Odd Prime Labeling For Some Arrow Related Graphs

In a graph G a mapping g is known as odd prime labeling , if g is abijection from V to f1; 3; 5; ::::; 2jVj - 1g satisfying the condition thatfor each line xy in G the gcd of the labels of end points (g(x); g(y)) isone. In this article we prove that some new arrow related graphs suchas A2y, A3 y,A5 y, are all odd prime graphs. Also we prove that doublearrow graphs, DA2 y and DA3 y are odd prime graphs

Comparative Bioinformatics Approach to Identify a ZnO Nanoparticle Drug Targeting Mutant CHRNA5 in Humans and Gorillas

Our current work focuses on the CHRNA5 protein\u27s susceptibility to lung cancer. This gene encodes nicotinic acetylcholine receptor subunits, which are ligand-gated ion channels that speed up signal transmission at synapses. A higher incidence of type 2 lung cancer (Non-Small Cell Lung Cancer (NSCLC)) has been linked to gene abnormalities. The primary purpose of this study is to investigate the efficacy of Cordia dichotoma-derived ZnO nanoparticles when combined with an existing anticancer drug against the mutant CHRNA5 of humans and Gorilla gorilla. Both humans and Gorillas are orthologous species as they share a similar sequence homology. The probable mutant areas were first identified using protein modelling tools and visualizers, and their three-dimensional structures studied. After modelling, we employed an automated docking service to link the modelled protein to our chosen molecule.  Discovery Studio Software, a powerful molecular visualization tool, was utilized to confirm the electrostatic interactions between the ligand and protein complex. Our chosen nano particles’ efficacy against the CHRNA5 protein was validated by binding interactions. Based on the docking scores and H-bond interactions, we conclude that the chosen molecule has the potential to be a promising Lung Cancer therapeutic agent. The drug was also tested against Gorilla gorilla to prove its efficiency against a homologous species. Our current study can be expanded into the areas of Clinical Oncology and Pharmacoinformatics

Seed priming with different levels and sources of zinc on the seed germination and seedling growth of barnyard millet (Echinocola frumentacea)

Seed priming with zinc increases the seed germination and seedling growth of many crops. The present study aimed to investigate the effect of seed priming with different levels and sources of zinc on seed germination and seedling growth of barnyard millet variety MDU1. A germination experiment was conducted with various Zn sources and concentrations viz., T1- Non-primed seeds (control); T2-water priming; T3-GA3 priming; T4-T6: seed priming with 0.10%,  0.25% & 0.50% ZnSO4 ; T7- T9:  seed priming with 0.10%, 0.25% & 0.50% Zn EDTA; T10-T12: seed priming with 0.10%, 0.25% & 0.50% Zn citrate and the experimental design was a completely randomized design (CRD) which were replicated five times. The seeds of MDU1 variety were treated with different sources and levels of Zn for 12h and the seed germination study was carried out for 15 days. After 15 days, the germination percentage, speed of germination, germination energy, germination index and the seedling growth parameters such as, root length, shoot length, vigour index and seedling dry weight were recorded. Seed priming with 0.50% ZnSO4 performed better in increasing the germination percentage (99%), speed of germination (76.2%), germination energy (69.4%), germination index (3.91) and seedlings growth parameters like shoot length (14.7cm), root length (16.5cm), seedlings dry weight (0.44g), vigour index I (3099) and II (44.6),  Zn content (21.9 mg kg-1) & its uptake (5.54 mg g-1). This was closely followed by seed priming of Zn EDTA at 0.25% and Zn citrate at 0.50%. From this study, it can be concluded that seed priming with 0.50% ZnSO4 could be used to improve the germination and seedling growth of barnyard millet which was also economical.

