Effect of Adding Stretching Techniques to Standardized Intervention on Nonspecific Mechanical Neck Pain

Mechanical neck pain is becoming one of the leading causes of musculoskeletal disorders in the general adult population. Mobilization intervention is considered one of the most effective therapeutic techniques to treat non-specific neck pain. The purpose of this study was to investigate the benefit of adding stretching exercises as part of a rehabilitation program for patients with non-specific mechanical neck pain. Methods: Thirty-eight subjects with non-specific neck pain for at least 2 weeks with mean± SD age 30.9±8.1 years and body mass index (BMI) 26.8±6.7 kg/m2 participated in the study. Participants were randomly assigned to either the combined intervention (passive cervical mobilization and stretching techniques) (n1=18) or standard intervention group (n2=20). The outcome measures were Cervical range of motion (CROM), Numeric Pain Rating scale, Neck Disability Index, Global Rating of Change (GROC), and pressure pain threshold. Results: There was a significant difference in mean CROM during extension over time (p=0.002, η2=0.20), and a significant group by time interaction (p=0.02). The percent improvement from baseline to 4 weeks later was significant between the combined intervention and standard intervention groups (18.9% vs. 3.0%; p=0.02). Also, there was a significant difference in mean CROM during right lateral flexion over time (p\u3c0.001, η2=0.30), and a significant group by time interaction (p=0.04). The percent improvement from baseline to 4 weeks was significant between the combined intervention and standard intervention groups (23.2% vs. 10.8%; p=0.04). However, subjective outcome measures including pain, patient’s satisfaction and neck disability index significantly improved overtime with no significant differences between the two study groups. Over time, there was a significant difference in mean right upper trapezius muscle pain threshold (p=0.02), and for GROC (p\u3c0.001, η2=0.54), however, there was no significant group by time interaction, and the improvement over time did not differ by study group (p\u3e0.05). Conclusions: Four weeks of combined techniques (cervical mobilization plus stretching exercises) showed to be more effective than standard intervention in terms of improving cervical extension and lateral flexion CROM

MRI Contrast Agents: Developments, Challenges, and Future Trends

Contrast agents in medicine are chemical materials used to improve tissue and fluid contrast in the body during medical imaging. It is mainly used in improving the visibility of blood vessels and the gastrointestinal tract. Some types of contrast materials are used in a medical imaging examination and can be classified according to the imaging technique used. The first contract agent dates back to 1988 which is called gadopentetate dimeglumine (Magnevist®) and was allocated for Magnetic Resonance Imaging (MRI). Then, I has become available in clinical use. Afterwards, many studies have examined the capability of MRI contrast agents to be used in diagnostic imaging in all parts of the body including the skin, the central nervous system, heart and circulation, breast, lungs, musculoskeletal and lymphatic systems, and even the gastrointestinal tract. Nowadays, MRI contrast agents are widely used in clinical practice and have expanded beyond the imitational expectations to be a key tool in disease diagnosis around the world. Contrast-Enhanced (CE) MRI keeps in development and new technologies have emerged and new agents were introduced, with great opportunity being provided to ensure better imaging and patient management practices. Also, new clinical challenges were associated with the progress in CE-MRI. This paper aims to overview the historical development of MRI and contrast materials in order to shed light on the clinical development of CE-MRI. Also, the paper overviews the contemporary perspectives and clinical challenges associated with CE-MRI with the provision of significant future trends

Superfast Set, Strong and Less Degradable Mineral Trioxide Aggregate Cement

Purpose. Despite the good sealing ability and biocompatibility of mineral trioxide aggregate (MTA), its slow setting, high degradation, and weakness limit its use in surgical endodontics and high stress-bearing areas. This study aimed to develop two new liquids to control these drawbacks. They were prepared from calcium chloride, fumed silica, and hydroxyapatite or calcium phosphate and coded “H” and “P,” respectively. Methods. Portland cement, Grey ProRoot® MTA, and white ProRoot MTA were mixed with distilled water (control) or liquid “H” or “P.” The pH, setting time, degradation rate, leachant/precipitate’ composition, compressive strength, and morphology were assessed. Results. Both liquids maintained MTA’s high alkalinity and reduced the setting time by 1-2 orders of magnitude. Both liquids, H in particular, significantly reduced the degradation rate of Grey ProRoot and White ProRoot MTA®. Calcite has been identified as the main phase of the leachant or precipitate formed during the cement’s degradation. Calcium hydroxide or hydroxyapatite was also identified with Grey ProRoot MTA mixed with H liquid. These liquids also significantly increased the compressive strength with no statistical differences between them; this was associated with the production of dense, consolidated structures. Conclusions. The modified MTA could be used in surgical endodontics and high stress-bearing areas

Fatigue effect on landing biomechanics among individuals with anterior cruciate ligament reconstruction: a systematic review

It is well established that knee stability can be altered during fatigue, which may increase the risk of anterior cruciate ligament (ACL) injury. This is due to a reduction in neuromuscular control that leads to abnormal movement patterns. This study aims to review the impact of fatigue on landing biomechanics among individuals who have undergone anterior cruciate ligament reconstruction. Four databases (Scopus, EBSCO, Web of Science, and Google Scholar) were searched for relevant articles, with a focus on full-text English-language research articles published between 2012 and 2022. The quality of the included studies was evaluated using the McMaster Critical Review Form for Quantitative Studies, and two independent reviewers were involved in the study evaluation, with a third reviewer resolving any discrepancies. Data on study demographics, fatigue simulation methods, landing tasks, outcome measures, and results were extracted from included studies. Eight studies met the inclusion criteria and were included in the analysis. The results of these studies showed that fatigue simulation reduced knee flexion only in two studies and increased hip flexion moment only in two studies during landing among individuals with ACLR. These inconclusive results show that fatigue may negatively impact landing biomechanics in people who have had an ACLR, potentially increasing their risk of re-injury. Fatigue did not affect the landing strategies adopted by individuals who have undergone ACLR. Some of these changes, such as reduced knee flexion and reduced hip flexion moment, could potentially increase the risk of re-injury. However, other changes, such as an increased hip flexion angle, may protect the joint from further injury. More research is needed to better understand the impact of fatigue on landing strategies in this population and to identify strategies that can minimize the risk of re-injury

