6 research outputs found
Circulation et archipels de l'exception
Ce numĂ©ro de Cultures & Conflits est le reflet des prĂ©occupations de nombreux chercheurs concernant les implications de certaines pratiques sur les libertĂ©s contemporaines. Le fil dâAriane que suivent les contributions concerne la circulation des personnes, leur droit, leur libertĂ© et leur dĂ©sir de mouvement Ă lâĂ©chelle internationale, ou la possibilitĂ© de pouvoir rester sur place. Ils analysent aussi la volontĂ© de contrĂŽle des gouvernements, y compris dĂ©mocratiques, de filtrer et trier ceux qui sont dĂ©sirables et ceux qui sont indĂ©sirables, et de recenser et de garder en mĂ©moire ces mouvements. Ils sâinterrogent enfin sur la mobilitĂ© et sa remise en cause par un appesantissement de la surveillance au nom de la prĂ©vention qui sâopĂ©rationnalise dans des contrĂŽles a priori sâappuyant sur des logiques de suspicion portant sur des groupes particuliers. Ce contrĂŽle de la circulation dĂ©bouche souvent sur des pratiques illibĂ©rales, et il gĂ©nĂšre des archipels dâexception sâil nâest pas lui mĂȘme soumis Ă des rĂšgles de contrĂŽle dĂ©mocratique. This issue of Cultures & Conflits reflects the concerns of many researchers about the implications of certain practices on contemporary liberties. The common thread running through the contributions relates to the circulation of people, their rights, their liberty and their desire to move internationally, or their possibility of remaining where they are. They analyze governmentsâ (including democratic governmentsâ) desire to control, to filter, to sort those who are desirable and those who are undesirable, and to take censuses and keep records of these movements. Furthermore, they look at the question of mobility, and its limitation through the increase of the use of surveillance in the name of prevention, that takes place through a priori controls based upon the logic of suspicion towards particular groups. If it is not subject to the rules of democratic control this control of circulation often leads to illiberal practices, and generates zones of exception
Reversible cardiac fibrosis and heart failure induced by conditional expression of an antisense mRNA of the mineralocorticoid receptor in cardiomyocytes
Cardiac failure is a common feature in the evolution of cardiac disease. Among the determinants of cardiac failure, the reninâangiotensinâaldosterone system has a central role, and antagonism of the mineralocorticoid receptor (MR) has been proposed as a therapeutic strategy. In this study, we questioned the role of the MR, not of aldosterone, on heart function, using an inducible and cardiac-specific transgenic mouse model. We have generated a conditional knock-down model by expressing solely in the heart an antisense mRNA directed against the murine MR, a transcription factor with unknown targets in cardiomyocytes. Within 2â3 mo, mice developed severe heart failure and cardiac fibrosis in the absence of hypertension or chronic hyperaldosteronism. Moreover, cardiac failure and fibrosis were fully reversible when MR antisense mRNA expression was subsequently suppressed