A COMPARATIVE STUDY ON THE EFFICACY OF AGNIKARMA AND SIRAVYADHA IN THE MANAGEMENT OF GRIDHRASI (SCIATICA)

Gridhrasi (Sciatica) is one of the Vataja Nanatmaja Vyadhi, caused by aggravated Vayu, the hip is afflicted by stiffness, pain, pricking sensation in the waist, back, thigh, knee and calf regions along the passage of sciatic nerve which makes the patient difficult to walk which hampers the individual’s daily routines. Aim: The present study was taken up with the objective of evaluating the efficacy of Agnikarma (treatment done with cauterization) and Siravyadha (Bloodletting with Venipuncture) in the management of Gridhrasi. Materials and Methods: The study was performed in comparative clinical randomized two groups parallel study with 40 Gridhrasi i.e., 20 patients in Group A (Patients were subjected to Agnikarma twice with an interval of 15 days) and 20 patients in Group B (Patients were subjected to Siravyadha twice with interval of 15 days. Results: In Group A out of 20 patients after the completion of treatment 10 patients were markedly improved, 5 moderately improved, and 5 reported mild improvement. In Group B out of 20 patients after the completion of treatment 1 were markedly improved, 7 reported moderate improvement, and in 12 patients reports mild improvement. Agnikarma is effective in both acute and chronic cases and provides quick results in relieving Ruk (100%), Toda (85%), Sthamba (90%), Spandana (65%). Siravyadha is effective in acute cases and provides gradual & effective results in relieving Ruk (90%), Toda (85%), Sthamba (60%), Spandana (65%). Statically both the groups showed significant changes making SLR and Bragard’s negative sign better in Group A. Marked response is significantly more in Group A with P value- 0.004** whichis highly significant. Conclusion: Agnikarma is effective in both acute and chronic cases and provides quick results; Siravyadha is effective in acute cases and provides gradual & effective results in relieving Gridhrasi

A Role of Shirodhara in Posterior Canal Benign Paroxysmal Positional Vertigo (PC-BPPV) with special reference to Bhrama - A Case Report

Introduction: This is a case report of 45 year old male who stepped into our OPD with complaints of dizziness during walking and heaviness of head since 7 months. The subject was not a known case of hypertension, diabetes mellitus, stroke or any cardiac problems. The Pure Tone Eudiometry results showed bilateral mild sensory neural hearing loss. But the subject had no symptoms of Tinnitus to be included in the vicinity of Meniere's disease. The Dix-Hallpike test was positive for left ear and confirmed the diagnosis as left posterior canal Benign Paroxysmal Positional Vertigo (PC-BPPV). Materials and Methods: The subject who approached Shalakya Tantra OPD of GAMC, with symptoms of dizziness, was systematically reviewed and intervention was planned for Doshic components involved in Bhrama. Results: The subject showed considerable improvement subjectively as shown by Dizziness Handicap Inventory (DHI) score. Discussion: The repositional maneuvers prescribed in the BPPV, though effective in most of the cases, recurrence is noted in one third of the patients. This study sheds light on holistic treatments like Shirodhara told in the Ayurveda classics that could be integrated with the maneuvers thereby improving the quality of life with no potential risk of side effects

A single case study to evaluate the applicability of Ayurveda treatment protocol in Otalgia w.s.r. to Kaphaja Karnashoola

