3,274 research outputs found
Orthopaedic surgeons: as strong as an ox and almost twice as clever? Multicentre prospective comparative study
Objective To compare the intelligence and grip strength of orthopaedic surgeons and anaesthetists
Nuclear Disks of Gas and Dust in Early Type Galaxies and the Hunt for Massive Black Holes: Hubble Space Telescope Observations of NGC 6251
We discuss Hubble Space Telescope optical images and spectra of NGC 6251, a
giant E2 galaxy and powerful radio source at a distance of 106 Mpc (for H_0 =
70 km/s/Mpc). The galaxy is known to host a very well defined dust disk (O'Neil
et al. 1994); the exceptional resolution of our V and I images allows a
detailed study of the disk structure. Furthermore, narrow band images centered
on the Halpha+[NII] emission lines, reveal the presence of ionized gas in the
inner 0.3 arcsec of the disk. We used the HST/Faint Object Spectrograph with
the 0.09 arcsec aperture to study the velocity structure of the disk. Dynamical
models were constructed for two extreme (in terms of central concentration)
analytical representations of the stellar surface brightness profile, from
which the mass density and corresponding rotational velocity are derived
assuming a constant mass-to-light ratio (M/L)_V ~ 8.5 M_solar/L_solar. For both
representations of the stellar component, the models show that the gas is in
Keplerian motion around a central mass ~ 4 - 8 X 10^8 solar masses, and that
the contribution of radial flows to the velocity field is negligible.Comment: 45 pages, submitted to Ap
A noncoding, regulatory mutation implicates HCFC1 in nonsyndromic intellectual disability
The discovery of mutations causing human disease has so far been biased toward protein-coding regions. Having excluded all annotated coding regions, we performed targeted massively parallel resequencing of the nonrepetitive genomic linkage interval at Xq28 of family MRX3. We identified in the binding site of transcription factor YY1 a regulatory mutation that leads to overexpression of the chromatin-associated transcriptional regulator HCFC1. When tested on embryonic murine neural stem cells and embryonic hippocampal neurons, HCFC1 overexpression led to a significant increase of the production of astrocytes and a considerable reduction in neurite growth. Two other nonsynonymous, potentially deleterious changes have been identified by X-exome sequencing in individuals with intellectual disability, implicating HCFC1 in normal brain function
Groups of Galaxies in AEGIS: The 200 ksec Chandra Extended X-ray Source catalogue
We present the discovery of seven X-ray emitting groups of galaxies selected
as extended X-ray sources in the 200 ksec Chandra coverage of the
All-wavelength Extended Groth Strip International Survey (AEGIS). In addition,
we report on AGN activity associated to these systems. Using the DEEP2 Galaxy
Redshift Survey coverage, we identify optical counterparts and determine
velocity dispersions. In particular, we find three massive high-redshift groups
at z>0.7, one of which is at z=1.13, the first X-ray detections of
spectroscopically selected DEEP2 groups. We also present a first look at the
the L_X-T, L_X-sigma, and sigma-T scaling relations for high-redshift massive
groups. We find that the properties of these X-ray selected systems agree well
with the scaling relations of similar systems at low redshift, although there
are X-ray undetected groups in the DEEP2 catalogue with similar velocity
dispersions. The other three X-ray groups with identified redshifts are
associated with lower mass groups at z~0.07 and together form part of a large
structure or "supergroup" in the southern portion of the AEGIS field. All of
the low-redshift systems are centred on massive elliptical galaxies, and all of
the high-redshift groups have likely central galaxies or galaxy pairs. All of
the central group galaxies host X-ray point sources, radio sources, and/or show
optical AGN emission. Particularly interesting examples of central AGN activity
include a bent-double radio source plus X-ray point source at the center of a
group at z=0.74, extended radio and double X-ray point sources associated to
the central galaxy in the lowest-redshift group at z=0.066, and a bright green
valley galaxy (part of a pair) in the z=1.13 group which shows optical AGN
emission lines.Comment: accepted to MNRAS, 15 pages, 11 figures, for version with full
resolution figures see http://www.ucolick.org/~tesla/aegis_groups.ps.g
A whole genome association study of neuroticism using DNA pooling.
