38 research outputs found
Effect of the anisotropy of monocrystalline silicon mechanical properties on the dynamic characteristics of a micromechanical gyroscope
The aim of the research was to determine the effect of temperature on mechanical properties of a micromechanical gyroscope with the sensing element mounted on a silicon wafer, with the crystallographic orientation of (100) (110) (111). The research is of current relevancy since the metrological characteristics that depend on the eigenfrequencies over the full temperature range are to be controlled. The temperature-modal analysis of the micromechanical gyroscope model was performed with ANSYS program. The temperature dependence for eigenfrequencies was obtained. The dependence of the scale factor on temperature for the most temperature-independent variant of sensor positioning on the wafer was determined. The developed mathematical model was used to find the forms of the output oscillations of the gyroscope
Effect of the anisotropy of monocrystalline silicon mechanical properties on the dynamic characteristics of a micromechanical gyroscope
The aim of the research was to determine the effect of temperature on mechanical properties of a micromechanical gyroscope with the sensing element mounted on a silicon wafer, with the crystallographic orientation of (100) (110) (111). The research is of current relevancy since the metrological characteristics that depend on the eigenfrequencies over the full temperature range are to be controlled. The temperature-modal analysis of the micromechanical gyroscope model was performed with ANSYS program. The temperature dependence for eigenfrequencies was obtained. The dependence of the scale factor on temperature for the most temperature-independent variant of sensor positioning on the wafer was determined. The developed mathematical model was used to find the forms of the output oscillations of the gyroscope
Clinicopathological features of nonspecific invasive breast cancer according to its molecular subtypes
The aim of the present study was to investigate the clinical and morphological features of nonspecific invasive breast cancer according to its molecular subtypes. Materials and Methods: 163 women with nonspecific invasive breast cancer (T1β4N0β3M0) were included in the present study. Luminal A type of breast cancer was detected in 101 women, luminal B type β in 23 women, overexpression of HER2/neu was identified in 14 women and triple-negative cancer β in 25 women. Results: The study revealed that various molecular subtypes of breast cancer differ in the morphological structure, the expression characteristics of the primary tumor and the rate of lymphogenous and hematogenous metastasis. Lymphogenous