Blood Coagulation Changes at High Altitude

The current concepts of blood coagulation changes in the pathogenesis of acute mountain sickness (AMS), high altitude pulmonary oedema (HAPO), high altitude pulmonary hypertension (HAPH) and chronic mountain sickness(CMS) which afflict the inductees and residents at high altitude have been reviewed. Hypercoagulable state which is more marked during the first few days of exposure is countered by enhanced fibrinolytic activity and accelerated cell mediated immunity. Magnesium levels are increased in normal residents at high altitudes and may be responsible for enhancing fibrinolytic activity and accelerating immune responses. Magnesium levels are significantly reduced in HAPO patients. Judicious use of furosemide in lower dosage is still the mainstay of treatment of HAPO and AMS

Seed dormancy and endogenous growth substances in Anab-e-Shahi grapes

Auxin, gibberellin and inhibitor contents were estimated in the freshly extracted seeds as well as in those moist stratified for 30, 45, 60, 75 and 90 days. The maximum seed germination was obtained when the seeds were stratified for 60 days. Auxin activity increased with the increase in the period of stratification and was found to be at its maximum in the germinating seeds. Fully ripe freshly extracted seeds did not show any gibberellin-like activity. It was maximum in the extracts of the seeds moist-stratified for 60 days. Abscisic acid-like inhibitor was present in the extracts of the fully ripe fresh seeds. Its quantity decreased with the period of stratification and was minimum when the seeds were stratified for 45 and 90 days. From these studies, it may be postulated that the seed germination in grapes is regulated by the appearance of growth promoting substances like auxins and gibberellins during stratification and disappearance of inhibitors like abscisic acid. In all the cultivars, stratification for 60 days was sufficient to create these conditions for the best seed germination.Samenruhe und endogene Wachstumsregulatoren bei der Rebensorte Anab-e-ShahiDer Gehalt an Auxin, Gibberellin und Hemmstoffen in frisch isolierten Samen von Anab-e-Shahi sowie in Samen, die 30, 45, 60, 75 und 90 Tage lang feucht stratifiziert worden waren, wurde bestimmt. Durch 60tägige Stratifikation wurde die Keimung am stärksten gefördert. Mit der Dauer der Stratifikation nahm auch die Auxinaktivität zu, um ihr Maximum in den keimenden Samen zu erreichen. Voll ausgereifte, frisch isolierte Samen zeigten keinerlei Gibberellin-artige Aktivität. Eine solche war in den Extrakten von Samen, die 60 Tage lang feucht stratifiziert worden waren, im Maximum vorhanden. In den Extrakten voll ausgereifter, frischer Samen trat ein Abscisinsäure-artiger Hemmstoff auf. Seine Konzentration nahm mit fortschreitender Stratifikation ab und erreichte ihr Minimum nach 45 und 90 Tagen. Aufgrund der vorliegenden Untersuchungen kann angenommen werden, daß die Samenkeimung bei Reben durch das verstärkte Auftreten wachstumsfördernder Substanzen wie Auxine und Gibberelline im Laufe der Stratifikation und den Rückgang Abscisinsäure-artiger Hemmstoffe reguliert wird. Auch bei anderen Rebensorten genügte durchweg eine 60tägige Stratifikation, um die bestmöglichen Bedingungen für die Samenkeimung zu schaffen

Non-invasive single-bunch matching and emittance monitor

On-line monitoring of beam quality for high brightness beams is only possible using non-invasive instruments. For matching measurements, very few such instruments are available. One candidate is a quadrupole pick-up. Therefore, a new type of quadrupole pick-up has been developed for the 26 GeV Proton Synchrotron (PS) at CERN, and a measurement system consisting of two such pick-ups is now installed in this accelerator. Using the information from these pick-ups, it is possible to determine both injection matching and emittance in the horizontal and vertical planes, for each bunch separately. This paper presents the measurement method and some of the results from the first year of use, as well as comparisons with other measurement methods.Comment: 10 pages, 10 figures; added figure, minor textual additions; To be resubmitted to Phys. Rev. ST-A

Synthesis, Characterization and Role of Anions (Nitrate, Sulphate, Oxalate and Acetate) \in the Biological Activity of Hydrazine Derived Compounds and Their Metal Chelates

Hydrazine derived compounds and its Co(II), Cu(II) and Ni(II) chelates having the same metal ion but different anions (e.g., nitrate, sulphate, oxalate and acetate) have been synthesised and characterised by their physical, spectral and analytical data. In order to evaluate the participating role of anions in the antibacterial activity, these synthesised ligands and its metal chelates have been screened against bacterial species such as Staphylococcus aureous, pseudomonas aeruginosa, Klebsiella pneumonae and Proteus vulgarus, and the results are reported

Integrating Technology and Heritage Design for Climate Resilient Courtyard House in Arid Region

