Effects of Contrarians in the Minority Game

We study the effects of the presence of contrarians in an agent-based model of competing populations. Contrarians are common in societies. These contrarians are agents who deliberately prefer to hold an opinion that is contrary to the prevailing idea of the commons or normal agents. Contrarians are introduced within the context of the Minority Game (MG), which is a binary model for an evolving and adaptive population of agents competing for a limited resource. Results of numerical simulations reveal that the average success rate among the agents depends non-monotonically on the fraction $a_{c}$ of contrarians. For small $a_{c}$, the contrarians systematically outperform the normal agents by avoiding the crowd effect and enhance the overall success rate. For high $a_{c}$, the anti-persistent nature of the MG is disturbed and the few normal agents outperform the contrarians. Qualitative discussion and analytic results for the small $a_{c}$ and high $a_{c}$ regimes are also presented, and the crossover behavior between the two regimes is discussed.Comment: revtex, 11 pages, 4 figure

Molecular Mechanisms of Proteinuria in Minimal Change Disease

Minimal change disease (MCD) is the most common type of idiopathic nephrotic syndrome in childhood and represents about 15% cases in adults. It is characterized by massive proteinuria, edema, hypoalbuminemia, and podocyte foot process effacement on electron microscopy. Clinical and experimental studies have shown an association between MCD and immune dysregulation. Given the lack of inflammatory changes or immunocomplex deposits in the kidney tissue, MCD has been traditionally thought to be mediated by an unknown circulating factor(s), probably released by T cells that directly target podocytes leading to podocyte ultrastructural changes and proteinuria. Not surprisingly, research efforts have focused on the role of T cells and podocytes in the disease process. Nevertheless, the pathogenesis of the disease remains a mystery. More recently, B cells have been postulated as an important player in the disease either by activating T cells or by releasing circulating autoantibodies against podocyte targets. There are also few reports of endothelial injury in MCD, but whether glomerular endothelial cells play a role in the disease remains unexplored. Genome-wide association studies are providing insights into the genetic susceptibility to develop the disease and found a link between MCD and certain human haplotype antigen variants. Altogether, these findings emphasize the complex interplay between the immune system, glomerular cells, and the genome, raising the possibility of distinct underlying triggers and/or mechanisms of proteinuria among patients with MCD. The heterogeneity of the disease and the lack of good animal models of MCD remain major obstacles in the understanding of MCD. In this study, we will review the most relevant candidate mediators and mechanisms of proteinuria involved in MCD and the current models of MCD-like injury

TSH-CHECK-1 test: diagnostic accuracy and potential application to initiating treatment for hypothyroidism in patients on anti-tuberculosis drugs.

Thyroid-stimulating hormone (TSH) promotes expression of thyroid hormones which are essential for metabolism, growth, and development. Second-line drugs to treat tuberculosis (TB) can cause hypothyroidism by suppressing thyroid hormone synthesis. Therefore, TSH levels are routinely measured in TB patients receiving second-line drugs, and thyroxin treatment is initiated where indicated. However, standard TSH tests are technically demanding for many low-resource settings where TB is prevalent; a simple and inexpensive test is urgently needed

Pathogenicity and fusaric acid production by fusarium proliferatum isolated from garlic in Spain

Fusarium proliferatum has been reported on garlic in the north west U.S.A., Spain and Serbia, causing as water-soaked tan lesions on cloves. Moreover, F. proliferatum is known to produce a range of toxins, including fumonisin B1, moniliformin, beauvericin, fusaproliferin and fusaric acid, which are implicated in pathogenesis. In this study six randomly selected F. proliferatum isolates from garlic were tested for pathogenicity and screened for fusaric acid production. Healthy seedlings of onion (Allium cepa), leek (A. porrum) and chives (A. schoenoprasum) and garlic clones (A. sativum) were inoculated. Onion seedlings and garlic clones were soaked in the conidial suspensions of each F. proliferatum isolate for 24 h and then planted in flats containing soil previously inoculated with the same isolate of F. proliferatum. Plants were maintained in a temperature and light-controlled greenhouse (12 h/12 h light/dark; 25/21°C). The root and bulb/clove rot disease symptoms were graded into five classes following the method of Stankovick et al. (2007). A disease severity index (DSI) was calculated as the mean of three plants of each species and four test replicates. Symptoms on onion and garlic plants were observed three weeks after inoculation. The overall effects of isolate, host and variety were analyzed. Effects were significant for all the studied isolates. The correlations between isolate pathogenicity and production of FA are also discussed

