Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus

Obesity has reached epidemic proportions in several regions of the world. General changes in lifestyle, including consumption of fat-rich food, are among the most important factors leading to an unprecedented increase in the prevalence of this disease. Weight gain results from an imbalance between caloric intake and energy expenditure. Both of these parameters are under the tight control of specialized neurons of the hypothalamus that respond to peripheral anorexigenic and adipostatic signals carried by leptin and insulin. Here we show, by macroarray analysis, that high-fat feeding [hyperlipidic diet (HL)] induces the expression of several proinflammatory cytokines and inflammatory responsive proteins in hypothalamus. This phenomenon is accompanied by increased activation of c-Jun N-terminal kinase and nuclear factor-kappa B. In addition, HL feeding leads to impaired functional and molecular activation of the insulin-signaling pathway, which is paralleled by increased serine phosphorylation of the insulin receptor and insulin receptor substrate-2. Intracerebroventricular treatment of HL rats with a specific inhibitor of c-Jun N-terminal kinase (SP600125) restores insulin signaling and leads to a reduced caloric intake and weight loss. We conclude that HL feeding induces a local proinflammatory status in the hypothalamus, which results in impaired anorexigenic insulin signaling.o TEXTO COMPLETO DESTE ARTIGO, ESTARÁ DISPONÍVEL À PARTIR DE AGOSTO DE 2015.146104192419

aidenybai/million: v2.6.0

What's Changed Update for.mdx by @viclafouch in https://github.com/aidenybai/million/pull/513 doc: updated contributing guide by @Timonwa in https://github.com/aidenybai/million/pull/520 feat: create kitchen sink by @aidenybai in https://github.com/aidenybai/million/pull/525 fixed your README links :) by @Sidd-underscore in https://github.com/aidenybai/million/pull/527 chore: Make sure to correctly attribute MIT license by @AbhiPrasad in https://github.com/aidenybai/million/pull/528 Fix 529: Background screen flash on reload by @sshkeda in https://github.com/aidenybai/million/pull/530 version on react + run prettier by @rishi-raj-jain in https://github.com/aidenybai/million/pull/537 fix typo for conflicts in docs:install.mdx by @mkanyar in https://github.com/aidenybai/million/pull/538 hotfix: contexts by @aidenybai in https://github.com/aidenybai/million/pull/545 Extend JSX Binary Operations Evaluation by @poteboy in https://github.com/aidenybai/million/pull/546 New kitchen sink carousel example added by @oliverloops in https://github.com/aidenybai/million/pull/550 fix(compiler): Directly import babel plugins by @AbhiPrasad in https://github.com/aidenybai/million/pull/533 Calculator example added by @oliverloops in https://github.com/aidenybai/million/pull/559 fix: spread attributes by @aidenybai in https://github.com/aidenybai/million/pull/565 docs: add bun to installation methods by @kul-sudo in https://github.com/aidenybai/million/pull/573 Updated Twitter Icon to X by @lalitkumawat1m in https://github.com/aidenybai/million/pull/574 feat: million cli by @kunal00000 in https://github.com/aidenybai/million/pull/572 Million cli by @kunal00000 in https://github.com/aidenybai/million/pull/578 feat: add common errors to docs by @tobySolutions in https://github.com/aidenybai/million/pull/579 fix(typo): extentions -> extensions by @hiro0218 in https://github.com/aidenybai/million/pull/580 docs: add bun to @tanstack/react-virtual@beta installation methods by @kul-sudo in https://github.com/aidenybai/million/pull/582 feat: implement hmr by @aidenybai in https://github.com/aidenybai/million/pull/587 feat: copy sentry telemetry by @aidenybai in https://github.com/aidenybai/million/pull/583 New Contributors @viclafouch made their first contribution in https://github.com/aidenybai/million/pull/513 @Timonwa made their first contribution in https://github.com/aidenybai/million/pull/520 @Sidd-underscore made their first contribution in https://github.com/aidenybai/million/pull/527 @AbhiPrasad made their first contribution in https://github.com/aidenybai/million/pull/528 @sshkeda made their first contribution in https://github.com/aidenybai/million/pull/530 @rishi-raj-jain made their first contribution in https://github.com/aidenybai/million/pull/537 @mkanyar made their first contribution in https://github.com/aidenybai/million/pull/538 @kul-sudo made their first contribution in https://github.com/aidenybai/million/pull/573 @lalitkumawat1m made their first contribution in https://github.com/aidenybai/million/pull/574 @kunal00000 made their first contribution in https://github.com/aidenybai/million/pull/572 @hiro0218 made their first contribution in https://github.com/aidenybai/million/pull/580 Full Changelog: https://github.com/aidenybai/million/compare/v2.5.13...v2.6.

aidenybai/million: v2.6.0-beta.15

What's Changed Million cli by @kunal00000 in https://github.com/aidenybai/million/pull/578 Full Changelog: https://github.com/aidenybai/million/compare/v2.6.0-beta.14...v2.6.0-beta.1

aidenybai/million: v2.6.0-beta.14

What's Changed docs: add bun to installation methods by @kul-sudo in https://github.com/aidenybai/million/pull/573 Updated Twitter Icon to X by @lalitkumawat1m in https://github.com/aidenybai/million/pull/574 feat: million cli by @kunal00000 in https://github.com/aidenybai/million/pull/572 New Contributors @kul-sudo made their first contribution in https://github.com/aidenybai/million/pull/573 @lalitkumawat1m made their first contribution in https://github.com/aidenybai/million/pull/574 @kunal00000 made their first contribution in https://github.com/aidenybai/million/pull/572 Full Changelog: https://github.com/aidenybai/million/compare/v2.6.0-beta.13...v2.6.0-beta.1

aidenybai/million: v2.6.0-beta.16

What's Changed feat: add common errors to docs by @tobySolutions in https://github.com/aidenybai/million/pull/579 Full Changelog: https://github.com/aidenybai/million/compare/v2.6.0-beta.15...v2.6.0-beta.1