3,996 research outputs found
Entanglement Equivalence of -qubit Symmetric States
We study the interconversion of multipartite symmetric -qubit states under
stochastic local operations and classical communication (SLOCC). We demonstrate
that if two symmetric states can be connected with a nonsymmetric invertible
local operation (ILO), then they belong necessarily to the separable, W, or GHZ
entanglement class, establishing a practical method of discriminating subsets
of entanglement classes. Furthermore, we prove that there always exists a
symmetric ILO connecting any pair of symmetric -qubit states equivalent
under SLOCC, simplifying the requirements for experimental implementations of
local interconversion of those states.Comment: Minor correction
Using skipgrams and POS-based feature selection for patent classification
Contains fulltext :
116289.pdf (publisher's version ) (Open Access)19 p
The Measurement Calculus
Measurement-based quantum computation has emerged from the physics community
as a new approach to quantum computation where the notion of measurement is the
main driving force of computation. This is in contrast with the more
traditional circuit model which is based on unitary operations. Among
measurement-based quantum computation methods, the recently introduced one-way
quantum computer stands out as fundamental.
We develop a rigorous mathematical model underlying the one-way quantum
computer and present a concrete syntax and operational semantics for programs,
which we call patterns, and an algebra of these patterns derived from a
denotational semantics. More importantly, we present a calculus for reasoning
locally and compositionally about these patterns.
We present a rewrite theory and prove a general standardization theorem which
allows all patterns to be put in a semantically equivalent standard form.
Standardization has far-reaching consequences: a new physical architecture
based on performing all the entanglement in the beginning, parallelization by
exposing the dependency structure of measurements and expressiveness theorems.
Furthermore we formalize several other measurement-based models:
Teleportation, Phase and Pauli models and present compositional embeddings of
them into and from the one-way model. This allows us to transfer all the theory
we develop for the one-way model to these models. This shows that the framework
we have developed has a general impact on measurement-based computation and is
not just particular to the one-way quantum computer.Comment: 46 pages, 2 figures, Replacement of quant-ph/0412135v1, the new
version also include formalization of several other measurement-based models:
Teleportation, Phase and Pauli models and present compositional embeddings of
them into and from the one-way model. To appear in Journal of AC
Azacytidine Enhances Regulatory T-Cells In Vivo and Prevents Experimental Xenogeneic Graft-Versus-Host Disease
Background
The demethylating agent 5-azacytidine (AZA) has proven its efficacy as treatment for myelodysplastic syndrome and acute myeloid leukemia. In addition, AZA can demethylate FOXP3 intron 1 (FOXP3i1) leading to the generation of regulatory T cells (Tregs).
Objective
We investigated the impact of AZA on xenogeneic graft-versus-host disease (xGVHD) in a humanized murine model of transplantation, and described the impact of the drug on human T cells in vivo.
Methods
In order to induce xGVHD, human peripheral blood mononuclear cells (huPBMC) were administered intravenously in NOD-scid IL-2Rγnull (NSG) mice.
Results
AZA successfully improved both survival (p<0.0001) and xGVHD scores (p<0.0001). Further, AZA significantly decreased human T-cell proliferation as well as INF-γ and TNF-α serum levels, and reduced the expression of GRANZYME B and PERFORIN 1 by cytotoxic T cells. In addition, AZA administration significantly increased the function, proliferation and frequency of Tregs through demethylation of FOXP3i1 and higher secretion of IL-2 by conventional T cells due to IL2 gene promoter site 1 demethylation. Interestingly, among AZA-treated mice surviving the acute phase of xGVHD, there was an inverse correlation between the presence of Tregs and signs of chronic GVHD. Finally, Tregs harvested from the spleen of AZA-treated mice were suppressive and stable over time since they persisted at high frequency in secondary transplant experiments.
Conclusion
These findings emphasize a potential role for AZA as prevention or treatment of GVHD
The Expectation Monad in Quantum Foundations
The expectation monad is introduced abstractly via two composable
adjunctions, but concretely captures measures. It turns out to sit in between
known monads: on the one hand the distribution and ultrafilter monad, and on
the other hand the continuation monad. This expectation monad is used in two
probabilistic analogues of fundamental results of Manes and Gelfand for the
ultrafilter monad: algebras of the expectation monad are convex compact
Hausdorff spaces, and are dually equivalent to so-called Banach effect
algebras. These structures capture states and effects in quantum foundations,
and also the duality between them. Moreover, the approach leads to a new
re-formulation of Gleason's theorem, expressing that effects on a Hilbert space
are free effect modules on projections, obtained via tensoring with the unit
interval.Comment: In Proceedings QPL 2011, arXiv:1210.029
SoLid : Search for Oscillations with Lithium-6 Detector at the SCK-CEN BR2 reactor
Sterile neutrinos have been considered as a possible explanation for the recent reactor and Gallium anomalies arising from reanalysis of reactor flux and calibration data of previous neutrino experiments. A way to test this hypothesis is to look for distortions of the anti-neutrino energy caused by oscillation from active to sterile neutrino at close stand-off (similar to 6-8m) of a compact reactor core. Due to the low rate of anti-neutrino interactions the main challenge in such measurement is to control the high level of gamma rays and neutron background.
