Morning melatonin ingestion and diurnal variation of short-term maximal performances in soccer players

Aim Very few studies have investigated the temporal specificity of melatonin (MEL) ingestion upon short-term maximal athletic performances. The aim of the present study was to explore the effect of morning MEL ingestion on cognitive and physical performances measured in the afternoon. Methods Twelve soccer players from a Tunisian squad (17.9 ± 1.3 years, 1.74 ± 0.06 m and 62.0 ± 8.8 kg) participated in the present study. They performed two testing sessions at 08:00 h, 12:00 h and 16:00 h after either MEL (5mg) or placebo (PLA) ingestion, in a randomized order. During each period, the participants performed the following cognitive and physical tests: reaction time and vigilance tests, medicine-ball throw (MBT), five jumps, handgrip strength (HG), and agility tests. Results cognitive and physical performances were significantly higher at 16:00 h compared to 08:00 h during the two conditions (p < 0.05). Moreover, performances of MBT and HG were lower in the morning with MEL in comparison to PLA (p < 0.05). However, MEL ingestion did not affect physical and cognitive performances measured at 12:00 h and 16:00 h. Conclusion morning MEL ingestion has no unfavourable effect on afternoon physical and cognitive performances in soccer players

Small Cell Carcinoma of the Ovary of Hypercalcemic Type: A Case Report

Introduction. The small cell carcinoma of hypercalcemic type of ovary is a very aggressive tumor. It is associated with two-thirds of cases with hypercalcemia most often asymptomatic. It occurs mostly for young women. The treatment combines surgery, chemotherapy, and radiotherapy. Case Presentation. We report a case of small cell carcinoma of the ovary hypercalcemic type in a young Tunisian woman aged 25 years after a severe abdominal pain syndrome and a large ovarian mass discovered in scanner; a laparotomy was performed by radical surgery. The pathological examination of the specimen confirmed the diagnosis. The radiological assessment performed after surgery showed a continuing evolution. Palliative chemotherapy was established, and the patient had died two months after diagnosis. Conclusion. The hypercalcemic small cell carcinoma of the ovary is a rare disease of poor prognosis

Trois observations de néphrome mésoblastique avant l’âge de 6 mois

Nous rapportons trois observations de néphrome mésoblastique chez deux nourrissons de 3 et 5 mois et chez un nouveau né de 5 jours. Le néphrome mésoblastique congénital ou tumeur de BOLANDE représente 2 à 3% des tumeurs rénales de l’enfant. elle présente des caractéristiques anatomopathologiques, thérapeutiques et pronostiques distinctes du néphroblastome. Il existe plusieurs controverses dans sa prise en charge

Radiothérapie adjuvante et néoadjuvante des cancers du sein : mise au point sur les données de la littérature disponibles en 2020

International audienceRadiation therapy has benefited from many developments over the past 20 years. These developments are mainly linked to the technology, imaging and informatics evolutions which allow better targets definitions, ensure better organs-at-risk sparing and excellent reproducibility of treatments, with a perfect control of patient positioning. In breast cancer radiotherapy, the evolution was marked by the possibility of reducing the duration of treatments from 6-7 to 3-4 weeks by using hypofractionated regimens, or by further reducing the irradiation to one week when treatment is solely focalised to the tumour bed. This concept of accelerated partial breast irradiation has challenged the paradigm of the obligation to irradiate the whole breast after conservative surgery in all patients. In addition, the technical mastery of accelerated partial breast irradiation and the development of stereotactic radiotherapy techniques are currently contributing to the development of research projects in neoadjuvant settings. Thus, numerous ongoing studies are evaluating the impact of high-dose preoperative tumour irradiation, alone or in combination with systemic treatments, on biological tumor changes, on anti-tumour immunity, and on the pathologic complete response, which is considered as predictive of better long-term survival in some molecular breast cancer subtypes. In this review, we discuss all these developments which allow breast radiation therapy to enter the era of personalisation of treatments in oncology

Le textilome : aspects épidémiologiques, difficultés diagnostiques et implications médico-légales à propos de 5 cas

Le textilome correspond à un corps étranger composé de compresse(s) ou de champ(s) chirurgicaux laissés au niveau d'un foyer opératoire. C’est une complication post-opératoire très rare mais bien  connue. Il peut mimer, tant sur le plan clinique que radiologique, un abcès ou une tumeur rendant ainsi  son diagnostic difficile. Le but de cette étude était de préciser les conditions de survenue, les difficultés diagnostiques du textilome et de discuter ses implications médico-légales à travers l’analyse de cinq cas. Il s’agissait d’une étude rétrospective portant sur cinq cas de textilomes, colligés durant une période de 20 ans, dans le département d’anatomie et de cytologie pathologique à l’Hôpital Universitaire Fatouma Bourguiba de Monastir (Tunisie). Les corps étrangers non  textiles ont été exclus de ce travail. Le recueil des données était effectué à partir des fiches du service d'anatomie et de cytologie pathologique, des dossiers cliniques des patients et des compte-rendus opératoires. L’âge moyen de notre population d’étude était de 55 ans avec une exclusivité féminine. Le délai de découverte du textilome était au-delà de six mois dans tous les cas avec un extrême allant à 24 ans. Des antécédents de chirurgie gynécologique ont été notés dans 3 cas et de chirurgie abdominale dans 2 cas. La sensation d’une masse palpable en intra-abdominale avait motivé les patientes à consulter dans 4 cas. Aucun examen radiologique n’avait permis de confirmer le diagnostic. Dans tous les cas, l’examen anatomopathologique de la masse prélevée avait permis de faire le diagnostic. Ce travail met l’accent sur les implications médico-légales du textilome qui reste toujours décrit dans la pratique des chirurgiens. La prévention nécessite l’éducation et la promotion de moyens technologiques dans la salle opératoire.Mots clés : textilome, chirurgie, anatomie pathologique, implications médico-légales.Textiloma is a surgical complication resulting from foreign materials, such as a surgical sponge,  accidentally left inside a patient's body. Its actual incidence is difficult to determine. It can often present, clinically or radiologically, similar to tumors or abscesses, with widely variable complications and manifestations, making diagnosis difficult. This study aimed to stress out the diagnostic pitfalls and to discuss its medicolegal implications.This study was retrospective including five cases of textiloma collected in the department of anatomy and pathology of the university hospital of Fattouma Bourguiba Monastir (Tunisia) during a period of 20 years. Diagnosis was made after histological tests. Non-textile foreign bodies were excluded from this study. Data collection was summarized from files of anatomy and cytology department, clinical records of patients and operative reports. The average age of our study population was 55 years. All patients were female. The textiloma was discovered beyond six months in all cases with extreme up to 24 years. History of gynecological surgery was noted in 3 cases and abdominal surgery in 2 cases. Clinically, 4 patients consulted for intra-abdominal mass lesion. Radiologically, the diagnosis was misidentified in all cases. Therefore, histological examination of the removed mass helped to make the diagnosis.Keys words: textiloma, surgery, pathology, medico-legal implication