Enhanced ROS-generation in lymphocytes from Alzheimer’s patients

Introduction: Reactive oxygen species (ROS) have been implicated in neurodegeneration and seem to be involved in the physiology and pathophysiology of several diseases, including normal aging and Alzheimer’s disease (AD). Enhanced ROS production in aging or AD is not restricted to the brain, but can also been seen in several peripheral tissues. The objective of the present study was to evaluate whether the mechanisms involved in the generation of oxidative stress in normal senescence and Alzheimer’s disease are identical or not. Methods: We analysed intracellular basal levels of ROS in lymphocytes from AD patients and healthy young and aged not-demented subjects as well as ROS levels following stimulation with d-ribose and staurosporine in all three groups. ROS levels were measured by flow cytometry using the intracellular fluorescence dye dihydrorhodamine123 (DHR123). Results: Our study shows that AD lymphocytes have increased basal levels of ROS, low susceptibility to ROS stimulation by 2-deoxy-D-ribose (dRib) and an increased response to staurosporine when compared with age-matched controls. Discussion: The data suggest that the defect(s) responsible for enhanced ROS production in AD may involve different or additional biological pathways than those involved in enhanced ROS generation during aging

Biogas production by co-ensiling catch crops and straw, effect of substrate blend and microbial communities

The combination of catch crop (CC) and barley straw(S) for biogas production was investigated in order to evaluate the ensiling process in batch assay and in continuous process. Based on two new agriculture strategies designed to produce energy and improve nutrient cycling in organic farming are being evaluated, one of them consisting on the harvest of straw and catch crop in different periods whereas the other strategy consists on harvesting them at the same time. Catch crops is promoted to reduce nutrient leaching during rainy season and straw that is not used for animal feeding or bedding is generally left in the field. Mixtures of CC and S provides several advantages: 1) Provides adequate TS for silage, 2) Absorbs the silage effluent, 3) Produces high LAB activity, and 4) Provides an optimal C/N for anaerobic digestion (AD). The effect of feeding compositions (straw or manurea ddition) on the microbial community structures were also investigated

Directed forgetting of source memory in normal aging and Alzheimer's disease

BACKGROUND AND AIMS: Using the source directed forgetting method, the present paper investigated whether older adults and Alzheimer\u27s disease (AD) patients were able to inhibit source information. METHODS: Younger adults, older adults and AD participants were presented with two sets of six items each: Set1 and Set2. Each item was presented by one of two sources: an experimenter black- or white-gloved hand. After the presentation of the Set1 items, participants were instructed either to forget or to continue remembering the source of the items. Afterward, all participants were presented with the Set2 items, and were asked to remember their source. Finally, subjects were exposed to the Set1 and Set2 items, and were asked to recall, for each item, its original source presentation (i.e., the experimenter black- or white-gloved hand). RESULTS: In comparison with younger adults, older adults and AD participants showed no differences in remembering the source of the Set1 and Set2 items. In other words, they failed to inhibit the source information. DISCUSSION AND CONCLUSION: Our outcomes are discussed in terms of retrieval inhibition deficits and changes in adaptive nature of memory in normal aging and AD

Directed forgetting of source memory in normal aging and Alzheimer's disease

BACKGROUND AND AIMS: Using the source directed forgetting method, the present paper investigated whether older adults and Alzheimer\u27s disease (AD) patients were able to inhibit source information. METHODS: Younger adults, older adults and AD participants were presented with two sets of six items each: Set1 and Set2. Each item was presented by one of two sources: an experimenter black- or white-gloved hand. After the presentation of the Set1 items, participants were instructed either to forget or to continue remembering the source of the items. Afterward, all participants were presented with the Set2 items, and were asked to remember their source. Finally, subjects were exposed to the Set1 and Set2 items, and were asked to recall, for each item, its original source presentation (i.e., the experimenter black- or white-gloved hand). RESULTS: In comparison with younger adults, older adults and AD participants showed no differences in remembering the source of the Set1 and Set2 items. In other words, they failed to inhibit the source information. DISCUSSION AND CONCLUSION: Our outcomes are discussed in terms of retrieval inhibition deficits and changes in adaptive nature of memory in normal aging and AD

Antonii Avgvstini Archiepiscopi Tarraconensis Dialogorum Libri Duo de emendatione Gratiani

Stephanvs Balvzivs Tutelensis emendavit, Notis illustravit, & novas Emendationes adjecit ad GratianumBibliogr. Nachweis: GK 2.4243Vorlageform des Erscheinungsvermerks: Parisiis, Excudebat Franciscus Muguetus Regis & illustrissimi Archiepiscopi Parisiensis Typographus. MDCLXXII.Auf dem Titelbl. nach S. 420: Stephani Balvzii Tvtelensis Notae Ad Antonivm Avgvstinvm Et Gratianvm. - Im Kopf auf S. 593: Andreae Schotti Oratio In Fvnere Antonii Avgvstini Archiepiscopi Tarraconensis Anno MDLXXXV

Ivan Tatarinov, Organ

Praeludium in e minor ( Big ) / Nicolaus Bruhns; Trio-sonata in e minor BWV 528 / Johann Sebastian Bach; Dieu parmi nous from La Nativité du Seigneur”(1935) / Olivier Messiaen; Preludes Op. 103 Nos. 2, 3 ( Imitating Old Masters ) / Mikael Tariverdiev; Fantasy and fugue on choral Ad nos, ad salutarem undam S. 259 (edited by Karl Straube) / Franz Lisz