How Can Chemometrics Support the Development of Point of Need Devices?

The necessity to establish novel solutions for decentralized monitoring is attracting attention in all fields of analytical chemistry, i.e., clinical, pharmaceutical, environmental, agri-food. The research around the terms "point-of-need", "point-of-care", "lab-on-chip", "biosensor", "microfluidics", etc. is/has been always aimed at the possibility to produce easy-to-use and fast-response devices to be used by nonspecialists. However, the routes to produce the optimal device might be time-consuming and costly. In this Feature, we would like to highlight the role of chemometric-based approaches that are useful in the conceptualization, production, and data analysis in developing reliable portable devices and also decrease the amount of experiments (thus, costs) at the same time. Readers will be provided a concise overview regarding the most employed chemometric tools used for target identification, design of experiments, data analysis, and digitalization of results applied to the development of diverse portable analytical platforms. This Feature provides a tutorial perspective regarding all the major methods and applications that have been currently developed. In particular, the presence of a concise and informative table assists analytical chemists in utilizing the right chemometrics-based tool depending on the architectures and transduction

Electrochemical biosensors for tracing cyanotoxins in food and environmental matrices

The adoption of electrochemical principles to realize on-field analytical tools for detecting pollutants represents a great possibility for food safety and environmental applications. With respect to the existing transduction mechanisms, i.e., colorimetric, fluorescence, piezoelectric etc., electrochemical mechanisms offer the tremendous advantage of being easily miniaturized, connected with low cost (commercially available) readers and unaffected by the color/turbidity of real matrices. In particular, their versatility represents a powerful approach for detecting traces of emerging pollutants such as cyanotoxins. The combination of electrochemical platforms with nanomaterials, synthetic receptors and microfabrication makes electroanalysis a strong starting point towards decentralized monitoring of toxins in diverse matrices. This review gives an overview of the electrochemical biosensors that have been developed to detect four common cyanotoxins, namely microcystin-LR, anatoxin-a, saxitoxin and cylindrospermopsin. The manuscript provides the readers a quick guide to understand the main electrochemical platforms that have been realized so far, and the presence of a comprehensive table provides a perspective at a glance

Corrigendum to "Co-seismic surface effects from very high resolution panchromatic images: the case of the 2005 Kashmir (Pakistan) earthquake" published in Nat. Hazards Earth Syst. Sci., 11, 931–943, 2011

No abstract available

The case of the 2005 Kashmir earthquake

The use of Very High Resolution (VHR) satellite panchromatic image is nowadays an effective tool to detect and investigate surface effects of natural disasters. We specifically examined the capabilities of VHR images to analyse earthquake features and detect changes based on the combination of visual inspection and automatic classification tools. In particular, we have used Quickbird (0.6m spatial resolution) images for detecting the three main coseismic surface features: damages, ruptures and landslides. The present approach has been applied to the 8 October 2005, Mw7.6 Kashmir, Pakistan, earthquake. We have focused our study in and around the main urban areas hit by the above earthquake specifically at Muzaffarabad and Balakot towns. The automatic classification techniques provided the best results wherever dealing with the damage to man-made structures and landslides. On the other hand, the visual inspection method demonstrated in addressing the identification of rupture traces and associated features. The synoptic view (concerning landslide, more than 190 millions of pixels have been automatically classified), the spatiotemporal sampling and the fast automatic damage detection using satellite images provided a reliable contribution to the prompt response during natural disaster and for the evaluation of seismic hazard as well

A Hybrid Screen-Printed Strip for Enhanced Electroanalysis towards Lead and Cadmium in Multi-Matrices

Although heavy metals represent a major treat for ecosystem and human health, reference methods for their monitoring are characterized by time-consuming procedures, skilled personel and sophisticated equipment (e.g. ICP-MS, AAS). The development of portable solutions is required, particularly improving interventions and reducing complexity. To this regards, an electrochemical strip for the determination of lead and cadmium in clinical, environmental and food matrices have been developed. The Bismuth film-based flexible device has been optimized and it has been able to detect cadmium and lead, respectively, down to the detection limit of 1.3 and 2 ppb. The use of Whatman No.1 chromatographic paper has allowed to improve the sensitivity towards the detection of heavy metals, because of the porosity that allowed to pre-concentrate species. This led to an improvement in the sensitivity, with a detection limit of 0.3 and 0.5 ppb, respectively, to cadmium and lead, and offers the possibility to tune the sensitivity according to needs, e.g., improving the number of pre-concentration steps. Subsequently, the application of the electrochemical sensor in drinking water, mussel and blood serum was evaluated, demonstrating how these hybrid polyester-paper electrochemical strips can significantly lower the time and costs for on-site measurements, through analytical methods of simple use. The accuracy has been evaluated by comparison with ICP-MS measurements, giving satisfactory results

The August 17, 1999 Izmit, Turkey, earthquake: slip distribution from dislocation modeling of DInSAR and surface offset

We show the results of application of Differential SAR Interferometry to the MW 7.4, August 17, 1999, Izmit earthquake, Western Turkey. The differential interferogram is obtained using an interferometric ERS2 ascending pair with a time interval of 35 days (August 13th - September 17th). The fringe pattern clearly defines the coseismic displacement field extended in an area of about 100 km N-S and 120 km E-W. The analysis of the interferogram shows the right-lateral strike-slip movement on the activated section of the North Anatolian fault system. The maximum SAR-detected displacement ranges between 117.6 cm and 134.4 cm in the proximity of Gölcük. We invert SAR data for uniform dislocation on a single fault plane using a Montecarlo procedure, with the aim of testing a large set of a priori possible asperity distributions on the fault. We then use a forward modeling approach to evaluate the slip variability for the dislocation using additional constraints as surface offsets and seismicity distribution: in this case we allow unit cells to undergo different values of slip in order to refine the initial dislocation model. Misfits between SAR data and modeled slant range displacements are generally low for all our models (~ 12 cm). Our results indicate that slip is concentrated in the central-western part of the fault, in the upper 10-15 km, tapering to the fault tips. For the Izmit case, we note that a well constrained fault model can be obtained only integrating DInSAR data with additional observations. This is mainly due to an undersampling of the displacement field by DInSAR, caused by decorrelation and lack of image data

Validation of an optical, computer-assisted technique for intraoperative tracking of 3-dimensional canine stifle joint motion

Background: Cranial cruciate ligament (CCL) rupture is the most common orthopedic pathology in dog and in men. In human, optical computer-assisted technique is considered as a repeatable and reliable method for the biomechanical assessment of joint kinematics and laxity in case of CCL surgery. Aim: To evaluate the repeatability and reliability afforded by clinical tests in terms of laxity measured by means of a computer-assisted tracking system in two canine CCL conditions: CCL-Intact, CCL-Deficient. Methods: Fourteen fresh frozen canine stifles were passively subjected to Internal/External (IE) rotation at 120\ub0 of flexion and Cranial drawer test (CC). To quantify the repeatability and the reliability, intra-class correlation coefficient (ICC) and the mean percent error were evaluated (\u394 r %). Results: The study showed a very good intra-class correlation, before and after CCL resection for kinematics tests. It was found a minimum ICC = 0.73 during the IE rotation in CCL-Intact and a maximum value of ICC = 0.97 for the CC displacement in CC-Deficient. IE rotation with CCL-Intact is the condition with the greatest \u394 r % = 14%, while the lowest \u394 r % = 6% was obtained for CC displacement in CCL-Deficient. Conclusion: The presented work underlined the possibility of using a computer-assisted method also for biomechanical studies concerning stifle kinematics and laxity