Background: Otalgia or ear ache is a symptom which will hamper the daily activities of individual, and a cause of unease or discomfort. Even today there is no specific permanent remedy to this condition in advance modern medical system despite of some Otogesics which will only mask the pain. The common over the Counter medicines available on medical stores are having side effects on continuous usage. So there is a need for safe Ayurvedic medicine which can act better like modern analgesics but fewer side effects. Methodology: In this Case study, Agastya Haritaki Avaleha, Dashamoola Katutraya Kashaya and Capsule Grab, internally and Haridradi Karnadhoopana and Anu Taila Nasya as Sthanika Chikitsa were tried on patient of otalgia with ASOM (Kaphaja Karnashoola) Patient was treated in 2 stages. Observations: It was observed in the present study that in stage 1 there was 50% improvement as compared to stage 2 which showed better results in reducing the symptoms of Otalgia with ASOM. Re-occurrence of symptoms were merely less in stage 2 as compared to stage 1 Conclusion: There is a false assumption that Ayurvedic medicines are slow acting and allopathic medicines are desperately used for pain management and acute conditions. But this study throwing a light to substantiate that, Ayurvedic medicines are potent enough to manage acute otalgia also, just like Otogesics in Modern Medical Science. The study revealed that the re-occurrence rate of symptoms was very less in patients who used Agastya Haritaki Avaleha, Dashamoola Katutraya Kashaya and grab along with Haridradi Karnadhoopana and Anu Taila

Evaluation of the effect of Apamargadi Taila Gandusha in the management of Tundikeri (Tonsillitis) in children - A Case Report

Introduction: This is a case report of a 15-year-old male child complained of Fever, Pain and Difficulty in swallowing since 2 days. On Examination observed Congested soft palate, uvula, bilateral enlarged tonsils and confirmed the diagnosis as Tundikeri (Tonsillitis). In the present study Gandusha with Apamargadi Taila is selected for Clinical Trail. Materials and Methods: A 15-year-old male child suffering from the signs and symptoms of Tundikeri was taken for the study from Shalakya tantra opd of SJIIM, Bengaluru. He was treated with Apamargadi Taila Gandusha for a time period of 7days. Result: There was considerable improvement both subjectively and objectively. Discussion: Tundikeri is the Bhedya roga and should be treated like Kaphaja Rohini according to Asthanga Sangraha. Kaphaja Rohini Chikitsa includes Swedana, Lekhana, Pratisarana, Gandusha, Kavala, and Nasya. All drugs should have the properties such as Lekhana, Shothahara, Sandhaniya, Ropana, Rakta Sthambhana and Vedana Sthapana. The drugs used in the Apamargadi Taila also possess the properties like Bhedana, Lekhana, Ropana, Shoshana, Sthambana. Therefore, the present study was planned to evaluate the effect of Apamargadi Taila Gandusha in the management of Tundikeri (Tonsillitis)

Effect of classical Virechana Karma in the management of Eka Kushtha (Psoriasis) - A Case Study

Psoriasis is one among the most common clinical conditions encountered in day today clinical practice. Eka-Kushtha has greater resemblance with Psoriasis. The clinical features of Eka-Kushtha mentioned by Acharya Kashyapa represent remission, relapse and seasonal variation which are present in Psoriasis. Current treatment modalities have their own limitation and side effects, so significant result can’t be expected. There is a need for safe and effective treatment for psoriasis, where Ayurveda plays an important role. The basic principles and unique treatment modalities of Ayurveda i.e. Shodhana, Shamana etc. have long lasting results and provide better life to patients. A male patient aged 28 years reported to our department OPD, with signs and symptoms of Eka-Kushtha since 1 years, as small round erythematous scaly patches over groin, face, both the hands and legs with burning sensation, itching and dryness over affected lesion. Patient was treated with Shodhana in the form of Virechana Karma followed by oral medication. The patient reported symptomatic improvement

Ayurvedic understanding and management of Trigeminal Neuralgia w.s.r. to Anantavaata - A Case Study