Rethinking Man and Nature in The Old Man and The Sea

This paper explores the intricate relationship between man and nature in Ernest Hemingway’s The Old Man and the Sea through the lens of deep ecology. It challenges the traditional anthropocentric interpretation of the novella, proposing that the protagonist Santiago’s struggle is not merely a tale of human triumph over nature but a journey towards understanding and coexisting with the natural world. By applying the principles of deep ecology, the study reveals how Santiago’s evolving relationship with the marlin and other sea elements reflects a broader ecological consciousness. The analysis also draws parallels between Santiago’s experience and the Biblical narrative of Jonah, suggesting that Santiago’s success is not solely due to his physical endurance but also the cosmic forces that aid him. This paper ultimately rethinks the themes of struggle and victory in the novella, emphasising the need for a harmonious relationship between humanity and the environment

Assessment of Knowledge, Attitude & Practices regarding Breast Feeding among Lactating Mothers in urban areas of Srinagar Garhwal, Uttarakhand

Background: Breastfeeding is widely recognized as the most crucial measure for lowering infant mortality rates and promoting optimal growth and development in children. However, its practices and implementation remain limited. According to NFHS-5 only 63.7% of the children were exclusively breastfed. Objectives: The study aims to assess lactating mothers\u27 knowledge, attitude, and practices regarding breastfeeding, identify socio-demographic determinants influencing their knowledge, and examine barriers that prevent adherence to correct breastfeeding practices. Methods: A cross-sectional study was conducted, involving randomly selected lactating mothers of children less than 2 years, registered in Anganwadi centres of urban Srinagar Garhwal, Uttarakhand. Mothers were interviewed using pretested semi structured questionnaire. Results: In this research conducted among 359 lactating mothers, 35.4% were between 25-29yrs, 87.5% were housewife, 80.8% literate, and 66% living in joint family. 41.8% of the study participants, initiated breast feeding within one hour, and 55% of mothers also continued exclusive breastfeeding (EBF) until six months. Most common reason (50%) for not practicing EBF was inadequate milk production. Conclusion: In our sample, we observed that exclusive breastfeeding (EBF) practices and the initiation of breastfeeding within the first hour after birth was suboptimal compared to NFHS-5 India but better compared to the state NFHS- 5

Cohort profile: The Golestan Cohort Study-a prospective study of oesophageal cancer in Northern Iran

[No abstract available

Eco Trauma: Unveiling the Anthropocentric Destruction, the Pathway to Apocalypse

Humans have evolved to the point where we are the most sophisticated animals in the world. The point of evolution is for creatures to become more suited to their natural habitat. A new degree of evolutionary adaption has been attained through humans. Massive technological advancements, new governments, and metropolises have all taken place. Every one of these societal advancements has one overarching goal: to ensure that our species continues to exist. As a species, we’ve figured out how to divide ourselves up into nations defined by shared values, religion, geography, and history. Divergences in geography, culture, and history have always been a source of contention among human beings. These disparities have, in the worst-case scenarios, led to war. Many various things, including religion and wealth, have sparked wars throughout history. War, though, never ends well; destruction is an inevitable byproduct. After a conflict, everyone is talking about how many lives were lost, how much property was destroyed, and how much money was spent. But the ecosystem is a quiet casualty of war. Seldom given a second thought are the deaths and devastation that befall Earth’s ecosystems, natural resources, and population. One can not help but question the impact of modern warfare on the environment and the consequences for humanity as a whole. The moral and social consequences of modern warfare’s assault on the environment can be seen by looking at the historical record of environmental degradation caused by this conflict. It is possible to learn about past and future efforts to safeguard the environment from human aggression by considering the problem from philosophical, scientific, and religious vantage points. If the Earth is to be further devastated by contemporary weaponry and combat, the loss endured by the environment will make the death toll of any contemporary battle appear negligible. The preservation of the natural world is crucial to the continuation of the human race