The SoLid experiment is a proposal to search for active-to-sterile anti-neutrino oscillation at very short baseline of the SCK center dot CEN BR2 research reactor.
This experiment uses a novel approach to detect anti-neutrino with a highly segmented detector based on Lithium-6. With the combination of high granularity, high neutron-gamma discrimination using 6LiF:ZnS(Ag) and precise localization of the Inverse Beta Decay products, a better experimental sensitivity can be achieved compared to other state-of-the-art technology. This compact system requires minimum passive shielding allowing for very close stand off to the reactor. The experimental set up of the SoLid experiment and the BR2 reactor will be presented. The new principle of neutrino detection and the detector design with expected performance will be described. The expected sensitivity to new oscillations of the SoLid detector as well as the first measurements made with the 8 kg prototype detector deployed at the BR2 reactor in 2013-2014 will be reported
Bacterial diversity and community composition from seasurface to subseafloor
© The International Society for Microbial Ecology, 2015. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in ISME Journal 10 (2016): 979–989, doi:10.1038/ismej.2015.175.We investigated compositional relationships between bacterial communities in the water column and those in deep-sea sediment at three environmentally distinct Pacific sites (two in the Equatorial Pacific and one in the North Pacific Gyre). Through pyrosequencing of the v4–v6 hypervariable regions of the 16S ribosomal RNA gene, we characterized 450 104 pyrotags representing 29 814 operational taxonomic units (OTUs, 97% similarity). Hierarchical clustering and non-metric multidimensional scaling partition the samples into four broad groups, regardless of geographic location: a photic-zone community, a subphotic community, a shallow sedimentary community and a subseafloor sedimentary community (greater than or equal to1.5 meters below seafloor). Abundance-weighted community compositions of water-column samples exhibit a similar trend with depth at all sites, with successive epipelagic, mesopelagic, bathypelagic and abyssopelagic communities. Taxonomic richness is generally highest in the water-column O2 minimum zone and lowest in the subseafloor sediment. OTUs represented by abundant tags in the subseafloor sediment are often present but represented by few tags in the water column, and represented by moderately abundant tags in the shallow sediment. In contrast, OTUs represented by abundant tags in the water are generally absent from the subseafloor sediment. These results are consistent with (i) dispersal of marine sedimentary bacteria via the ocean, and (ii) selection of the subseafloor sedimentary community from within the community present in shallow sediment.This study was funded by the Biological Oceanography Program of the US National Science Foundation (grant OCE-0752336) and by the NSF-funded Center for Dark Energy Biosphere Investigations (grant NSF-OCE-0939564)
Biogeographical distribution and diversity of microbes in methane hydrate-bearing deep marine sediments, on the Pacific Ocean Margin
The deep subseafloor biosphere is among the least-understood habitats on Earth, even though the huge microbial biomass therein plays an important role for potential long-term controls on global biogeochemical cycles. We report here the vertical and geographical distribution of microbes and their phylogenetic diversities in deeply buried marine sediments of the Pacific Ocean Margins. During the Ocean Drilling Program Legs 201 and 204, we obtained sediment cores from the Peru and Cascadia Margins that varied with respect to the presence of dissolved methane and methane hydrate. To examine differences in prokaryotic distribution patterns in sediments with or without methane hydrates, we studied >2,800 clones possessing partial sequences (400–500 bp) of the 16S rRNA gene and 348 representative clone sequences (≈1 kbp) from the two geographically separated subseafloor environments. Archaea of the uncultivated Deep-Sea Archaeal Group were consistently the dominant phylotype in sediments associated with methane hydrate. Sediment cores lacking methane hydrates displayed few or no Deep-Sea Archaeal Group phylotypes. Bacterial communities in the methane hydrate-bearing sediments were dominated by members of the JS1 group, Planctomycetes, and Chloroflexi. Results from cluster and principal component analyses, which include previously reported data from the West and East Pacific Margins, suggest that, for these locations in the Pacific Ocean, prokaryotic communities from methane hydrate-bearing sediment cores are distinct from those in hydrate-free cores. The recognition of which microbial groups prevail under distinctive subseafloor environments is a significant step toward determining the role these communities play in Earth’s essential biogeochemical processes
Obesity and motor skills among 4 to 6-year-old children in the united states: nationally-representative surveys
Few population-based studies have assessed relationships between body weight and motor skills in young children. Our objective was to estimate the association between obesity and motor skills at 4 years and 5-6 years of age in the United States. We used repeated cross-sectional assessments of the national sample from the Early Childhood Longitudinal Survey-Birth Cohort (ECLS-B) of preschool 4-year-old children (2005-2006; n = 5 100) and 5-6-year-old kindergarteners (2006-2007; n = 4 700). Height, weight, and fine and gross motor skills were assessed objectively via direct standardized procedures. We used categorical and continuous measures of body weight status, including obesity (Body Mass Index (BMI) ≥ 95th percentile) and BMI z-scores. Multivariate logistic and linear models estimated the association between obesity and gross and fine motor skills in very young children adjusting for individual, social, and economic characteristics and parental involvement.info:eu-repo/semantics/publishe
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