Incidence of Sarcoma Histotypes and Molecular Subtypes in a Prospective Epidemiological Study with Central Pathology Review and Molecular Testing

International audienceBACKGROUND: The exact overall incidence of sarcoma and sarcoma subtypes is not known. The objective of the present population-based study was to determine this incidence in a European region (Rhone-Alpes) of six million inhabitants, based on a central pathological review of the cases. METHODOLOGY/PRINCIPAL FINDINGS: From March 2005 to February 2007, pathology reports and tumor blocks were prospectively collected from the 158 pathologists of the Rhone-Alpes region. All diagnosed or suspected cases of sarcoma were collected, reviewed centrally, examined for molecular alterations and classified according to the 2002 World Health Organization classification. Of the 1287 patients screened during the study period, 748 met the criteria for inclusion in the study. The overall crude and world age-standardized incidence rates were respectively 6.2 and 4.8 per 100,000/year. Incidence rates for soft tissue, visceral and bone sarcomas were respectively 3.6, 2.0 and 0.6 per 100,000. The most frequent histological subtypes were gastrointestinal stromal tumor (18%; 1.1/100,000), unclassified sarcoma (16%; 1/100,000), liposarcoma (15%; 0.9/100,000) and leiomyosarcoma (11%; 0.7/100,000). CONCLUSIONS/SIGNIFICANCE: The observed incidence of sarcomas was higher than expected. This study is the first detailed investigation of the crude incidence of histological and molecular subtypes of sarcomas

Is the rhythm of vertical migration of Daphnia longispina circadian or simply nycthemeral ?

From an ecological viewpoint, diel vertical migration (DVM) of zooplankton is an adapted response to environmental factors. DVM coincides with changes in light intensity, but persists also under constant illumination conditions. This fact suggests the existence of an internal clock. In Daphnia longispina, it could be located in the eye. Indeed, the spatial distribution of the pigments containing in the eye ommatidia exhibits significant changes over time when Daphnia are kept under light/dark (LD) conditions. These variations coincide with displacements of the organisms. Furthermore, it is observed that the blue/dark conditions, which inhibit DVM, also stop changes in the distribution of pigments in the ommatidia. The modifications of the eye observed under LD white light represent either the internal clock or its manifestation

Structuration of the genetic diversity in sunflower cultivars using RFLPs

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Les émissions d'ammoniac d'origine agricole dans l'atmosphère: État des connaissances et perspectives de réduction des émissions

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Les émissions d'ammoniac d'origine agricole dans l'atmosphère: État des connaissances et perspectives de réduction des émissions

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