Trigeminal Neuralgia is one of the painful disorders involving fifth cranial nerve, causes severe unilateral pain over regions supplied by the branches of trigeminal nerve associated with tempero mandibular joint stiffness. Trigeminal neuralgia nearly can be correlated to Anantavaata, one of the 11 types of Shirorogas explained by Acharya Sushruta and is Vaatapradhaana Tridoshaja Vyadhi. Present study is conducted to know the efficacy of ayurvedic line of management in TN. A female patient of age 46 years, diagnosed with Trigeminal Neuralgia was treated with allopathy medications. But did not get satisfactory results. Hence patient approached our hospital and got Vaatahara and Brihmana line of management involving Nasya with Karpasasthyaadi Taila for 7 days, Shiropichu and Karnapoorana with Ksheerabala Taila, Gandoosha with Murchita Tila Taila and oral medications. Patient’s complaints were assessed before and after treatment with VAS pain scale and verbal descriptor scale for TMJ stiffness After Follow up patient had got relieved with the complaints and got satisfactory results with ayurvedic line of management

Vaitarana Basti for acute pain management in VataKaphaja Gridhrasi w.s.r. Sciatica - A Case Report

Pain is one of the chief factors to visit a doctor. In today’s scenario low back pain is one among the emerging pains faced by 90% of population in their lifetime. Low back pain presents with different symptoms among them, the one with radiating to lower extremities unilaterally or bilaterally is termed as Gridhrasi. Gridhrasi is Shoola Pradhana Nanatamaja Vatavyadhi. The gait of a person resembles with that of Gridhra or Vulture. The condition presents with Ruk, Toda, Stambha, Spandana in Sphik Pradesha and radiates downwards to Kati, Prusta, Uru, Janu, Jangha, and Pada causing Sakthishepanigraha. Vata-Kaphaja type of Gridhrasi involves above symptoms along with Tandra, Gaurava, Arochaka, Bhaktadvesha, Staimitya. Gridhrasi can be compared with Sciatica. Vaitarana Basti is effective in Vata-Kaphaja Vikara’s as well as Shoola Chikitsa. Hence in the case study a male patient of age 28 years presenting with signs and symptoms of Gridhrasi was treated especially focused on acute pain management

A Case Study on Vataja Timira w.s.r. to Keratoconus

According to Ayurveda, Vata is responsible for formation of all body parts. Vayu is said to be Sarva Dhatu Vyuhakara and Kartagarbhakritam. It means that Vayu is responsible for the regular function and amount of Dhatus in body. In Ayurveda there is no direct reference of keratoconus, based on the symptoms it can be considered as Vataja Timira. This can be correlated to advanced condition of keratoconus, considering Dosha involvement Vatahara and Bruhmana line of treatment in the form of Nasya, Tarpana and Pindi is more beneficial in keratoconus

ENRICHMENT OF IN VIVO EFFICACY OF CATECHIN RICH EXTRACT WITH THE APPLICATION OF NANOTECHNOLOGY

Objective: The primary goal of this study was to convert a natural catechin-rich extract into nanoparticles by using a biodegradable and non-toxic polymer Eudragit L 100 to address the various biopharmaceutical problems of catechin.Methods: Nanoparticles were prepared by emulsion solvent evaporation technique using Eudragit L 100 in increasing concentration. Optimization of processing conditions like a selection of organic solvents, diluent and surfactant concentrations, drug and polymer ratio and method of drying to increase the biological efficiency were duly attempted. Parameters such as dynamic light scattering, zeta potential, SEM and energy-dispersive X-ray spectroscopy were assessed for the evaluation of nanoparticles.Results: The entrapment efficiency was found to be between 35-45 % with methanol compared to other organic solvents. The zeta potential values of all the formulations were in the range of±30 mV to±60 mV) which confirms moderate to good stability. A rapid or ‘burst' effect of the drug release in pH 6.8 buffer showing 92 % in the first 30 min which gradually decreased to 52 % by the end of 180 min but in the pH 7.4, the release was found to be moderate. SEM and DLS indicated particles were of spherical shape lying in a nanometer range of 100 to 200 nm with a proportional influence of polymer on the particles size.Conclusion: Nanoformulations were found to be more stable and confirmed the presence of major elements such as carbon and oxygen. The findings collectively indicate that it may be worthwhile to apply nanotechnology for the design of an advanced oral dosage form for an enhanced bioavailability and biological efficacy