A segmented Hybrid Photon Detector with integrated auto-triggering front-end electronics for a PET scanner

We describe the design, fabrication and test results of a segmented Hybrid Photon Detector with integrated auto-triggering front-end electronics. Both the photodetector and its VLSI readout electronics are custom designed and have been tailored to the requirements of a recently proposed novel geometrical concept of a Positron Emission Tomograph. Emphasis is put on the PET specific features of the device. The detector has been fabricated in the photocathode facility at CERN

Nematicidal activity of the essential oil from Cinnamomum cassia and (E)‐cinnamaldehyde against phytoparasitic nematodes

The activity of Cinnamomum cassia essential oil (EO) and (E)-cinnamaldehyde was investigated on the phytoparasitic spe- cies Meloidogyne incognita, Globodera rostochiensis, and Xiphinema index. Juveniles (J2) or eggs of M. incognita and G. rostochiensis and mixed-age specimens of X. index were exposed to 12.5–100 μg mL −1 concentrations of the two products. The suppressiveness of soil treatments with 100–800 mg kg −1 soil rates of the C. cassia EO and (E)-cinnamaldehyde to M. incognita and G. rostochiensis was assessed on potted tomato and potato, respectively. A 24-h exposure to a 12.5 μg mL −1 solution of (E)-cinnamaldehyde resulted in more than 68% mortality of M. incognita J2, while a poor mortality occurred at the same concentration of the whole EO. The mortality of G. rostochiensis J2 ranged 39 and 42%, respectively, since after a 4-h exposure to a 12.5 μg mL −1 solution of both products. All the X. index specimens died after a 48- and 8-h exposure to a 100 μg mL −1 solution of the EO and (E)-cinnamaldehyde, respectively. Egg hatch was reduced by more than 90% after exposing the M incognita egg masses or the G. rostochiensis cysts to 800 μg mL −1 concentration of both EO and (E)- cinnamaldehyde for 24 and 96 h, respectively. The infestation of M. incognita and G. rostochiensis on tomato and potato, respectively, was significantly reduced by all soil treatments with both products, though (E)-cinnamaldehyde generally resulted more suppressive than the whole EO to both nematode species. According to these results, C. cassia EO and (E)- cinnamaldehyde could be suggested as a potential source of new environment-friendly nematicides

Relationship between chemical composition and nematicidal activity of different essential oils

In this study, the relationship between nematicidal activity and chemical composition of ten essential oils (EOs) from different plant species was investigated both in in vitro assays on juveniles (J2) and eggs of the root-knot nematode Meloidogyne incognita and in experiments on tomato in soil infested by M. incognita. Nematode J2 were exposed for 4, 8 or 24 h to 0.78–100 µg mL−1 concentrations of each EO, whereas 24, 48 or 96 h exposures to 250, 500 and 1000 µg mL−1 solutions were tested on M. incognita egg masses. Treatments with 50, 100 or 200 µg kg soil rates of each EO were applied in the experiment on potted tomato. The highest nematicidal potential resulted for the C. verum EO, as highly toxic to both M. incognita J2 and eggs and strongly suppressive on nematode multiplication on tomato roots. The infestation of M. incognita on tomato roots was also strongly reduced by the EOs from E. citriodora and S. aromaticum, both highly toxic to M. incognita J2 but less active on nematode eggs. Adversely, R. graveolens EO strongly inhibited the egg hatch but was limitedly toxic to the infective J2. Chemical composition of the EOs was determined by GC-FID and GC-MS. The ten EOs showed a very different chemical composition in terms of major phytochemicals, with one or two dominant components totally amounting up to 85%. The structure–activity relationship based on the main phytochemicals identified in the assayed EOs and their nematicidal effects on M. incognita was also discussed. Results from this study confirmed that the selection of suitable EO raw materials can lead to the formulation on new effective nematicidal products

Characterizing historical transformation trajectories of the forest landscape in Rome's metropolitan area (Italy) for effective planning of sustainability goals

With the aim at developing a landscape dynamics framework for environmental planning and management and testing the effectiveness of protected areas in achieving the 2030 Agenda of the United Nations sustainability goals, we characterized the historical transformation trajectories of forest area changes from 1936 to 2010 in the Metropolitan City of Rome Capital (Italy). Remote sensing-based products coupled with landscape pattern metrics and fragmentation analysis have been implemented, comparing different historical forest maps. The results show a remarkable forest area gain – from 17.6% to 25.5% – thanks to 68,299 ha of recently established forest. Statistical descriptors showed that the highest relative gain occurred in mountain zones, confirming a wide European forest recovery pattern in marginal areas from past deforestation and overexploitation. Deforestation mainly occurred in the flat and hilly areas where almost 26,000 ha of forests were lost since 1936. In summary, two main forest landscape dynamics were reconstructed: (I) the increase of forest cover fragmentation in the lowland areas; and (II) the rise in the forest area in the interior sectors of the mountain landscape, mainly within protected areas. Restoring the forest ecosystem's bioecological integrity has been highlighted as an urgent action for biodiversity conservation and carbon mitigation. In lowland areas, the study revealed the urgent need to establish new protected areas and rewilding spaces as landscape metrics are relatively below the sustainability targets for healthy forest ecosystems. The proposed framework can be used for testing the effectiveness of environmental planning and management in other forest landscapes to achieve the Agenda 2030 goals