metastases were more frequently (in 71%) detected in HER2/neu overexpressing breast cancer than in luminal A (41%), luminal B (39%) and triple-negative tumors (40%). Hematogenous metastasis did not depend on the morphological structure of carcinoma infiltrative component, the state of tumor stroma as well as the proliferative activity in all the investigated groups. Conclusion: The revealed clinicopathological characteristics of different molecular subtypes of invasive breast cancer allow to predict the possible outcome of the disease and select personalized treatment strategy for patients more reasonably
ΠΠ ΠΠΠΠΠ‘Π’ΠΠ§ΠΠ‘ΠΠΠ― Π ΠΠΠ¬ ΠΠΠΠΠΠ£ΠΠ―Π ΠΠ«Π₯ ΠΠΠΠ’ΠΠΠΠ Π ΠΠΠ Π’ΠΠΠ‘Π’ΠΠ ΠΠΠ¨ΠΠ. Π‘ΠΠΠ ΠΠΠΠΠΠ«Π ΠΠΠΠΠ―Π ΠΠ ΠΠ ΠΠΠΠΠΠ£
Purpose of the study: to review the available data on the heterogeneity of colon cancer and to assess the prognostic significance of colon cancer subtypes.Material and Methods. Medline, PubMed, Cochrane library, elibrary databases were used to identify studies that characterized the current view on the problem of choosing the optimal postoperative treatment for colon cancer.Results. the review showed the results of international studies of colon cancer subtypes based on complex multomics characteristics. Particular attention was paid to the description of modern studies on the search for prognostic markers for colon cancer. The relevance of the study of immunohistochemical markers was confirmed by the analysis of the world literature. the outcomes will make it possible to classify colon cancer into molecular subtypes in real clinical practice and, as a consequence, significantly improve the effectiveness of adjuvant therapy.Π¦Π΅Π»Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ β ΠΎΠ±ΠΎΠ±ΡΠ΅Π½ΠΈΠ΅ ΠΈΠΌΠ΅ΡΡΠΈΡ
ΡΡ ΡΠ²Π΅Π΄Π΅Π½ΠΈΠΉ ΠΎ Π³Π΅ΡΠ΅ΡΠΎΠ³Π΅Π½Π½ΠΎΡΡΠΈ ΡΠ°ΠΊΠ° ΡΠΎΠ»ΡΡΠΎΠΉ ΠΊΠΈΡΠΊΠΈ ΠΈ ΠΎΡΠ΅Π½ΠΊΠ° ΠΏΡΠΎΠ³Π½ΠΎΡΡΠΈΡΠ΅ΡΠΊΠΎΠΉ Π·Π½Π°ΡΠΈΠΌΠΎΡΡΠΈ Π΅Π³ΠΎ ΠΏΠΎΠ΄ΡΠΈΠΏΠΎΠ².ΠΠ°ΡΠ΅ΡΠΈΠ°Π» ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. ΠΠΎΠΈΡΠΊ Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΡ ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄ΠΈΠ»ΡΡ Π² ΡΠΈΡΡΠ΅ΠΌΠ°Ρ
Medline, Cochrane library, elibrary ΠΈ PubMed, Π²ΠΊΠ»ΡΡΠ°Π»ΠΈΡΡ ΠΏΡΠ±Π»ΠΈΠΊΠ°ΡΠΈΠΈ, Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΡΡΡΠΈΠ΅ ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΡΠΉ Π²Π·Π³Π»ΡΠ΄ Π½Π° ΠΏΡΠΎΠ±Π»Π΅ΠΌΡ Π²ΡΠ±ΠΎΡΠ° ΡΡΡΠ°ΡΠ΅Π³ΠΈΠΈ ΠΏΠΎΡΠ»Π΅ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ Π»Π΅ΡΠ΅Π½ΠΈΡ ΡΠ°ΠΊΠ° ΡΠΎΠ»ΡΡΠΎΠΉ ΠΊΠΈΡΠΊΠΈ.Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. Π ΠΎΠ±Π·ΠΎΡΠ΅ ΠΎΡΠ²Π΅ΡΠ΅Π½Ρ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΌΠ΅ΠΆΠ΄ΡΠ½Π°ΡΠΎΠ΄Π½ΡΡ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ ΠΏΠΎΠ΄ΡΠΈΠΏΠΎΠ² ΡΠ°ΠΊΠ° ΡΠΎΠ»ΡΡΠΎΠΉ ΠΊΠΈΡΠΊΠΈ, ΠΎΡΠ½ΠΎΠ²Π°Π½Π½ΡΠ΅ Π½Π° ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ½ΡΡ
