Wavelet-based Techniques in MRS

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Estimation of metabolite T1 relaxation times using tissue specific analysis, signal averaging and bootstrapping from magnetic resonance spectroscopic imaging data

Object A novel method of estimating metabolite T1 relaxation times using MR spectroscopic imaging (MRSI) is proposed. As opposed to conventional single-voxel metabolite T1 estimation methods, this method investigates regional and gray matter (GM)/white matter (WM) differences in metabolite T1 by taking advantage of the spatial distribution information provided by MRSI

In vivo magnetic resonance spectroscopy: basic methodology and clinical applications

The clinical use of in vivo magnetic resonance spectroscopy (MRS) has been limited for a long time, mainly due to its low sensitivity. However, with the advent of clinical MR systems with higher magnetic field strengths such as 3 Tesla, the development of better coils, and the design of optimized radio-frequency pulses, sensitivity has been considerably improved. Therefore, in vivo MRS has become a technique that is routinely used more and more in the clinic. In this review, the basic methodology of in vivo MRS is described—mainly focused on 1H MRS of the brain—with attention to hardware requirements, patient safety, acquisition methods, data post-processing, and quantification. Furthermore, examples of clinical applications of in vivo brain MRS in two interesting fields are described. First, together with a description of the major resonances present in brain MR spectra, several examples are presented of deviations from the normal spectral pattern associated with inborn errors of metabolism. Second, through examples of MR spectra of brain tumors, it is shown that MRS can play an important role in oncology

In vivo short echo time localized 1H MRS of the rat brain at 7T: influence of two strategies of background-accommodation on the metabolite concentration estimation using QUEST

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MRS 2D quantification vs 1D quantification

International audienc

Novel quantification strategy for in vivo 2D J-Resolved spectroscopy

International audienc

Estimation d\textquoterightune mixture de gaussiennes par l\textquoterightalgorithme d\textquoterightEspérance-Maximisation pour la modélisation des signaux de macromolécules acquis par inversion-récupération

International audienc

Simultaneous two-channel mice brain chemical shift imaging using a standard Biospec spectrometer

International audienc