Verbal autopsy of 80,000 adult deaths in Tamilnadu, South India

Background: Registration of the fact of death is almost complete in the city of Chennai and not so in the rural Villupuram district in Tamilnadu, India. The cause of death is often inadequately recorded on the death certificate in developing countries like India. A special verbal autopsy (VA) study of 48 000 adult (aged ≥ 25 yrs) deaths in the city of Chennai (urban) during 1995–97 and 32 000 in rural Villupuram during 1997–98 was conducted to arrive at the probable underlying cause of death to estimate cause specific mortality. Methods: A ten day training on writing verbal autopsy (VA) report for adult deaths was given to non-medical graduates with at least 15 years of formal education. They interviewed surviving spouse/close associates of the deceased to write a verbal autopsy report in local language (Tamil) on the complaints, symptoms, signs, duration and treatment details of illness prior to death. Each report was reviewed centrally by two physicians independently. Random re-interviewing of 5% of the VA reports was done to check the reliability and reproducibility of the VA report. The validity of VA diagnosis was assessed only for cancer deaths. Results: Verbal autopsy reduced the proportion of deaths attributed to unspecified and unknown causes from 54% to 23% (p < 0.0001) in urban and from 41% to 26% (p < 0.0001) in rural areas in Tamilnadu for adult deaths (≥ 25). The sensitivity of VA to identify cancer was 95% in the age group 25–69. Conclusion: A ten day training programme to write verbal autopsy report with adequate feed back sessions and random sampling of 5% of the verbal autopsy reports for re-interview worked very well in Tamilnadu, to arrive at the probable underlying cause of death reliably for deaths in early adult life or middle age (25–69 years) and less reliably for older ages (70+). Thus VA is practicable for deaths in early adult life or middle age and is of more limited value in old age

Epidemiologic application of verbal autopsy to investigate the high occurrence of cancer along Huai River Basin, China

<p>Abstract</p> <p>Background</p> <p>In 2004, the media repeatedly reported water pollution and "cancer villages" along the Huai River in China. Due to the lack of death records for more than 30 years, a retrospective survey of causes of death using verbal autopsy was carried out to investigate cancer rates in this area.</p> <p>Methods</p> <p>An epidemiologic study was designed to compare numbers of deaths and causes of death between the study areas with water pollution and the control areas without water pollution in S County and Y District in 2005. The study areas were selected based on the distribution of the Huai River and its tributaries. Verbal autopsy was used to assist cause of death (COD) diagnoses and to verify mortality rates. The standard mortality rates (SMRs) of cancer in the study area were compared with those in the control areas. In order to verify the difference between mortality rates due to cancers in the study and the control areas, patients who reported having cancer in the survey received a second diagnosis by national and provincial oncologists with pathological and laboratory examinations. Comparisons were made to determine if differential cancer prevalence rates in the study and control areas were similar to the difference in mortality due to cancer in these study and control areas. Mortality rates of cancers in study and control areas were also compared with national statistics for the rural population of China.</p> <p>Results</p> <p>Over five years, 3,301 deaths were identified, including 1,158 cancer deaths. The annual average SMRs of cancer in the study areas of S County and Y District were 277.8/100,000 and 223.6/100,000, respectively, which is three to four times higher than those in the control areas. In addition, a total of 626 cases of cancer in the study and control areas were confirmed. The prevalence rates of cancer were 545/100,000 and 128.1/100,000 per year in the study and control areas in S County, respectively, and 440.9/100,000 and 200/100,000 per year in the study and control areas in Y District, respectively. The mortality and prevalence rates of digestive cancers were higher in the study areas than the control areas. In 2000, the SMR for cancer in rural areas nationwide was 120.9/100,000, and in study areas in S County and Y District, the excess rates of deaths were 184/100,000 and 138.8/100,000, respectively.</p> <p>Conclusions</p> <p>The death rates of digestive cancers were much higher in the study areas of S County and Y District. The patterns for between-area differences in prevalence and mortality rates of cancer were similar. Verbal autopsy is shown to be a useful tool in retrospective mortality surveys in low-resource areas with limited access to health care.</p

Role of paan chewing and dietary habits in cervical carcinoma in Chennai, India

/=5 paan day(-1)=4.0; 95% CI 1.2-13.3). Among dietary habits, the highest vs lowest intake tertile for vegetables and fruit was associated with an OR of 0.5 (95% CI 0.2-1.0). Low education level and low body weight were also risk factors for ICC, but they did not account for the associations of paan chewing and low vegetable and fruit intake. In the analyses restricted to HPV-positive cases and controls, the inverse association with vegetable and fruit intake was confirmed. Conversely, the adverse influence of paan chewing on ICC risk seemed to be attributable to a higher prevalence of cervical HPV infection in women who chewed