ΠΌΡΠ»ΡΡΠΈΠΎΠΌΠ½ΡΡ
Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊΠ°Ρ
. ΠΡΠΎΠ±ΠΎΠ΅ Π²Π½ΠΈΠΌΠ°Π½ΠΈΠ΅ ΡΠ΄Π΅Π»Π΅Π½ΠΎ ΠΎΠΏΠΈΡΠ°Π½ΠΈΡ ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΡΡ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ ΠΏΠΎ ΠΏΠΎΠΈΡΠΊΡ ΠΏΡΠΎΠ³Π½ΠΎΡΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΌΠ°ΡΠΊΠ΅ΡΠΎΠ² ΡΠ°ΠΊΠ° ΡΠΎΠ»ΡΡΠΎΠΉ ΠΊΠΈΡΠΊΠΈ. ΠΡΠΎΠ²Π΅Π΄Π΅Π½ Π°Π½Π°Π»ΠΈΠ· ΠΌΠΈΡΠΎΠ²ΠΎΠΉ Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΡ, ΠΏΠΎΠ΄ΡΠ²Π΅ΡΠΆΠ΄Π°ΡΡΠΈΠΉ Π°ΠΊΡΡΠ°Π»ΡΠ½ΠΎΡΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΈΠΌΠΌΡΠ½ΠΎΠ³ΠΈΡΡΠΎΡ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΌΠ°ΡΠΊΠ΅ΡΠΎΠ², ΠΊΠΎΡΠΎΡΡΠ΅ Π΄Π°Π΄ΡΡ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΡ ΠΊΠ»Π°ΡΡΠΈΡΠΈΡΠΈΡΠΎΠ²Π°ΡΡ ΡΠ°ΠΊ ΡΠΎΠ»ΡΡΠΎΠΉ ΠΊΠΈΡΠΊΠΈ Π½Π° ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΡΠ΅ ΠΏΠΎΠ΄ΡΠΈΠΏΡ Π² ΡΠ΅Π°Π»ΡΠ½ΠΎΠΉ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΏΡΠ°ΠΊΡΠΈΠΊΠ΅ ΠΈ, ΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΠ΅Π»ΡΠ½ΠΎ, Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½ΠΎ ΡΠ»ΡΡΡΠΈΡΡ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ Π°Π΄ΡΡΠ²Π°Π½ΡΠ½ΠΎΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ
ROLE OF TRANSFORMING GROWTH FACTOR RECEPTOR B I TYPE (TGF-BRI) IN THE PROGRESSION OF THE LUMINAL BREAST CANCER SUBTYPE
Introduction. The crosstalk between the estrogen and growth factor receptors signaling may play an important role in the resistance to endocrine therapy. The aim of the study was to examine the relationship between the protein and receptor gene expression of transforming growth factor Ξ² type I (TGF-Ξ²RI) and its polymorphism with progression of luminal breast cancer patients treated by adjuvant tamoxifen. Material and methods.Β The study included 105 patients with luminal breast cancer (T1-3N0β3M0), who had received adjuvant tamoxifenΒ at a dose of 20 mg/day for at least 5 years. Patients who developed distant metastasis or recurrence after tamoxifen therapy were defined as tamoxifen resistance (TR) group, while distant metastasis-free patients were analyzed as tamoxifen sensitive (TS) group. TGF-Ξ²RI expression level was evaluated using immunohistochemistry. TGF-BRI gene expression and genotypes for rs334354 SNP were detected by a Real-time PCR. Results. We found high TGF-Ξ²RI gene expression in patients with luminal A subtype compared with luminal B breast cancer (p=0.050). The Int7G24AA and Int7G24A mutant carriers were more prevalent in luminal A breast cancer patients (p=0.019 and p=0.007, respectively). TGF-Ξ²RI protein expression level was significantly higher in the tamoxifen sensitive group compared to tamoxifen resistance breast cancer patients regardless of molecular subtypes (p=0.043). There was a trend for a tamoxifen sensitivity among luminal B breast cancer patients with a high TGF-Ξ²RI protein expression (p=0.090). Conclusion. TGF-Ξ²RI protein expression level can be a potential molecular marker of tamoxifen resistance in luminal breast cancer patients
