Freeform Bioprinting of Liver Encapsulated in Alginate Hydrogels Tissue Constructs for Pharmacokinetic Study

An in vitro model that can be realistically and inexpensively used to predict human response to various drug administration and toxic chemical exposure is needed. By fabricating a microscale 3D physiological tissue construct consisting of an array of channels and tissue-embedded chambers, one can selectively develop various biomimicking mammalian tissues for a number of pharmaceutical applications, for example, experimental pharmaceutical screening for drug efficacy and toxicity along with apprehending the disposition and metabolic profile of a candidate drug. This paper addresses issues relating to the development and implementation of a bioprinting process for freeform fabrication of a 3D cell-encapsulated hydrogel-based tissue construct, the direct integration onto a microfluidic device for pharmacokinetic study, and the underlying engineering science for the fabrication of a 3D microscale tissue chamber as well as its application in pharmacokinetic study. To this end, a prototype 3D microfluidic tissue chamber embedded with liver cells encapsulated within a hydrogel matrix construct is bioprinted as a physiological in vitro model for pharmacokinetic study. The developed fabrication processes are further validated and parameters optimized by assessing cell viability and liver cell phenotype, in which metabolic and synthetic liver functions are quantitated.Mechanical Engineerin

Identifying the Strongest or the Weakest Link: Effects on Subsequent Ratings

The current study investigated the effect of a negative designation performance rating purpose in contrast to a positive designation purpose or a deservedness purpose on a) the ability of raters to differentiate amongst ratees at a later time and b) raters\u27 tendencies to provide subsequently more severe or lenient ratings. Results from a laboratory study involving 102 participants indicated that positive designations tend to result in subsequently lenient ratings, while negative designations result in severe ratings. However, the nature of a rater’s previous decision had no discernable effect on the ability to differentiate levels of performance. Implications of these findings for the structuring of performance ratings procedures in contexts of short-term performance observation, such as assessment centers, are discussed. Keywords: Assessment centers; Performance rating; Assimilation effect; Rating lenienc

Functional forms of competence: Interviewing

Citation: Huffcutt, A. I., Culbertson, S. S., & Riforgiate, S. E. (2015). Functional forms of competence: Interviewing. In A. F. Hannawa & B. H. Spitzberg (Eds.), Communication Competence (Vol. 24) (pp. 431-448). Boston: De Gruyer Mouton.Employment interviews are ubiquitous in the workplace, providing a necessary step in the hiring process and influencing organizational composition and applicant employment. Research pertaining to professional interviewing is frequently conducted outside of the communication discipline, yet the nature of the interview interaction is highly communicative. The purpose of this chapter is to develop a solid foundation for understanding communication in employment interviews by utilizing the concept of communication competence as a theoretical basis. Specifically, we address aspects of communication effectiveness and appropriateness in employment interviews, including how they vary according to the degree of their standardization. For instance, both parties (interviewer and interviewee) have the goal of reducing uncertainty, although the nature of those goals differ (e.g., organizational perspectives regarding potential interviewee performance verses interviewee perceptions of job fit and the likelihood of being offered the job). Directions for future research are presented, including a pressing need for research examining how the two parties adjust communication during the interaction based on perceptions of the other’s communication behaviors

Crossbreeding hogs for pork production

Some 11 or 12 million slaughter hogs are produced on Iowa farms each year. The sale of these hogs produces the largest single item (about 40 percent) of the annual farm income of the state. Any procedure that will produce these hogs more efficiently will increase the net income o f the farmer who uses it, as well as that of the state as a whole

The Interactive Influence of Ambition and Sociability on Performance in a Behavior Description Interview

The purpose of this study was to present and empirically test the potential influence on ratings in a behavior description interview (BDI) of the personality traits ambition and sociability, two facets of extraversion. Results suggest a relatively strong role for ambition in the administration and outcomes of BDIs in organizational selection, particularly when its interaction with sociability is taken into consideration. In a sample of 85 participants working in entry-level positions, the correlation with BDI ratings was .22 for ambition alone, which increased to .44 when sociability and its interaction with ambition were added. Adding sociability by itself to ambition without the interaction term resulted in a minimal increase in predictability of BDI ratings. Implications of these results include the possibility of a general BDI performance factor, one that may tend to capture maximal (rather than typical) behavior