17 research outputs found

    An Insertion Within SIRPß1 Shows a Dual Effect Over Alzheimer's Disease Cognitive Decline Altering the Microglial Response

    Get PDF

    Balance de 25 años de jurisprudencia de la Corte Constitucional

    Get PDF
    La Corte Constitucional de Colombia ha tenido un importante impacto en la vida social, cultural y política del país, a tal punto que, desde su creación, la jurisprudencia de este tribunal se ha convertido en un referente mundial acerca de las diversas materias sobre las que se ha pronunciado . Este libro presenta un balance de la jurisprudencia que durante sus primeros veinticinco años la Corte ha expedido. Con este fin, el magistrado Luis Guillermo Guerrero Pérez y los magistrados auxiliares Miguel Polo Rosero y Claudia Escobar García recogen los trabajos de expertos nacionales e internacionales, funcionarios del Estado y Miembros de la sociedad civil que se presentaron en el XII Encuentro de la Jurisdicción Constitucional, realizado en la ciudad de San Juan de Pasto entre el 27 y el 30 de septiembre de 2017. En ese encuentro, se ratificó que la Corte Constitucional tiene la tarea de velar por la integridad de los compromisos de la Constitución. Los capítulos que conforman este libro ofrecen una mirada multidisciplinaria sobre la eficacia y el impacto de las decisiones de la Corte, específicamente en lo que tiene que ver con la democracia y la participación, el sistema de salud, el sistema pensional, el medio ambiente y el fenómeno discriminatorio con la relación al género y a la condición de discapacidad en Colombia.Bogot

    Outpatient Parenteral Antibiotic Treatment vs Hospitalization for Infective Endocarditis: Validation of the OPAT-GAMES Criteria

    Get PDF

    Role of age and comorbidities in mortality of patients with infective endocarditis

    Get PDF
    [Purpose]: The aim of this study was to analyse the characteristics of patients with IE in three groups of age and to assess the ability of age and the Charlson Comorbidity Index (CCI) to predict mortality. [Methods]: Prospective cohort study of all patients with IE included in the GAMES Spanish database between 2008 and 2015.Patients were stratified into three age groups:<65 years,65 to 80 years,and ≥ 80 years.The area under the receiver-operating characteristic (AUROC) curve was calculated to quantify the diagnostic accuracy of the CCI to predict mortality risk. [Results]: A total of 3120 patients with IE (1327 < 65 years;1291 65-80 years;502 ≥ 80 years) were enrolled.Fever and heart failure were the most common presentations of IE, with no differences among age groups.Patients ≥80 years who underwent surgery were significantly lower compared with other age groups (14.3%,65 years; 20.5%,65-79 years; 31.3%,≥80 years). In-hospital mortality was lower in the <65-year group (20.3%,<65 years;30.1%,65-79 years;34.7%,≥80 years;p < 0.001) as well as 1-year mortality (3.2%, <65 years; 5.5%, 65-80 years;7.6%,≥80 years; p = 0.003).Independent predictors of mortality were age ≥ 80 years (hazard ratio [HR]:2.78;95% confidence interval [CI]:2.32–3.34), CCI ≥ 3 (HR:1.62; 95% CI:1.39–1.88),and non-performed surgery (HR:1.64;95% CI:11.16–1.58).When the three age groups were compared,the AUROC curve for CCI was significantly larger for patients aged <65 years(p < 0.001) for both in-hospital and 1-year mortality. [Conclusion]: There were no differences in the clinical presentation of IE between the groups. Age ≥ 80 years, high comorbidity (measured by CCI),and non-performance of surgery were independent predictors of mortality in patients with IE.CCI could help to identify those patients with IE and surgical indication who present a lower risk of in-hospital and 1-year mortality after surgery, especially in the <65-year group

    Sociedad, estado y derecho. Homenaje a Álvaro Tafur Galvis. Tomo II: Equilibrios institucionales transformaciones de la administración

    No full text
    El Colegio Mayor de Nuestra Señora del Rosario ha querido exaltar la vida y obra del Señor Colegial, Catedrático, Profesor Titular y Honorario, Decano y Rector magnífico, Álvaro Tafur Galvis. En homenaje al gran intelectual, jurista, magistrado y maestro, que ha honrado a cabalidad la definición dada por Fray Cristóbal de Torres para este Colegio Mayor, como varón insigne ilustrador de la República, que con sus grandes letras y destinos que ha merecido con ellas, ha sido en todo dechado del culto divino y de las buenas costumbres conforme al estado de su profesión, las directivas de la Institución lideradas por su actual Rector, Hans Peter Knudsen y su Vicerrector, Alejandro Venegas Franco, en asocio con sus discípulos, colegas, compañeros y amigos, han preparado en su honor la obra que aquí se presenta bajo el título Sociedad, Estado y Derecho. Pocas veces ha visto la Academia colombiana tan entusiasta y calificada respuesta a una iniciativa de esta naturaleza. La persona y la obra del homenajeado lo explican sin duda. Él ha sido un verdadero modelo admirado y respetado por todos. Y es él también quien nos recuerda con cada una de sus actuaciones cómo la humildad, la discreción y el decoro son los hilos indelebles con los que se encadena la gloria. Los autoresThe Colegio Mayor de Nuestra Señora del Rosario has wanted to exalt the life and work of the Collegiate, Professor, Titular and Honorary Professor, Dean and Grand Rector, Álvaro Tafur Galvis. In homage to the great intellectual, jurist, magistrate and teacher, who has Fully honored the definition given by Fray Cristóbal de Torres for this Colegio Mayor, as an illustrious male illustrator of the Republic, who with his great letters and destinies that he has deserved with them, has been a paragon of divine worship and good customs. According to the state of his profession, the directives of the Institution led by its current Rector, Hans Peter Knudsen and his Vice-Rector, Alejandro Venegas Franco, in association with his disciples, colleagues, colleagues and friends, have prepared in his honor the work that here It is presented under the title Society, State and Law. Rarely has the Colombian Academy seen such an enthusiastic and qualified response to an initiative of this nature. The person and the work of the honoree explain it without a doubt. He has been a true role model admired and respected by all. And he is also the one who reminds us with each of his performances how humility, discretion and decorum are the indelible threads with which glory is chained. The autor