Π‘Π²ΡΠ·Ρ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ ΠΌΠ°ΡΠΊΠ΅ΡΠΎΠ² ΡΠΏΠΈΡΠ΅Π»ΠΈΠ°Π»ΡΠ½ΠΎ-ΠΌΠ΅Π·Π΅Π½Ρ ΠΈΠΌΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΏΠ΅ΡΠ΅Ρ ΠΎΠ΄Π° Ρ ΠΊΠ»ΠΈΠ½ΠΈΠΊΠΎ-ΠΌΠΎΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ ΠΏΠ°ΡΠ°ΠΌΠ΅ΡΡΠ°ΠΌΠΈ ΡΠ°ΠΊΠ° ΡΠΎΠ»ΡΡΠΎΠΉ ΠΊΠΈΡΠΊΠΈ
The treatment of colon cancer with a mesenchymal-like phenotype poses a great challenge. Purpose of the study: to research expression of FRMD6, ZEB1, HTR2B, CDX2 in the primary tumor tissue with relation of the clinical and pathological features of colon cancer. Material and methods. a combined analysis of the expression of FRMD6, ZEB1, HTR2B, CDX2 with pathological criteria was performed in 100 patients with T1β4bN0β2bM0Β colonΒ cancer.Β ResultsΒ ofΒ theΒ studyΒ showΒ thatΒ tumorsΒ withΒ mesenchymalΒ signsΒ are characterized by a large size of the primary tumor, a high grade of differentiation, regional metastases, and eventually advanced stage of the disease. The frequency and expression levels of FRMD6, ZEB1 and HTR2B are depended of grade of adenocarcinoma. in cases with positive expression and a high percentage of expression of these proteins in the cancer cells, the degree of tumor morphological anaplasia increases. Conclusion. The study made it possible to reveal the relationship of IHC markers (FRMD6, ZEB1, HTR2B, CDX2) with tumor characteristics that determine the outcome. The studied markers may have prognostic and predictive value in treatment approaches of colon cancer.ΠΠΊΡΡΠ°Π»ΡΠ½ΠΎΠΉ ΠΏΡΠΎΠ±Π»Π΅ΠΌΠΎΠΉ ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΠΉ ΠΎΠ½ΠΊΠΎΠ»ΠΎΠ³ΠΈΠΈ ΡΠ²Π»ΡΡΡΡΡ ΠΎΠΏΡΡ
ΠΎΠ»ΠΈ ΡΠΎΠ»ΡΡΠΎΠΉ ΠΊΠΈΡΠΊΠΈ Ρ ΠΌΠ΅Π·Π΅Π½Ρ
ΠΈΠΌΠ°Π»ΡΠ½ΠΎ-ΠΏΠΎΠ΄ΠΎΠ±Π½ΡΠΌ ΠΏΠΎΠ΄ΡΠΈΠΏΠΎΠΌ, ΠΊΠΎΡΠΎΡΡΠΉ ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΠ΅Ρ Π½Π΅Π±Π»Π°Π³ΠΎΠΏΡΠΈΡΡΠ½ΠΎΠ΅ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ. Π¦Π΅Π»Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ β ΠΈΠ·ΡΡΠΈΡΡ ΠΊΠ»ΠΈΠ½ΠΈΠΊΠΎ-ΠΌΠΎΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠ΅ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊΠΈ ΡΠ°ΠΊΠ° ΡΠΎΠ»ΡΡΠΎΠΉ ΠΊΠΈΡΠΊΠΈ Π² Π·Π°Π²ΠΈΡΠΈΠΌΠΎΡΡΠΈ ΠΎΡ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ ΠΌΠ°ΡΠΊΠ΅ΡΠΎΠ² FRMD6, ZEB1, HTR2B, CDX2 Π² ΡΠΊΠ°Π½ΠΈ ΠΏΠ΅ΡΠ²ΠΈΡΠ½ΠΎΠΉ ΠΎΠΏΡΡ