Palliative Electrochemotherapy in Vulvar Carcinoma: Preliminary Results of the ELECHTRA (Electrochemotherapy Vulvar Cancer) Multicenter Study

Vulvar cancer (VC) is a rare disease of which recurrence poses management problems due to patients’ advanced age and comorbidities, and to the localization of the disease. Palliative treatments, allowing local disease control in patients previously treated with multimodal therapies or with comorbidities, are lacking. In this study we tested electrochemotherapy (ECT) on recurrent VC refractory to standard therapies to assess the tumor response and to define the selection criteria for patient’s candidate to ECT. This is a multicenter observational study carried out in five Italian centers. Data about patients and tumor characteristics, treatment, toxicity, and clinical response were recorded. In all procedures, intravenous bleomycin was administered according to European Standard Operative Procedure ECT (ESOPE) guidelines. Sixty-one patients, with a median age 79 years (range: 39–85) and mainly affected by squamous cellular carcinoma (91.8%), were treated with ECT. No serious adverse events were reported. Patients were discharged after three days (median, range: 0–8 days). Two months after ECT, the clinical response rate was 83.6% and was not related to age, body mass index, International Federation of Gynecology and Obstetrics (FIGO) stage, number of treated nodules, or previous treatments. ECT is a safe procedure with a favorable cost-effectiveness ratio and should be considered as a treatment option for local disease control in patients unsuitable for standard therapies

Microtremor Measurements in the City of Palermo, Italy: Analysis of the Correlation between Local Geology and Damage

This study presents the results of 90 seismic ambient noise measurements in Palermo, the main city of Sicily (Italy). The dataset has been processed using the horizontal-to-vertical spectral ratio (HVNSR) technique and interpreted in terms of local geology, which is characterized by the presence of alluvial sediments of two riverbeds masked by urbanization since the seventeenth century. HVNSRs show significant variations in the study area: when the transition stiff to soft is crossed, a typical spectral peak appears in the HVNSRs, mostly in the frequency band 1–2 Hz, and exceeding a factor of 3 in amplitude. Using available information on subsurface geological structure, we compute theoretical 1D and 2D transfer functions. The resonance frequencies of soft soils obtained by HVNSR are well reproduced by the fundamental frequencies from numerical modeling. The distribution of frequency peaks of HVNSR and their amplitudes are also compared with the local damage caused by historical earthquakes. Previous studies demonstrated that damage variations in Palermo were controlled more by near-surface geology than building vulnerability. A uniform vulnerability is an ideal condition to test statistical methods and their capability in seeking correlation between HVNSR and potential damage due to local geological conditions. We apply two well-established multivariate statistical methodologies (factor analysis and canonical correlation) to the HVNSR dataset and macroseismic data (damage grades of the European macroseismic scale). Through these analyses we quantify the significance of the correlation between the HVNSR peak in the low-medium frequency range (0.5–3 Hz) and the occurrence of the highest damage grades. This approach allows us (1) to estimate the threshold value in the resulting linear combination of the HVNSR amplitudes, which separates zones of light damage from zones of significant damage, and therefore (2) to improve the spatial definition of potentially high hazard zones through a denser grid of microtremor measurements

Fusarium proliferatum isolated from garlic in Spain: Identification, toxigenic potential and pathogenicity on related Allium species