Characterization of greater middle eastern genetic variation for enhanced disease gene discovery

The Greater Middle East (GME) has been a central hub of human migration and population admixture. The tradition of consanguinity, variably practiced in the Persian Gulf region, North Africa, and Central Asia1-3, has resulted in an elevated burden of recessive disease4. Here we generated a whole-exome GME variome from 1,111 unrelated subjects. We detected substantial diversity and admixture in continental and subregional populations, corresponding to several ancient founder populations with little evidence of bottlenecks. Measured consanguinity rates were an order of magnitude above those in other sampled populations, and the GME population exhibited an increased burden of runs of homozygosity (ROHs) but showed no evidence for reduced burden of deleterious variation due to classically theorized ‘genetic purging’. Applying this database to unsolved recessive conditions in the GME population reduced the number of potential disease-causing variants by four- to sevenfold. These results show variegated genetic architecture in GME populations and support future human genetic discoveries in Mendelian and population genetics

Effect of autoclave sterilisation and heat activated sodium hypochlorite irrigation on the performance of nickel-titanium rotary files against cyclic fatigue

The present study aims to assess the impact of heat-activated sodium hypochlorite (NaOCl) and/or autoclave sterilisation on the cyclic fatigue resistance (CFR) of heat-treated nickel-titanium rotary files used in root canal treatment. The CFR of One Curve (OC) files was evaluated under the following conditions: as received (Group 1; control), immersion in NaOCl at 23 ± 1ºC (Group 2), immersion in NaOCl at 60 ± 1ºC (Group 3), autoclave sterilisation at 135 1ºC (Group 4), combined treatment of autoclave sterilisation and immersion in NaOCl at 23 ± 1ºC (Group 5), and combined treatment of autoclave sterilisation and immersion in NaOCl at 60 ± 1ºC (Group 6). A simulated root canal in a zirconia block was utilised to test the performance of the files. All the types of treatments resulted in significant reductions in fracture resistance of the OC files. Immersion of the files in NaOCl at 23ºC revealed the smallest reduction, while combined treatment of autoclaving and immersion in NaOCl at 60ºC caused the greatest reduction. Autoclave sterilisation or exposure of OC files to 2.5% NaOCl adversely affect the cyclic fatigue life and increasing solution temperature or combined treatment caused additionally significant reduction in CFR

A novel frameshift MSX1 mutation in a Saudi family with autosomal dominant premolar and third molar agenesis

OBJECTIVES: In this study, the aim was to investigate a consanguineous Saudi family with non-syndromic premolars and third molars agenesis and to identify the causal mutation(s) using whole exome sequencing. DESIGN: Family phenotype and family pedigree were constructed from clinical and radiographic examinations. Whole exome sequencing was performed in two affected members of the Saudi family using the SureSelect Human all Exon 50 Mb kit (Agilent Technologies, Inc., Santa Clara, CA) and then sequenced on an Illumina HiSeq. SNP and indel calling were performed using samtools version 0.18 and were annotated using the software ANNOVAR. RESULTS: The family pedigree showed that the inheritance was autosomal dominant. Whole exome sequencing revealed that the affected members in this family were heterozygous with a novel frameshift mutation in exon 2 of the MSX1 gene, (NM_002448:c.750_751insACCGGCTGCC, p.F251PfsX92). CONCLUSIONS: The novel MSX1 frameshift mutation was linked to a family with moderate to severe tooth agenesis phenotype affecting second premolars and third molars in both arches. This expands the genotype-phenotype of MSX1 associated conditions

The Relationships between Various Factors and Sleep Status: A Cross-Sectional Study among Healthy Saudi Adults

Impaired sleep can adversely affect daily life. This study assesses the association between different factors and sleep status among apparently healthy Saudi adults. In total, 478 adults were included in this study. Data on anthropometrics, body composition, stress scales, physical activity, and dietary habits were collected. Fasting blood glucose and lipid profile were measured. Sleep quality and duration were assessed using the Pittsburgh Sleep Quality Index. Larger neck circumference (NC) was associated with short sleep duration (odds ratio (OR) 1.23; 95% confidence interval (CI) [1.08, 1.41]; p = 0.002). Higher triglyceride levels were associated with poor sleep quality (OR 1.01; 95% CI [1.002, 1.02]; p = 0.019) and short sleep duration (OR 1.01; 95% CI [1.004, 1.02]; p = 0.005). Stress was a risk factor for poor sleep quality (OR 1.15; 95% CI [1.09, 1.22]; p p = 0.009), while being single was correlated with longer sleep duration (OR 0.46; 95% CI [0.22, 0.96]; p = 0.039). Other factors such as having a larger waist circumference and more muscle mass were protective factors against poor sleep quality and/or short sleep duration. In conclusion, a larger NC is suggested as a risk factor for short sleep duration and a higher triglyceride level for both short and poor sleep among healthy Saudis. Investigating the factors associated with sleep status may help alleviate sleep disturbances and improve overall health. Further studies are needed to confirm causality using objective sleep measures