ΠΎΠ»ΠΈ. ΠΠ°ΡΠ΅ΡΠΈΠ°Π» ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. ΠΡΠΎΠ²Π΅Π΄Π΅Π½ ΡΠΎΠ²ΠΎΠΊΡΠΏΠ½ΡΠΉ Π°Π½Π°Π»ΠΈΠ· ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ FRMD6, ZEB1, HTR2B, CDX2 Ρ ΠΏΠ°ΡΠΎΠΌΠΎΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ ΠΊΡΠΈΡΠ΅ΡΠΈΡΠΌΠΈ Ρ 100 Π±ΠΎΠ»ΡΠ½ΡΡ
ΡΠ°ΠΊΠΎΠΌ ΡΠΎΠ»ΡΡΠΎΠΉ ΠΊΠΈΡΠΊΠΈ T1β4bN0β2bM0. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. ΠΠΏΡΡ
ΠΎΠ»ΠΈ Ρ Π²ΡΡΠ°ΠΆΠ΅Π½Π½ΡΠΌΠΈ ΠΌΠ΅Π·Π΅Π½Ρ
ΠΈΠΌΠ½ΡΠΌΠΈ ΠΏΡΠΈΠ·Π½Π°ΠΊΠ°ΠΌΠΈ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΡΡΡΡΡ Π±ΠΎΠ»ΡΡΠΈΠΌ ΡΠ°Π·ΠΌΠ΅ΡΠΎΠΌ ΠΏΠ΅ΡΠ²ΠΈΡΠ½ΠΎΠΉ ΠΎΠΏΡΡ
ΠΎΠ»ΠΈ, Π½ΠΈΠ·ΠΊΠΎΠΉ ΡΡΠ΅ΠΏΠ΅Π½ΡΡ Π΄ΠΈΡΡΠ΅ΡΠ΅Π½ΡΠΈΡΠΎΠ²ΠΊΠΈ, ΠΏΠΎΡΠ°ΠΆΠ΅Π½ΠΈΠ΅ΠΌ ΡΠ΅Π³ΠΈΠΎΠ½Π°ΡΠ½ΡΡ
Π»ΠΈΠΌΡΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠ·Π»ΠΎΠ² ΠΈ, ΠΊΠ°ΠΊ ΡΠ»Π΅Π΄ΡΡΠ²ΠΈΠ΅, Π±ΠΎΠ»ΡΡΠ΅ΠΉ ΡΡΠ°Π΄ΠΈΠ΅ΠΉ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ. ΠΠ±Π½Π°ΡΡΠΆΠ΅Π½Π° Π·Π°Π²ΠΈΡΠΈΠΌΠΎΡΡΡ ΡΠ°ΡΡΠΎΡΡ ΠΈ ΡΡΠΎΠ²Π½Ρ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ FRMD6, ZEB1 Π HTR2B Π² ΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΠΈ ΡΡΠ΅ΠΏΠ΅Π½ΠΈ Π΄ΠΈΡΡΠ΅ΡΠ΅Π½ΡΠΈΡΠΎΠ²ΠΊΠΈ Π°Π΄Π΅Π½ΠΎΠΊΠ°ΡΡΠΈΠ½ΠΎΠΌΡ ΠΊΠΈΡΠΊΠΈ, ΠΏΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ ΠΏΡΠΈ Π½Π°Π»ΠΈΡΠΈΠΈ ΠΏΠΎΠ·ΠΈΡΠΈΠ²Π½ΠΎΠΉ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ ΠΈ Π²ΡΡΠΎΠΊΠΈΡ
Π·Π½Π°ΡΠ΅Π½ΠΈΡΡ
ΠΏΡΠΎΡΠ΅Π½ΡΠ° ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ Π΄Π°Π½Π½ΡΡ
Π±Π΅Π»ΠΊΠΎΠ² Π² ΡΠΊΠ°Π½ΠΈ Π½ΠΎΠ²ΠΎΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡ ΠΏΠΎΠ²ΡΡΠ°Π΅ΡΡΡ ΡΡΠ΅ΠΏΠ΅Π½Ρ ΠΌΠΎΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ Π°Π½Π°ΠΏΠ»Π°Π·ΠΈΠΈ ΠΎΠΏΡΡ
ΠΎΠ»ΠΈ. ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅. ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΏΠΎΠ·Π²ΠΎΠ»ΠΈΠ»ΠΎ ΠΎΠ±Π½Π°ΡΡΠΆΠΈΡΡ ΡΠ²ΡΠ·Ρ ΠΈΠΌΠΌΡΠ½ΠΎΠ³ΠΈΡΡΠΎΡ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΌΠ°ΡΠΊΠ΅ΡΠΎΠ² FRMD6, ZEB1, HTR2B, CDX2 Ρ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊΠ°ΠΌΠΈ ΠΎΠΏΡΡ
ΠΎΠ»ΠΈ, ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΡΡΠΈΠΌΠΈ ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ ΠΎΠ½ΠΊΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΏΡΠΎΡΠ΅ΡΡΠ°. ΠΠ·ΡΡΠ΅Π½Π½ΡΠ΅ ΠΌΠ°ΡΠΊΠ΅ΡΡ Π² Π΄Π°Π»ΡΠ½Π΅ΠΉΡΠ΅ΠΌ ΠΌΠΎΠ³ΡΡ ΠΈΠΌΠ΅ΡΡ ΠΏΡΠΎΠ³Π½ΠΎΡΡΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΠΈ ΠΏΡΠ΅Π΄ΠΈΠΊΡΠΈΠ²Π½ΠΎΠ΅ Π·Π½Π°ΡΠ΅Π½ΠΈΠ΅ ΠΏΡΠΈ ΡΠ°ΠΊΠ΅ ΡΠΎΠ»ΡΡΠΎΠΉ ΠΊΠΈΡΠΊΠΈ
ΠΠΠ’ΠΠ ΠΠΠΠΠΠΠ‘Π’Π¬ ΠΠΠ‘ΠΠ ΠΠ‘Π‘ΠΠ ΠΠΠ ΠΠΠ ΠΠ, ΠΠ‘Π‘ΠΠ¦ΠΠΠ ΠΠΠΠΠΠ«Π₯ Π‘ ΠΠΠΠΠΠΠΠΠ«Π ΠΠΠΠ’ΠΠ§ΠΠ«Π Π ΠΠ‘Π’ΠΠ, ΠΠ Π Π ΠΠΠ ΠΠΠΠΠ§ΠΠΠ ΠΠΠΠΠΠ«