This research has investigated the sustainability and climate resilience of courtyard houses of adobe architecture in the UAE. It analyzed design effectiveness in terms of power consumption, CO2 emissions, thermal comfort, and daylight use, employing simulations to assess building structures and construction systems. Adopting a three-phase mixed-methods approach, the study began with a literature review on courtyard house design, construction, and environmental performance, emphasizing sustainable design and passive ventilation. The second phase involved a case study of a UAE courtyard house (Al Midfa), including site visits, interviews, and energy consumption and CO2 emission data collection. The final phase used building energy simulation software to model energy performance and evaluate passive ventilation's role in reducing energy consumption and CO2 emissions, with simulation results validated against real-world data. Advanced Sefaira simulations with the Energy Plus Engine identified one out of seven modified models (M5) as exceptionally thermally efficient, influencing the architectural design of the Al Midfa house. To transform the Al Midfa house into a sustainable climate-resistant structure, the research suggested retrofitting with new glazing and insulation on the inside of external walls and on the roof surface at a combined U-value of 0.4 W/m2to enhance energy efficiency without altering the exterior. A notable innovation was the use of injected cellulose insulation in wall systems, combining efficient insulation with architectural aesthetics, signifying a shift towards energy-efficient interior modifications. The study's findings contribute to the evolution of traditional house designs toward climate change resilience and a sustainable future. Doi: 10.28991/CEJ-2024-010-03-018 Full Text: PD

Synthesis, Characterization and Biological Properties of Anions of Bivalent Transition Metal [Co(II) and Ni(II)] Complexes With Acylhydrazine Derived ONO Donor Schiff Bases

Some acylhydrazine derived ONO donor Schiff bases and their Co(II) and Ni(II) complexes have been prepared having the same metal ion (cation) but different anions. These synthesized metal(II) complexes have been characterized on the basis of their elemental analyses, magnetic moment, molar conductance, and IR and electronic spectral data. All of the Schiff base ligands function as tridentates and the deprotonated enolic form is preferred for coordination. In order to evaluate the effect of anions on the bactericidal activity, these synthesized complexes, in comparison to the uncomplexed Schiff bases have been screened against bacterial species., Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa and the results are reported

Screening of systemic fungicides and biochemicals against seed borne mycoflora associated with Momordica charantia

Study of seed borne fungi associated with bitter gourd seeds were conducted under in vitro condition in Department of Plant Pathology, Bahauddin Zakariya University, Multan, Pakistan. Two hundred (200) seed samples of Momordica charantia (bitter gourd) were collected from southern regions of Punjab province (Multan, Khanewal and Bahawalpur). Six fungal species were isolated out of which Aspergillus flavus showed highest percentage that is, 27.3% followed by Rhizopus stolonifer 17.98%, Alternaria alternata 13.34%, Aspergillus niger 5.23%, Myrothecium roridum 7.37% and Fusarium solani 6.69%. More number of fungi was observed by using blotter paper technique when compared with agar plate method. Of the three systemic fungicides used include ridomil gold MZ, bavistin, and score; and two low cost chemicals such as salicylic acid and boric acid. Ridomil gold MZ gave good results at all concentrations (20, 30 and 40 mg/10 ml) against all the isolated fungi compared with other fungicides. Salicyclic acid gave the best results against isolated fungi compared to boric acid.Key words: Myrothecium roridum, bitter gourd, salicyclic acid, southern Punjab, bavistin, Pakistan

Synthesis, Ligational and Biological Properties of Cobalt(II), Copper(II), Nickel(II) and Zinc(II) Complexes With Pyrazinedicarboxaimide Derived Furanyl, Thienyl and Pyrrolyl Compounds

Preparation, ligational and biological properties of some pyrazinedicarboxaimide derived furanyl, thienyl and pyrrolyl compounds with Co(ll), Cu(ll), Ni(ll) and Zn(ll) metals are described. Magnetic moments, electronic, infrared, nuclear magnetic resonance spectra and elemental analysis data indicate that co-ordination of the ligands with the metal ions take place through the pyrazine ring nitrogen, azomethine nitrogen and heteroatom of heterocyclic ring system. The compounds are all novel and are proposed to possess an octahedral geometry for Co(ll) and Ni(ll), and a distorted octahedral geometry for Cu(ll) and Zn(ll) complexes. The comparative biological properties of the title ligands and their metal chelates against different bacterial species are also described

Measurement of the mean radial position of a lead ion beam in the CERN PS

The intensity of the lead ion beam in the PS, nominally 4×108 charges of Pb53+ per bunch, is too low for the closed orbit measurement system. However, for successful acceleration it is sufficient to know the mean radial position (MRP). A system was thus designed for simultaneous acquisition of revolution frequency and magnetic field. The frequency measurement uses a direct digital synthesiser (DDS), phase-locked to the beam signal from a special high-sensitivity pick-up. The magnetic field is obtained from the so-called B-train. From these two values, the MRP is calculated. The precision depends on the frequency measurement and on the accuracy of the value for the magnetic field. Furthermore, exact knowledge of the transition energy is essential. This paper describes the hardware and software developed for the MRP system, and discusses the issue of calibration, with a proton beam, of the B measurement