THE ECONOMICS OF NON-GMO SEGREGATION AND IDENTITY PRESERVATION

We survey grain and soybean handlers and producers in the U.S. and EU to estimate costs of preserving the identities of GMO and non-GMO crops in marketing channels. We introduce our estimates into the IFPRI IMPACT model to simulate the effects of identity preservation on farm incomes and consumer well-being.Research and Development/Tech Change/Emerging Technologies,

Management of dyslipidemias with fibrates, alone and in combination with statins: role of delayed-release fenofibric acid

Cardiovascular disease (CVD) represents the leading cause of mortality worldwide. Lifestyle modifications, along with low-density lipoprotein cholesterol (LDL-C) reduction, remain the highest priorities in CVD risk management. Among lipid-lowering agents, statins are most effective in LDL-C reduction and have demonstrated incremental benefits in CVD risk reduction. However, in light of the residual CVD risk, even after LDL-C targets are achieved, there is an unmet clinical need for additional measures. Fibrates are well known for their beneficial effects in triglycerides, high-density lipoprotein cholesterol (HDL-C), and LDL-C subspecies modulation. Fenofibrate is the most commonly used fibric acid derivative, exerts beneficial effects in several lipid and nonlipid parameters, and is considered the most suitable fibrate to combine with a statin. However, in clinical practice this combination raises concerns about safety. ABT-335 (fenofibric acid, Trilipix®) is the newest formulation designed to overcome the drawbacks of older fibrates, particularly in terms of pharmacokinetic properties. It has been extensively evaluated both as monotherapy and in combination with atorvastatin, rosuvastatin, and simvastatin in a large number of patients with mixed dyslipidemia for up to 2 years and appears to be a safe and effective option in the management of dyslipidemia

Interleukin-6 and Interleukin-10 Gene Polymorphisms in Patients with Chronic Periodontitis and Response to Treatment after 3 Years

Cilj: Istraživalo se utječe li genetska osjetljivost na kronični parodontitis, potvrđena genotipom IL-6-572GGili alelom IL-10-592A, na rezultate nekirurške parodontne terapije (NSPT) nakon duljeg vremena. Materijal i metode: U dvije skupine raspoređeno je 37 pacijenata s kroničnim parodontitisom prema genotipu i to kao podložni (SCP) i otporni (NSCP). Svi ispitanici klinički su procijenjeni na početku i tri godine poslije NSPT-a. Uzorci krvi za određivanje polaznih vrijednosti prikupljeni su od onih koji su ispunili uvjete za sudjelovanje. Svi su primili NSPT od jednog specijalista parodontologije koji nije znao genotip statusa pacijenata. Provedena je statistička analiza usporedbom varijabli za skupine u kojima se koristio Mann-Whitneyjev U-test, između Wilcoxov test. Rezultati: Prosječna dob ispitanika bila je 47,68 ± 8,64 godine, a sudjelovalo je 51,4 % žena, 48,6 % pušača i 45,9 % konzumenata alkohola. Nakon genetske analize zaključeno je da su 70,3 % pacijenata homozigotni nositelji IL-6-572G(IL-6 SCP), a njih 46,0 % bili su nositelji alela IL-10 592A(IL-10 SCP). NSPT je smanjio sve ispitivane parametre ispitanicima (dubina sondiranja, gubitak epitelnog pričvrstka, krvarenje poslije sondiranja, postotak mjesta sa džepovima od 4 do 6 mm i ≥ 7 mm i gubitak epitelnog pričvrstka), ali ishod liječenja nije bio povezan s genotipom. Osobe s SCP-om i NSCP-om imale su slične kliničke parametre na početku tretmana i poslije tri godine. Zaključak: Unutar ove trogodišnje kohortne studije u kojoj su sudjelovali bijelci s dijagnosticiranim kroničnim parodontitisom, pojedincima podložnima parodontitisu, kako je određeno prisutnošću genotipa IL-6 -572GGili alela IL-10 -592A, nakon NSPT-a rezultat liječenja bio je sličan.Objective: The aim of this study was to investigate whether genetic susceptibility to chronic peri-odontitis, conferred by the presence of the IL-6 -572GG genotype or the IL-10 -592A allele, influences the outcomes following a non-surgical periodontal therapy (NSPT)over a long period of time. Material and methods: Thirty-seven chronic periodontitis patients were divided into two groups according to genotype as susceptible (SCP) and non-susceptible (NSCP). All subjects were clinically evaluated at baseline and 3 years following NSPT. Blood samples were collected at baseline from the individuals who fulfilled the inclusion criteria. All participants received NSPT from a single periodontist who was blind to the genotype status of each patient. A statistical analysis was performed by comparing the variables between groups using the Mann-Whitney U test and between baseline and 3 years for each group using the Wilcoxon test. Results: The mean age of the population was estimated to be 47.68±8.64 years and it included 51.4% females, 48.6% smokers, and 45.9% alcohol consumers. Following a genetic analysis, 70.3% of patients were homozygous carriers of the IL-6 -572G (IL-6 SCP), and 46.0% of them were carriers, bleeding on probing, percentage of sites with 4-6mm and ≥7mm pocket depth and attachment loss) to all participants, but the treatment outcome NSCP individuals showed similar clinical parameters at baseline and at 3 years. Conclusions: Within the limitations of this 3-year prospective cohort study in Caucasians diagnosed with chronic periodontitis, individuals susceptible to periodontal disease as determined by the presence of the IL-6 -572GG genotype or the IL-10 -592A allele showed similar treatment outcome following NSPT

OEKG: The Open Event Knowledge Graph

Accessing and understanding contemporary and historical events of global impact such as the US elections and the Olympic Games is a major prerequisite for cross-lingual event analytics that investigate event causes, perception and consequences across country borders. In this paper, we present the Open Event Knowledge Graph (OEKG), a multilingual, event-centric, temporal knowledge graph composed of seven different data sets from multiple application domains, including question answering, entity recommendation and named entity recognition. These data sets are all integrated through an easy-to-use and robust pipeline and by linking to the event-centric knowledge graph EventKG. We describe their common schema and demonstrate the use of the OEKG at the example of three use cases: type-specific image retrieval, hybrid question answering over knowledge graphs and news articles, as well as language-specific event recommendation. The OEKG and its query endpoint are publicly available

Alterations of gut microbiome following gastrointestinal surgical procedures and their potential complications

Intestinal microorganisms play a crucial role in shaping the host immunity and maintaining homeostasis. Nevertheless, alterations in gut bacterial composition may occur and these alterations have been linked with the pathogenesis of several diseases. In surgical practice, studies revealed that the microbiome of patients undergoing surgery changes and several post-operative complications seem to be associated with the gut microbiota composition. In this review, we aim to provide an overview of gut microbiota (GM) in surgical disease. We refer to several studies which describe alterations of GM in patients undergoing different types of surgery, we focus on the impacts of peri-operative interventions on GM and the role of GM in development of post-operative complications, such as anastomotic leak. The review aims to enhance comprehension regarding the correlation between GM and surgical procedures based in the current knowledge. However, preoperative and postoperative synthesis of GM needs to be further examined in future studies, so that GM-targeted measures could be assessed and the different surgery complications could be reduced

‘The only game in town?’: football match-fixing in Greece

The final publication is available at Springer via http://dx.doi.org/10.1007/s12117-014-9239-3Football match-fixing in Greece has a relatively long history, however, from the late 1990s it has been considered as a serious problem for the sport in the country. Despite the history of the phenomenon in the country, Greece has only relatively recently been identified as one of the hotspots for football match-fixing on an international level. Following the recent scandal exposure of fixed matches in Greece in 2011, also known as Koriopolis (a pun name on the Italian scandal Calciopolis and the Greek word ‘korios’ or phone-tap), detailed information about numerous matches played in the 2008/09, 2009/10 and 2010/11 seasons that attracted UEFA’s attention were brought into the public eye. Soon after, legal action was taken against individuals involved in the process, with a number of club officials facing lifelong bans from any footballrelated activity, and football clubs either relegated or excluded from European competitions and the Super League itself for their involvement in the scandal. In May 2013, the number of people facing charges exceeded 200, with some of them having already been imprisoned for their involvement in the scandal. Following the aforementioned scandal exposure, a vast amount of information regarding football match-fixing was made available to the public. The aim of the current article is to provide an account of the social organisation of football match-fixing in Greece. Our account is based on three main sources of data: the telephone conversations that were the result of wiretapping by the National Intelligence Agency in relation to the latest football match-fixing scandal (of 2011), published media sources, and interviews with informed actors from the realm of Greek football

Developmental regulation of tau splicing is disrupted in stem cell-derived neurons from frontotemporal dementia patients with the 10 + 16 splice-site mutation in MAPT

The alternative splicing of the tau gene, MAPT, generates six protein isoforms in the adult human CNS. Tau splicing is developmentally regulated and dysregulated in disease. Mutations in MAPT that alter tau splicing cause frontotemporal dementia (FTD) with tau pathology, providing evidence for a causal link between altered tau splicing and disease. The use of induced pluripotent stem cell (iPSC) derived neurons has revolutionized the way we model neurological disease in vitro. However, as most tau mutations are located within or around the alternatively spliced exon 10, it is important that iPSC-neurons splice tau appropriately in order to be used as disease models. To address this issue, we analysed the expression, and splicing of tau in iPSC-derived cortical neurons from control patients and FTD patients with the 10+16 intronic mutation in MAPT. We show that control neurons only express the fetal tau isoform (0N3R), even at extended time points of 100 days in vitro. Neurons from FTD patients with the 10+16 mutation in MAPT express both 0N3R and 0N4R tau isoforms, demonstrating that this mutation overrides the developmental regulation of exon 10 inclusion in our in vitro model. Further, at extended time-points of 365 days in vitro, we observe a switch in tau splicing to include six tau isoforms as seen the adult human CNS. Our results demonstrate the importance of neuronal maturity for use in in vitro modeling and provide a system that will be important for understanding the functional consequences of altered tau splicing