The paper is devoted to the study of the expression of markers associated with invasive breast carcinoma. The study included a surgical material from 107 patients with invasive carcinoma of the non-specific type of breast cancer who had not previously received neoadjuvant therapy. The study revealed a number of markers related to invasive tumor growth, characterized by a pronounced heterogeneous expression pattern in all cases. Study of the expression of markers associated with invasive breast carcinoma showed that not all cells are able to promote invasive growth in different periods of time, but the fact of detecting the positive expression of the markers in tissue tumors indicates a more aggressive cancer phenotype with a high potential for invasion.Β Π‘ΡΠ°ΡΡΡ ΠΏΠΎΡΠ²ΡΡΠ΅Π½Π° ΠΈΠ·ΡΡΠ΅Π½ΠΈΡ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠ΅ΠΉ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ ΠΌΠ°ΡΠΊΠ΅ΡΠΎΠ², Π°ΡΡΠΎΡΠΈΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
Ρ ΠΈΠ½Π²Π°Π·ΠΈΠ²Π½ΡΠΌ ΠΊΠ»Π΅ΡΠΎΡΠ½ΡΠΌ ΡΠΎΡΡΠΎΠΌ, ΠΏΡΠΈ ΡΠ°ΠΊΠ΅ ΠΌΠΎΠ»ΠΎΡΠ½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Ρ. Π ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ Π±ΡΠ» Π²ΠΊΠ»ΡΡΠ΅Π½ ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΎΠ½Π½ΡΠΉ ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π» ΠΎΡ 107 ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠΊ Ρ ΠΈΠ½Π²Π°Π·ΠΈΠ²Π½ΠΎΠΉ ΠΊΠ°ΡΡΠΈΠ½ΠΎΠΌΠΎΠΉ Π½Π΅ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠΈΠΏΠ° ΠΌΠΎΠ»ΠΎΡΠ½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Ρ, Π½Π΅ ΠΏΠΎΠ»ΡΡΠ°Π²ΡΠΈΡ
Π½Π΅ΠΎΠ°Π΄ΡΡΠ²Π°Π½ΡΠ½ΠΎΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ. Π Ρ
ΠΎΠ΄Π΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ Π±ΡΠ»ΠΎ Π²ΡΡΠ²Π»Π΅Π½ΠΎ, ΡΡΠΎ ΡΡΠ΄ ΠΌΠ°ΡΠΊΠ΅ΡΠΎΠ², ΠΈΠΌΠ΅ΡΡΠΈΡ
ΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΠ΅ ΠΊ ΠΈΠ½Π²Π°Π·ΠΈΠ²Π½ΠΎΠΌΡ ΠΎΠΏΡΡ
ΠΎΠ»Π΅Π²ΠΎΠΌΡ ΡΠΎΡΡΡ, Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΡΠ΅ΡΡΡ Π½Π°Π»ΠΈΡΠΈΠ΅ΠΌ Π²ΡΡΠ°ΠΆΠ΅Π½Π½ΠΎΠ³ΠΎ Π³Π΅ΡΠ΅ΡΠΎΠ³Π΅Π½Π½ΠΎΠ³ΠΎ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠ° ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ Π²ΠΎ Π²ΡΠ΅Ρ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½Π½ΡΡ
ΡΠ»ΡΡΠ°ΡΡ
. ΠΠ·ΡΡΠ΅Π½ΠΈΠ΅ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΎΠ½Π½ΡΡ
ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠ΅ΠΉ ΠΌΠ°ΡΠΊΠ΅ΡΠΎΠ², ΡΠ²ΡΠ·Π°Π½Π½ΡΡ
Ρ ΠΈΠ½Π²Π°Π·ΠΈΠ΅ΠΉ ΠΏΡΠΈ ΠΊΠ°ΡΡΠΈΠ½ΠΎΠΌΠ΅ ΠΌΠΎΠ»ΠΎΡΠ½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Ρ, ΠΏΠΎΠΊΠ°Π·Π°Π»ΠΎ, ΡΡΠΎ ΡΠΏΠΎΡΠΎΠ±Π½ΠΎΡΡΡΡ ΠΊ ΠΈΠ½Π²Π°Π·ΠΈΠ²Π½ΠΎΠΌΡ ΡΠΎΡΡΡ Π² ΡΠ°Π·Π½ΡΠ΅ Π²ΡΠ΅ΠΌΠ΅Π½Π½ΡΠ΅ ΠΏΠ΅ΡΠΈΠΎΠ΄Ρ ΠΎΠ±Π»Π°Π΄Π°ΡΡ Π½Π΅ Π²ΡΠ΅ ΠΊΠ»Π΅ΡΠΊΠΈ, ΠΎΠ΄Π½Π°ΠΊΠΎ ΡΠ°ΠΌ ΡΠ°ΠΊΡ Π²ΡΡΠ²Π»Π΅Π½ΠΈΡ ΠΏΠΎΠ·ΠΈΡΠΈΠ²Π½ΠΎΠΉ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ ΠΈΠ·ΡΡΠ°Π΅ΠΌΡΡ
ΠΌΠ°ΡΠΊΠ΅ΡΠΎΠ² Π² ΡΠΊΠ°Π½ΠΈ Π½ΠΎΠ²ΠΎΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡ ΡΠΊΠ°Π·ΡΠ²Π°Π΅Ρ Π½Π° Π½Π°Π»ΠΈΡΠΈΠ΅ Π±ΠΎΠ»Π΅Π΅ Π°Π³ΡΠ΅ΡΡΠΈΠ²Π½ΡΡ
ΡΠ²ΠΎΠΉΡΡΠ² ΠΈ Π²ΡΡΠΎΠΊΠΈΠΉ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π» ΠΎΠΏΡΡ
ΠΎΠ»ΠΈ ΠΊ ΠΎΡΡΡΠ΅ΡΡΠ²Π»Π΅Π½ΠΈΡ ΠΈΠ½Π²Π°Π·ΠΈΠΈ.
