Social issues in A. Madhavan's Stories

It is said that literature is a mirror that reflects human life. They attempt to guide and guide human life by pointing to the social situation by reflecting the society in which man lives. A. Madhavan is a native of Nanjil nadu. He is now a tamil writer living in Thiruvananthapuram. He used to trade in 'Salai', a commercial street in the heart of Thiruvananthapuram, and based on the experiences and characters he encountered in his daily business life, he has created stories in a Tamil style mixed with Malayalam. Thus, the social problems that A. Madhavan expresses in his stories are examined in detail here

A. Madhavan Characterization in Short Stories

Madhavan is a Tamil writer from Thiruvananthapuram. He was a businessman in a commercial street called 'Salai' located in the heart of Thiruvananthapuram. His works are based on his experiences and roles in his daily business life, in Malayalam mixed with Tamil. Many of his works have been translated into English, Telugu, Kannada and Malayalam. He has received the Vishnupuram Literary Award for the year 2010 and the Sahitya Akademi Award for the year 2015. Characterization is an essential element in a literary work. When we think of a story, what comes to our mind should be the characters in it. Kambar's 'Raman', Silamb's 'Kannagi', Manonmaniam's 'Kudilanum', Kalki's 'Sivakami' and Jayakanthan's 'Ganga' are specially talked about because of their creative style. In this regard, this article examines the style of character creation in A. Madhavan's stories

Chemoenzymatic Probes for Detecting and Imaging Fucose-α(1-2)-galactose Glycan Biomarkers

The disaccharide motif fucose-α(1-2)-galactose (Fucα(1-2)Gal) is involved in many important physiological processes, such as learning and memory, inflammation, asthma, and tumorigenesis. However, the size and structural complexity of Fucα(1-2)Gal-containing glycans have posed a significant challenge to their detection. We report a new chemoenzymatic strategy for the rapid, sensitive detection of Fucα(1-2)Gal glycans. We demonstrate that the approach is highly selective for the Fucα(1-2)Gal motif, detects a variety of complex glycans and glycoproteins, and can be used to profile the relative abundance of the motif on live cells, discriminating malignant from normal cells. This approach represents a new potential strategy for biomarker detection and expands the technologies available for understanding the roles of this important class of carbohydrates in physiology and disease

A prospective study on the impact of gestational diabetes mellitus on auditory function in newborn

Background: Gestational diabetes is a potential risk factor for neonatal hearing loss. Increased circulating sugars in mothers during pregnancy can impair the micro circulation and can cause congenital anomalies of the inner ear resulting in congenital hearing loss. Prevalence of deafness in neonates of mothers with diabetes mellitus is 4.16%. Otoacoustic emissions (OAE) and brainstem evoked response audiometry (BERA), are used to evaluate hearing impairment. Methods: This prospective case-control study was conducted by the Department of Obstetrics and Gynecology, among 92 antenatal mothers between the age of 21 to 35 years, who were classified into two groups, based on their gestational diabetes status. All these newborns were screened for hearing as per universal protocol using OAE within 72 hours of birth and on the 10th day. The aim of the study is to ascertain the effects of gestational diabetes mellitus on auditory function in newborns. Results: In this study a total of 92 pregnant women were selected and divided into two groups, A and B. The mean age was observed as 27.8±5.4 year. On assessment done within 72 hours after birth, 39.1% (18) of the neonates in group A failed in OAE, whereas only 8.7% (4) of the neonates in group B failed in OAE. Children born to mother with gestational diabetes mellitus are at a 6.7 times higher risk to develop congenital hearing loss. Conclusions: This present study shows a significant association between gestational diabetes mellitus and neonatal hearing impairment. Neonates born to GDM mothers had higher failure rate in OAE screening compared to neonates born to non-GDM mothers

Effectiveness of music therapy and reminiscence therapy on depressive symptoms among elderly people in selected geriatric home, Chennai; Pilot study

Introduction:With ageing, the likelihood of experiencing age-related health issues increase. Other than systemic diseases, many people experience mental illnesses in old age.Music and reminiscence therapy has been proposed as a potentially effective strategy for elderly geriatric home residents with depressive symptoms.Methods:In this pilot study, residents of elderly were evaluated for depressive symptoms through revised geriatric depression scale, and modified beck depression inventory respectively.Music and reminiscence therapy were applied to them and post-intervention assessment was done using the same scales.Results:Depressive symptoms showed a mean reduction in score but statistically not significant. When graded into severity, outcomes showed improvement from higher severity grade to lower grade in post-intervention assessment. The intervention resulted in an reduction of depressive symptoms.Conclusions:The study found music and reminiscence therapy could be encouraging in Indian settings. Hence, we recommend for further exploration of the long-term effects of this program, its feasibility, cost-effectiveness, and validation of the content for large-scale implementation

BIOANALYSIS METHOD DEVELOPMENT AND VALIDATION OF SMALL MOLECULES IN PHARMACEUTICAL INDUSTRY: A BIOANALYST REVIEW POINT

The focus of bioanalysis employed for the quantitative determination of an active analyte(s) and their metabolite(s) in the biological matrix such as plasma, serum, blood, cerebrospinal fluid, and tissues. The extraction of analyte and metabolite in the biological fluids is carried out using different separation methods such as protein precipitation, liquid-liquid extraction, and solid phase extraction. Bioanalytical method development and validation in the pharmaceutical industry are to provide an assessment and interpretation of pharmacokinetics, pharmacodynamics, toxicokinetics, bioavailability/bioequivalence, and therapeutic drug monitoring relationships. This review paper aims to provide a simple and accurate scientific background to improve the quality for development and validation of a bioanalytical method for small molecules with industrial technique as per regulatory agency requirements (United States Food and Drug Administration, EMEA, International Council for Harmonisation and ANVISA)

Prediction of Indoor Air Quality in a School Building Using Risk Model

Source: ICHE Conference Archive - https://mdi-de.baw.de/icheArchiv