    El derecho público en Iberoamérica. Libro homenaje al profesor Jaime Vidal Perdomo. Tomos I y II

    No full text
    La obra que se entrega hoy es un gran ejemplo de la riqueza académica con la que todos cuentan en Iberoamérica, motor de una nueva integración, que mueve y motiva por encima de intereses políticos y partidarios. Para una mejor lectura de las evoluciones y las expectativas en derecho público en Iberoamérica, así como del balance del derecho administrativo colombiano, en sus primeros cien años de justicia contencioso-administrativa, en este orden de ideas se ha dividido la publicación en dos tomos. El primero de ellos se divide en tres partes: derecho constitucional, teoría general del derecho administrativo, y acto y procedimiento administrativo. El segundo tomo viene distribuido en cinco partes: la primera parte se ha denominado contratos administrativos, la segunda parte régimen local, la tercera parte, denominada bienes del Estado, la cuarta parte, contencioso-administrativo y la última parte, se ha descrito como temas varios. En ella se encuentran reflexiones sobre la evolución de la teoría del daño especial en Colombia. Con lo anterior, se espera haber cumplido con un buen balance bicentenario del derecho público en Iberoamérica y del derecho administrativo colombiano en estos cien primeros años de justicia contencioso-administrativa, en homenaje al maestro Jaime Vidal Perdomo, eximio jurista colombiano consagrado al estudio y análisis del derecho público y exponente calificado y reconocido de la academia en Colombia y en los países iberoamericanos

    Contemporary use of cefazolin for MSSA infective endocarditis: analysis of a national prospective cohort

    Get PDF
    Objectives: This study aimed to assess the real use of cefazolin for methicillin-susceptible Staphylococcus aureus (MSSA) infective endocarditis (IE) in the Spanish National Endocarditis Database (GAMES) and to compare it with antistaphylococcal penicillin (ASP). Methods: Prospective cohort study with retrospective analysis of a cohort of MSSA IE treated with cloxacillin and/or cefazolin. Outcomes assessed were relapse; intra-hospital, overall, and endocarditis-related mortality; and adverse events. Risk of renal toxicity with each treatment was evaluated separately. Results: We included 631 IE episodes caused by MSSA treated with cloxacillin and/or cefazolin. Antibiotic treatment was cloxacillin, cefazolin, or both in 537 (85%), 57 (9%), and 37 (6%) episodes, respectively. Patients treated with cefazolin had significantly higher rates of comorbidities (median Charlson Index 7, P <0.01) and previous renal failure (57.9%, P <0.01). Patients treated with cloxacillin presented higher rates of septic shock (25%, P = 0.033) and new-onset or worsening renal failure (47.3%, P = 0.024) with significantly higher rates of in-hospital mortality (38.5%, P = 0.017). One-year IE-related mortality and rate of relapses were similar between treatment groups. None of the treatments were identified as risk or protective factors. Conclusion: Our results suggest that cefazolin is a valuable option for the treatment of MSSA IE, without differences in 1-year mortality or relapses compared with cloxacillin, and might be considered equally effective

    Mural Endocarditis: The GAMES Registry Series and Review of the Literature

    No full text

    French Basque and Béarnais trade diaspora from the Spanish Basque Country during the eighteenth century

    No full text

    Role of age and comorbidities in mortality of patients with infective endocarditis.

    No full text
    The aim of this study was to analyse the characteristics of patients with IE in three groups of age and to assess the ability of age and the Charlson Comorbidity Index (CCI) to predict mortality. Prospective cohort study of all patients with IE included in the GAMES Spanish database between 2008 and 2015.Patients were stratified into three age groups: A total of 3120 patients with IE (1327  There were no differences in the clinical presentation of IE between the groups. Age ≥ 80 years, high comorbidity (measured by CCI),and non-performance of surgery were independent predictors of mortality in patients with IE.CCI could help to identify those patients with IE and surgical indication who present a lower risk of in-hospital and 1-year mortality after surgery, especially in th
    corecore