ΠΠ΅ΡΡΡΡΠΊΡΡΡΠ½Π°Ρ ΡΠΎΠ»Ρ ΡΠΈΡΠΎΠΊΠ΅ΡΠ°ΡΠΈΠ½ΠΎΠ² ΠΏΡΠΈ Π·Π»ΠΎΠΊΠ°ΡΠ΅ΡΡΠ²Π΅Π½Π½ΡΡ Π½ΠΎΠ²ΠΎΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡΡ
Cytokeratins (CKs) are well studied as intermediate filaments of the cytoskeleton of epithelial cells, providing specific cell structure and morphology, in particular, apico-basal cell polarization. Meanwhile, a certain specificity of the association of CK with different types of epithelia is noted. CK heterogeneityΒ in the glandular epithelium is particularly pronounced and is associated with anatomical localization. The relative specificity of CKs in epithelium of different localization is preserved to a great extent in carcinomas originating from this epithelium as well. Due to this fact the determination of CK spectrum in tumor cells is quite an effective tool for nosological diagnostics of carcinomas. however, the function of CKs is not limited to providing the cell structure. The presence and amount of CK changes during the most important processes in normal and tumor cells: movement/invasion, apoptosis, proliferation, epithelial-mesenchymal plasticity.A question arises: Is initiation of the above-listed processes happens first, and therefore CK changes are secondary and Β«passiveΒ», or in some processes CK changes can play a role of a trigger? Knowing the answer to this question is not only of fundamental importance, but is also important for finding ways to control the above processes by influencing the CKs.Π¦ΠΈΡΠΎΠΊΠ΅ΡΠ°ΡΠΈΠ½Ρ (Π¦Π) ΡΠ²Π»ΡΡΡΡΡ ΠΏΡΠΎΠΌΠ΅ΠΆΡΡΠΎΡΠ½ΡΠΌΠΈ ΡΠΈΠ»Π°ΠΌΠ΅Π½ΡΠ°ΠΌΠΈ ΡΠΈΡΠΎΡΠΊΠ΅Π»Π΅ΡΠ° ΡΠΏΠΈΡΠ΅Π»ΠΈΠ°Π»ΡΠ½ΡΡ
ΠΊΠ»Π΅ΡΠΎΠΊ ΠΈ ΠΎΠ±Π΅ΡΠΏΠ΅ΡΠΈΠ²Π°ΡΡ ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ΅ΡΠΊΡΡΒ ΡΡΡΡΠΊΡΡΡΡ ΠΈ ΠΌΠΎΡΡΠΎΠ»ΠΎΠ³ΠΈΡ ΠΊΠ»Π΅ΡΠΎΠΊ, Π² ΡΠ°ΡΡΠ½ΠΎΡΡΠΈ Π°ΠΏΠΈΠΊΠΎ-Π±Π°Π·Π°Π»ΡΠ½ΡΡ ΠΏΠΎΠ»ΡΡΠΈΠ·Π°ΡΠΈΡ ΠΊΠ»Π΅ΡΠΎΠΊ. ΠΡΠΌΠ΅ΡΠ°Π΅ΡΡΡ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½Π½Π°Ρ ΡΠΏΠ΅ΡΠΈΡΠΈΠΊΠ° Π°ΡΡΠΎΡΠΈΠ°ΡΠΈΠΈ Π¦Π Ρ ΡΠ°Π·Π½ΡΠΌΠΈ ΡΠΈΠΏΠ°ΠΌΠΈ ΡΠΏΠΈΡΠ΅Π»ΠΈΡ. ΠΠ΅ΡΠ΅ΡΠΎΠ³Π΅Π½Π½ΠΎΡΡΡ Π¦Π, ΠΊΠΎΡΠΎΡΠ°Ρ ΡΠΎΠΏΡΡΠΆΠ΅Π½Π° Ρ Π°Π½Π°ΡΠΎΠΌΠΈΡΠ΅ΡΠΊΠΎΠΉ Π»ΠΎΠΊΠ°Π»ΠΈΠ·Π°ΡΠΈΠ΅ΠΉ, ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎ Π²ΡΡΠ°ΠΆΠ΅Π½Π° Π² ΠΆΠ΅Π»Π΅Π·ΠΈΡΡΠΎΠΌ ΡΠΏΠΈΡΠ΅Π»ΠΈΠΈ. ΠΡΠ½ΠΎΡΠΈΡΠ΅Π»ΡΠ½Π°Ρ ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ½ΠΎΡΡΡ Π¦Π Π² ΡΠΏΠΈΡΠ΅Π»ΠΈΠΈ ΡΠ°Π·Π½ΠΎΠΉ Π»ΠΎΠΊΠ°Π»ΠΈΠ·Π°ΡΠΈΠΈ ΡΠΎΡ
ΡΠ°Π½ΡΠ΅ΡΡΡ Π² Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½ΠΎΠΉ ΡΡΠ΅ΠΏΠ΅Π½ΠΈ ΠΈ ΠΏΡΠΈ Π΅Π³ΠΎ Π·Π»ΠΎΠΊΠ°ΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎΠΉ ΡΡΠ°Π½ΡΡΠΎΡΠΌΠ°ΡΠΈΠΈ. ΠΠ»Π°Π³ΠΎΠ΄Π°ΡΡ ΡΡΠΎΠΌΡ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ ΡΠΏΠ΅ΠΊΡΡΠ° Π¦Π Π² ΠΎΠΏΡΡ
ΠΎΠ»Π΅Π²ΡΡ
ΠΊΠ»Π΅ΡΠΊΠ°Ρ
ΡΠ²Π»ΡΠ΅ΡΡΡ Π΄ΠΎΠ²ΠΎΠ»ΡΠ½ΠΎ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΡΠΌ ΠΈΠ½ΡΡΡΡΠΌΠ΅Π½ΡΠΎΠΌ Π½ΠΎΠ·ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠΈ ΠΊΠ°ΡΡΠΈΠ½ΠΎΠΌ. ΠΠ΄Π½Π°ΠΊΠΎ ΡΡΠ½ΠΊΡΠΈΡ Π¦Π Π½Π΅ ΠΈΡΡΠ΅ΡΠΏΡΠ²Π°Π΅ΡΡΡ ΠΎΠ±Π΅ΡΠΏΠ΅ΡΠ΅Π½ΠΈΠ΅ΠΌ ΡΡΡΡΠΊΡΡΡΡ ΠΊΠ»Π΅ΡΠΊΠΈ. ΠΠ°Π»ΠΈΡΠΈΠ΅/ΠΎΡΡΡΡΡΡΠ²ΠΈΠ΅ Π¦Π ΠΈ ΠΈΡ
ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²ΠΎ ΠΎΠ±ΡΡΠ»ΠΎΠ²Π»Π΅Π½Ρ Π²Π°ΠΆΠ½Π΅ΠΉΡΠΈΠΌΠΈ ΠΏΡΠΎΡΠ΅ΡΡΠ°ΠΌΠΈ Π² Π½ΠΎΡΠΌΠ°Π»ΡΠ½ΡΡ
ΠΈ ΠΎΠΏΡΡ
ΠΎΠ»Π΅Π²ΡΡ
ΠΊΠ»Π΅ΡΠΊΠ°Ρ
: Π΄Π²ΠΈΠΆΠ΅Π½ΠΈΠ΅ΠΌ/ΠΈΠ½Π²Π°Π·ΠΈΠ΅ΠΉ, Π°ΠΏΠΎΠΏΡΠΎΠ·ΠΎΠΌ, ΠΏΡΠΎΠ»ΠΈΡΠ΅ΡΠ°ΡΠΈΠ΅ΠΉ, ΡΠΏΠΈΡΠ΅Π»ΠΈΠ°Π»ΡΠ½ΠΎ-ΠΌΠ΅Π·Π΅Π½Ρ
ΠΈΠΌΠ°Π»ΡΠ½ΡΠΌ ΠΏΠ΅ΡΠ΅Ρ
ΠΎΠ΄ΠΎΠΌ. ΠΠΎΠ·Π½ΠΈΠΊΠ°Π΅Ρ Π²ΠΎΠΏΡΠΎΡ: Β«ΠΠ΅ΡΠ²ΠΈΡΠ½Π° Π»ΠΈ ΠΈΠ½ΠΈΡΠΈΠ°ΡΠΈΡ ΠΏΠ΅ΡΠ΅ΡΠΈΡΠ»Π΅Π½Π½ΡΡ
ΠΏΡΠΎΡΠ΅ΡΡΠΎΠ², ΠΈ ΡΠΎΠ³Π΄Π° ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΡ Π¦Π Π²ΡΠΎΡΠΈΡΠ½Ρ ΠΈ Β«ΠΏΠ°ΡΡΠΈΠ²Π½ΡΒ», ΠΈΠ»ΠΈ Π² ΠΊΠ°ΠΊΠΈΡ
-ΡΠΎ ΠΏΡΠΎΡΠ΅ΡΡΠ°Ρ
ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΡ Π¦Π ΠΌΠΎΠ³ΡΡ ΠΈΠ³ΡΠ°ΡΡ ΡΠΎΠ»Ρ ΡΡΠΈΠ³Π³Π΅ΡΠ°?Β» ΠΡΠ²Π΅Ρ Π½Π° Π½Π΅Π³ΠΎ Π½Π΅ ΡΠΎΠ»ΡΠΊΠΎ ΠΈΠΌΠ΅Π΅Ρ ΡΡΠ½Π΄Π°ΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΠΎΠ΅ Π·Π½Π°ΡΠ΅Π½ΠΈΠ΅, Π½ΠΎ ΠΈ Π²Π°ΠΆΠ΅Π½ Π΄Π»Ρ ΠΏΠΎΠΈΡΠΊΠ° ΡΠΏΠΎΡΠΎΠ±ΠΎΠ² ΡΠΏΡΠ°Π²Π»Π΅Π½ΠΈΡ ΡΠΊΠ°Π·Π°Π½Π½ΡΠΌΠΈ ΠΏΡΠΎΡΠ΅ΡΡΠ°ΠΌΠΈ ΠΏΡΡΠ΅ΠΌ Π²ΠΎΠ·Π΄Π΅ΠΉΡΡΠ²ΠΈΡ Π½Π° Π¦Π