groupe plus large d’adeptes du magnétisme.This article is based on an unpublished correspondence (1844-1846) between an upper-class Swiss woman and her physician, Antoine Despine. The patient was treated in Aix-les-Bains in Savoy by spa water, electrotherapy and mesmerism. This correspondence is situated within an historical context including controversies of that time on animal magnetism and, more precisely, Despine’s theories, practices and therapeutic style. The article focuses on the female character and analyses how the patient-therapist relationship interplays with a larger group of followers of animal magnetism