LINEARNO PROGRAMIRANJE KAO ALAT ZA PROJEKTIRANJE SIROVINSKE SMJESE U TVORNICI CEMENTA

This study uses linear programming to develop a methodology for selecting the best raw material mix in an ASCOM cement plant in Egypt. In cement factories, this type adheres to Egyptian chemical composition criteria for raw feed (e.g. 82.5% calcium carbonate, 14.08% silica, 2.5% alumina and 0.92% iron oxide). Furthermore, the model is bound by industry-specific characteristics (e.g. lime saturation factor, silica modulus, alumina modulus and loss of ignition). The results reveal that the model is able to accurately reproduce the mixing of high-quality feed with varying constituent percentages. It is also capable of determining the combining limitations of each ingredient. Furthermore, it demonstrates optimality for additive sourcing short-term planning and capping limestone quality to meet changeable component combinations. Additionally, improving the raw mix reduces limestone feed quality from 51 to 50.6%, resulting in the inclusion of extra limestone reserves.Studija prikazuje metodu linearnoga programiranja uporabljenu sa svrhom odabira najbolje sirovinske smjese u tvornici cementa ASCOM (Egipat). Takva smjesa poštuje egipatske standarde kemijskoga sastava sirovine (npr. 82,5 % kalcijeva karbonata, 14,08 % silikata, 2,5 % aluminijeva oksida, 0,92 % željeznoga oksida). Također, model je uvjetovan industrijskim standardima (npr. faktorom zasićenja vapnom, silikatnim i aluminatnim modulom te gubitkom (oksida) žarenjem). Modelom se mogla točno izračunati visokokvalitetna mješavina različitih (postotnih) komponenti te je dokazan kao optimalan za brz izračun raznih aditiva i postizanje najveće kvalitete vapnenačke sirovine uz doziranje ostalih komponenti. Time je udjel vapnenca bilo moguće smanjiti na 50,6 – 51 %, što je otvorilo put eksploataciji dodatnih rezervi te sirovine

Renal cell carcinoma in children: Case report and literature review

Renal cell carcinoma is infrequent in children; consequently it is important to communicate its diagnosis and follow up. The behaviour of this type of tumor is better characterized in adults and in this setting the treatment of choice is surgical resection. However, the place of chemo- and radiotherapy has not been well defined. Here, we present a 9-year-old boy with renal cell carcinoma demonstrating only hematuria without any pathological physical examination findings. The mass was described by abdominal ultrasonography and computed tomography in the left kidney. After the left nephroureterectomy, the patient was given no adjuvant therapy

Synthesis, Characterization, and Biological Studies of Organotin(IV) Derivatives with o- or p-hydroxybenzoic Acids

Organotin(IV) complexes with o- or p-hydroxybenzoic acids (o-H2BZA or p-H2BZA) of formulae [R2Sn(HL)2] (where H2L = o-H2BZA and R = Me- (1), n-Bu- (2)); [R3Sn(HL)] (where H2L = o-H2BZA and R = n-Bu- (3), Ph- (4) or H2L = p-H2BZA and R = n-Bu- (5), Ph- (6)) were synthesized by reacting a methanolic solution of di- and triorganotin(IV) compounds with an aqueous solution of the ligand (o-H2BZA or p-H2BZA) containing equimolar amounts of potassium hydroxide. The complexes were characterized by elemental analysis, FT-IR, Far-IR, TGA-DTA, FT-Raman, Mössbauer spectroscopy, 1H, 119Sn-NMR, UV/Vis spectroscopy, and Mass spectroscopy. The X-ray crystal structures of complexes 1 and 2 have also been determined. Finally, the influence of these complexes 1–6 upon the catalytic peroxidation of linoleic acid to hydroperoxylinoleic acid by the enzyme lipoxygenase (LOX) was kinetically studied and the results showed that triorganotin(IV) complex 6 has the lowest IC50 value. Also complexes 1–6 were studied for their in vitro cytotoxicity against sarcoma cancer cells (mesenchymal tissue) from the Wistar rat, and the results showed that the complexes have high activity against these cell lines with triphenyltin((IV) complex 4 to be the most active one

Parallel Rendering on Hybrid Multi-GPU Clusters

Achieving efficient scalable parallel rendering for interactive visualization applications on medium-sized graphics clusters remains a challenging problem. Framerates of up to 60hz require a carefully designed and fine-tuned parallel rendering implementation that fits all required operations into the 16ms time budget available for each rendered frame. Furthermore, modern commodity hardware embraces more and more a NUMA architecture, where multiple processor sockets each have their locally attached memory and where auxiliary devices such as GPUs and network interfaces are directly attached to one of the processors. Such so called fat NUMA processing and graphics nodes are increasingly used to build cost-effective hybrid shared/distributed memory visualization clusters. In this paper we present a thorough analysis of the asynchronous parallelization of the rendering stages and we derive and implement important optimizations to achieve highly interactive framerates on such hybrid multi-GPU clusters. We use both a benchmark program and a real-world scientific application used to visualize, navigate and interact with simulations of cortical neuron circuit models

