290 research outputs found

    A non-linear degenerate equation for direct aggregation and traveling wave dynamics

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    The gregarious behavior of individuals of populations is an important factor in avoiding predators or for reproduction. Here, by using a random biased walk approach, we build a model which, after a transformation, takes the general form [u_{t}=[D(u)u_{x}]_{x}+g(u)] . The model involves a density-dependent non-linear diffusion coefficient [D] whose sign changes as the population density [u] increases. For negative values of [D] aggregation occurs, while dispersion occurs for positive values of [D] . We deal with a family of degenerate negative diffusion equations with logistic-like growth rate [g] . We study the one-dimensional traveling wave dynamics for these equations and illustrate our results with a couple of examples. A discussion of the ill-posedness of the partial differential equation problem is included

    From pre- to young Planetary Nebulae: radio continuum variability

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    Searching for variability, we have observed a sample of hot post-AGB stars and young Planetary Nebulae candidates with the Very Large Array at 4.8, 8.4, and 22.4 GHz. The sources had been previously detected in the radio continuum, which is a proof that the central stars have started ionising their circumstellar envelopes and an increase in radio flux with time can be expected as a result of the progression of the ionisation front. Such a behaviour has been found in IRAS 18062+2410, whose radio modelling has allowed us to determine that its ionised mass has increased from 10^{-4} to 3.3 10^{-4} M_sun in 8 years and its envelope has become optically thin at lower frequencies. Different temporal behaviours have been found for three other sources. IRAS 17423-1755 has shown a possibly periodic pattern and an inversion of its radio spectral index, as expected from a varying stellar wind. We estimate that the radio flux arises from a very compact region around the central star (10^{15} cm) with an electron density of 2 10^6 cm^{-3}. IRAS 22568+6141 and 17516-2525 have decreased their radio flux densities of about 10% per year over 4 years. While a linear increase of the flux density with time points out to the progression of the ionisation front in the envelope, decreases as well as quasi-periodic patterns may indicate the presence of unstable stellar winds/jets or thick dusty envelopes absorbing ionising photons.Comment: 9 pages, 5 figures, accepted for publication on MNRA

    hypersaline infusion protocol through the portal vein may focus electroporation on tumor tissue, but is it really safe? Ppreliminary results

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    Introduction: irreversible Electroporation (IRE) is highly dependent on the electrical conductivity of the tissue and the high conductivity of tumor tissue, which leads to a lower field than that in the surrounding healthy tissue. Hypersaline Infusion (HI) through the portal vein focuses IRE on scattered liver tumors, by creating a differential conductivity between the different types of tissue. The aim of this study is to determine the effects of the HI protocol on the hepatic and histological biochemical results. Methods: Ten male Sprague Dawley rats were used for HI protocol. Blood samples were collected at pre-, immediately post-, 24-hrs, 72-hrs, 1- week and 3-weeks post-HI. All the animals were sacrificed after a one-month follow-up in order to collect histological samples. Results: The mortality rate in this procedure reached 30% (3/10). Only the pH and transaminases at 24-hrs were significantly and directly linked to mortality (p=0.036 and p=0.004, respectively). The three non-surviving animals had a four-time higher AST level at 24-hrs. Natremianormalized at 24-hrs post-HI. Statistically significant differences were found in hepatic necrosis between the non-surviving (n=3) and surviving rats (n=7) (30.67 ± 10.97 vs. 2.86 ± 7.56% respectively, p=0.01). Discussion: HI through the portal system involves a significant risk of possibly lethal cytolysis and acidosis. Therefore, compensatory measures and a reduced saline overload are warranted to improve the survival rates

    Oxidative Stress and Parkinson’s Disease: Effects on Environmental Toxicology

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    Epidemiological studies have found an increased risk of Parkinson’s disease (PD) with environmental factors such as exposure to substances derived from industrial processes, use of agrochemicals, or living in a rural environment. The hypothesis that certain environmental toxins could be the source of the EP is supported by the discovery that chemicals such as herbicides paraquat, diquat, and the fungicide maneb are selectively toxic in nigrostriatal dopaminergic neurons. Also, one of the insecticides produced by plants, such as rotenone, and by-product of the synthesis of synthetic heroin MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) can be reproduced in animal models where neurochemicals, histopathological, and clinical characteristic of PD can be found. Interestingly, there are similarities in the chemical structure of paraquat and MPTP. Recent evidence exhibited that inflammation and oxidative stress play an essential role in the development of PD. So, in our laboratory we found that in an animal model melatonin decreases the products of lipid oxidation, nitric oxide metabolites, and the activity of cyclooxygenase 2, which are induced by an intraperitoneal injection of MPTP. This suggests that the neuroprotective effects of melatonin are partially attributed to its antioxidant scavenging and anti-inflammatory action

    Time-dependent ejection velocity model for the outflow of Hen 3--1475

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    We present 2D axisymmetric and 3D numerical simulations of the proto-planetary nebula Hen 3-1475, which is characterized by a remarkably highly collimated optical jet, formed by a string of shock-excited knots along the axis of the nebula. It has recently been suggested that the kinematical and morphological properties of the Hen 3-1475 jet could be the result of an ejection variability of the central source (Riera et al. 2003). The observations suggest a periodic variability of the ejection velocity superimposed on a smoothly increasing ejection velocity ramp. From our numerical simulations, we have obtained intensity maps (for different optical emission lines) and position-velocity diagrams, in order to make a direct comparison with the HST observations of this object. Our numerical study allows us to conclude that a model of a precessing jet with a time-dependent ejection velocity, which is propagating into an ISM previously perturbed by an AGB wind, can succesfully explain both the morphological and the kinematical characteristics of this proto-planetary nebula.Comment: Astronomy and Astrophysics (accepted) (8 figures

    Personality in patients with migraine evaluated with the "Temperament and Character Inventory"

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    The objective of this study was to assess the personality profile of a sample of Mexican patients with migraine using the Temperament and Character Inventory (TCI). A cross-sectional study was performed including adult migraine patients identified from the outpatient neurology clinics of two large teaching hospitals in Mexico City. Patients were asked to voluntarily participate in the study. A physician conducted a standardised diagnostic interview adhering to the criteria of the International Headache Society (IHS). Patients were interviewed and administered the TCI. We used two healthy controls groups and a third group of non-migraine pain controls. One hundred and fortytwo subjects with migraine, 108 healthy blood donors, 269 young healthy controls and 30 patients with non-migraine pain (NMP) were included in the study. Patients with migraine had higher scores in the dimension harm avoidance (HA) and all its sub-dimensions (p<0.05) than healthy patients. Patients with non-migraine pain had high scores in HA and low scores in novelty seeking, self-directedness and cooperativeness. Blood donors had high scores in the following subdimensions: HA1, HA4 and C3 (Cooperativeness). Personality features consistent with migraine are avoidance, rigidity, reserve and obsessivity. Our study shows that patients with chronic pain share some of the personality features of patients with migraine but their TCI profile could be indicative of cluster C avoidant personality. Blood donors were shown to have more energy, with a tendency to help other people and be more optimistic. The results support serotoninergic involvement as explaining the physiopathology of migraine
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