Framing the Real: Lefèbvre and NeoRealist Cinematic Space as Practice

In 1945 Roberto Rossellini's Neo-realist Rome, Open City set in motion an approach to cinema and its representation of real life – and by extension real spaces – that was to have international significance in film theory and practice. However, the re-use of the real spaces of the city, and elsewhere, as film sets in Neo-realist film offered (and offers) more than an influential aesthetic and set of cinematic theories. Through Neo-realism, it can be argued that we gain access to a cinematic relational and multidimensional space that is not made from built sets, but by filming the built environment. On the one hand, this space allows us to "notice" the contradictions around us in our cities and, by extension, the societies that have produced those cities, while on the other, allows us to see the spatial practices operative in the production and maintenance of those contradictions. In setting out a template for understanding the spatial practices of Neo-realism through the work of Henri Lefèbvre, this paper opens its films, and those produced today in its wake, to a spatio-political reading of contemporary relevance. We will suggest that the rupturing of divisions between real spaces and the spaces of film locations, as well the blurring of the difference between real life and performed actions for the camera that underlies much of the central importance of Neo-realism, echoes the arguments of Lefèbvre with regard the social production of space. In doing so, we will suggest that film potentially had, and still has, a vital role to play in a critique of contemporary capitalist spatial practices

New live screening of plant-nematode interactions in the rhizosphere

Abstract Free living nematodes (FLN) are microscopic worms found in all soils. While many FLN species are beneficial to crops, some species cause significant damage by feeding on roots and vectoring viruses. With the planned legislative removal of traditionally used chemical treatments, identification of new ways to manage FLN populations has become a high priority. For this, more powerful screening systems are required to rapidly assess threats to crops and identify treatments efficiently. Here, we have developed new live assays for testing nematode responses to treatment by combining transparent soil microcosms, a new light sheet imaging technique termed Biospeckle Selective Plane Illumination Microscopy (BSPIM) for fast nematode detection, and Confocal Laser Scanning Microscopy for high resolution imaging. We show that BSPIM increased signal to noise ratios by up to 60 fold and allowed the automatic detection of FLN in transparent soil samples of 1.5 mL. Growing plant root systems were rapidly scanned for nematode abundance and activity, and FLN feeding behaviour and responses to chemical compounds observed in soil-like conditions. This approach could be used for direct monitoring of FLN activity either to develop new compounds that target economically damaging herbivorous nematodes or ensuring that beneficial species are not negatively impacted

Serum Amyloid P Therapeutically Attenuates Murine Bleomycin-Induced Pulmonary Fibrosis via Its Effects on Macrophages

Macrophages promote tissue remodeling but few mechanisms exist to modulate their activity during tissue fibrosis. Serum amyloid P (SAP), a member of the pentraxin family of proteins, signals through Fcγ receptors which are known to affect macrophage activation. We determined that IPF/UIP patients have increased protein levels of several alternatively activated pro-fibrotic (M2) macrophage-associated proteins in the lung and monocytes from these patients show skewing towards an M2 macrophage phenotype. SAP therapeutically inhibits established bleomycin-induced pulmonary fibrosis, when administered systemically or locally to the lungs. The reduction in aberrant collagen deposition was associated with a reduction in M2 macrophages in the lung and increased IP10/CXCL10. These data highlight the role of macrophages in fibrotic lung disease, and demonstrate a therapeutic action of SAP on macrophages which may extend to many fibrotic indications caused by over-exuberant pro-fibrotic macrophage responses

Early stage sinkhole formation in the acque albule basin of central Italy from geophysical and geochemical observations

Sinkhole occurrence along the Tyrrhenian margin of the Central Apennines is of great importance for applied research, land management and civil protection. This study reports on GPS-altimetry magnetic, gravity, geoelectric, seismic, and soil gas measurements of a rapidly developing sinkhole near the Guidonia military airport. The measurements revealed an elliptical 2-m depression elongated 220 m in the NNE-SSW direction with the minor axis of 110 m. In spring of 2013, two vertical cavities formed in the eastern and northeastern flanks of the depression whose depths and shapes are rapidly evolving with the formation of widespread fracturing along the same side. The geophysical observations image the developing sinkhole to a depth of some 50 m, the presence of the Travertino lithotype around the depression (down to at least 40 m), and the lack of this lithotype below the lowered area. The sinkhole's evolution appears to be structurally controlled by local and regional faulting. These results are useful for designing further geophysical, geotechnical and geochemical studies to monitor the sinkhole's evolution and to assess the hazard it presents in densely urbanized area.Published36-477A. Geofisica di esplorazioneJCR Journalreserve

Semantic Object Prediction and Spatial Sound Super-Resolution with Binaural Sounds

Humans can robustly recognize and localize objects by integrating visual and auditory cues. While machines are able to do the same now with images, less work has been done with sounds. This work develops an approach for dense semantic labelling of sound-making objects, purely based on binaural sounds. We propose a novel sensor setup and record a new audio-visual dataset of street scenes with eight professional binaural microphones and a 360 degree camera. The co-existence of visual and audio cues is leveraged for supervision transfer. In particular, we employ a cross-modal distillation framework that consists of a vision `teacher' method and a sound `student' method -- the student method is trained to generate the same results as the teacher method. This way, the auditory system can be trained without using human annotations. We also propose two auxiliary tasks namely, a) a novel task on Spatial Sound Super-resolution to increase the spatial resolution of sounds, and b) dense depth prediction of the scene. We then formulate the three tasks into one end-to-end trainable multi-tasking network aiming to boost the overall performance. Experimental results on the dataset show that 1) our method achieves promising results for semantic prediction and the two auxiliary tasks; and 2) the three tasks are mutually beneficial -- training them together achieves the best performance and 3) the number and orientations of microphones are both important. The data and code will be released to facilitate the research in this new direction.Comment: Project page: https://www.trace.ethz.ch/publications/2020/sound_perception/index.htm