DFT, TD-DFT and Biological Activity Studies of Some Maleanilic Acid Derivatives Ligands and Their Organometallic Complexes

This study is a complementary study to our previous study that included the synthesis and characterization of some maleanilic acid derivatives ligands (L1-4) and their metal carbonyl complexes (2-4)a-d as effective compounds for cancer cell inhibition against three cancer cell lines: HCT-116 (colon cancer), HepG-2 cells (Hepatocellular cancer) and MCF-7 (breast cancer). The activity data manifested that p-nitrophenyl maleanilic acid ligand (L2) and its chromium complex (2b) showed higher inhibitory than the other complexes against the tested cancer cells. Additionally, DFT and TD-DFT studies were performed to investigate their frontier molecular orbital (FMO), optical properties, and the correlation between the structure and biological activity. The calculated optical energy gap (Eg) was in the range of 1.78- 2.13 eV, and electron cloud delocalization of HOMO/LUMO levels revealed that all complexes show effective charge separation. DFT results show a great relation between Eg values of the carbonyl complexes and their experimental biological activity. Where it was obvious that complex (2b) with the lowest (Eg) value exhibits the highest inhibition potency against cancer cells. In contrast, complex (2d) with the highest (Eg) value exhibits the lowest inhibition potency. These results translate the reverse relationship between Eg values of the complexes and the inhibition potency against cancer cells

DFT, TD-DFT and biological activity studies of some maleanilic acid derivatives ligands and their organometallic complexes

1564-1573This study is a complementary study to our previous study that included the synthesis and characterization of some maleanilic acid derivative ligands (L1-4) and their metal carbonyl complexes (2-4)a-d as effective compounds for cancer cell growth inhibition against three cancer cell lines: HCT-116, HepG-2 cells and MCF-7. The activity data has manifested that the p-nitrophenyl maleanilic acid ligand (L2) and its chromium complex (2b) inhibited the tested cancer cells more effectively than the other complexes. Additionally, DFT and TD-DFT studies are performed to investigate their frontier molecular orbital (FMO), optical properties, and the correlation between the structure and biological activity. The calculated optical energy gap (Eg) is in the range of 1.78- 2.13 eV, and electron cloud delocalization of HOMO/LUMO levels revealed that all complexes show effective charge separation. The DFT results show a strong relation between Eg values of the carbonyl complexes and their experimental biological activity, where it is obvious that complex (2b) with the lowest Eg value has the greatest inhibitory potency against cancer cells. In contrast, complex (2d) with the highest Eg value exhibits the lowest inhibition potency. These findings translate the inverse relationship between Eg values of the complexes and the inhibition potency against cancer cells

Targeted mutation of barley (1,3;1,4)-β-glucan synthases reveals complex relationships between the storage and cell wall polysaccharide content

Barley (Hordeum vulgare L) grain is comparatively rich in (1,3;1,4)-β-glucan, a source of fermentable dietary fibre that protects against various human health conditions. However, low grain (1,3;1,4)-β-glucan content is preferred for brewing and distilling. We took a reverse genetics approach, using CRISPR/Cas9 to generate mutations in members of the Cellulose synthase-like (Csl) gene superfamily that encode known (HvCslF6 and HvCslH1) and putative (HvCslF3 and HvCslF9) (1,3;1,4)-β-glucan synthases. Resultant mutations ranged from single amino acid (aa) substitutions to frameshift mutations causing premature stop codons, and led to specific differences in grain morphology, composition and (1,3;1,4)-β-glucan content. (1,3;1,4)-β-Glucan was absent in the grain of cslf6 knockout lines, whereas cslf9 knockout lines had similar (1,3;1,4)-β-glucan content to wild-type (WT). However, cslf9 mutants showed changes in the abundance of other cell-wall-related monosaccharides compared with WT. Thousand grain weight (TGW), grain length, width and surface area were altered in cslf6 knockouts, and to a lesser extent TGW in cslf9 knockouts. cslf3 and cslh1 mutants had no effect on grain (1,3;1,4)-β-glucan content. Our data indicate that multiple members of the CslF/H family fulfil important functions during grain development but, with the exception of HvCslF6, do not impact the abundance of (1,3;1,4)-β-glucan in mature grain.</p