We describe a multistage approach to identify single nucleotide polymorphisms (SNPs) associated with neuroticism, a personality trait that shares genetic determinants with major depression and anxiety disorders. Whole genome association with 452 574 SNPs was performed on DNA pools from approximately 2000 individuals selected on extremes of neuroticism scores from a cohort of 88 142 people from southwest England. The most significant SNPs were then genotyped on independent samples to replicate findings. We were able to replicate association of one SNP within the PDE4D gene in a second sample collected by our laboratory and in a family-based test in an independent sample; however, the SNP was not significantly associated with neuroticism in two other independent samples. We also observed an enrichment of low P-values in known regions of copy number variations. Simulation indicates that our study had approximately 80% power to identify neuroticism loci in the genome with odds ratio (OR)>2, and approximately 50% power to identify small effects (OR=1.5). Since we failed to find any loci accounting for more than 1% of the variance, the heritability of neuroticism probably arises from many loci each explaining much less than 1%. Our findings argue the need for much larger samples than anticipated in genetic association studies and that the biological basis of emotional disorders is extremely complex
Direct Measurement of the Top Quark Mass at D0
We determine the top quark mass m_t using t-tbar pairs produced in the D0
detector by \sqrt{s} = 1.8 TeV p-pbar collisions in a 125 pb^-1 exposure at the
Fermilab Tevatron. We make a two constraint fit to m_t in t-tbar -> b W^+bbar
W^- final states with one W boson decaying to q-qbar and the other to e-nu or
mu-nu. Likelihood fits to the data yield m_t(l+jets) = 173.3 +- 5.6 (stat) +-
5.5 (syst) GeV/c^2. When this result is combined with an analysis of events in
which both W bosons decay into leptons, we obtain m_t = 172.1 +- 5.2 (stat) +-
4.9 (syst) GeV/c^2. An alternate analysis, using three constraint fits to fixed
top quark masses, gives m_t(l+jets) = 176.0 +- 7.9 (stat) +- 4.8 (syst)
GeV/C^2, consistent with the above result. Studies of kinematic distributions
of the top quark candidates are also presented.Comment: 43 pages, 53 figures, 33 tables. RevTeX. Submitted to Phys. Rev.
Measurement of the Boson Mass
A measurement of the mass of the boson is presented based on a sample of
5982 decays observed in collisions at
= 1.8~TeV with the D\O\ detector during the 1992--1993 run. From a
fit to the transverse mass spectrum, combined with measurements of the
boson mass, the boson mass is measured to be .Comment: 12 pages, LaTex, style Revtex, including 3 postscript figures
(submitted to PRL
Search for a Fourth Generation Charge -1/3 Quark via Flavor Changing Neutral Current Decay
We report on a search for pair production of a fourth generation charge -1/3
quark (b') in pbar p collisions at sqrt(s) = 1.8 TeV at the Fermilab Tevatron
using an integrated luminosity of 93 pb^-1. Both quarks are assumed to decay
via flavor changing neutral currents (FCNC). The search uses the signatures
gamma + 3 jets + mu-tag and 2 gamma + 2 jets. We see no significant excess of
events over the expected background. We place an upper limit on the production
cross section times branching fraction that is well below theoretical
expectations for a b' quark decaying exclusively via FCNC for b' quark masses
up to m(Z) + m(b).Comment: Eleven pages, two postscript figures, submitted to Physical Review
Letter
Search for bottom squarks in pbarp collisions at sqrt(s)=1.8 TeV
We report on a search for bottom squarks produced in pbarp collisions at
sqrt(s) = 1.8 TeV using the D0 detector at Fermilab. Bottom squarks are assumed
to be produced in pairs and to decay to the lightest supersymmetric particle
(LSP) and a b quark with branching fraction of 100%. The LSP is assumed to be
the lightest neutralino and stable. We set limits on the production cross
section as a function of bottom squark mass and LSP mass.Comment: 5 pages, Latex. submitted 3-12-1999 to PRD - Rapid Communicatio
Bilateral femoral neck fractures due to transient osteoporosis of pregnancy: a case report
We describe a case of bilateral femoral neck fractures secondary to transient osteoporosis of pregnancy, which were diagnosed after delivery due to the desire to avoid ionising radiation. These fractures were presumed to be secondary to transient osteoporosis of pregnancy and were treated successfully with internal fixation despite delayed presentation. We discuss the role of MRI in the evaluation of hip pain in pregnancy
- …