Neural mechanisms of interstimulus interval-dependent responses in the primary auditory cortex of awake cats

<p>Abstract</p> <p>Background</p> <p>Primary auditory cortex (AI) neurons show qualitatively distinct response features to successive acoustic signals depending on the inter-stimulus intervals (ISI). Such ISI-dependent AI responses are believed to underlie, at least partially, categorical perception of click trains (elemental vs. fused quality) and stop consonant-vowel syllables (eg.,/da/-/ta/continuum).</p> <p>Methods</p> <p>Single unit recordings were conducted on 116 AI neurons in awake cats. Rectangular clicks were presented either alone (single click paradigm) or in a train fashion with variable ISI (2–480 ms) (click-train paradigm). Response features of AI neurons were quantified as a function of ISI: one measure was related to the degree of stimulus locking (temporal modulation transfer function [tMTF]) and another measure was based on firing rate (rate modulation transfer function [rMTF]). An additional modeling study was performed to gain insight into neurophysiological bases of the observed responses.</p> <p>Results</p> <p>In the click-train paradigm, the majority of the AI neurons ("synchronization type"; <it>n </it>= 72) showed stimulus-locking responses at long ISIs. The shorter cutoff ISI for stimulus-locking responses was on average ~30 ms and was level tolerant in accordance with the perceptual boundary of click trains and of consonant-vowel syllables. The shape of tMTF of those neurons was either band-pass or low-pass. The single click paradigm revealed, at maximum, four response periods in the following order: 1st excitation, 1st suppression, 2nd excitation then 2nd suppression. The 1st excitation and 1st suppression was found exclusively in the synchronization type, implying that the temporal interplay between excitation and suppression underlies stimulus-locking responses. Among these neurons, those showing the 2nd suppression had band-pass tMTF whereas those with low-pass tMTF never showed the 2nd suppression, implying that tMTF shape is mediated through the 2nd suppression. The recovery time course of excitability suggested the involvement of short-term plasticity. The observed phenomena were well captured by a single cell model which incorporated AMPA, GABA_A, NMDA and GABA_Breceptors as well as short-term plasticity of thalamocortical synaptic connections.</p> <p>Conclusion</p> <p>Overall, it was suggested that ISI-dependent responses of the majority of AI neurons are configured through the temporal interplay of excitation and suppression (inhibition) along with short-term plasticity.</p

Optimal Control of Saccades by Spatial-Temporal Activity Patterns in the Monkey Superior Colliculus

A major challenge in computational neurobiology is to understand how populations of noisy, broadly-tuned neurons produce accurate goal-directed actions such as saccades. Saccades are high-velocity eye movements that have stereotyped, nonlinear kinematics; their duration increases with amplitude, while peak eye-velocity saturates for large saccades. Recent theories suggest that these characteristics reflect a deliberate strategy that optimizes a speed-accuracy tradeoff in the presence of signal-dependent noise in the neural control signals. Here we argue that the midbrain superior colliculus (SC), a key sensorimotor interface that contains a topographically-organized map of saccade vectors, is in an ideal position to implement such an optimization principle. Most models attribute the nonlinear saccade kinematics to saturation in the brainstem pulse generator downstream from the SC. However, there is little data to support this assumption. We now present new neurophysiological evidence for an alternative scheme, which proposes that these properties reside in the spatial-temporal dynamics of SC activity. As predicted by this scheme, we found a remarkably systematic organization in the burst properties of saccade-related neurons along the rostral-to-caudal (i.e., amplitude-coding) dimension of the SC motor map: peak firing-rates systematically decrease for cells encoding larger saccades, while burst durations and skewness increase, suggesting that this spatial gradient underlies the increase in duration and skewness of the eye velocity profiles with amplitude. We also show that all neurons in the recruited population synchronize their burst profiles, indicating that the burst-timing of each cell is determined by the planned saccade vector in which it participates, rather than by its anatomical location. Together with the observation that saccade-related SC cells indeed show signal-dependent noise, this precisely tuned organization of SC burst activity strongly supports the notion of an optimal motor-control principle embedded in the SC motor map as it fully accounts for the straight trajectories and kinematic nonlinearity of saccades

An assessment of uncertainties in V S profiles obtained from microtremor observations in the phased 2018 COSMOS blind trials

Site response is a critical consideration when assessing earthquake hazards. Site characterization is key to understanding site effects as influenced by seismic site conditions of the local geology. Thus, a number of geophysical site characterization methods were developed to meet the demand for accurate and cost-effective results. As a consequence, a number of studies have been administered periodically as blind trials to evaluate the state-of-practice on-site characterization. We present results from the Consortium of Organizations for Strong Motion Observation Systems (COSMOS) blind trials, which used data recorded from surface-based microtremor array methods (MAM) at four sites where geomorphic conditions vary from deep alluvial basins to an alpine valley. Thirty-four invited analysts participated. Data were incrementally released to 17 available analysts who participated in all four phases: (1) two-station arrays, (2) sparse triangular arrays, (3) complex nested triangular or circular arrays, and (4) all available geological control site information including drill hole data. Another set of 17 analysts provided results from two sites and two phases only. Although data from one site consisted of recordings from three-component sensors, the other three sites consisted of data recorded only by vertical-component sensors. The sites cover a range of noise source distributions, ranging from one site with a highly directional microtremor wave field to others with omni-directional (azimuthally distributed) wave fields. We review results from different processing techniques (e.g., beam-forming, spatial autocorrelation, cross-correlation, or seismic interferometry) applied by the analysts and compare the effectiveness between the differing wave field distributions. We define the M index as a quality index based on estimates of the time-averaged shear-wave velocity of the upper 10 (VS10), 30 (VS30), 100 (VS100), and 300 (VS300) meters and show its usefulness in quantitative comparisons of VS profiles from multiple analysts. Our findings are expected to aid in building an evidence-based consensus on preferred cost-effective arrays and processing methodology for future studies of seismic site effects

Surface wave group velocity in the Osaka sedimentary basin, Japan, estimated using ambient noise cross-correlation functions

Inter-station cross-correlation functions estimated using continuous ambient noise or microtremor records were used to extract the seismic wave propagation characteristics of the Osaka sedimentary basin, Japan. Temporary continuous observations were conducted at 15 sites in the Osaka basin between 2011 and 2013. The data were analyzed using seismic interferometry. The target period range was 2–8 s. Cross-correlations between all of the possible station pairs were calculated and stacked to produce a year-long data set, and Rayleigh wave signals in the vertical and radial components and Love wave signals in the transverse component were identified from the results. Simulation of inter-station Green’s functions using the finite difference method was conducted to check the performance of the current three-dimensional velocity structure model. The measured time lag between the observed and theoretical Green’s functions was less than 2 s for most station pairs, which is less than the wave period of interest in the target frequency range. Group velocity tomography was applied to group delay times estimated by means of multiple filter analysis. The estimated group velocities for longer periods of 5–8 s exhibited spatial variation within the basin, which is consistent with the bedrock depth distribution; however, the group velocities for shorter periods of 2–3 s were almost constant over the studied area. The waveform and group velocity information obtained by seismic interferometry analysis can be useful for future reconstruction of a three-dimensional velocity structure model in the Osaka basin