56 research outputs found
Zein-based nanospheres and nanocapsules for the encapsulation and oral delivery of quercetin
In this study, the ability of zein nanospheres (NS) and zein nanocapsules containing wheat germ oil (NC) to
enhance the bioavailability and efficacy of quercetin was evaluated. Both types of nanocarriers had similar
physico-chemical properties, including size (between 230 and 250 nm), spherical shape, negative zeta potential,
and surface hydrophobicity. However, NS displayed a higher ability than NC to interact with the intestinal
epithelium, as evidenced by an oral biodistribution study in rats. Moreover, both types of nanocarriers offered
similar loading efficiencies and release profiles in simulated fluids. In C. elegans, the encapsulation of quercetin in
nanospheres (Q-NS) was found to be two twice more effective than the free form of quercetin in reducing lipid
accumulation. For nanocapsules, the presence of wheat germ oil significantly increased the storage of lipids in
C. elegans; although the incorporation of quercetin (Q-NC) significantly counteracted the presence of the oil.
Finally, nanoparticles improved the oral absorption of quercetin in Wistar rats, offering a relative oral
bioavailability of 26% and 57% for Q-NS and Q-NC, respectively, compared to a 5% for the control formulation.
Overall, the study suggests that zein nanocarriers, particularly nanospheres, could be useful in improving the
bioavailability and efficacy of quercetin
Analysis of the influence of multiple parameters on the commercial categories of Extremadura virgin olive oils
Quantitative determination of coenzyme Q10 from dietary supplements by FT-NIR spectroscopy and statistical analysis
Multi-objective optimisation strategy based on desirability functions used for chromatographic separation and quantification of proline and organic acids in vinegar.
An optimisation strategy based on desirability functions together with experimental design has been used to optimise a chromatographic method applied to the separation and quantification of L-proline and seven organic acids in vinegar samples. Chromatographic problems often force to reach a compromise between different experimental variables in order to achieve the best chromatographic separation. The importance of the use of multi-objective optimisation methods lies in the ability to cope with this kind of problems. The quality of the multicriteria optimisation method was tested through the validation of the analytical parameters of the final chromatographic method developed. The versatility of this methodology allows to use it in other chromatographic applications resulting in a suitable adaptive procedure to solve new analytical problems. Furthermore, the determination of L-proline and organic acids in vinegar is useful for several industrial goals such as the correct monitoring of fermentation, for the study of nutrient needs at all times during the twofold fermentation process and for the detection of possible adulterations in the final product. © 2004 Elsevier B.V. All rights reserved
Classification of Wine and Alcohol Vinegar Samples Based on Near-Infrared Spectroscopy. Feasibility Study on the Detection of Adulterated Vinegar Samples
Optimisation of lactic acid fermentation for improved vinegar flavour during rosy vinegar brewing
Application of Competitive Adaptive Reweighted Sampling Method to Determine Effective Wavelengths for Prediction of Total Acid of Vinegar
Monitoring of Alcoholic Fermentation of Onion Juice by NIR Spectroscopy: Valorization of Worthless Onions
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