Fusarium proliferatum has been reported on garlic in the Northwest USA, Spain and Serbia, causing water-soaked tan-colored lesions on cloves. In this work, Fusarium proliferatum was isolated from 300 symptomatic garlic bulbs. Morphological identification of Fusarium was confirmed using species-specific PCR assays and EF-1α sequencing. Confirmation of pathogenicity was conducted with eighteen isolates. Six randomly selected F. proliferatum isolates from garlic were tested for specific pathogenicity and screened for fusaric acid production. Additionally, pathogenicity of each F. proliferatum isolate was tested on healthy seedlings of onion (Allium cepa), leek (A. porrum), scallions (A. fistulosum), chives (A. schoenoprasum) and garlic (A. sativum). A disease severity index (DSI) was calculated as the mean severity on three plants of each species with four test replicates. Symptoms on onion and garlic plants were observed three weeks after inoculation. All isolates tested produced symptoms on all varieties inoculated. Inoculation of F. proliferatum isolates from diseased garlic onto other Allium species provided new information on host range and pathogenicity. The results demonstrated differences in susceptibility with respect to host species and cultivar. The F. proliferatum isolates tested all produced fusaric acid (FA); correlations between FA production and isolate pathogenicity are discussed. Additionally, all isolates showed the presence of the FUM1 gene suggesting the ability of Spanish isolates to produce fumonisins

Statistical mechanics of the mixed majority-minority game with random external information

We study the asymptotic macroscopic properties of the mixed majority-minority game, modeling a population in which two types of heterogeneous adaptive agents, namely ``fundamentalists'' driven by differentiation and ``trend-followers'' driven by imitation, interact. The presence of a fraction f of trend-followers is shown to induce (a) a significant loss of informational efficiency with respect to a pure minority game (in particular, an efficient, unpredictable phase exists only for f<1/2), and (b) a catastrophic increase of global fluctuations for f>1/2. We solve the model by means of an approximate static (replica) theory and by a direct dynamical (generating functional) technique. The two approaches coincide and match numerical results convincingly.Comment: 19 pages, 3 figure

Total Reflection X-ray Fluorescence Reference Materials for Cascade Impactor Air Quality Monitoring Systems

The 12th International Conference on “Instrumental Methods of Analysis” www.ima2021.gr (accessed on 8 November 2021)), was organized by the Aristotle University of Thessaloniki and National Technical University of Athens, during 20–23 September 2021 as a virtual event, providing the opportunity for high-level analytical scientists from all around the world to promote their relevant research. IMA is a biannual series of conferences that started in 1999 and cover all areas of Chemical Analysis, including the development of new techniques, modern trends, and applications in a wide range of scientific disciplines. To date, several leading analytical chemists from Greece and abroad have presented their research work at previous IMA meetings. The 12th IMA conference (in a virtual format for the first time), had the ambition to bring together some of the most talented and innovative analytical chemists from all over the world for an excellent scientific online conference. The program of the 4-day event attended by 260 participants from 23 countries, included 14 invited speakers, 73 oral presentations, and 98 poster contributions. Covered topics included: spectrometric and electrometric analysis; chromatographic, mass spectrometric, microscopic, and thermal analysis methods; proteomics, metabolomics, metallomics, and elemental speciation analysis; chemical and biosensors; field analysis—mobile analytical instruments; miniaturized analytical systems (lab-on-a-chip), micro-, and nanofluidics; immunoassays and electrophoretic separation techniques; sampling techniques and strategies; robotics and automation; quality control—quality assurance in analysis; metrology; data processing and chemometrics; environmental analysis; biomedical (ecotoxicological and clinical) and pharmaceutical analysis; food analysis; materials analysis (nanomaterials, smart/advanced materials, and surface analysis); archaeometry; and analytical chemistry markets and possibilities for commercialization. Special sessions, focused on aerosol metrology (supported by EU Project AEROMET II), advanced X-ray techniques (supported by the European X-ray Spectrometry Association), and application of chemical analysis in the study of virus spread analytics (airborne and wastewaters), were also organized within the frame of IMA-2021